Memantine Hydrochloride

Dementia, Vascular, Dementia, Vascular, Alzheimer's Disease + 3 more
Treatment
4 FDA approvals
20 Active Studies for Memantine Hydrochloride

What is Memantine Hydrochloride

MemantineThe Generic name of this drug
Treatment SummaryMemantine is a drug approved by the FDA in 2013 to treat Alzheimer's Disease. It works differently than other Alzheimer's medications, as it targets the neurotransmitter glutamate which can cause too much stimulation in the brain. The number of people with Alzheimer's Disease is expected to grow significantly over the next couple of decades, making it a global priority to find a cure or treatment. Memantine is one of the medications being used to help manage the symptoms of Alzheimer's Disease.
Namendais the brand name
image of different drug pills on a surface
Memantine Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Namenda
Memantine
2003
235

Approved as Treatment by the FDA

Memantine, commonly known as Namenda, is approved by the FDA for 4 uses like Alzheimer's Disease and moderate Alzheimer's Type Dementia .
Alzheimer's Disease
Used to treat moderate Alzheimer's Type Dementia in combination with Donepezil
moderate Alzheimer's Type Dementia
Used to treat moderate Alzheimer's Type Dementia in combination with Donepezil
severe Alzheimer's Type Dementia
Helps manage severe Alzheimer's Type Dementia
Alzheimer's Disease
Helps manage severe Alzheimer's Type Dementia

Effectiveness

How Memantine Hydrochloride Affects PatientsMemantine works by blocking calcium from entering cells in the brain that are affected by chronic activation of the NMDA receptor. This helps to improve Alzheimer's dementia symptoms, and increase cognition. It can also act as a neuroprotectant against the destruction of neurons caused by excitatory neurotransmitters and improve memory. While memantine does not interfere with other receptors or channels, it does act as an antagonist of the 5HT3 receptor. Unlike other drugs used to treat Alzheimer's, memantine does not affect the reversible inhibition of the acetylcholinesterase.
How Memantine Hydrochloride works in the bodyGlutamate is a molecule that can over-activate certain receptors in the brain, which have been linked to Alzheimer's symptoms. Memantine works by blocking these receptors and preventing the glutamate from over-activating them. This helps to reduce the neurotoxicity associated with too much glutamate. Studies have not yet found that memantine can prevent or slow down the damage caused by Alzheimer's disease.

When to interrupt dosage

The proposed dosage of Memantine Hydrochloride is dependent upon the diagnosed disorder, including Alzheimer's Disease, Alzheimer's Disease and Dementia, Vascular. The measure of dosage shifts as per the method of delivery (e.g. Kit - Oral or Solution - Oral) presented in the below table.
Condition
Dosage
Administration
Alzheimer's Disease
, 5.0 mg, 10.0 mg, 2.0 mg/mL, 7.0 mg, 14.0 mg, 28.0 mg, 20.0 mg, 5.0 mg/pump actuation, 21.0 mg, 10.0 mg/mL, 15.0 mg, 70.0 mg
, Oral, Tablet, Tablet - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, Capsule - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Alzheimer's Disease
, 5.0 mg, 10.0 mg, 2.0 mg/mL, 7.0 mg, 14.0 mg, 28.0 mg, 20.0 mg, 5.0 mg/pump actuation, 21.0 mg, 10.0 mg/mL, 15.0 mg, 70.0 mg
, Oral, Tablet, Tablet - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, Capsule - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Dementia, Vascular
, 5.0 mg, 10.0 mg, 2.0 mg/mL, 7.0 mg, 14.0 mg, 28.0 mg, 20.0 mg, 5.0 mg/pump actuation, 21.0 mg, 10.0 mg/mL, 15.0 mg, 70.0 mg
, Oral, Tablet, Tablet - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, Capsule - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Dementia, Vascular
, 5.0 mg, 10.0 mg, 2.0 mg/mL, 7.0 mg, 14.0 mg, 28.0 mg, 20.0 mg, 5.0 mg/pump actuation, 21.0 mg, 10.0 mg/mL, 15.0 mg, 70.0 mg
, Oral, Tablet, Tablet - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, Capsule - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Alzheimer's Disease
, 5.0 mg, 10.0 mg, 2.0 mg/mL, 7.0 mg, 14.0 mg, 28.0 mg, 20.0 mg, 5.0 mg/pump actuation, 21.0 mg, 10.0 mg/mL, 15.0 mg, 70.0 mg
, Oral, Tablet, Tablet - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, Capsule - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Alzheimer's Disease
, 5.0 mg, 10.0 mg, 2.0 mg/mL, 7.0 mg, 14.0 mg, 28.0 mg, 20.0 mg, 5.0 mg/pump actuation, 21.0 mg, 10.0 mg/mL, 15.0 mg, 70.0 mg
, Oral, Tablet, Tablet - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, Capsule - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Memantine Hydrochloride has one contraindication, and so should not be employed when confronted with any of the conditions in the table below.Memantine Hydrochloride Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Memantine may interact with Pulse Frequency
There are 20 known major drug interactions with Memantine Hydrochloride.
Common Memantine Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Memantine.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Memantine.
Antipyrine
Major
The metabolism of Antipyrine can be decreased when combined with Memantine.
Apomorphine
Major
The metabolism of Apomorphine can be decreased when combined with Memantine.
Artemether
Major
The metabolism of Artemether can be decreased when combined with Memantine.
Memantine Hydrochloride Toxicity & Overdose RiskThe toxic dose of memantine in mice is 437-498mg/kg and 328-370mg/kg in rats. No evidence of carcinogenicity or genotoxicity was found when tested in mice or rats, and no effects on fertility or reproductive performance were observed in rats. There are not enough controlled studies to determine the safety of memantine during pregnancy, so it should only be taken if the potential benefit outweighs the potential risk to the fetus. It is unknown whether memantine is present in human milk, so caution should be taken if the drug is taken by a nursing mother.
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Memantine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Memantine Hydrochloride?

41 active trials are being conducted to explore the potential of Memantine Hydrochloride as a treatment option for Alzheimer's Disease, Dementia, Vascular and Alzheimer's Disease related symptoms.
Condition
Clinical Trials
Trial Phases
Alzheimer's Disease
3 Actively Recruiting
Phase 3, Phase 2
Alzheimer's Disease
0 Actively Recruiting
Alzheimer's Disease
35 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1
Dementia, Vascular
0 Actively Recruiting
Alzheimer's Disease
0 Actively Recruiting
Dementia, Vascular
0 Actively Recruiting

Memantine Hydrochloride Reviews: What are patients saying about Memantine Hydrochloride?

5Patient Review
6/27/2017
Memantine Hydrochloride for Moderate to Severe Alzheimer's Type Dementia
This medication, in combination with Aricept, has been very effective for my spouse. They've shown significant improvement in cognitive skills, writing ability, alertness, and even sense of humor. I couldn't be happier with how well it's working.
4.7Patient Review
6/29/2018
Memantine Hydrochloride for Moderate to Severe Alzheimer's Type Dementia
I'm a caregiver for a 65 year old woman and I've noticed that since she started this medication, she's been feeling more like herself. It seems to help stabilize her mood, which is great.
4.3Patient Review
2/7/2022
Memantine Hydrochloride for Moderate to Severe Alzheimer's Type Dementia
My spouse and I made the switch to this treatment about two months ago, and it's been working much better for her than the previous medication. She's more alert during the day now and doesn't have nearly as many issues with confusion or restlessness. Plus, she sleeps soundly at night and takes regular naps without any problems. We've noticed a big change in her overall attitude - she's much happier now. Thanks!
2Patient Review
3/8/2013
Memantine Hydrochloride for Moderate to Severe Alzheimer's Type Dementia
In week three of the treatment, I began to experience serious confusion. My body ached all over and I could barely stand up without losing my balance. Speaking was also become difficult and incoherent.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about memantine hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of taking memantine?

"The side effects of memantine may include feeling dizzy, confused, or having a headache."

Answered by AI

Does memantine improve memory?

"Memantine's purpose is to treat moderate to severe confusion that is related to Alzheimer's disease. It does not have the ability to cure Alzheimer's disease, but it may lead to an individual having improvements in their memory, awareness, and ability to perform daily tasks."

Answered by AI

What does memantine hydrochloride do?

"Memantine is a medication used to treat the symptoms of Alzheimer's disease. Memantine works by decreasing abnormal activity in the brain."

Answered by AI

What stage of dementia is memantine used for?

"The European Medicines Agency and the US Food and Drug Administration have both approved memantine for use in Alzheimer's disease."

Answered by AI

Clinical Trials for Memantine Hydrochloride

Have you considered Memantine Hydrochloride clinical trials? We made a collection of clinical trials featuring Memantine Hydrochloride, we think they might fit your search criteria.
Have you considered Memantine Hydrochloride clinical trials? We made a collection of clinical trials featuring Memantine Hydrochloride, we think they might fit your search criteria.
Have you considered Memantine Hydrochloride clinical trials? We made a collection of clinical trials featuring Memantine Hydrochloride, we think they might fit your search criteria.
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