Repetitive Transcranial Magnetic Stimulation for Chronic Pain

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
VA San Diego Healthcare System, San Diego, CA, San Diego, CA
Chronic Pain+2 More
Repetitive Transcranial Magnetic Stimulation - Device
Eligibility
Any Age
All Sexes
What conditions do you have?
Select

Study Summary

Veterans with comorbid chronic pain and depression are highly prevalent, have poor functional status and low quality of life, are at increased risk of suicide and lack access to effective treatments. To address this problem, the proposed research will examine the feasibility of a novel approach that integrates repetitive Transcranial Magnetic Stimulation and Acceptance and Commitment Therapy with the overall goal of maximizing functional improvement in Veterans with chronic pain and depression. This is an important first-step in preparation for a future randomized efficacy trial. The investigators will also include two cognitive control tasks with concurrent electroencephalography to explore as a potential objective indicator of treatment response. This application addresses a critical need within the Veterans Health Administration and is closely aligned with the focus area of developing suicide prevention treatments that influence participation in life roles.

Eligible Conditions

  • Chronic Pain
  • Depression

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 2 Secondary · Reporting Duration: Baseline, weekly during ACT intervention, 9 weeks

Week 9
PROMIS Pain Intensity change
PROMIS Pain Interference change
Patient Health Questionnaire-9 (PHQ-9) change

Trial Safety

Trial Design

2 Treatment Groups

Sham-rTMS + ACT
1 of 2
DLPFC-rTMS + ACT
1 of 2
Active Control
Experimental Treatment

24 Total Participants · 2 Treatment Groups

Primary Treatment: Repetitive Transcranial Magnetic Stimulation · No Placebo Group · N/A

DLPFC-rTMS + ACTExperimental Group · 2 Interventions: Repetitive Transcranial Magnetic Stimulation, Acceptance and Commitment Therapy · Intervention Types: Device, Behavioral
Sham-rTMS + ACT
Behavioral
ActiveComparator Group · 1 Intervention: Acceptance and Commitment Therapy · Intervention Types: Behavioral
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Repetitive Transcranial Magnetic Stimulation
2013
Completed Phase 3
~1130
Acceptance and Commitment Therapy
2010
Completed Phase 1
~1490

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, weekly during act intervention, 9 weeks
Closest Location: VA San Diego Healthcare System, San Diego, CA · San Diego, CA
Photo of san diego  1Photo of san diego  2Photo of san diego  3
2006First Recorded Clinical Trial
3 TrialsResearching Chronic Pain
41 CompletedClinical Trials

Eligibility Criteria

Age Any Age · All Participants · 3 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You have a diagnosis of a chronic, non-terminal pain condition (pain most days for at least 6 months).

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.