Leukeran

Lymphoma, Follicular, Lymphoma, Chronic Lymphocytic Leukemia + 8 more
Treatment
20 FDA approvals
20 Active Studies for Leukeran

What is Leukeran

ChlorambucilThe Generic name of this drug
Treatment SummaryNitrogen mustard is a medication used to treat various cancers and non-cancerous diseases. It works by targeting and destroying cancer cells. However, it is considered a carcinogen and can cause cancer if used for a long period of time.
Leukeranis the brand name
image of different drug pills on a surface
Leukeran Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Leukeran
Chlorambucil
1985
4

Approved as Treatment by the FDA

Chlorambucil, commonly known as Leukeran, is approved by the FDA for 20 uses such as giant follicular lymphoma and MALT Lymphoma .
giant follicular lymphoma
MALT Lymphoma
Mantle Cell Lymphoma (MCL)
Chronic Lymphocytic Leukemia (CLL)
Lymphoma, Diffuse
Malignant Lymphomas
Non-Hodgkin's Lymphoma (NHL)
Hodgkins Disease (HD)
Waldenström's Macroglobulinemia (WM)
Indolent Lymphoma
Hodgkin Disease
Waldenstrom Macroglobulinemia
Lymphoma, B-Cell, Marginal Zone
Mantle Cell Lymphoma
Lymphoma, Non-Hodgkin
Chronic Lymphocytic Leukemia
Lymphoma, Follicular
Lymphoma
Lymphoma, Non-Hodgkin
Non-Hodgkin's Lymphoma

Effectiveness

How Leukeran Affects PatientsChlorambucil is a medication used to treat cancer. It belongs to a class of drugs called alkylating agents, which can add alkyl groups to molecules in cells and stop tumor growth by damaging the DNA inside cells. This prevents the cell from reproducing, and also changes the way the DNA is read, which can cause the cell to die. Alkylating agents work in different ways, but all of them cause disruption to the DNA and ultimately the death of the cell.
How Leukeran works in the bodyAlkylating agents work to kill cancer cells by damaging their DNA. This damage can take the form of attaching alkyl groups to DNA bases, creating bonds between atoms in the DNA, or causing mispairing of the DNA's nucleotides. This damage makes it difficult for the cell to make new DNA or transcribe its existing DNA, resulting in cell death.

When to interrupt dosage

The suggested measure of Leukeran is contingent upon the diagnosed affliction, like Hodgkin Disease, Indolent Lymphoma and Waldenstrom Macroglobulinemia. The amount of dosage is contingent upon the approach of delivery (e.g. Tablet or Tablet - Oral) as detailed in the table beneath.
Condition
Dosage
Administration
Non-Hodgkin's Lymphoma
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Mantle Cell Lymphoma
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Chronic Lymphocytic Leukemia
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Lymphoma
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Lymphoma, B-Cell, Marginal Zone
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Lymphoma, Non-Hodgkin
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Lymphoma, Follicular
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Waldenstrom Macroglobulinemia
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Lymphoma, Non-Hodgkin
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Hodgkin Disease
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Glomerulonephritis
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet

Warnings

Leukeran Contraindications
Condition
Risk Level
Notes
prior resistance to the agent
Do Not Combine
There are 20 known major drug interactions with Leukeran.
Common Leukeran Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Chlorambucil is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Chlorambucil is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Chlorambucil is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Chlorambucil is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Chlorambucil is combined with Acteoside.
image of a doctor in a lab doing drug, clinical research

Leukeran Novel Uses: Which Conditions Have a Clinical Trial Featuring Leukeran?

At present, 454 active clinical trials are delving into the potential of Leukeran to address Chronic Lymphocytic Leukemia, Waldenstrom Macroglobulinemia and Hodgkin Disease.
Condition
Clinical Trials
Trial Phases
Lymphoma, Follicular
0 Actively Recruiting
Chronic Lymphocytic Leukemia
148 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Early Phase 1, Phase 4
Mantle Cell Lymphoma
124 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Early Phase 1
Waldenstrom Macroglobulinemia
8 Actively Recruiting
Phase 2, Phase 1
Lymphoma, B-Cell, Marginal Zone
0 Actively Recruiting
Glomerulonephritis
1 Actively Recruiting
Phase 3
Lymphoma, Non-Hodgkin
0 Actively Recruiting
Lymphoma
0 Actively Recruiting
Lymphoma, Non-Hodgkin
2 Actively Recruiting
Phase 1
Non-Hodgkin's Lymphoma
125 Actively Recruiting
Phase 1, Phase 2, Early Phase 1, Not Applicable, Phase 3, Phase 4
Hodgkin Disease
3 Actively Recruiting
Not Applicable, Phase 1

Leukeran Reviews: What are patients saying about Leukeran?

5Patient Review
1/29/2009
Leukeran for Chronic Lymphoid Leukemia
I had no problems whatsoever when taking this drug.
5Patient Review
2/21/2008
Leukeran for Waldenstrom's Macroglobulinemia
4Patient Review
3/14/2014
Leukeran for Chronic Lymphoid Leukemia
This is an effective treatment, but it's slow-acting and expensive.
4Patient Review
11/1/2008
Leukeran for Chronic Lymphoid Leukemia
3Patient Review
4/13/2011
Leukeran for Destruction of Red Blood Cells by Body's Own Antibodies
My 74 year old brother contracted CLL. The hemoatologist precribed Leukeran. After only 7 weeks my brothers white cell count went from 207,000 all the way down to 4,800. He was take off the pills. Now white count increasing slightly each week, but no where near what it was. After 8 weeks off the pill the white cell count is only at 13,100. We highly recommend that you ask your doctor about this drug if you contract CLL.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about leukeran

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Leukeran used for?

"This medication is used to treat certain types of cancer, such as leukemia and lymphoma. Chlorambucil works by slowing or stopping the growth of cancer cells."

Answered by AI

Is Leukeran chemotherapy?

"Chlorambucil is a chemotherapy drug that is sold under the brand name Leukeran. It is most often used to treat chronic lymphocytic leukemia and non-Hodgkin lymphoma."

Answered by AI

What are the side effects of Leukeran?

"Overdose symptoms include nausea, vomiting, diarrhea, tremors, numbness, burning, pain, and tingling."

Answered by AI

What is another name for Leukeran?

"This medication is classified as an "alkylating agent." (For more detail, see "How this drug works" section below).

The trade name for chlorambucil is Leukeran. Chlorambucil is an anti-cancer chemotherapy drug and is classified as an "alkylating agent.""

Answered by AI

Clinical Trials for Leukeran

Have you considered Leukeran clinical trials? We made a collection of clinical trials featuring Leukeran, we think they might fit your search criteria.
Have you considered Leukeran clinical trials? We made a collection of clinical trials featuring Leukeran, we think they might fit your search criteria.
Have you considered Leukeran clinical trials? We made a collection of clinical trials featuring Leukeran, we think they might fit your search criteria.
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Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
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