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What is Leucovorin Calcium
LeucovorinThe Generic name of this drug
Treatment SummaryFolinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is a medication used to counteract the effects of certain cancer treatments, such as methotrexate, which inhibit the enzyme dihydrofolate reductase (DHFR). It is also used to treat megaloblastic anemias and in combination with 5-fluorouracil to prolong survival in patients with advanced colorectal cancer. Folinic Acid is a form of folic acid, a B vitamin required for the synthesis of DNA and proteins. It is available in two
Leucovorin Calciumis the brand name
Leucovorin Calcium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Leucovorin Calcium
Leucovorin
1987
65
Approved as Treatment by the FDA
Leucovorin, also known as Leucovorin Calcium, is approved by the FDA for 2 uses like methotrexate toxicity and Colorectal Carcinoma .methotrexate toxicity
Colorectal Carcinoma
Used to treat Advanced Colorectal Cancer in combination with Fluorouracil
Effectiveness
How Leucovorin Calcium Affects PatientsLeucovorin is a form of folic acid that is used to counteract the effects of drugs that block folic acid. Its active component is (-)-folinic acid, which does not need to be reduced by an enzyme in order to be used. Leucovorin is given to reduce the therapeutic and toxic effects of drugs like methotrexate and to make other drugs like fluorouracil more effective.
How Leucovorin Calcium works in the bodyLeucovorin is a form of folic acid and is used to increase levels of folic acid when it has been blocked by other drugs, like methotrexate. It also helps a drug called fluorouracil work better by reinforcing the bond that allows it to attach to an enzyme called thymidylate synthetase.
When to interrupt dosage
The recommended dosage of Leucovorin Calcium is contingent upon the diagnosed condition, such as Macrocytic anemia, Anemia of Pregnancy and Bladder Cancer. The amount of dosage varies, as per the administration technique (e.g. Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous or Tablet) presented in the following table.Condition
Dosage
Administration
Colorectal Carcinoma
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
hypochromic anemia
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Folate deficiency
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Macrocytic anemia
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
methotrexate toxicity
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Advanced Esophageal Cancers
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
HIV
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Pancreatic Metastatic Cancer
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
folic acid
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
normochromic anemia
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Bladder Cancer
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Megaloblastic anemia
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
pyrimethamine
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Advanced Gastric Cancer
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Anemia
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Anemia of Pregnancy
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Iron deficiency
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
folate
, 10.0 mg/mL, 5.0 mg, 25.0 mg, 15.0 mg, 10.0 mg, 2.5 mg, 20.0 mg, 350.0 mg, 50.0 mg, 35.0 mg/mL, 20.0 mg/mL, 50.0 mg/mL, 1.0 mg, 3.0 mg, 3.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Solution - Intravenous, Intravenous, Tablet, chewable, Tablet, chewable - Oral, Kit, Injection, Injection - Intramuscular; Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Liquid - Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Warnings
There are 20 known major drug interactions with Leucovorin Calcium.Common Leucovorin Calcium Drug Interactions
Drug Name
Risk Level
Description
5-fluorouridine
Major
The risk or severity of adverse effects can be increased when Leucovorin is combined with 5-fluorouridine.
Capecitabine
Major
The risk or severity of adverse effects can be increased when Leucovorin is combined with Capecitabine.
Doxifluridine
Major
The risk or severity of adverse effects can be increased when Leucovorin is combined with Doxifluridine.
Flucytosine
Major
The risk or severity of adverse effects can be increased when Leucovorin is combined with Flucytosine.
Fluorouracil
Major
The risk or severity of adverse effects can be increased when Leucovorin is combined with Fluorouracil.
Leucovorin Calcium Toxicity & Overdose RiskThe lowest toxic dose of leucovorin in rats is over 8000mg/kg when taken orally. Taking too much leucovorin may reduce the effectiveness of drugs that block folic acid.
Leucovorin Calcium Novel Uses: Which Conditions Have a Clinical Trial Featuring Leucovorin Calcium?
262 active clinical trials are assessing the potential of Leucovorin Calcium in providing relief from Pancreatic Metastatic Cancer, Anemia of Pregnancy and Colorectal Carcinoma.Condition
Clinical Trials
Trial Phases
folic acid
0 Actively Recruiting
Anemia of Pregnancy
1 Actively Recruiting
Phase 4
Anemia
0 Actively Recruiting
Advanced Gastric Cancer
4 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Bladder Cancer
104 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 1, Early Phase 1
normochromic anemia
0 Actively Recruiting
Megaloblastic anemia
0 Actively Recruiting
Advanced Esophageal Cancers
0 Actively Recruiting
HIV
146 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
methotrexate toxicity
0 Actively Recruiting
Macrocytic anemia
0 Actively Recruiting
Iron deficiency
2 Actively Recruiting
Phase 2, Not Applicable
pyrimethamine
0 Actively Recruiting
folate
0 Actively Recruiting
Folate deficiency
0 Actively Recruiting
Pancreatic Metastatic Cancer
29 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 3, Early Phase 1
Colorectal Carcinoma
4 Actively Recruiting
Phase 2, Phase 3, Not Applicable
hypochromic anemia
0 Actively Recruiting
Leucovorin Calcium Reviews: What are patients saying about Leucovorin Calcium?
3.7Patient Review
8/11/2009 I originally took this medication orally, but had to switch to injections because of stomach problems. The leucovorine helped somewhat, but I still needed the injection in order to get relief.
2Patient Review
7/13/2012 I haven't felt any benefits from this yet. Not sure if it's worth continuing.
Patient Q&A Section about leucovorin calcium
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is leucovorin calcium a chemo drug?
"Leucovorin is not a chemotherapy medication, but can be given alongside chemotherapy to enhance its effects. For example, it is often used in conjunction with the chemotherapy medication fluorouracil (5-FU)."
Answered by AI
Does leucovorin have side effects?
"It is possible to have an allergic reaction to Leucovorin, which may cause a rash, itching, and facial flushing. These side effects are rare and usually not severe. Nausea and vomiting are also possible side effects, but are even rarer."
Answered by AI
What is leucovorin calcium used for?
"The purpose of this medication is to either treat or prevent serious blood cell disorders that are caused by certain drugs."
Answered by AI
Is leucovorin calcium the same as folic acid?
"Folic acid is a type of folate that does not require metabolism by dihydrofolate reductase in order to be active. Folic acid antagonists are a type of chemotherapeutic drug that target this molecule."
Answered by AI