Leukeran

giant follicular lymphoma, Lymphoma, Chronic Lymphocytic Leukemia + 8 more
Treatment
10 FDA approvals
20 Active Studies for Leukeran

What is Leukeran

ChlorambucilThe Generic name of this drug
Treatment SummaryNitrogen mustard is a medication used to treat various cancers and non-cancerous diseases. It works by targeting and destroying cancer cells. However, it is considered a carcinogen and can cause cancer if used for a long period of time.
Leukeranis the brand name
image of different drug pills on a surface
Leukeran Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Leukeran
Chlorambucil
1985
4

Approved as Treatment by the FDA

Chlorambucil, commonly known as Leukeran, is approved by the FDA for 10 uses such as Chronic Lymphocytic Leukemia and Malignant Lymphomas .
Chronic Lymphocytic Leukemia
Malignant Lymphomas
MALT Lymphoma
Indolent Lymphoma
giant follicular lymphoma
Non-Hodgkin's Lymphoma
Hodgkin Disease
Lymphoma
Waldenstrom Macroglobulinemia
Mantle Cell Lymphoma

Effectiveness

How Leukeran Affects PatientsChlorambucil is a medication used to treat cancer. It belongs to a class of drugs called alkylating agents, which can add alkyl groups to molecules in cells and stop tumor growth by damaging the DNA inside cells. This prevents the cell from reproducing, and also changes the way the DNA is read, which can cause the cell to die. Alkylating agents work in different ways, but all of them cause disruption to the DNA and ultimately the death of the cell.
How Leukeran works in the bodyAlkylating agents work to kill cancer cells by damaging their DNA. This damage can take the form of attaching alkyl groups to DNA bases, creating bonds between atoms in the DNA, or causing mispairing of the DNA's nucleotides. This damage makes it difficult for the cell to make new DNA or transcribe its existing DNA, resulting in cell death.

When to interrupt dosage

The suggested measure of Leukeran is contingent upon the diagnosed affliction, like Hodgkin Disease, Indolent Lymphoma and Waldenstrom Macroglobulinemia. The amount of dosage is contingent upon the approach of delivery (e.g. Tablet or Tablet - Oral) as detailed in the table beneath.
Condition
Dosage
Administration
MALT Lymphoma
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Malignant Lymphomas
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Lymphoma
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
giant follicular lymphoma
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Non-Hodgkin's Lymphoma
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Glomerulonephritis
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Hodgkin Disease
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Chronic Lymphocytic Leukemia
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Indolent Lymphoma
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Mantle Cell Lymphoma
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Waldenstrom Macroglobulinemia
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet

Warnings

Leukeran Contraindications
Condition
Risk Level
Notes
prior resistance to the agent
Do Not Combine
There are 20 known major drug interactions with Leukeran.
Common Leukeran Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Chlorambucil is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Chlorambucil is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Chlorambucil is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Chlorambucil is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Chlorambucil is combined with Acteoside.
image of a doctor in a lab doing drug, clinical research

Leukeran Novel Uses: Which Conditions Have a Clinical Trial Featuring Leukeran?

At present, 454 active clinical trials are delving into the potential of Leukeran to address Chronic Lymphocytic Leukemia, Waldenstrom Macroglobulinemia and Hodgkin Disease.
Condition
Clinical Trials
Trial Phases
giant follicular lymphoma
0 Actively Recruiting
Lymphoma
0 Actively Recruiting
Glomerulonephritis
0 Actively Recruiting
Malignant Lymphomas
3 Actively Recruiting
Phase 1
Hodgkin Disease
4 Actively Recruiting
Not Applicable, Phase 1
MALT Lymphoma
1 Actively Recruiting
Phase 1
Waldenstrom Macroglobulinemia
8 Actively Recruiting
Phase 2, Phase 1
Indolent Lymphoma
4 Actively Recruiting
Phase 2, Phase 1
Chronic Lymphocytic Leukemia
164 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3
Non-Hodgkin's Lymphoma
159 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Early Phase 1
Mantle Cell Lymphoma
97 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1

Leukeran Reviews: What are patients saying about Leukeran?

5Patient Review
1/29/2009
Leukeran for Chronic Lymphoid Leukemia
I had no problems whatsoever when taking this drug.
5Patient Review
2/21/2008
Leukeran for Waldenstrom's Macroglobulinemia
4Patient Review
3/14/2014
Leukeran for Chronic Lymphoid Leukemia
This is an effective treatment, but it's slow-acting and expensive.
4Patient Review
11/1/2008
Leukeran for Chronic Lymphoid Leukemia
3Patient Review
4/13/2011
Leukeran for Destruction of Red Blood Cells by Body's Own Antibodies
My 74 year old brother contracted CLL. The hemoatologist precribed Leukeran. After only 7 weeks my brothers white cell count went from 207,000 all the way down to 4,800. He was take off the pills. Now white count increasing slightly each week, but no where near what it was. After 8 weeks off the pill the white cell count is only at 13,100. We highly recommend that you ask your doctor about this drug if you contract CLL.
2.7Patient Review
3/21/2009
Leukeran for Chronic Lymphoid Leukemia
About three weeks after starting this medication, I developed cancer cells on my skin. They started to look a lot like chickenpox, but eventually turned into red bumps that had to be biopsied.
1.7Patient Review
6/3/2013
Leukeran for Non-Hodgkin's Lymphoma
Although this drug has some serious side effects, I wanted to share my positive experience in the hopes that it may help others. My cat was prescribed Leukeran after Cyclosporine failed to work, and we have seen good results so far. She is currently taking prednisone to suppress her immune system, and cyproheptadine to help her gain weight. I am praying that the Leukeran will continue to be effective for her.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about leukeran

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Leukeran used for?

"This medication is used to treat certain types of cancer, such as leukemia and lymphoma. Chlorambucil works by slowing or stopping the growth of cancer cells."

Answered by AI

Is Leukeran chemotherapy?

"Chlorambucil is a chemotherapy drug that is sold under the brand name Leukeran. It is most often used to treat chronic lymphocytic leukemia and non-Hodgkin lymphoma."

Answered by AI

What are the side effects of Leukeran?

"Overdose symptoms include nausea, vomiting, diarrhea, tremors, numbness, burning, pain, and tingling."

Answered by AI

What is another name for Leukeran?

"This medication is classified as an "alkylating agent." (For more detail, see "How this drug works" section below).

The trade name for chlorambucil is Leukeran. Chlorambucil is an anti-cancer chemotherapy drug and is classified as an "alkylating agent.""

Answered by AI

Clinical Trials for Leukeran

Have you considered Leukeran clinical trials? We made a collection of clinical trials featuring Leukeran, we think they might fit your search criteria.
Have you considered Leukeran clinical trials? We made a collection of clinical trials featuring Leukeran, we think they might fit your search criteria.
Have you considered Leukeran clinical trials? We made a collection of clinical trials featuring Leukeran, we think they might fit your search criteria.
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