Mavik

Congestive Heart Failure, Heart Attack, Ventricular Dysfunction, Left + 1 more

Treatment

20 Active Studies for Mavik

Treatment for

Congestive Heart Failure

What is Mavik

TrandolaprilThe Generic name of this drug

Treatment SummaryTrandolapril is a medication that belongs to the ACE inhibitor class. It works by blocking an enzyme in the body called angiotensin-converting enzyme (ACE), which helps regulate blood pressure. This drug is used to treat mild to moderate high blood pressure, improve heart function after a heart attack, treat congestive heart failure, and slow down kidney disease progression in people with diabetes and kidney problems.

Mavikis the brand name

image of different drug pills on a surface

Mavik Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Mavik

Trandolapril

1996

Effectiveness

How Mavik Affects PatientsTrandolapril works by blocking an enzyme (ACE) in the body that helps control blood pressure. ACE is part of the RAAS system, which helps to regulate and maintain healthy blood pressure by releasing hormones like aldosterone, vasopressin, and antidiuretic hormone. These hormones then help the body to reabsorb sodium, potassium, and water from the kidneys, which leads to increased blood pressure. Trandolapril prevents this process from happening, which lowers blood pressure and relaxes the muscles of the arteries. It also helps boost levels of bradykinin, a naturally occurring chemical that can

How Mavik works in the bodyACE inhibitors work by blocking two different types of ACE proteins - one found in the body and one found in the testicles. The body-found ACE protein has two parts that do different things - one helps regulate blood pressure, and the other helps with the growth and development of blood cells. Trandolaprilat, the active form of trandolapril, blocks both parts of this ACE protein. This reduces the amount of ACE molecules in the body and also increases renin activity, which helps to reduce blood pressure.

When to interrupt dosage

The prescribed dosage of Mavik is contingent upon the determined condition, including Heart Attack, Left Ventricular Dysfunction and Hypertensive disease. The amount of dosage fluctuates, contingent upon the method of delivery indicated in the table below.

Condition

Dosage

Administration

Congestive Heart Failure

4.0 mg, , 1.0 mg, 2.0 mg, 0.5 mg

, Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral

Heart Attack

4.0 mg, , 1.0 mg, 2.0 mg, 0.5 mg

, Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral

Ventricular Dysfunction, Left

4.0 mg, , 1.0 mg, 2.0 mg, 0.5 mg

, Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral

Hypertensive disease

4.0 mg, , 1.0 mg, 2.0 mg, 0.5 mg

, Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral

Warnings

Mavik Contraindications

Condition

Risk Level

Notes

Angioedema

Do Not Combine

Angioedemas, Hereditary

Do Not Combine

Type 2 Diabetes

Do Not Combine

There are 20 known major drug interactions with Mavik.

Common Mavik Drug Interactions

Drug Name

Risk Level

Description

Amifostine

Major

Trandolapril may increase the hypotensive activities of Amifostine.

Azathioprine

Major

The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Trandolapril is combined with Azathioprine.

Lithium carbonate

Major

The serum concentration of Lithium carbonate can be increased when it is combined with Trandolapril.

Lithium citrate

Major

The serum concentration of Lithium citrate can be increased when it is combined with Trandolapril.

Lithium hydroxide

Major

The serum concentration of Lithium hydroxide can be increased when it is combined with Trandolapril.

Mavik Toxicity & Overdose RiskOverdosing on trandolapril can cause low blood pressure, coughing, headaches, and dizziness. Studies in mice, rats, and dogs have shown that very high doses of trandolapril may be necessary to cause death or serious health issues.

image of a doctor in a lab doing drug, clinical research

Mavik Novel Uses: Which Conditions Have a Clinical Trial Featuring Mavik?

391 active clinical trials are in progress to investigate the potential of Mavik in treating Hypertensive disease, Left Ventricular Dysfunction and Congestive Heart Failure.

Condition

Clinical Trials

Trial Phases

Hypertensive disease

23 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Heart Attack

26 Actively Recruiting

Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1, Phase 3

Ventricular Dysfunction, Left

0 Actively Recruiting

Congestive Heart Failure

175 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1

Mavik Reviews: What are patients saying about Mavik?

5Patient Review

7/11/2012

Mavik for High Blood Pressure

This drug is awesome. I'm grateful for modern medicine.

5Patient Review

3/26/2011

Mavik for High Blood Pressure

This drug is awesome. I'm grateful for modern medicine.

5Patient Review

7/30/2011

Mavik for High Blood Pressure

This drug is awesome. I love drugs.

4.7Patient Review

12/12/2018

Mavik for High Blood Pressure

I experience some side effects like a dry throat and increased mucus production, but it's manageable. My blood pressure has stayed normal for the four years I've been taking this medication (I upped the dosage from 1mg to 2mg).

4.3Patient Review

12/10/2012

Mavik for High Blood Pressure

I experienced a lot of side effects with this treatment, like dizziness, nausea, and excessive sweating. Surely there's a better solution out there.

View All Reviews

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Patient Q&A Section about mavik

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is mavik prescribed for?

"This medication, Trandolapril, is used to lower high blood pressure in order to prevent strokes, heart attacks, and kidney problems. It is also used to treat heart failure and improve survival rates after a heart attack."

Answered by AI

When is the best time to take mavik?

"Take the capsules as prescribed by your doctor. Your doctor may tell you to take your first dose at bedtime as you may feel dizzy when you first start taking the medication."

Answered by AI

What are the side effects of mavik?

"You may experience dizziness, drowsiness, lightheadedness, diarrhea, dry cough, or blurred vision as your body adjusts to the medication."

Answered by AI

What class of drug is mavik?

"Mavik works by relaxing blood vessels so that blood can flow more easily.

Mavik is a prescription medication that is used to treat hypertension, congestive heart failure, or left ventricular dysfunction post-MI. It may be used alone or in combination with other medications. Mavik falls under a class of drugs known as ACE inhibitors. Its mechanism of action is by relaxing blood vessels so that blood can flow more easily."

Answered by AI