Leukeran

Lymphoma, Follicular, Lymphoma, Chronic Lymphocytic Leukemia + 8 more
Treatment
20 FDA approvals
20 Active Studies for Leukeran

What is Leukeran

ChlorambucilThe Generic name of this drug
Treatment SummaryNitrogen mustard is a medication used to treat various cancers and non-cancerous diseases. It works by targeting and destroying cancer cells. However, it is considered a carcinogen and can cause cancer if used for a long period of time.
Leukeranis the brand name
image of different drug pills on a surface
Leukeran Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Leukeran
Chlorambucil
1985
4

Approved as Treatment by the FDA

Chlorambucil, commonly known as Leukeran, is approved by the FDA for 20 uses such as MALT Lymphoma and Non-Hodgkin's Lymphoma (NHL) .
MALT Lymphoma
Non-Hodgkin's Lymphoma (NHL)
Waldenström's Macroglobulinemia (WM)
giant follicular lymphoma
Indolent Lymphoma
Hodgkins Disease (HD)
Lymphoma, Diffuse
Malignant Lymphomas
Chronic Lymphocytic Leukemia (CLL)
Mantle Cell Lymphoma (MCL)
Hodgkin Disease
Waldenstrom Macroglobulinemia
Lymphoma, B-Cell, Marginal Zone
Mantle Cell Lymphoma
Lymphoma, Non-Hodgkin
Chronic Lymphocytic Leukemia
Lymphoma, Follicular
Lymphoma
Lymphoma, Non-Hodgkin
Non-Hodgkin's Lymphoma

Effectiveness

How Leukeran Affects PatientsChlorambucil is a medication used to treat cancer. It belongs to a class of drugs called alkylating agents, which can add alkyl groups to molecules in cells and stop tumor growth by damaging the DNA inside cells. This prevents the cell from reproducing, and also changes the way the DNA is read, which can cause the cell to die. Alkylating agents work in different ways, but all of them cause disruption to the DNA and ultimately the death of the cell.
How Leukeran works in the bodyAlkylating agents work to kill cancer cells by damaging their DNA. This damage can take the form of attaching alkyl groups to DNA bases, creating bonds between atoms in the DNA, or causing mispairing of the DNA's nucleotides. This damage makes it difficult for the cell to make new DNA or transcribe its existing DNA, resulting in cell death.

When to interrupt dosage

The suggested measure of Leukeran is contingent upon the diagnosed affliction, like Hodgkin Disease, Indolent Lymphoma and Waldenstrom Macroglobulinemia. The amount of dosage is contingent upon the approach of delivery (e.g. Tablet or Tablet - Oral) as detailed in the table beneath.
Condition
Dosage
Administration
Non-Hodgkin's Lymphoma
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Mantle Cell Lymphoma
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Chronic Lymphocytic Leukemia
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Lymphoma
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Lymphoma, B-Cell, Marginal Zone
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Lymphoma, Non-Hodgkin
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Lymphoma, Follicular
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Waldenstrom Macroglobulinemia
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Lymphoma, Non-Hodgkin
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Hodgkin Disease
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Glomerulonephritis
, 2.0 mg, 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet

Warnings

Leukeran Contraindications
Condition
Risk Level
Notes
prior resistance to the agent
Do Not Combine
There are 20 known major drug interactions with Leukeran.
Common Leukeran Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Chlorambucil is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Chlorambucil is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Chlorambucil is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Chlorambucil is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Chlorambucil is combined with Acteoside.
image of a doctor in a lab doing drug, clinical research

Leukeran Novel Uses: Which Conditions Have a Clinical Trial Featuring Leukeran?

At present, 454 active clinical trials are delving into the potential of Leukeran to address Chronic Lymphocytic Leukemia, Waldenstrom Macroglobulinemia and Hodgkin Disease.
Condition
Clinical Trials
Trial Phases
Lymphoma, Follicular
0 Actively Recruiting
Chronic Lymphocytic Leukemia
142 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Early Phase 1, Phase 4
Mantle Cell Lymphoma
73 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Waldenstrom Macroglobulinemia
8 Actively Recruiting
Phase 2, Phase 1
Lymphoma, B-Cell, Marginal Zone
0 Actively Recruiting
Glomerulonephritis
1 Actively Recruiting
Phase 3
Lymphoma, Non-Hodgkin
0 Actively Recruiting
Lymphoma
0 Actively Recruiting
Lymphoma, Non-Hodgkin
1 Actively Recruiting
Phase 1
Non-Hodgkin's Lymphoma
114 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Early Phase 1, Phase 4
Hodgkin Disease
3 Actively Recruiting
Not Applicable, Phase 1

Leukeran Reviews: What are patients saying about Leukeran?

5Patient Review
1/29/2009
Leukeran for Chronic Lymphoid Leukemia
I had no problems whatsoever when taking this drug.
5Patient Review
2/21/2008
Leukeran for Waldenstrom's Macroglobulinemia
4Patient Review
3/14/2014
Leukeran for Chronic Lymphoid Leukemia
This is an effective treatment, but it's slow-acting and expensive.
4Patient Review
11/1/2008
Leukeran for Chronic Lymphoid Leukemia
3Patient Review
4/13/2011
Leukeran for Destruction of Red Blood Cells by Body's Own Antibodies
My 74 year old brother contracted CLL. The hemoatologist precribed Leukeran. After only 7 weeks my brothers white cell count went from 207,000 all the way down to 4,800. He was take off the pills. Now white count increasing slightly each week, but no where near what it was. After 8 weeks off the pill the white cell count is only at 13,100. We highly recommend that you ask your doctor about this drug if you contract CLL.
2.7Patient Review
3/21/2009
Leukeran for Chronic Lymphoid Leukemia
About three weeks after starting this medication, I developed cancer cells on my skin. They started to look a lot like chickenpox, but eventually turned into red bumps that had to be biopsied.
1.7Patient Review
6/3/2013
Leukeran for Non-Hodgkin's Lymphoma
Although this drug has some serious side effects, I wanted to share my positive experience in the hopes that it may help others. My cat was prescribed Leukeran after Cyclosporine failed to work, and we have seen good results so far. She is currently taking prednisone to suppress her immune system, and cyproheptadine to help her gain weight. I am praying that the Leukeran will continue to be effective for her.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about leukeran

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Leukeran used for?

"This medication is used to treat certain types of cancer, such as leukemia and lymphoma. Chlorambucil works by slowing or stopping the growth of cancer cells."

Answered by AI

Is Leukeran chemotherapy?

"Chlorambucil is a chemotherapy drug that is sold under the brand name Leukeran. It is most often used to treat chronic lymphocytic leukemia and non-Hodgkin lymphoma."

Answered by AI

What are the side effects of Leukeran?

"Overdose symptoms include nausea, vomiting, diarrhea, tremors, numbness, burning, pain, and tingling."

Answered by AI

What is another name for Leukeran?

"This medication is classified as an "alkylating agent." (For more detail, see "How this drug works" section below).

The trade name for chlorambucil is Leukeran. Chlorambucil is an anti-cancer chemotherapy drug and is classified as an "alkylating agent.""

Answered by AI

Clinical Trials for Leukeran

Image of The University of Arizona Cancer Center in Tucson, United States.

DLI-X for Leukemia

Any Age
All Sexes
Tucson, AZ
The primary objective of this proposal is to conduct the first-in-human randomized clinical trial evaluating prophylactic DLI-X (pro-DLI-X) for relapse prevention following matched sibling donor (MSD) or haploidentical (haplo) hematopoietic cell transplantation (HCT) in patients with hematologic malignancies. Additionally, the study aims to assess the safety and efficacy of therapeutic DLI-X (t-DLI-X) compared to t-DLI alone in patients with minimal residual disease (MRD+) or overt relapse post-alloHCT. For patients with CD19-positive lymphoid malignancies, the study will incorporate blinatumomab, while those with myeloid or CD19-negative lymphoid malignancies will receive t-DLI-X or t-DLI alone. We hypothesize that both pro-DLI-X and t-DLI-X, with or without blinatumomab, will demonstrate safety and superior efficacy by enhancing graft-versus-leukemia (GvL) effects mediated by natural killer (NK) cells, γδ T cells, and CD8+ T cells, while maintaining manageable and treatment-responsive graft-versus-host disease (GvHD).
Phase 1
Waitlist Available
The University of Arizona Cancer CenterEmmanuel Katsanis, MD
Image of Case Comprehensive Cancer Center, University Hospitals Seidman Cancer Center in Cleveland, United States.

Rituximab + Tafasitamab + NK Cells for Non-Hodgkin's Lymphoma

18+
All Sexes
Cleveland, OH
This research study is for people who have relapsed or refractory B-cell non-Hodgkin's lymphoma (NHL) that has not responded to two or more lines of therapy. The purpose of this study is to identify the recommended dose of allogeneic NK cells in combination with IL-2, Tafasitamab and Rituximab for the treatment of relapsed or refractory B-cell non-Hodgkin's lymphoma. NK cells are an investigational (experimental) treatment which means they are not approved by the Food and Drug Administration (FDA). NK cells are a type of lymphocyte that's part of the body's natural immune system, and they can kill cancer cells by creating pores in the cancer cell membranes and inducing apoptosis (programmed cell death). Participants in this study will receive lymphodepleting chemotherapy, as well as Allogeneic NK cells, Tafasitamab and Interleukin-2 (IL-2) by an intravenous (IV) infusion. Participants are expected to complete one cycle, and they may be eligible to complete a second cycle of the same regiment if they have stable disease, partial or complete remission at the end of the first cycle. Participants will be in this study for about 12 months.
Phase 1
Waitlist Available
Case Comprehensive Cancer Center, University Hospitals Seidman Cancer Center (+1 Sites)Paolo Caimi, MDIncyte Corporation
Image of University of California, San Diego in La Jolla, United States.

SB-4826 for Non-Hodgkin's Lymphoma

18+
All Sexes
La Jolla, CA
The goal of this clinical trial is to learn what dose of the drug SB-4826 can be given safely in patients with solid tumors and non-Hodgkin lymphomas. This drug will be used alone in patients with solid tumors, and will be used alone or in combination with rituximab in patients with non-Hodgkin lymphomas. The main questions this clinical trial aims to answer are: What is the maximum dose of SB-4826 that can be used safely in patients with solid tumors and non-Hodgkin lymphomas, and will it work? How does SB-4826 work in people with cancer? How is SB-4826 absorbed, broken down, and excreted by the body? Participants will: Take drug SB-4826 every other day for up to 1 year; keep a diary of when they take SB-4826 at home; visit the clinic for checkups, tests, and fill out study questionnaires.
Phase 1 & 2
Waitlist Available
University of California, San DiegoPeter Vu, MD
Have you considered Leukeran clinical trials? We made a collection of clinical trials featuring Leukeran, we think they might fit your search criteria.Go to Trials
Have you considered Leukeran clinical trials? We made a collection of clinical trials featuring Leukeran, we think they might fit your search criteria.Go to Trials
Image of City of Hope Medical Center in Duarte, United States.

CMV-MVA Triplex Vaccine for Cancer

18 - 75
All Sexes
Duarte, CA
This phase Ib trial tests the safety, side effects, and how well cytomegalovirus (CMV)-modified vaccinia Ankara (MVA) Triplex vaccine works in enhancing CMV-specific immunity and preventing CMV viremia in patients undergoing haploidentical hematopoietic stem cell transplant. Haploidentical stem cell transplantation (haploHCT) has advanced to become the predominant procedure for patients lacking a matched donor. Compared to matched related donor transplants, the rate of significant CMV infection is higher in patients undergoing a haploHCT. Significant CMV infection is associated with an increased risk of complications and death. Vaccination is the main preventative approach to limit complications and death in immunocompromised patients at high risk of post-stem cell transplant infections. CMV-MVA Triplex vaccine, is a CMV vaccine based on the attenuated poxvirus, modified vaccinia Ankara (MVA), developed to enhance CMV-specific immunity in both healthy stem cell transplant donors and stem cell transplant patients to prevent significant CMV infection post-stem cell transplant. Giving CMV-MVA triplex vaccine may be safe, tolerable and/or effective in enhancing cytomegalovirus (CMV)-specific immunity and preventing CMV viremia in patients undergoing a haploHCT.
Phase 1
Waitlist Available
City of Hope Medical Center (+2 Sites)Ryotaro Nakamura
Have you considered Leukeran clinical trials? We made a collection of clinical trials featuring Leukeran, we think they might fit your search criteria.Go to Trials