Lamisil At

Onychomycosis, Sporotrichosis, Tinea Pedis + 8 more
Treatment
0 Active Studies for Lamisil At

What is Lamisil At

TerbinafineThe Generic name of this drug
Treatment SummaryTerbinafine hydrochloride, also known as Lamisil, is a drug used to treat fungal infections. It works by blocking the production of an enzyme called squalene monooxygenase found in fungal cells, preventing the growth of fungi. Terbinafine hydrochloride was approved by the FDA in 1992.
Lamisilis the brand name
image of different drug pills on a surface
Lamisil At Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lamisil
Terbinafine
1996
143

Effectiveness

How Lamisil At Affects PatientsTerbinafine is an antifungal medication used to treat fungal infections. It works by stopping the growth of the fungal cells, which leads to the death of the fungus. It stays in the body for a long time, so it is effective over a long period of time. Taking too much of this drug is rare, so it is considered to be a very safe medication. Before taking terbinafine, patients should have tests done to make sure their liver is healthy to reduce the risk of any liver injury.
How Lamisil At works in the bodyTerbinafine blocks an enzyme called squalene monooxygenase. This enzyme helps create a molecule called ergosterol, which is important for making cell walls. When terbinafine prevents the creation of ergosterol, it causes too much squalene to build up in the cell. This weakens the cell wall and causes vesicles to form, further weakening it.

When to interrupt dosage

The proposed measure of Lamisil At is contingent upon the diagnosed condition, including Onychomycosis, Tinea cruris and Pityriasis versicolor. The amount of dosage is contingent upon the technique of administration (e.g. Aerosol, spray or Gel) as detailed in the table below.
Condition
Dosage
Administration
severe Tinea Corporis
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Onychomycosis
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Sporotrichosis
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
cutaneous candidiasis
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Tinea Versicolor
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Kerion Celsi
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Tinea cruris
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Tinea cruris
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Tinea Pedis
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Tinea Pedis
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Tinea
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical

Warnings

Lamisil At has three contraindications, and should not be used when managing the conditions listed in the below table.Lamisil At Contraindications
Condition
Risk Level
Notes
Liver Diseases
Do Not Combine
Chronic Liver Diseases (CLD)
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Terbinafine may interact with Pulse Frequency
There are 20 known major drug interactions with Lamisil At.
Common Lamisil At Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Terbinafine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Terbinafine.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Terbinafine.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Terbinafine.
Axitinib
Major
The metabolism of Axitinib can be increased when combined with Terbinafine.
Lamisil At Toxicity & Overdose RiskThe lowest toxic dose of terbinafine in rats and mice is greater than 2g/kg. Women are particularly sensitive to terbinafine, with the lowest toxic dose being 210mg/kg over a period of 6 weeks. Overdosing on terbinafine may cause nausea, vomiting, stomach pain, dizziness, rash, increased urination, and headaches. If someone overdoses on terbinafine, activated charcoal and symptomatic or supportive therapy should be used.
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Lamisil At Novel Uses: Which Conditions Have a Clinical Trial Featuring Lamisil At?

Currently, six studies are underway to assess the potential of Lamisil At in treating severe Tinea Pedis, Pityriasis versicolor and Onychomycosis.
Condition
Clinical Trials
Trial Phases
Tinea cruris
0 Actively Recruiting
Tinea cruris
0 Actively Recruiting
Onychomycosis
0 Actively Recruiting
cutaneous candidiasis
0 Actively Recruiting
severe Tinea Corporis
0 Actively Recruiting
Sporotrichosis
0 Actively Recruiting
Tinea
0 Actively Recruiting
Tinea Pedis
0 Actively Recruiting
Kerion Celsi
0 Actively Recruiting
Tinea Versicolor
0 Actively Recruiting
Tinea Pedis
0 Actively Recruiting

Lamisil At Reviews: What are patients saying about Lamisil At?

5Patient Review
11/27/2019
Lamisil At for Fungal Infection of Toenails
I've now taken Lamisil twice, both times after getting a fungus from a pedicure. The first time it took four months of treatment, and even then the fungus started growing back once I stopped taking the medication. My doctor prescribed me one more month this time around, and told me to take it every other day. So far so good!
5Patient Review
11/27/2019
Lamisil At for Fungal Infection of Toenails
I've had to take Lamisil twice in the last ten years, both times as a result of getting fungus from a pedicure. The first time it took four months of prescription medication to get rid of it. This most recent time, I am on my third month and it appears to be working beautifully! Neither time have I experienced any side effects, which is great.
5Patient Review
5/27/2020
Lamisil At for Fungal Disease of the Nails
I've been taking this medication for over a year and it has done wonders for my nails. Almost all of the problem has cleared up, though I still have some minor issues.
5Patient Review
5/27/2020
Lamisil At for Fungal Disease of the Nails
I've been taking this medication for over a year and it has done wonders for my nails. Almost all of the problem has disappeared.
4Patient Review
4/29/2022
Lamisil At for Ringworm of Groin Area
I took this medication 15 years ago for a toenail fungus and it worked great. Unfortunately, the fungus returned on my toenail and I started taking it again 2 months ago. I haven't seen any noticeable changes yet, but I know it takes some time. There are no side effects that I'm aware of. It is clearing up some scaly athlete's foot issue on the bottoms of my feet. Not being able to have a few beers while taking the meds for 3 months isn't fun...
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about lamisil at

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does it take for Lamisil AT to work?

"Terbinafine drugs usually start to work within a week when applied as cream, gel, or spray. The tablets can take between 2 weeks and a few months to work. Some brand names for terbinafine tablets and cream include Lamisil. A brand name for the solution for athlete's foot that only needs to be applied once is Lamisil Once."

Answered by AI

Are Lamisil and Lotrimin the same thing?

"The creams Lamisil and Lotrimin are used to treat skin conditions caused by fungi, including fungal nails, jock itch, and athlete's foot. Lotrimin also comes in other forms that can be used to treat vaginal yeast infections, oral thrush, tinea versicolor, or tinea corporis."

Answered by AI

What is Lamisil AT cream used for?

"This is a rash with itchy, stinging or burning sensation. There may also be blisters, cracked skin or peeling.

Lamisil AT 1% Cream is an antifungal cream containing the active ingredient terbinafine hydrochloride. Terbinafine hydrochloride is used to treat fungal skin infections such as athlete's foot (tinea pedis). Athlete's foot usually appears as a rash on the feet (usually both feet, but not always), usually in between the toes. The rash may have an itchy, stinging or burning sensation. There may also be blisters, cracked skin or peeling."

Answered by AI

Can I buy Lamisil over-the-counter?

"Is Lamisil (terbinafine) only available by prescription? No, the topical versions of Lamisil (terbinafine) (cream, gel, and spray) are available over-the-counter, but Lamisil (terbinafine) tablets are available by prescription only."

Answered by AI
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