Marcaine

Stevens-Johnson Syndrome, Ophthalmia, Sympathetic, Berylliosis + 71 more

Treatment

16 FDA approvals

20 Active Studies for Marcaine

Treatment for

Stevens-Johnson Syndrome

What is Marcaine

Bupivacaine

The Generic name of this drug

Treatment Summary

Bupivacaine is a medication used as a local anesthetic to numb a specific area of the body.

Bupivacaine Hydrochloride and Epinephrine

is the brand name

image of different drug pills on a surface

Marcaine Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bupivacaine Hydrochloride and Epinephrine

Bupivacaine

1988

197

Approved as Treatment by the FDA

Bupivacaine, also known as Bupivacaine Hydrochloride and Epinephrine, is approved by the FDA for 16 uses including Alopecia Areata and Inflammation .

Alopecia Areata

Used to treat Alopecia Areata (AA) in combination with Lidocaine

Inflammation

Used to treat inflammatory lesions of lichen simplex in combination with Lidocaine

Psoriasis

Used to treat Psoriatic plaque in combination with Lidocaine

Inflammation

Used to treat inflammatory lesions of granuloma annulare in combination with Lidocaine

Nerve Block

Discoid Lupus Erythematosus (DLE)

Used to treat Discoid Lupus Erythematosus (DLE) in combination with Lidocaine

Flatfoot

Used to treat inflammatory lesions of lichen planus in combination with Lidocaine

Tendon structure

Used to treat cystic tumors of tendon in combination with Lidocaine

Alopecia Areata (AA)

Used to treat Alopecia Areata (AA) in combination with Lidocaine

Aponeurosis structure

Used to treat cystic tumors of aponeurosis in combination with Lidocaine

General Anesthesia

Keloids Scars

Used to treat Keloids Scars in combination with Lidocaine

Psoriatic plaque

Used to treat Psoriatic plaque in combination with Lidocaine

Lupus Erythematosus, Discoid

Used to treat Discoid Lupus Erythematosus (DLE) in combination with Lidocaine

Local Anaesthesia therapy

Necrobiosis Lipoidica

Used to treat Necrobiosis lipoidica diabeticorum in combination with Lidocaine

Effectiveness

How Marcaine Affects Patients

Bupivacaine is a common local anesthetic used to reduce pain, often injected near surgical sites or into the spine prior to major operations. It is long lasting and can reduce pain for up to 20 hours after surgery. However, it is also very toxic to the heart when taken in large doses, so other anesthetics, such as ropivacaine and levobupivacaine, are usually used instead. These anesthetics can lead to changes in the heart's conduction and contractility and can even cause cardiac arrest. They can also affect the central nervous system, causing stimulation, depression, or both

How Marcaine works in the body

Bupivacaine is a type of local anesthetic that stops nerve signals from travelling down nerves. It does this by blocking sodium channels in the cells. The size, myelination, and conduction velocity of the nerve determines how fast the anesthesia takes effect. Pain is the first sensation to be lost, followed by temperature, touch, proprioception, and muscle tone. Bupivacaine also works by attaching to a receptor that reduces inflammation and fever, which helps decrease pain.

When to interrupt dosage

The proposed dose of Marcaine is contingent upon the diagnosed condition, including Idiopathic Nephrotic Syndrome, Lupus and Thyroiditis. The amount of dosage is contingent upon the technique of delivery specified in the following table.

Condition

Dosage

Administration

Berylliosis

, 5.0 mg/mL, 7.5 mg/mL, 2.5 mg/mL, 1.25 mg/mL, 1.0 mg/mL, 2.5 mg, 5.0 mg, 7.5 mg, 13.3 mg/mL, 15.0 mg, 100.0 mg, 50.0 mg, 150.0 mg, 125.0 mg, 250.0 mg, 3.0 mg/mL, 1.0 mg/mg, 3.75 mg/mL, 9.0 mg/mL, 12.5 mg/mL, 25.0 mg/mL, 26.6 mg/mL, 200.0 mg, 60.0 mg, 400.0 mg, 200.0 mg/mL, 30.0 mg/mL, 40.0 mg/mL, 60.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 660.0 mg/mL

, Injection, solution, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Retrobulbar, Injection, solution - Epidural; Infiltration; Intracaudal, Injection, solution - Subarachnoid, Subarachnoid, Epidural; Infiltration; Intracaudal, Injection, solution - Epidural; Retrobulbar, Epidural, Injection, solution - Epidural, Perineural, Injection, solution - Perineural, Injection, solution - Epidural; Infiltration, Epidural; Infiltration, Infiltration, Injection, solution - Infiltration, Injection, solution - Epidural; Intracaudal, Epidural; Intracaudal, Kit, Infiltration; Perineural, Injection, solution - Infiltration; Perineural, Epidural; Infiltration; Intracaudal; Perineural, Epidural; Intracaudal; Perineural, Injection, solution - Epidural; Infiltration; Intracaudal; Perineural, Injection, solution - Epidural; Intracaudal; Perineural, Solution, Solution - Epidural; Infiltration, Intraspinal, Solution - Intraspinal, Solution - Epidural; Retrobulbar, Solution - Infiltration, Liquid, Liquid - Epidural; Retrobulbar, Liquid - Epidural; Infiltration, Liquid - Intraspinal, Liquid - Infiltration, Solution - Epidural; Infiltration; Intracaudal, Kit - Topical, Topical, Injection, suspension, liposomal, Injection, suspension, liposomal - Infiltration, Injection, solution - Intraspinal, Kit - Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue, Kit - Epidural; Infiltration, Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Dental; Infiltration, Dental; Infiltration, Epidural; Infiltration; Intramuscular; Intrasynovial; Soft tissue; Topical, Kit - Epidural; Infiltration; Intramuscular; Intrasynovial; Soft tissue; Topical, Epidural; Infiltration; Intravenous, Kit - Epidural; Infiltration; Intravenous, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular, Epidural; Infiltration; Topical, Kit - Epidural; Infiltration; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Epidural; Infiltration; Intra-articular; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical, Epidural; Parenteral, Injection, Injection - Epidural; Parenteral, Injection - Epidural; Parenteral; Retrobulbar, Spray, metered - Topical, Spray, metered, Epidural; Intra-articular; Intramuscular; Topical, Kit - Epidural; Intra-articular; Intramuscular; Topical, Retrobulbar, Injection - Retrobulbar, Epidural; Parenteral; Retrobulbar, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Epidural; Infiltration; Parenteral, Injection - Epidural; Infiltration; Parenteral, Infiltration; Parenteral, Injection - Infiltration; Parenteral, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Parenteral, Injection - Parenteral, Kit - Epidural; Infiltration; Intracaudal; Perineural, Enteral; Epidural; Intracaudal, Injection, solution - Enteral; Epidural; Intracaudal, Injection - Subarachnoid, Injection - Epidural; Intracaudal; Perineural, Intravenous, Injection - Intravenous, Intra-articular; Intramuscular, Implant, Implant - Parenteral, Solution - Intralesional, Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Kit - Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Intralesional

Psoriasis

Psoriatic Arthritis

Red-Cell Aplasia, Pure

Arthritis, Gouty

General Anesthesia

Epidural Block

Anesthesia, Conduction

Idiopathic Nephrotic Syndrome

Inflammation

Analgesics

Multiple Sclerosis

Bullous dermatitis herpetiformis

Arthroscopy

Lupus

Anemia, Hemolytic

Lymphoma, Non-Hodgkin

Inflammation

Interscalene Nerve Block

Lupus erythematosus cell

Warnings

Marcaine Contraindications

Condition

Risk Level

Notes

Coronary Artery Bypass Grafting

Do Not Combine

history of NSAID allergy

Do Not Combine

obstetrical paracervical block anesthesia

Do Not Combine

Asthma

Do Not Combine

obstetrical paracervical block anesthesia

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Bupivacaine may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Bupivacaine may interact with Pulse Frequency

There are 20 known major drug interactions with Marcaine.

Common Marcaine Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Bupivacaine.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Bupivacaine.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Bupivacaine.

Azelastine

Major

Bupivacaine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Clomipramine

Major

The metabolism of Clomipramine can be decreased when combined with Bupivacaine.

Marcaine Toxicity & Overdose Risk

The average toxic dose of bupivacaine in monkeys is 4.4mg/kg and the lethal dose in mice is 6 to 8mg/kg through intravenous administration and 38 to 54mg/kg through subcutaneous administration. Patients who experience convulsions due to bupivacaine may develop hypoxia, hypercarbia, and acidosis within a minute, so it is important to provide oxygen and effective ventilation immediately to avoid cardiac arrest.

image of a doctor in a lab doing drug, clinical research

Marcaine Novel Uses: Which Conditions Have a Clinical Trial Featuring Marcaine?

288 active trials are examining the possibility of Marcaine to ameliorate Ulcerative Colitis, Lupus and Rheumatoid Arthritis.

Condition

Clinical Trials

Trial Phases

Lupus

65 Actively Recruiting

Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1

Rheumatoid Arthritis

55 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Labor Pain

0 Actively Recruiting

Osteoarthritis

0 Actively Recruiting

General Anesthesia

1 Actively Recruiting

Phase 4

Regional Analgesia

0 Actively Recruiting

Hypersensitivity

0 Actively Recruiting

Local Analgesia

0 Actively Recruiting

Craniotomy

0 Actively Recruiting

Alopecia Areata

1 Actively Recruiting

Phase 1

Local Anaesthesia therapy

0 Actively Recruiting

Idiopathic Nephrotic Syndrome

0 Actively Recruiting

Ulcerative Colitis

14 Actively Recruiting

Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1

Adrenal Insufficiency

0 Actively Recruiting

induction of Local Anaesthesia

0 Actively Recruiting

Inflammation

0 Actively Recruiting

Open Abdominal Surgery

1 Actively Recruiting

Not Applicable

Multiple Sclerosis

0 Actively Recruiting

Inflammation

0 Actively Recruiting

Tuberculosis, Pulmonary

0 Actively Recruiting

Marcaine Reviews: What are patients saying about Marcaine?

Patient Review

4/22/2009

Marcaine for Local Anesthesia for Surgical or Other Procedure

I had an allergic reaction that resulted in my skin blistering. I also still have numbness in part of my foot, even 4 weeks later.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about marcaine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the drug Marcaine used for?

"Marcaine Injection is a local anesthetic used for a spinal block. Marcaine is available in generic form."

Answered by AI

Are lidocaine and Marcaine the same?

"Local anesthetics like Xylocaine (lidocaine) and Marcaine (bupivacaine hydrochloride) work by numbing the area where they're applied. Marcaine is longer-acting, so it's often used for a spinal block. Lidocaine is used for both local and regional anesthesia."

Answered by AI

Where do you inject Marcaine?

"A longer-lasting local anesthetic is desired for procedures that are generally associated with significant postoperative pain, and Marcaine with epinephrine 0.5% (5 mg/mL) is recommended for infiltration and block injections in the maxillary and mandibular area."

Answered by AI

How long do Marcaine injections last?

"Anesthesia following dental injections typically lasts 2-10 minutes. In many cases, it can last up to 7 hours. This is due to the addition of epinephrine 1:200,000."

Answered by AI