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What is Mannitol 20%
MannitolThe Generic name of this drug
Treatment SummaryMannitol is a natural sugar or sugar alcohol found in fruits and vegetables. It is used to reduce swelling in the brain and other tissues, as well as promoting diuresis and aiding in the removal of toxic substances from the body. In 2020, mannitol was approved by the FDA as a maintenance therapy for cystic fibrosis in adults. It is sold under the brand name BRONCHITOL® by Chiesi USA Inc.
Osmitrolis the brand name
Mannitol 20% Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Osmitrol
Mannitol
1964
80
Approved as Treatment by the FDA
Mannitol, commonly known as Osmitrol, is approved by the FDA for 9 uses which include Increased Intra Ocular Pressure (IOP) and transurethral surgery .Increased Intra Ocular Pressure (IOP)
Helps manage Increased Intra Ocular Pressure (IOP)
transurethral surgery
Used to treat transurethral surgery in combination with Sorbitol
Brain
Kidney Failure, Acute
Urinary Bladder
collection, processing, and preservation of blood components
Used to treat collection, processing, and preservation of blood components in combination with Adenine
Diuresis
Irrigation
induction of Diuresis
Effectiveness
How Mannitol 20% Affects PatientsMannitol is a type of sugar alcohol that when added to water can make the solution acidic. For this reason, it is sometimes combined with a substance, such as sodium bicarbonate, to adjust its pH. Mannitol is usually taken to increase urine production and to treat medical conditions caused by excessive fluid in the body. It is often combined with other diuretics and/or fluids given intravenously. Inhaling mannitol can cause bronchospasm and coughing up blood, so it should be stopped if either of these occur.
How Mannitol 20% works in the bodyMannitol is a natural sugar found in fruits and vegetables that helps reduce swelling in the brain and eyes. It also helps flush out toxins from the body and can be used to measure the filtration rate of the kidneys. In people with cystic fibrosis, mannitol works by creating an osmotic gradient that draws fluid out of the cells in the airway, making it easier for mucus to be cleared.
When to interrupt dosage
The prescribed dose of Mannitol 20% is dependent upon the diagnosed situation, including glomerular filtration rate measurement, transurethral surgery and Kidney Failure, Acute. The amount of dosage is contingent upon the method of delivery (e.g. Kit - Intravenous or Liquid) indicated in the table below.Condition
Dosage
Administration
Irrigation
, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 250.0 mg/mL, 5.0 %, 40.0 mg, 1250.0 mg/mL, 5.4 mg/mL, 7.5 mg/mL, 0.525 %, 8.25 mg/mL, 5.0 mg, 5.25 mg/mL, 5250.0 mg, 10.0 mg, 0.3 mg/mg, 20.0 %, 25.0 %, 10.0 %, 60.0 mg/mL, 5.0 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Liquid - Irrigation, Solution - Irrigation, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Urethral, Irrigant - Urethral, Topical, Liquid - Topical, Kit, Kit - Intravenous, Kit; Powder, Kit; Powder - Respiratory (inhalation), Cream, Cream - Topical, Solution - Extracorporeal, Extracorporeal, Powder, Powder - Topical, Kit - Topical, Kit - Respiratory (inhalation)
Diuresis
, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 250.0 mg/mL, 5.0 %, 40.0 mg, 1250.0 mg/mL, 5.4 mg/mL, 7.5 mg/mL, 0.525 %, 8.25 mg/mL, 5.0 mg, 5.25 mg/mL, 5250.0 mg, 10.0 mg, 0.3 mg/mg, 20.0 %, 25.0 %, 10.0 %, 60.0 mg/mL, 5.0 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Liquid - Irrigation, Solution - Irrigation, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Urethral, Irrigant - Urethral, Topical, Liquid - Topical, Kit, Kit - Intravenous, Kit; Powder, Kit; Powder - Respiratory (inhalation), Cream, Cream - Topical, Solution - Extracorporeal, Extracorporeal, Powder, Powder - Topical, Kit - Topical, Kit - Respiratory (inhalation)
glomerular filtration rate measurement
, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 250.0 mg/mL, 5.0 %, 40.0 mg, 1250.0 mg/mL, 5.4 mg/mL, 7.5 mg/mL, 0.525 %, 8.25 mg/mL, 5.0 mg, 5.25 mg/mL, 5250.0 mg, 10.0 mg, 0.3 mg/mg, 20.0 %, 25.0 %, 10.0 %, 60.0 mg/mL, 5.0 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Liquid - Irrigation, Solution - Irrigation, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Urethral, Irrigant - Urethral, Topical, Liquid - Topical, Kit, Kit - Intravenous, Kit; Powder, Kit; Powder - Respiratory (inhalation), Cream, Cream - Topical, Solution - Extracorporeal, Extracorporeal, Powder, Powder - Topical, Kit - Topical, Kit - Respiratory (inhalation)
Kidney Failure, Acute
, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 250.0 mg/mL, 5.0 %, 40.0 mg, 1250.0 mg/mL, 5.4 mg/mL, 7.5 mg/mL, 0.525 %, 8.25 mg/mL, 5.0 mg, 5.25 mg/mL, 5250.0 mg, 10.0 mg, 0.3 mg/mg, 20.0 %, 25.0 %, 10.0 %, 60.0 mg/mL, 5.0 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Liquid - Irrigation, Solution - Irrigation, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Urethral, Irrigant - Urethral, Topical, Liquid - Topical, Kit, Kit - Intravenous, Kit; Powder, Kit; Powder - Respiratory (inhalation), Cream, Cream - Topical, Solution - Extracorporeal, Extracorporeal, Powder, Powder - Topical, Kit - Topical, Kit - Respiratory (inhalation)
Glucose tolerance test
, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 250.0 mg/mL, 5.0 %, 40.0 mg, 1250.0 mg/mL, 5.4 mg/mL, 7.5 mg/mL, 0.525 %, 8.25 mg/mL, 5.0 mg, 5.25 mg/mL, 5250.0 mg, 10.0 mg, 0.3 mg/mg, 20.0 %, 25.0 %, 10.0 %, 60.0 mg/mL, 5.0 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Liquid - Irrigation, Solution - Irrigation, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Urethral, Irrigant - Urethral, Topical, Liquid - Topical, Kit, Kit - Intravenous, Kit; Powder, Kit; Powder - Respiratory (inhalation), Cream, Cream - Topical, Solution - Extracorporeal, Extracorporeal, Powder, Powder - Topical, Kit - Topical, Kit - Respiratory (inhalation)
Cystic Fibrosis (CF)
, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 250.0 mg/mL, 5.0 %, 40.0 mg, 1250.0 mg/mL, 5.4 mg/mL, 7.5 mg/mL, 0.525 %, 8.25 mg/mL, 5.0 mg, 5.25 mg/mL, 5250.0 mg, 10.0 mg, 0.3 mg/mg, 20.0 %, 25.0 %, 10.0 %, 60.0 mg/mL, 5.0 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Liquid - Irrigation, Solution - Irrigation, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Urethral, Irrigant - Urethral, Topical, Liquid - Topical, Kit, Kit - Intravenous, Kit; Powder, Kit; Powder - Respiratory (inhalation), Cream, Cream - Topical, Solution - Extracorporeal, Extracorporeal, Powder, Powder - Topical, Kit - Topical, Kit - Respiratory (inhalation)
Urinary Bladder
, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 250.0 mg/mL, 5.0 %, 40.0 mg, 1250.0 mg/mL, 5.4 mg/mL, 7.5 mg/mL, 0.525 %, 8.25 mg/mL, 5.0 mg, 5.25 mg/mL, 5250.0 mg, 10.0 mg, 0.3 mg/mg, 20.0 %, 25.0 %, 10.0 %, 60.0 mg/mL, 5.0 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Liquid - Irrigation, Solution - Irrigation, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Urethral, Irrigant - Urethral, Topical, Liquid - Topical, Kit, Kit - Intravenous, Kit; Powder, Kit; Powder - Respiratory (inhalation), Cream, Cream - Topical, Solution - Extracorporeal, Extracorporeal, Powder, Powder - Topical, Kit - Topical, Kit - Respiratory (inhalation)
Brain
, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 250.0 mg/mL, 5.0 %, 40.0 mg, 1250.0 mg/mL, 5.4 mg/mL, 7.5 mg/mL, 0.525 %, 8.25 mg/mL, 5.0 mg, 5.25 mg/mL, 5250.0 mg, 10.0 mg, 0.3 mg/mg, 20.0 %, 25.0 %, 10.0 %, 60.0 mg/mL, 5.0 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Liquid - Irrigation, Solution - Irrigation, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Urethral, Irrigant - Urethral, Topical, Liquid - Topical, Kit, Kit - Intravenous, Kit; Powder, Kit; Powder - Respiratory (inhalation), Cream, Cream - Topical, Solution - Extracorporeal, Extracorporeal, Powder, Powder - Topical, Kit - Topical, Kit - Respiratory (inhalation)
Increased Intra Ocular Pressure (IOP)
, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 250.0 mg/mL, 5.0 %, 40.0 mg, 1250.0 mg/mL, 5.4 mg/mL, 7.5 mg/mL, 0.525 %, 8.25 mg/mL, 5.0 mg, 5.25 mg/mL, 5250.0 mg, 10.0 mg, 0.3 mg/mg, 20.0 %, 25.0 %, 10.0 %, 60.0 mg/mL, 5.0 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Liquid - Irrigation, Solution - Irrigation, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Urethral, Irrigant - Urethral, Topical, Liquid - Topical, Kit, Kit - Intravenous, Kit; Powder, Kit; Powder - Respiratory (inhalation), Cream, Cream - Topical, Solution - Extracorporeal, Extracorporeal, Powder, Powder - Topical, Kit - Topical, Kit - Respiratory (inhalation)
transurethral surgery
, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 250.0 mg/mL, 5.0 %, 40.0 mg, 1250.0 mg/mL, 5.4 mg/mL, 7.5 mg/mL, 0.525 %, 8.25 mg/mL, 5.0 mg, 5.25 mg/mL, 5250.0 mg, 10.0 mg, 0.3 mg/mg, 20.0 %, 25.0 %, 10.0 %, 60.0 mg/mL, 5.0 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Liquid - Irrigation, Solution - Irrigation, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Urethral, Irrigant - Urethral, Topical, Liquid - Topical, Kit, Kit - Intravenous, Kit; Powder, Kit; Powder - Respiratory (inhalation), Cream, Cream - Topical, Solution - Extracorporeal, Extracorporeal, Powder, Powder - Topical, Kit - Topical, Kit - Respiratory (inhalation)
collection, processing, and preservation of blood components
, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 250.0 mg/mL, 5.0 %, 40.0 mg, 1250.0 mg/mL, 5.4 mg/mL, 7.5 mg/mL, 0.525 %, 8.25 mg/mL, 5.0 mg, 5.25 mg/mL, 5250.0 mg, 10.0 mg, 0.3 mg/mg, 20.0 %, 25.0 %, 10.0 %, 60.0 mg/mL, 5.0 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Liquid - Irrigation, Solution - Irrigation, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Urethral, Irrigant - Urethral, Topical, Liquid - Topical, Kit, Kit - Intravenous, Kit; Powder, Kit; Powder - Respiratory (inhalation), Cream, Cream - Topical, Solution - Extracorporeal, Extracorporeal, Powder, Powder - Topical, Kit - Topical, Kit - Respiratory (inhalation)
induction of Diuresis
, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 250.0 mg/mL, 5.0 %, 40.0 mg, 1250.0 mg/mL, 5.4 mg/mL, 7.5 mg/mL, 0.525 %, 8.25 mg/mL, 5.0 mg, 5.25 mg/mL, 5250.0 mg, 10.0 mg, 0.3 mg/mg, 20.0 %, 25.0 %, 10.0 %, 60.0 mg/mL, 5.0 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Liquid - Irrigation, Solution - Irrigation, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Urethral, Irrigant - Urethral, Topical, Liquid - Topical, Kit, Kit - Intravenous, Kit; Powder, Kit; Powder - Respiratory (inhalation), Cream, Cream - Topical, Solution - Extracorporeal, Extracorporeal, Powder, Powder - Topical, Kit - Topical, Kit - Respiratory (inhalation)
Warnings
Mannitol 20% has eleven contraindications, thus it should not be administered in combination with the circumstances listed in the following table.Mannitol 20% ContraindicationsCondition
Risk Level
Notes
Adrenal gland hypofunction
Do Not Combine
Craniotomy
Do Not Combine
mannitol-driven progressive heart failure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Mannitol may interact with Pulse Frequency
Anuria
Do Not Combine
Dehydration
Do Not Combine
mannitol-driven progressive oliguria
Do Not Combine
Pulmonary Edema
Do Not Combine
mannitol-driven progressive pulmonary congestion
Do Not Combine
Azotemia
Do Not Combine
mannitol-driven progressive renal damage
Do Not Combine
Common Mannitol 20% Drug Interactions
Drug Name
Risk Level
Description
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Neomycin.
Acebutolol
Minor
The risk or severity of adverse effects can be increased when Mannitol is combined with Acebutolol.
Aceclofenac
Minor
The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Aceclofenac.
Acyclovir
Minor
The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Acyclovir.
Adefovir
Minor
The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Adefovir.
Mannitol 20% Toxicity & Overdose RiskOverdosing on mannitol can lead to constriction of the airways, which can be treated by administering a short-acting bronchodilator. Other supportive and symptomatic care may also be necessary.
Mannitol 20% Novel Uses: Which Conditions Have a Clinical Trial Featuring Mannitol 20%?
Three active clinical trials are currently examining the potential of Mannitol 20% to alleviate Brain, Kidney Failure, Acute and Diuresis Symptoms.Condition
Clinical Trials
Trial Phases
Irrigation
0 Actively Recruiting
Increased Intra Ocular Pressure (IOP)
0 Actively Recruiting
transurethral surgery
0 Actively Recruiting
Diuresis
0 Actively Recruiting
glomerular filtration rate measurement
0 Actively Recruiting
induction of Diuresis
0 Actively Recruiting
collection, processing, and preservation of blood components
0 Actively Recruiting
Brain
2 Actively Recruiting
Not Applicable, Early Phase 1
Urinary Bladder
0 Actively Recruiting
Cystic Fibrosis (CF)
0 Actively Recruiting
Glucose tolerance test
0 Actively Recruiting
Kidney Failure, Acute
0 Actively Recruiting
Mannitol 20% Reviews: What are patients saying about Mannitol 20%?
3.7Patient Review
12/21/20083.3Patient Review
11/9/2011 I had an acute stroke in my MCA.
3Patient Review
9/20/2012 This treatment is just okay. It didn't really help me that much.
Patient Q&A Section about mannitol 20%
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is 10% mannitol used for?
"Mannitol 10% is an osmotic diuretic that is prescribed to help relieve increased pressure in the brain and eyes, as well as to promote the excretion of toxins through urine in patients with kidney failure."
Answered by AI
What is 20% mannitol used for?
"This medicine is used to treat acute renal (kidney) failure, cerebral edema (accumulation of excessive fluid in the brain), and to reduce the pressure inside the eyes in a condition called glaucoma."
Answered by AI
What is the use of mannitol solution?
"This indicates that the 10% solution of Mannitol is effective in preventing renal failure by promoting diuresis, or the increased production of urine."
Answered by AI