Meclizine Hydrochloride

Disease, Vertigo, Airsickness

Treatment

5 FDA approvals

20 Active Studies for Meclizine Hydrochloride

Treatment for

Disease

What is Meclizine Hydrochloride

MeclizineThe Generic name of this drug

Treatment SummaryMeclizine is a medication used to prevent nausea, vomiting and dizziness caused by motion sickness and certain conditions that affect the inner ear. It works by blocking the action of histamine in the body. It is sold under the brand name Antivert in the U.S. and comes in the form of oral tablets.

Meclizine Hydrochlorideis the brand name

image of different drug pills on a surface

Meclizine Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Meclizine Hydrochloride

Meclizine

1981

193

Approved as Treatment by the FDA

Meclizine, commonly known as Meclizine Hydrochloride, is approved by the FDA for 5 uses including Motion Sickness and Disease .

Motion Sickness

Disease

Helps manage diseases affecting vestibular system

Airsickness

Vertigo

Helps manage Vertigo

diseases affecting vestibular system

Helps manage diseases affecting vestibular system

Effectiveness

How Meclizine Hydrochloride Affects PatientsMeclizine helps reduce feelings of nausea, vomiting, and dizziness. It is commonly used to treat motion sickness or other conditions that affect the balance system. It will start to work an hour after it is taken, and effects can last up to 24 hours. Meclizine may make you drowsy, as it has anticholinergic properties.

How Meclizine Hydrochloride works in the bodyVomiting and motion sickness are regulated by the brainstem. Different receptors in the brainstem, such as histamine, serotonin, enkephalins, substance P, and dopamine, are activated by different stimuli and cause the body to vomit. Meclizine helps prevent vomiting by blocking the histamine H1 receptors. This blocks signals from the vestibular nuclei and nucleus of the solitary tract to the brainstem and vomiting center. Meclizine may also reduce overactivity in the inner ear, which can cause motion sickness.

When to interrupt dosage

The suggested dosage of Meclizine Hydrochloride is contingent upon the diagnosed affliction, which includes Disease, Vertigo and Airsickness. The measure of dosage is delineated in the table below, as per the technique of application.

Condition

Dosage

Administration

Disease

, 12.5 mg, 25.0 mg, 50.0 mg, 0.25 mg, 30.0 mg

, Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Film, soluble, Film, soluble - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated

Vertigo

, 12.5 mg, 25.0 mg, 50.0 mg, 0.25 mg, 30.0 mg

Airsickness

, 12.5 mg, 25.0 mg, 50.0 mg, 0.25 mg, 30.0 mg

Warnings

Meclizine Hydrochloride Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Meclizine may interact with Pulse Frequency

There are 20 known major drug interactions with Meclizine Hydrochloride.

Common Meclizine Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Meclizine.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Meclizine.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Meclizine.

Azelastine

Major

Meclizine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Clomipramine

Major

The metabolism of Clomipramine can be decreased when combined with Meclizine.

Meclizine Hydrochloride Toxicity & Overdose RiskThe lowest toxic dose of meclizine in mice is 1600mg/kg when taken orally and 625mg/kg when given through an injection into the abdomen. For rats, the lowest toxic dose is 800mg/kg when taken orally. An overdose of meclizine can result in drowsiness, confusion, seizures, breathing problems, and low blood pressure, especially in the elderly. In children, symptoms may include hallucinations, insomnia, and anticholinergic effects. If someone has recently overdosed on meclizine, they should induce vomiting or use a gastric lavage to prevent further absorption of the drug.

image of a doctor in a lab doing drug, clinical research

Meclizine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Meclizine Hydrochloride?

10 active clinical trials are presently being conducted to examine the potential of Meclizine Hydrochloride as a therapy for Disease, Airsickness and Vertigo.

Condition

Clinical Trials

Trial Phases

Disease

15 Actively Recruiting

Not Applicable

Vertigo

3 Actively Recruiting

Phase 4, Not Applicable

Airsickness

4 Actively Recruiting

Phase 1, Not Applicable

Meclizine Hydrochloride Reviews: What are patients saying about Meclizine Hydrochloride?

5Patient Review

2/24/2022

Meclizine Hydrochloride for Motion Sickness

I've found this medication to be really effective in combating motion sickness, both on planes and more generally. I take a full dose an hour before takeoff with food, and it's helped me immensely.

5Patient Review

5/6/2017

Meclizine Hydrochloride for Prevention of Motion Sickness

I experience pain in my stomach whenever I take this pill, and have seen no other effects.

5Patient Review

9/1/2016

Meclizine Hydrochloride for Sensation of Spinning or Whirling

I don't get dizzy when I'm actively moving, just when I'm sitting or lying down. The Meclizine has been helping, but I remain perplexed as to why this is the case.

4.7Patient Review

8/22/2017

Meclizine Hydrochloride for Sensation of Spinning or Whirling

I was diagnosed with vertigo and given this medication. While it definitely lessened the severity of my symptoms, I'm still experiencing dizziness and spinning two months later.

4.7Patient Review

7/18/2021

Meclizine Hydrochloride for Motion Sickness

For nausea and motion sickness, this is my go-to drug. It takes effect in about half an hour, and while it does make me sleepy, that's a small price to pay for feeling better.

View All Reviews

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Patient Q&A Section about meclizine hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is it OK to take Meclizine everyday?

"Meclizine is not recommended for older adults due to the potential for negative side effects, but it is still prescribed regularly."

Answered by AI

Does Meclizine 25 mg make you sleepy?

"Meclizine may cause drowsiness which could affect your ability to drive or operate machinery. There may also be other side effects."

Answered by AI

How often can I take Meclizine 25 mg for vertigo?

"The recommended dosage of meclizine to prevent and treat motion sickness is 25-50 mg an hour before travel, and may be repeated every 24 hours as needed."

Answered by AI

What are the most common side effects of Meclizine?

"Some possible side effects of this medication include vision problems, a dry mouth, constipation, dizziness, drowsiness, headaches, vomiting, or fatigue."

Answered by AI

Clinical Trials for Meclizine Hydrochloride

Have you considered Meclizine Hydrochloride clinical trials? We made a collection of clinical trials featuring Meclizine Hydrochloride, we think they might fit your search criteria.

Explore trials for Meclizine Hydrochloride

Have you considered Meclizine Hydrochloride clinical trials? We made a collection of clinical trials featuring Meclizine Hydrochloride, we think they might fit your search criteria.