Mannitol 20%

Irrigation, Brain, induction of Diuresis + 9 more

Treatment

12 FDA approvals

0 Active Studies for Mannitol 20%

Treatment for

Irrigation

What is Mannitol 20%

Mannitol

The Generic name of this drug

Treatment Summary

Mannitol is a natural sugar or sugar alcohol found in fruits and vegetables. It is used to reduce swelling in the brain and other tissues, as well as promoting diuresis and aiding in the removal of toxic substances from the body. In 2020, mannitol was approved by the FDA as a maintenance therapy for cystic fibrosis in adults. It is sold under the brand name BRONCHITOL® by Chiesi USA Inc.

Osmitrol

is the brand name

image of different drug pills on a surface

Mannitol 20% Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Osmitrol

Mannitol

1964

Approved as Treatment by the FDA

Mannitol, commonly known as Osmitrol, is approved by the FDA for 12 uses which include Increased Intra Ocular Pressure (IOP) and Brain .

Increased Intra Ocular Pressure (IOP)

Helps manage Increased Intra Ocular Pressure (IOP)

Brain

Acute Renal Failure (ARF)

collection, processing, and preservation of blood components

Used to treat collection, processing, and preservation of blood components in combination with Adenine

Edema of the cerebrum

Diuresis

Urinary Bladder

transurethral surgery

Used to treat transurethral surgery in combination with Sorbitol

Kidney Failure, Acute

Irrigation

Glaucoma

Helps manage Increased Intra Ocular Pressure (IOP)

induction of Diuresis

Effectiveness

How Mannitol 20% Affects Patients

Mannitol is a type of sugar alcohol that when added to water can make the solution acidic. For this reason, it is sometimes combined with a substance, such as sodium bicarbonate, to adjust its pH. Mannitol is usually taken to increase urine production and to treat medical conditions caused by excessive fluid in the body. It is often combined with other diuretics and/or fluids given intravenously. Inhaling mannitol can cause bronchospasm and coughing up blood, so it should be stopped if either of these occur.

How Mannitol 20% works in the body

Mannitol is a natural sugar found in fruits and vegetables that helps reduce swelling in the brain and eyes. It also helps flush out toxins from the body and can be used to measure the filtration rate of the kidneys. In people with cystic fibrosis, mannitol works by creating an osmotic gradient that draws fluid out of the cells in the airway, making it easier for mucus to be cleared.

When to interrupt dosage

The prescribed dose of Mannitol 20% is dependent upon the diagnosed situation, including glomerular filtration rate measurement, transurethral surgery and Kidney Failure, Acute. The amount of dosage is contingent upon the method of delivery (e.g. Kit - Intravenous or Liquid) indicated in the table below.

Condition

Dosage

Administration

glomerular filtration rate measurement

, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 250.0 mg/mL, 5.0 %, 40.0 mg, 1250.0 mg/mL, 5.4 mg/mL, 7.5 mg/mL, 0.525 %, 8.25 mg/mL, 5.0 mg, 5.25 mg/mL, 5250.0 mg, 10.0 mg, 0.3 mg/mg, 20.0 %, 25.0 %, 10.0 %, 60.0 mg/mL, 5.0 mg/mL

, Irrigation, Irrigant, Irrigant - Irrigation, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Liquid - Irrigation, Solution - Irrigation, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Urethral, Irrigant - Urethral, Topical, Liquid - Topical, Kit, Kit - Intravenous, Kit; Powder, Kit; Powder - Respiratory (inhalation), Cream, Cream - Topical, Solution - Extracorporeal, Extracorporeal, Powder, Powder - Topical, Kit - Topical, Kit - Respiratory (inhalation)

Brain

induction of Diuresis

Kidney Failure, Acute

Glucose tolerance test

Irrigation

Diuresis

Urinary Bladder

Glaucoma

Cystic Fibrosis

transurethral surgery

collection, processing, and preservation of blood components

Warnings

Mannitol 20% has eleven contraindications, thus it should not be administered in combination with the circumstances listed in the following table.

Mannitol 20% Contraindications

Condition

Risk Level

Notes

Adrenal gland hypofunction

Do Not Combine

Craniotomy

Do Not Combine

mannitol-driven progressive heart failure

Do Not Combine

Anuria

Do Not Combine

Dehydration

Do Not Combine

mannitol-driven progressive oliguria

Do Not Combine

Pulmonary Edema

Do Not Combine

mannitol-driven progressive pulmonary congestion

Do Not Combine

Azotemia

Do Not Combine

mannitol-driven progressive renal damage

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Mannitol may interact with Pulse Frequency

There are 20 known major drug interactions with Mannitol 20%.

Common Mannitol 20% Drug Interactions

Drug Name

Risk Level

Description

Neomycin

Major

The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Neomycin.

Acebutolol

Minor

The risk or severity of adverse effects can be increased when Mannitol is combined with Acebutolol.

Aceclofenac

Minor

The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Aceclofenac.

Acyclovir

Minor

The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Acyclovir.

Adefovir

Minor

The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Adefovir.

Mannitol 20% Toxicity & Overdose Risk

Overdosing on mannitol can lead to constriction of the airways, which can be treated by administering a short-acting bronchodilator. Other supportive and symptomatic care may also be necessary.

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Mannitol 20% Novel Uses: Which Conditions Have a Clinical Trial Featuring Mannitol 20%?

Three active clinical trials are currently examining the potential of Mannitol 20% to alleviate Brain, Kidney Failure, Acute and Diuresis Symptoms.

Condition

Clinical Trials

Trial Phases

glomerular filtration rate measurement

0 Actively Recruiting

Glucose tolerance test

0 Actively Recruiting

Diuresis

0 Actively Recruiting

Urinary Bladder

0 Actively Recruiting

Cystic Fibrosis

0 Actively Recruiting

induction of Diuresis

0 Actively Recruiting

Glaucoma

0 Actively Recruiting

Kidney Failure, Acute

0 Actively Recruiting

Brain

0 Actively Recruiting

transurethral surgery

0 Actively Recruiting

Irrigation

0 Actively Recruiting

collection, processing, and preservation of blood components

0 Actively Recruiting

Mannitol 20% Reviews: What are patients saying about Mannitol 20%?

3.7

Patient Review

12/21/2008

Mannitol 20% for Fluid Accumulation in the Brain

3.3

Patient Review

11/9/2011

Mannitol 20% for Fluid Accumulation in the Brain

I had an acute stroke in my MCA.

Patient Review

9/20/2012

Mannitol 20% for High Pressure Within the Skull

This treatment is just okay. It didn't really help me that much.

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Patient Q&A Section about mannitol 20%

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is 10% mannitol used for?

"Mannitol 10% is an osmotic diuretic that is prescribed to help relieve increased pressure in the brain and eyes, as well as to promote the excretion of toxins through urine in patients with kidney failure."

Answered by AI

What is 20% mannitol used for?

"This medicine is used to treat acute renal (kidney) failure, cerebral edema (accumulation of excessive fluid in the brain), and to reduce the pressure inside the eyes in a condition called glaucoma."

Answered by AI

What is the use of mannitol solution?

"This indicates that the 10% solution of Mannitol is effective in preventing renal failure by promoting diuresis, or the increased production of urine."

Answered by AI