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What is Maxzide
TriamtereneThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a diuretic medication used to treat fluid retention, high blood pressure, and some other medical conditions. It is the most commonly prescribed thiazide diuretic. Hydrochlorothiazide is usually prescribed in combination with other medications such as angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers. It was approved by the FDA in 1959.
Maxzideis the brand name
Maxzide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Maxzide
Triamterene
1988
188
Effectiveness
How Maxzide Affects PatientsHydrochlorothiazide stops the body from reabsorbing salt and water from the kidneys, which in turn increases the amount of water passed out in the urine. It is usually prescribed on an individual basis and the dose can range from 25-100mg. People with reduced kidney or liver function should use this drug with caution.
How Maxzide works in the bodyHydrochlorothiazide works to reduce water absorption in the body. It enters cells that line the distal convoluted tubule, a part of the kidney, using special transporters. Normally, sodium is reabsorbed into these cells and creates a concentration gradient that absorbs water. Hydrochlorothiazide blocks this process by preventing sodium from being reabsorbed, reducing the concentration gradient and water absorption.
When to interrupt dosage
The measure of Maxzide is reliant upon the diagnosed condition, including Antepartum magnesium sulfate prophylaxis, inadequately managed blood pressure with monotherapy and antihypertensives. The dosage will depend on the method of delivery (e.g. Tablet, coated - Oral or Oral) as outlined in the table beneath.Condition
Dosage
Administration
Edema
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Diuretics
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Cirrhosis
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypertensive disease
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypokalemia
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Swollen feet or ankles
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Nephrotic Syndrome
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Edema
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Edema
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Thiazides
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Congestive Heart Failure
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Warnings
Maxzide ContraindicationsCondition
Risk Level
Notes
severe progressive kidney disease
Do Not Combine
elevated serum potassium levels
Do Not Combine
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
Liver diseases
Do Not Combine
Common Maxzide Drug Interactions
Drug Name
Risk Level
Description
Cyclosporine
Major
The risk or severity of hyperkalemia can be increased when Triamterene is combined with Cyclosporine.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Neomycin.
Tacrolimus
Major
The risk or severity of hyperkalemia can be increased when Triamterene is combined with Tacrolimus.
Tenofovir
Major
Triamterene may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Triamterene may increase the nephrotoxic activities of Tenofovir alafenamide.
Maxzide Toxicity & Overdose RiskThe least toxic dose of hydrochlorothiazide in mice and rats is higher than 10g/kg. Symptoms of an overdose may include low levels of potassium, chloride, and sodium in the blood, as well as low blood pressure. Treatment for this condition can include fluids and electrolytes, and medications to raise blood pressure if necessary. Oxygen may also be given if the patient has difficulty breathing.
Maxzide Novel Uses: Which Conditions Have a Clinical Trial Featuring Maxzide?
158 active studies are currently examining the capacity of Maxzide to ameliorate Cirrhosis, Edema and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Nephrotic Syndrome
10 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Edema
0 Actively Recruiting
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Cirrhosis
50 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Diuretics
0 Actively Recruiting
Edema
0 Actively Recruiting
Congestive Heart Failure
24 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Thiazides
0 Actively Recruiting
Edema
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Hypokalemia
0 Actively Recruiting
Maxzide Reviews: What are patients saying about Maxzide?
5Patient Review
10/6/2012 I've been using this for a while and it's really helped me. I was very satisfied with it, but then I lost my insurance and now I'm out of medication.
5Patient Review
10/16/2014 The only downside to this medication is that it makes me have to urinate frequently; however, it's doing what it's supposed to do.
5Patient Review
12/10/2011 I initially had some trouble when I started taking this medication; specifically, I was nauseous and lost a lot of weight. However, after making some adjustments to my diet and eating breakfast before taking the medication, I have not experienced any negative side effects. This has been an incredibly effective treatment for me.
5Patient Review
8/11/20115Patient Review
8/22/20115Patient Review
4/22/2012 This medication helped me a lot, but one of the side effects is that my fingers and toes are always cold.
4.7Patient Review
8/9/20114.3Patient Review
5/21/2012 I've been taking this for about five years now, and my blood pressure has always been monitored. Recently, it spiked up to 200/120, so I went to the ER. They found out that my kidneys were failing as a result of taking Maxzide. So beware if you're thinking of taking this drug--make sure to get your renal function checked often!
4Patient Review
6/30/2012 This medication has been effective in reducing the swelling in my feet and ankles. I've also had fewer kidney stones since starting this medication, and I've lost 28 pounds.
4Patient Review
8/30/2013 The pill is easy to swallow and I haven't had any significant side effects. My blood pressure is now under control, which is great. The only issue I've had is needing to urinate shortly after taking the medication, but it's not a big deal if you plan around it.
4Patient Review
3/31/2013 Maxzide does lower my blood pressure, but not by enough. Additionally, I feel incredibly fatigued and dizzy less than an hour after taking the medication.
3.3Patient Review
4/13/2012 I had to stop taking this medication because my local pharmacy didn't have it in stock.
3Patient Review
7/26/2013 I stopped taking this medication because I started experiencing terrible lower back pain, which was the only symptom I could link to the drug. Lupus might have been exacerbating my reaction to it.
3Patient Review
9/3/20112.3Patient Review
12/9/2012 I've been using maxzide for a while now and have found it to be effective.
2.3Patient Review
7/17/20111.7Patient Review
9/16/2011 I stopped taking this medication because it made me feel incredibly dizzy and drowsy. I've never experienced anything like it. Thankfully, I'm feeling better now. However, I have gained five pounds of water weight in the meantime.
Patient Q&A Section about maxzide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of Maxzide?
"The side effects of this medication include nausea, diarrhea, constipation, fatigue, headache, insomnia, and dry mouth."
Answered by AI
What is the drug Maxzide used for?
"This medication is used to lower blood pressure. This is done by a combination of two different "water pills", triamterene and hydrochlorothiazide. This lowers the risk of strokes, heart attacks, and kidney problems."
Answered by AI
What are the side effects of Maxzide 25?
"If you have any of the following symptoms, you should seek medical help immediately: yellow skin or eyes, a blistering, peeling, red skin rash, unusual bleeding or bruising, confusion, weakness, an uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips, or a fever, chills, cough, sore throat, or body aches."
Answered by AI
Is hydrochlorothiazide the same as Maxzide?
"Which component of MAXZIDE is responsible for reducing excessive potassium loss?
The triamterene component of MAXZIDE is responsible for reducing excessive potassium loss."
Answered by AI