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What is Loxapine Succinate
LoxapineThe Generic name of this drug
Treatment SummaryAn antipsychotic medication used to treat schizophrenia.
Loxapineis the brand name
Loxapine Succinate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Loxapine
Loxapine
1988
78
Effectiveness
How Loxapine Succinate Affects PatientsLoxapine is a type of medication used to reduce anxiety and aggression. Its exact effects are not known, but it is thought to work by blocking the activity of two important brain messengers, dopamine and serotonin. This results in a calming effect on the brain.
How Loxapine Succinate works in the bodyLoxapine works by blocking dopamine and serotonin, two brain chemicals that play a role in emotion. This helps to stop over-excitability in the brain, which can lead to calming effects and reduced aggression. The exact way that Loxapine works is unknown.
When to interrupt dosage
The advised dosage of Loxapine Succinate is contingent upon the diagnosed state, such as Acute Agitation, Schizophrenia and Bipolar Disorder. The amount of dosage changes in accordance with the technique of application featured in the table below.Condition
Dosage
Administration
Schizophrenia
, 5.0 mg, 10.0 mg, 50.0 mg, 25.0 mg, 2.5 mg, 13.6 mg, 34.0 mg, 6.8 mg, 68.0 mg, 4.5 mg, 9.1 mg, 50.0 mg/mL, 25.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Liquid, Liquid - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid - Oral, Respiratory (inhalation), Powder, metered, Powder, metered - Respiratory (inhalation), Aerosol, powder, Aerosol, powder - Respiratory (inhalation)
Bipolar Disorder
, 5.0 mg, 10.0 mg, 50.0 mg, 25.0 mg, 2.5 mg, 13.6 mg, 34.0 mg, 6.8 mg, 68.0 mg, 4.5 mg, 9.1 mg, 50.0 mg/mL, 25.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Liquid, Liquid - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid - Oral, Respiratory (inhalation), Powder, metered, Powder, metered - Respiratory (inhalation), Aerosol, powder, Aerosol, powder - Respiratory (inhalation)
Acute Agitation
, 5.0 mg, 10.0 mg, 50.0 mg, 25.0 mg, 2.5 mg, 13.6 mg, 34.0 mg, 6.8 mg, 68.0 mg, 4.5 mg, 9.1 mg, 50.0 mg/mL, 25.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Liquid, Liquid - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid - Oral, Respiratory (inhalation), Powder, metered, Powder, metered - Respiratory (inhalation), Aerosol, powder, Aerosol, powder - Respiratory (inhalation)
Warnings
Loxapine Succinate has twenty-one contraindications and should not be administered concurrently with any of the conditions outlined in the subsequent table.Loxapine Succinate ContraindicationsCondition
Risk Level
Notes
Asthma
Do Not Combine
Lung Disorder
Do Not Combine
Brain Injuries, Traumatic
Do Not Combine
Shock
Do Not Combine
Disease
Do Not Combine
history of COPD
Do Not Combine
Comatose
Do Not Combine
Pulse Frequency
Do Not Combine
severe heart disorder
Do Not Combine
phoechromocytoma
Do Not Combine
Chronic Obstructive Pulmonary Disease
Do Not Combine
severe, drug-induced depressed states
Do Not Combine
Pulse Frequency
Do Not Combine
history of asthma
Do Not Combine
Impaired Renal Function
Do Not Combine
acute respiratory symptoms
Do Not Combine
Anesthesia, Cardiac Procedures
Do Not Combine
severe,drug-induced depressive states
Do Not Combine
Comatose
Do Not Combine
Disease
Do Not Combine
Pulse Frequency
Do Not Combine
Common Loxapine Succinate Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Loxapine.
Aclidinium
Major
The therapeutic efficacy of Aclidinium can be decreased when used in combination with Loxapine.
Amisulpride
Major
Loxapine may increase the antipsychotic activities of Amisulpride.
Arformoterol
Major
The therapeutic efficacy of Arformoterol can be decreased when used in combination with Loxapine.
Axitinib
Major
The serum concentration of Axitinib can be increased when it is combined with Loxapine.
Loxapine Succinate Toxicity & Overdose RiskThe lowest toxic dose of this drug for mice when taken orally is 65mg/kg.
Loxapine Succinate Novel Uses: Which Conditions Have a Clinical Trial Featuring Loxapine Succinate?
171 active clinical trials are being conducted to assess the potential of Loxapine Succinate to relieve symptoms of Schizophrenia, Bipolar Disorder and Acute Agitation.Condition
Clinical Trials
Trial Phases
Bipolar Disorder
1 Actively Recruiting
Phase 4
Schizophrenia
175 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Acute Agitation
0 Actively Recruiting
Loxapine Succinate Reviews: What are patients saying about Loxapine Succinate?
5Patient Review
1/31/20083.3Patient Review
1/28/2013 This drug is dangerous and should be removed from the market.
3.3Patient Review
5/26/20093Patient Review
5/17/2015 I appreciate that this medication helps me feel more capable, but the side effects are really tough to deal with. I've noticed a significant change in my weight and appearance in just a week; has anyone else experienced this?
2.7Patient Review
10/22/2009 My husband has been taking this medication for bipolar disorder and recently developed a blockage in the common bile duct. I'm wondering if there could be a connection between the two.
1Patient Review
1/25/2012 I've been on loxapine for over 30 years and it's saved my life. That being said, you should never stop taking this medicine suddenly as it can lead to serious health complications.
Patient Q&A Section about loxapine succinate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is another name for loxapine?
"Loxapine powder for inhalation is approved by the FDA for treating acute agitation associated with schizophrenia or bipolar disorder in adults."
Answered by AI
What class of drug is loxapine?
"Loxapine is aripiprazole, which is an antipsychotic medication that works by decreasing the abnormal excitement in the brain."
Answered by AI
What is loxapine succinate used for?
"Loxapine is used to treat schizophrenia and other mental disorders. This medicine helps patients think more clearly, feel less nervous, and take part in everyday life. It can reduce aggression and the desire to hurt oneself/others."
Answered by AI
Is loxapine an antidepressant?
"It has a volume of distribution of 55L/kg.
Loxapine is metabolized in the liver through aromatic hydroxylation, N-demethylation, or N-oxidation, with the metabolite amoxapine being active and marketed as an antidepressant. Loxapine is distributed throughout the body, including the central nervous system, with a volume of distribution of 55L/kg."
Answered by AI