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What is Lamisil At
TerbinafineThe Generic name of this drug
Treatment SummaryTerbinafine hydrochloride, also known as Lamisil, is a drug used to treat fungal infections. It works by blocking the production of an enzyme called squalene monooxygenase found in fungal cells, preventing the growth of fungi. Terbinafine hydrochloride was approved by the FDA in 1992.
Lamisilis the brand name
Lamisil At Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lamisil
Terbinafine
1996
143
Effectiveness
How Lamisil At Affects PatientsTerbinafine is an antifungal medication used to treat fungal infections. It works by stopping the growth of the fungal cells, which leads to the death of the fungus. It stays in the body for a long time, so it is effective over a long period of time. Taking too much of this drug is rare, so it is considered to be a very safe medication. Before taking terbinafine, patients should have tests done to make sure their liver is healthy to reduce the risk of any liver injury.
How Lamisil At works in the bodyTerbinafine blocks an enzyme called squalene monooxygenase. This enzyme helps create a molecule called ergosterol, which is important for making cell walls. When terbinafine prevents the creation of ergosterol, it causes too much squalene to build up in the cell. This weakens the cell wall and causes vesicles to form, further weakening it.
When to interrupt dosage
The proposed measure of Lamisil At is contingent upon the diagnosed condition, including Onychomycosis, Tinea cruris and Pityriasis versicolor. The amount of dosage is contingent upon the technique of administration (e.g. Aerosol, spray or Gel) as detailed in the table below.Condition
Dosage
Administration
Tinea cruris
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Pityriasis versicolor
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
severe Tinea Corporis
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Kerion Celsi
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Tinea cruris
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Onychomycosis
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Tinea Pedis
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
severe Tinea Pedis
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Sporotrichosis
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Tinea Corporis
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
cutaneous candidiasis
0.0125 mL/mL, , 0.01 mg/mg, 0.01 mL/mL, 250.0 mg, 1.0 %, 125.0 mg, 187.5 mg, 10.0 mg/mL, 40.0 mg/mL, 8.4 mg/mL, 0.05 mg/mg, 2.5 mg/mg, 0.04 mg/mg
, Topical, Cream, Cream - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Liquid, Liquid - Topical, Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Solution - Topical, Solution, Aerosol, spray - Topical, Aerosol, spray, Kit, Kit - Topical
Warnings
Lamisil At has three contraindications, and should not be used when managing the conditions listed in the below table.Lamisil At ContraindicationsCondition
Risk Level
Notes
active liver disease
Do Not Combine
Chronic Liver Diseases (CLD)
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Terbinafine may interact with Pulse Frequency
Common Lamisil At Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Terbinafine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Terbinafine.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Terbinafine.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Terbinafine.
Axitinib
Major
The metabolism of Axitinib can be increased when combined with Terbinafine.
Lamisil At Toxicity & Overdose RiskThe lowest toxic dose of terbinafine in rats and mice is greater than 2g/kg. Women are particularly sensitive to terbinafine, with the lowest toxic dose being 210mg/kg over a period of 6 weeks. Overdosing on terbinafine may cause nausea, vomiting, stomach pain, dizziness, rash, increased urination, and headaches. If someone overdoses on terbinafine, activated charcoal and symptomatic or supportive therapy should be used.
Lamisil At Novel Uses: Which Conditions Have a Clinical Trial Featuring Lamisil At?
Currently, six studies are underway to assess the potential of Lamisil At in treating severe Tinea Pedis, Pityriasis versicolor and Onychomycosis.Condition
Clinical Trials
Trial Phases
Sporotrichosis
0 Actively Recruiting
severe Tinea Pedis
0 Actively Recruiting
Kerion Celsi
0 Actively Recruiting
cutaneous candidiasis
0 Actively Recruiting
Pityriasis versicolor
0 Actively Recruiting
Tinea Corporis
0 Actively Recruiting
Tinea cruris
0 Actively Recruiting
Tinea cruris
0 Actively Recruiting
severe Tinea Corporis
0 Actively Recruiting
Tinea Pedis
0 Actively Recruiting
Onychomycosis
4 Actively Recruiting
Phase 2, Not Applicable, Phase 1
Lamisil At Reviews: What are patients saying about Lamisil At?
5Patient Review
11/27/2019 I've now taken Lamisil twice, both times after getting a fungus from a pedicure. The first time it took four months of treatment, and even then the fungus started growing back once I stopped taking the medication. My doctor prescribed me one more month this time around, and told me to take it every other day. So far so good!
5Patient Review
11/27/2019 I've had to take Lamisil twice in the last ten years, both times as a result of getting fungus from a pedicure. The first time it took four months of prescription medication to get rid of it. This most recent time, I am on my third month and it appears to be working beautifully! Neither time have I experienced any side effects, which is great.
5Patient Review
5/27/2020 I've been taking this medication for over a year and it has done wonders for my nails. Almost all of the problem has cleared up, though I still have some minor issues.
5Patient Review
5/27/2020 I've been taking this medication for over a year and it has done wonders for my nails. Almost all of the problem has disappeared.
4Patient Review
4/29/2022 I took this medication 15 years ago for a toenail fungus and it worked great. Unfortunately, the fungus returned on my toenail and I started taking it again 2 months ago. I haven't seen any noticeable changes yet, but I know it takes some time. There are no side effects that I'm aware of. It is clearing up some scaly athlete's foot issue on the bottoms of my feet. Not being able to have a few beers while taking the meds for 3 months isn't fun...
4Patient Review
4/29/2022 I took this medication 15 years ago for toe nail fungus and it worked great. Unfortunately, the fungus returned on my toenail, so I started taking it again 2 months ago. No noticeable changes yet but I know it takes some time. I'm not experiencing any side effects that I'm aware of. It is clearing up some scaly athlete foot issue on feet bottoms though. Not being able to have a few beers while taking the meds for 3 months is no fun...
3Patient Review
1/3/2022 I developed a fungus on my big toe from playing BJJ. I started taking Lamisil tabs 250mg/d and saw great results for the first four weeks. However, in the fifth week, I started to develop a rash. I also began to smell and taste garlic BO. I discontinues Lamisil and after seven days off the medicine, the rash had improved somewhat. Now, two weeks later, the rash is 75% improved but not gone. The nail looks better, but I'm sure I took some time off of my life by taking this medicine..
3Patient Review
3/25/2022 Even after five weeks of use, I saw no visible improvement to my toenail issue. Additionally, I developed an itchy rash that has since spread all over my arms and chest. While there are no other side effects to report, I would not recommend this treatment to others.
3Patient Review
1/3/2022 I got a toenail fungus from BJJ and started taking Lamisil. It was working great for the first month, but then I started getting a rash. I discontinued the Lamisil and the rash improved after a week, but it's still not gone. The nail looks better, but I'm concerned about the long-term side effects of this medicine.
3Patient Review
3/25/2022 Though I haven't seen any change in my toenail after five weeks, I have developed an itchy rash all over my arms and chest. As of right now, I would not recommend this medication to others; however, that may change if the rash disappears after discontinuation.
2.3Patient Review
3/3/2020 I started taking this medication about 12 weeks ago and recently began experiencing severe chest pain.
2.3Patient Review
3/3/2020 After taking this for almost 12 weeks, I started experiencing severe chest pain.
1.7Patient Review
4/9/2019 The side effects were unfortunately way too severe for me. I developed major insomnia, anxiety, and loss of appetite; in addition, my urine became dark in color. All of this within 18 days of use. Even 10 days after stopping the drug, I'm still struggling with insomnia at times to the point where it's hard to function or drive.
1.7Patient Review
4/9/2019 The severe side effects I experienced while on this drug were terrible. I couldn't sleep, was constantly anxious, and lost my appetite. My urine also became very dark in color. I had to stop taking the medication after only 18 days, and even 10 days after stopping I'm still suffering from insomnia. Some days I can't even work or drive because of it.
1Patient Review
11/29/2017 I would not advise anyone to take this drug. It has caused me 19 days of bloody diarrhea and I have been diagnosed with colitis.
1Patient Review
6/16/2020 I tried Lamisil three times over the course of six years, and it was completely ineffective. I recently removed my toenail and took Lamisil for three months every day, but my nail grew back even worse than before. No side effects, just disappointed that it didn't work for me.
1Patient Review
10/22/2020 I've now taken 60 pills and have 25 more to go. Unfortunately, my body isn't responding well to the medication. I'm experiencing insomnia, red patches and blisters on my arm, headaches every day, and a metallic taste in my mouth. I also don't see any improvement in my nails or toes. This is extremely frustrating, as the doctor said this would work. I don't know whether to keep going or stop taking the medication entirely.
1Patient Review
10/4/2020 I am currently on day four of taking the generic form of lamisil, terbinafine, and I have never felt this sick before. Some of the symptoms I are experiencing are extreme fatigue and tiredness, headache, stomach pain, dehydration, dry eyes, sore throat, and back pain.
1Patient Review
11/29/2017 Do not under any circumstances take this drug. The side effects are incredibly severe and not worth the risk.
1Patient Review
10/22/2020 I've now taken 60 pills, 25 more to go. Unfortunately, my body is really struggling with the treatment. I have insomnia, a red patch and blister on my arm, and aches all over my body. I also have a headache every day, and a metal taste in my mouth. I see no sign of improvement on my fingernails or toes. This is extremely frustrating as the doctor said it would work. I'm not sure whether to keep going or stop.
1Patient Review
10/4/2020 I am on day 4 of taking the generic form of lamisil, terbinafine and I feel awful. Iâ??ve never felt this bad before. Extreme fatigue and tiredness, headache, stomach hurts and canâ??t eat. When I do manage to eat a few bites, everything tastes terrible. I feel so dehydrated and my eyes are so dry. Sore throat and back pain.
1Patient Review
6/16/2020 I tried lamisil multiple times over the course of six years, and it did nothing to help my condition. In fact, after taking it for three months as directed, my toenail grew back even worse than before.
Patient Q&A Section about lamisil at
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long does it take for Lamisil AT to work?
"Terbinafine drugs usually start to work within a week when applied as cream, gel, or spray. The tablets can take between 2 weeks and a few months to work. Some brand names for terbinafine tablets and cream include Lamisil. A brand name for the solution for athlete's foot that only needs to be applied once is Lamisil Once."
Answered by AI
Are Lamisil and Lotrimin the same thing?
"The creams Lamisil and Lotrimin are used to treat skin conditions caused by fungi, including fungal nails, jock itch, and athlete's foot. Lotrimin also comes in other forms that can be used to treat vaginal yeast infections, oral thrush, tinea versicolor, or tinea corporis."
Answered by AI
What is Lamisil AT cream used for?
"This is a rash with itchy, stinging or burning sensation. There may also be blisters, cracked skin or peeling.
Lamisil AT 1% Cream is an antifungal cream containing the active ingredient terbinafine hydrochloride. Terbinafine hydrochloride is used to treat fungal skin infections such as athlete's foot (tinea pedis). Athlete's foot usually appears as a rash on the feet (usually both feet, but not always), usually in between the toes. The rash may have an itchy, stinging or burning sensation. There may also be blisters, cracked skin or peeling."
Answered by AI
Can I buy Lamisil over-the-counter?
"Is Lamisil (terbinafine) only available by prescription? No, the topical versions of Lamisil (terbinafine) (cream, gel, and spray) are available over-the-counter, but Lamisil (terbinafine) tablets are available by prescription only."
Answered by AI