Luvox Cr

Bulimia Nervosa, Obsessive-Compulsive Disorder, Depression
Treatment
1 FDA approval
20 Active Studies for Luvox Cr

What is Luvox Cr

FluvoxamineThe Generic name of this drug
Treatment SummaryFluvoxamine is an antidepressant medication used to treat obsessive-compulsive disorder. It works by increasing the levels of serotonin, a chemical in the brain that helps regulate mood. Fluvoxamine has been used in clinical practice since 1983 and has been used to treat over 10 million people worldwide. It was approved in the US in 1994 and Japan in 1999.
Fluvoxamine Maleateis the brand name
image of different drug pills on a surface
Luvox Cr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Fluvoxamine Maleate
Fluvoxamine
2000
76

Approved as Treatment by the FDA

Fluvoxamine, otherwise known as Fluvoxamine Maleate, is approved by the FDA for 1 uses including Depression .
Depression
Helps manage Major Depressive Disorder (MDD)

Effectiveness

How Luvox Cr Affects PatientsFluvoxamine is an antidepressant medication used to treat depression, body dysmorphic disorder, and anxiety. It works by blocking serotonin (a chemical in the brain) from being taken back up by the nerve cells, allowing it to remain active in the brain and work on improving mood. In addition to targeting serotonin, Fluvoxamine does not interact with other important brain chemicals like norepinephrine, dopamine, or GABA. This helps reduce the risk of any serious side effects like dry mouth, heart problems, or confusion. Some studies have also suggested that Fluvoxamine can downregulate norepinephrine receptors in the
How Luvox Cr works in the bodyFluvoxamine helps to increase serotonin levels in the brain. It does this by blocking the reuptake of serotonin at the neuronal membrane. This prevents serotonin from being taken up and recycled, leaving more available to be used by the brain. Fluvoxamine does not interact with other receptors, such as adrenergic, muscarinic, dopamine, histamine, GABA-benzodiazepine, opiate, or 5-HT 1 or 2 receptors. It does, however, have an affinity for σ1 receptors.

When to interrupt dosage

The recommended dosage of Luvox Cr is contingent upon the identified condition, including Obsessive-Compulsive Disorder, Depression and Bulimia Nervosa. The amount of dosage varies, depending on the method of delivery (e.g. Tablet or Tablet, film coated - Oral) featured in the table below.
Condition
Dosage
Administration
Bulimia Nervosa
, 25.0 mg, 50.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Depression
, 25.0 mg, 50.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Obsessive-Compulsive Disorder
, 25.0 mg, 50.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Luvox Cr Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Luvox Cr.
Common Luvox Cr Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Fluvoxamine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Fluvoxamine.
Acyclovir
Major
The metabolism of Acyclovir can be decreased when combined with Fluvoxamine.
Agomelatine
Major
The serum concentration of Agomelatine can be increased when it is combined with Fluvoxamine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Fluvoxamine.
Luvox Cr Toxicity & Overdose RiskFluvoxamine is a type of antidepressant that has been linked to an increased risk of suicidal thoughts and behavior in children, teens, and young adults under the age of 24 in studies of depression and other mental health conditions. Fluvoxamine is not approved for use in children except for those with obsessive compulsive disorder. Common side effects may include loss of appetite, constipation, dry mouth, headache, nausea, feeling anxious, skin rash, difficulty sleeping, drowsiness, liver damage, mania, increased urination, seizures, increased sweating, tremors, or Tourette's syndrome.
image of a doctor in a lab doing drug, clinical research

Luvox Cr Novel Uses: Which Conditions Have a Clinical Trial Featuring Luvox Cr?

213 active clinical trials are assessing the potential of Luvox Cr in alleviating Obsessive-Compulsive Disorder, Bulimia Nervosa and Depressive symptoms.
Condition
Clinical Trials
Trial Phases
Depression
210 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1
Bulimia Nervosa
0 Actively Recruiting
Obsessive-Compulsive Disorder
66 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1

Luvox Cr Reviews: What are patients saying about Luvox Cr?

5Patient Review
1/27/2014
Luvox Cr for Extreme Apprehension or Fear of Social Interaction
This medication has been a complete game-changer for me. I was struggling with depression and anxiety, and this really helped lessen the intensity and frequency of both.
5Patient Review
7/21/2013
Luvox Cr for Obsessive Compulsive Disorder
This medication was really effective for me. It got rid of my obsessive thoughts and compulsive behaviors within a week, and also helped with my social anxiety. I would never have believed that something like this could be possible, but it completely changed my life for the better.
5Patient Review
9/25/2013
Luvox Cr for Obsessive Compulsive Disorder
I've been on this medication for three years and it has completely changed my life. I take it in the morning, which is when I find it to be most effective. The generic from Par Pharma is significantly less effective (in my opinion), so I would only recommend taking Jazz Pharma brand.
5Patient Review
5/11/2012
Luvox Cr for Depression
I experienced great results shortly after taking this medicine, and I continue to feel better than ever.
5Patient Review
10/19/2011
Luvox Cr for Extreme Apprehension or Fear of Social Interaction
I've been on Luvox for two weeks now, and while it's helped my depression and mood swings, I can't seem to get enough sleep. I'm constantly tired. That being said, I'm otherwise happy with the results of this medication.
5Patient Review
6/13/2022
Luvox Cr for Repeated Episodes of Anxiety
I'm so grateful that this medication was able to help me. It's truly a lifesaver.
5Patient Review
8/31/2011
Luvox Cr for Obsessive Compulsive Disorder
Caused me to experience paranoia and fearfulness.
5Patient Review
7/25/2011
Luvox Cr for Obsessive Compulsive Disorder
5Patient Review
5/14/2013
Luvox Cr for Obsessive Compulsive Disorder
I've been on 200mg of Luvox CR for about four years. I suffer from OCD but mostly just obbsesive thoughts. Most days I'm really good and can shut down the thoughts, some days are still tough but the good days far out number the bad days. I really don't suffer from any side effects. The beginnig was the usual, drowsiness,lack of energy but that was gone after a few weeks. This medication has done wonders for me.
5Patient Review
5/16/2013
Luvox Cr for Obsessive Compulsive Disorder
This medication has been an immense help in managing my OCD.
5Patient Review
7/25/2011
Luvox Cr for Obsessive Compulsive Disorder
5Patient Review
8/31/2011
Luvox Cr for Obsessive Compulsive Disorder
I felt really paranoid and scared while taking this medication.
5Patient Review
5/14/2013
Luvox Cr for Obsessive Compulsive Disorder
I've been taking 200mg of Luvox CR for four years to help with my OCD. I find that it's effective most days, allowing me to shut down intrusive thoughts. While there can be tough days, they are outnumbered by the good days. Additionally, I didn't experience any long-term side effects from the medication. When I first started taking it there was drowsiness and lack of energy, but those went away after a few weeks.
5Patient Review
10/19/2011
Luvox Cr for Extreme Apprehension or Fear of Social Interaction
I've been on Luvox CR for two weeks and it's helped my depression and mood swings. The only downside is that I can't seem to stay awake; I'm constantly tired.
5Patient Review
5/16/2013
Luvox Cr for Obsessive Compulsive Disorder
This medication has been a real game-changer for me and my OCD.
5Patient Review
9/25/2013
Luvox Cr for Obsessive Compulsive Disorder
I've been on Luvox for three years now to treat my OCD and SAD, and it has quite literally saved my life. I find that taking the medication in the morning is much more effective than at night; however, the generic from Par Pharma is significantly less effective. As a result, I only recommend Jazz Pharma.
5Patient Review
7/21/2013
Luvox Cr for Obsessive Compulsive Disorder
This medication completely relieved my obsessive thoughts and compulsive behavior within a week, which also dissolved my social anxiety to the point that I can enjoy myself in social situations. The initial few weeks of drowsiness actually proved beneficial as it combatted my anxiety-induced insomnia.
5Patient Review
1/27/2014
Luvox Cr for Extreme Apprehension or Fear of Social Interaction
This treatment has been a game changer for me. It's helped decrease my panic attacks and severe depression. If you're struggling with something similar, I highly recommend giving this a try.
5Patient Review
6/13/2022
Luvox Cr for Repeated Episodes of Anxiety
This medication completely changed my life for the better. I'm so thankful that my doctor found something that worked for me.
5Patient Review
5/11/2012
Luvox Cr for Depression
I'm so grateful that this medicine exists! It almost immediately helped me and I've been feeling better than ever for the past few months.
4.7Patient Review
1/21/2014
Luvox Cr for Extreme Apprehension or Fear of Social Interaction
This worked for me at first, but now it doesn't seem to be as effective.
4.7Patient Review
1/21/2014
Luvox Cr for Extreme Apprehension or Fear of Social Interaction
This medication was working well for me up until now. I'm not sure what changed, but it's no longer effective.
3.7Patient Review
6/11/2014
Luvox Cr for Obsessive Compulsive Disorder
I was on Luvox for 10 years and it helped with my OCD thoughts; however, I decided to try natural supplements. This didn't work out too well for me as I couldn't handle the obsessive thoughts at all. So, slowly, I increased my dosage until I was back up to 400mg a day. It worked great again for suppressing the thoughts, but now I'm tired all the time—which is my biggest problem.
3.7Patient Review
6/11/2014
Luvox Cr for Obsessive Compulsive Disorder
I've been on Luvox CR for a decade now, and it's been great for managing my OCD thoughts. I recently decided to try natural supplements instead, but found that they just didn't work as well for me. I had to go back up to 400mg a day, and am now slowly working my way back down again. The biggest downside for me is the fatigue; it's hard to function when you're constantly exhausted.
3Patient Review
6/7/2011
Luvox Cr for Depression
3Patient Review
6/7/2011
Luvox Cr for Depression
2.3Patient Review
1/2/2022
Luvox Cr for Depression
I had a really bad headache after taking this medication.
2.3Patient Review
1/2/2022
Luvox Cr for Depression
I had a really bad headache after taking this medication.
1.3Patient Review
3/25/2011
Luvox Cr for Obsessive Compulsive Disorder
1.3Patient Review
3/25/2011
Luvox Cr for Obsessive Compulsive Disorder
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about luvox cr

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Luvox CR still available?

"The Luvox CR brand of medication has been discontinued in the United States. However, if the Food and Drug Administration has approved generic versions of this product, there may be generic equivalents available."

Answered by AI

When should I take Luvox CR?

"The dosage is based on your medical condition, response to therapy, age, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Before taking fluvoxamine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

To use Luvox CR, read the Medication Guide provided by your pharmacist before starting to take fluvoxamine. If you have any questions, consult your doctor or pharmacist. This medication is usually taken by mouth once daily at bedtime with or without food, as directed by your doctor. The dosage is based on your medical condition, response to therapy, age, and other medications you may be taking. Make sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Before taking fluvoxamine, tell your doctor or pharmacist if you are allergic to it, or if you have any other allergies"

Answered by AI

Why was Luvox CR discontinued?

"Luvox was removed from the US market in 2002 after it was linked to violent behavior and suicidal thoughts in children and teenagers. The drug received renewed attention after the Columbine Massacre in 1999."

Answered by AI

What is Luvox CR prescribed for?

"LUVOX CR Capsules are indicated for the treatment of obsessive compulsive disorder (OCD) according to the DSM-IV."

Answered by AI

Clinical Trials for Luvox Cr

Image of St. Joseph's Healthcare Hamilton in Hamilton, Canada.

Psychotherapy for Depression

18 - 65
Female
Hamilton, Canada
The RESPOND trial explores the link between early life adversity and later life depressive symptoms. The investigators have designed a new psychological therapy tailored to address the symptoms that can be caused by difficult experiences in early life. These symptoms include low mood, emotional dysregulation, and distressing thoughts and beliefs related to difficult or traumatic experiences. The investigators would like to see if this new therapy helps people feel better. The investigators are also studying the biological changes that can occur as a result of early life adversity, and how this therapy may influence those changes. To do this, The investigators ask questions about participants' physical and mental health and take blood samples.
Recruiting
Has No Placebo
St. Joseph's Healthcare HamiltonSheryl Green, PhD
Image of Baylor College of Medicine in Houston, United States.

Stepped Care Treatment for Anxiety

7 - 17
All Sexes
Houston, TX
Childhood anxiety disorders (CAD) are common and impairing. Family based cognitive behavioral therapy (CBT) is efficacious in treating CAD. Yet, many children do not receive care due to barriers such as limited provider availably, high treatment costs, and constrained family resources (e.g., time). To combat these barriers, other treatment methods have been developed. The stepped care treatment models maximize resources by providing low-intensity, low-cost interventions as a first time treatment, while stepping up care for those needing more intensive treatment. Specifically, a stepped care model for CAD that begins with a parent-focus intervention has great promise to deliver efficacious and cost-effective treatment without having to engage the child. While stepped care approaches show promise in treating CAD with comparable efficacy to standard CBT, there remains a large research-to-practice gap. The stepped care model for CAD that begins with a parent-focused intervention has yet been explored, and very little is known about intervention mediators that explain mechanisms of change. This research is being done to improve the reach and quality of services using a stepped care model, offering an affordable and practical solution to the widespread gap in youth mental health care.
Waitlist Available
Has No Placebo
Baylor College of Medicine
Have you considered Luvox Cr clinical trials? We made a collection of clinical trials featuring Luvox Cr, we think they might fit your search criteria.Go to Trials
Image of Detroit Recovery Project in Detroit, United States.

Peer-Delivered Behavioral Activation for Depression

18+
All Sexes
Detroit, MI
Low-income individuals have limited access to evidence-based interventions for mental health. Peer recovery specialists, individuals in recovery from mental health and/or substance use problems, have the potential to increase access to evidence-based interventions for individuals from low-resource communities, particularly when trained and supervised in models that are acceptable and feasible in these communities. This study will examine the effectiveness and implementation potential of a peer-delivered evidence-based intervention (Behavioral Activation) among individuals receiving services from a community-based treatment setting providing integrated physical and behavioral healthcare.
Waitlist Available
Has No Placebo
Detroit Recovery Project
Image of UCSD Interventional Psychiatry in San Diego, United States.

Transcranial Direct Current Stimulation for Depression

18 - 85
All Sexes
San Diego, CA
The investigators propose a single-arm, open-label study to evaluate the effectiveness, safety, tolerability and feasibility of at-home transcranial direct current stimulation (tDCS) as a treatment for depression, particularly in cases where patients have not responded well to traditional therapies. Treatment will be delivered over a 2-week period with daily weekday treatments i.e., five tDCS sessions, each lasting 20 minutes, spaced by approximately 20-minute inter-session intervals, for a total of three hours a day. Participants will self-administer treatment at home under direct remote supervision. Pre- and post- treatment neurophysiological biomarkers sessions will also be carried out. The study aims to examine changes in mood, brain activity, and related clinical outcomes before, during, and after treatment, with the goal to provide more information that can be used for future studies.
Recruiting
Has No Placebo
UCSD Interventional Psychiatry
Have you considered Luvox Cr clinical trials? We made a collection of clinical trials featuring Luvox Cr, we think they might fit your search criteria.Go to Trials
Have you considered Luvox Cr clinical trials? We made a collection of clinical trials featuring Luvox Cr, we think they might fit your search criteria.Go to Trials
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