Kombiglyze Xr

Physical Activity, Type 2 Diabetes, Diet + 4 more
Treatment
6 FDA approvals
20 Active Studies for Kombiglyze Xr

What is Kombiglyze Xr

SaxagliptinThe Generic name of this drug
Treatment SummaryMetformin is a drug used to treat type 2 diabetes. It is the most commonly prescribed drug for this condition and is used by at least 120 million people worldwide. Metformin helps to lower blood sugar without causing low blood sugar and can also improve insulin sensitivity, leading to a decrease in insulin resistance and lower plasma fasting insulin levels. Additionally, it can cause modest weight loss. Metformin was approved in Canada in 1972 and in the United States in 1995. It is available in regular and extended-release forms.
Onglyzais the brand name
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Kombiglyze Xr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Onglyza
Saxagliptin
2009
19

Approved as Treatment by the FDA

Saxagliptin, also known as Onglyza, is approved by the FDA for 6 uses which include saxagliptin and dapagliflozin .
saxagliptin
Used to treat already treated with dapagliflozin and saxagliptin in combination with Dapagliflozin
dapagliflozin
Used to treat inadequate control with dapagliflozin in combination with Dapagliflozin
Diet
Used to treat Diet in combination with Metformin
Physical Activity
Used to treat Exercise in combination with Metformin
Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Metformin
Excercise
Used to treat Excercise in combination with Dapagliflozin

Effectiveness

How Kombiglyze Xr Affects PatientsInsulin is a hormone that helps control the amount of sugar in the blood. People with type 2 diabetes can either be resistant to insulin, meaning they don't respond to it as well, or they may not produce enough insulin. Metformin works by reducing the amount of sugar produced by the liver, limiting how much sugar is absorbed from food, and making cells more sensitive to insulin. Unlike other diabetes drugs, Metformin doesn't increase the amount of insulin in your body. In one study, people taking Metformin saw their fasting plasma glucose levels go down by 59 mg/dL on average, compared to an average increase of
How Kombiglyze Xr works in the bodyMetformin works differently than other diabetes medications by decreasing the body's production of glucose, reducing glucose absorption in the intestines, and increasing insulin sensitivity. When taken, metformin accumulates in cells and the mitochondria, where it inhibits mitochondrial complex I and activates AMP-activated protein kinase. This enzyme helps regulate glucose metabolism by inhibiting fat synthesis, increasing fat oxidation, and reducing liver lipid stores, making it more sensitive to insulin. Metformin also increases the metabolism of glucose in the intestines, leading to reduced net glucose uptake and increased lactate delivery to the liver. It also promotes the metabolism of glucose

When to interrupt dosage

The measure of Kombiglyze Xr is contingent upon the established disorder, including Diet, inadequate response to metformin and Diabetic Ketoacidosis. The amount of dosage deviates, dependent on the method of delivery (e.g. Oral or Tablet - Oral) featured in the table beneath.
Condition
Dosage
Administration
Physical Activity
2.5 mg, , 5.0 mg
Tablet, film coated, , Oral, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, Tablet - Oral
inadequate response to other therapeutic measures
2.5 mg, , 5.0 mg
Tablet, film coated, , Oral, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, Tablet - Oral
Type 2 Diabetes
2.5 mg, , 5.0 mg
Tablet, film coated, , Oral, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, Tablet - Oral
dapagliflozin
2.5 mg, , 5.0 mg
Tablet, film coated, , Oral, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, Tablet - Oral
Diet
2.5 mg, , 5.0 mg
Tablet, film coated, , Oral, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, Tablet - Oral
saxagliptin
2.5 mg, , 5.0 mg
Tablet, film coated, , Oral, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, Tablet - Oral
Excercise
2.5 mg, , 5.0 mg
Tablet, film coated, , Oral, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, Tablet - Oral

Warnings

There are 20 known major drug interactions with Kombiglyze Xr.
Common Kombiglyze Xr Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Saxagliptin.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Saxagliptin.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Saxagliptin.
Carbamazepine
Major
The metabolism of Carbamazepine can be decreased when combined with Saxagliptin.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Saxagliptin.
Kombiglyze Xr Toxicity & Overdose RiskThe toxic dose of Metformin in rats is 1g/kg orally, 500mg/kg intraperitoneally and 300mg/kg subcutaneously. In mice, the toxic dose is 1450mg/kg orally, 420mg/kg intraperitoneally and 225mg/kg subcutaneously. Metformin may lead to lactic acidosis, a condition where lactate levels are higher than normal in the blood. Symptoms may include malaise, muscle pain, abdominal pain, respiratory distress and increased sleepiness. There is an increased risk of lactic acidosis in those with reduced kidney function
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Kombiglyze Xr Novel Uses: Which Conditions Have a Clinical Trial Featuring Kombiglyze Xr?

346 active studies are presently examining the potential of Kombiglyze XR to alleviate Type 2 Diabetes, Type 1 Diabetes and an inadequate response to Metformin therapy.
Condition
Clinical Trials
Trial Phases
Physical Activity
38 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
saxagliptin
0 Actively Recruiting
inadequate response to other therapeutic measures
0 Actively Recruiting
dapagliflozin
0 Actively Recruiting
Diet
3 Actively Recruiting
Not Applicable
Excercise
1 Actively Recruiting
Not Applicable
Type 2 Diabetes
190 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3

Kombiglyze Xr Reviews: What are patients saying about Kombiglyze Xr?

5Patient Review
3/25/2013
Kombiglyze Xr for Type 2 Diabetes Mellitus
I've only been on the medication for a short time, but I've already experienced lower abdominal pain, as well as left shoulder and body aches. I'm wondering how long I should give it before deciding if it's effective or not. My blood sugar levels haven't dropped significantly yet.
5Patient Review
7/2/2014
Kombiglyze Xr for Type 2 Diabetes Mellitus
At first, I experienced some stomach problems, but they dissipated after about a month. My A1C was 10.5 when I started this treatment, and after only four months it had lowered to 7. And all without having to diet or exercise!
5Patient Review
9/10/2016
Kombiglyze Xr for Type 2 Diabetes Mellitus
Kombiglyze was a much better fit for me than metformin and glipizide. My A1C levels dropped significantly, and my blood sugar was more consistent throughout the day. I also didn't have any episodes of hypoglycemia like I did with glipizide.
5Patient Review
4/6/2013
Kombiglyze Xr for Type 2 Diabetes Mellitus
I just started taking this, and it is quite expensive. One review I read mentioned a card used to register with the manufacturer; apparently, it reduced her cost to $10 per month. I would love to know more about this program!
5Patient Review
6/2/2014
Kombiglyze Xr for Type 2 Diabetes Mellitus
I haven't been thrilled with this treatment so far as it's made me quite ill; however, I'm hoping my body will adjust to it in the next week or so.
4.3Patient Review
6/6/2016
Kombiglyze Xr for Type 2 Diabetes Mellitus
Kombiglyze helped improve my A1c marginally more than Metformin did when used as a supplement to injected insulin. I will have to reassess whether or not I want to continue using it due to the cost, although there were no negative side effects that I experienced.
4Patient Review
2/8/2015
Kombiglyze Xr for Type 2 Diabetes Mellitus
I would not recommend this drug to anyone. It caused a lot of problems for me, including heart and brain damage. I was on it for almost four years and experienced severe insomnia, memory loss, muscle pain, and constant trips to the bathroom. I'm only off now because of the anxiety and nausea it caused.
4Patient Review
1/2/2017
Kombiglyze Xr for Type 2 Diabetes Mellitus
I've been taking this medicine for the past four years and, while it has helped to control my sugar levels, I have noticed a significant decline in my sex life.
4Patient Review
3/6/2013
Kombiglyze Xr for Type 2 Diabetes Mellitus
I'm experiencing some serious leg cramps in my right lower leg. I'm not sure if it's a side effect of the medicine, but I'll be sure to ask my doctor about it.
4Patient Review
1/13/2013
Kombiglyze Xr for Type 2 Diabetes Mellitus
3.7Patient Review
1/23/2014
Kombiglyze Xr for Type 2 Diabetes Mellitus
I've found this medication really helpful in dropping the pounds. With a solid workout routine and healthy eating habits, I was able to lose 50 pounds while taking this drug.
3.7Patient Review
1/13/2013
Kombiglyze Xr for Type 2 Diabetes Mellitus
3.3Patient Review
6/29/2013
Kombiglyze Xr for Type 2 Diabetes Mellitus
As a 47-year old male, Glucophage didn't lower my blood sugar levels enough. Therefore, the doctor put me on this medication. I found that drinking lots of water helped with any headaches I got and that stomach issues only lasted about three weeks. It's important to take this drug with food, as it is much more effective that way. I also found that aspartame caused bad gas pains, but Splenda did not.
3Patient Review
3/6/2013
Kombiglyze Xr for Type 2 Diabetes Mellitus
I take one metformin pill in the morning and one at night, along with Kombiglyze. My sugars have improved noticeably without any side effects.
3Patient Review
1/19/2013
Kombiglyze Xr for Type 2 Diabetes Mellitus
1.3Patient Review
9/27/2015
Kombiglyze Xr for Type 2 Diabetes Mellitus
I've been on this for about a month and it's helped, but I've also experienced some pretty nasty side effects like constipation, diarrhea, and headaches. I'm concerned about the potential long-term effects of this medication on my pancreas.
1Patient Review
8/18/2014
Kombiglyze Xr for Type 2 Diabetes Mellitus
Even though all medications have potential side effects, I found this one to be very effective. My AC1 levels decreased within three months and it didn't cause any stomach upset.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about kombiglyze xr

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic for kombiglyze?

"There are no alternative medicines to Kombiglyze XR at the moment."

Answered by AI

Is kombiglyze the same as Janumet?

"It’s more expensive than some other diabetes drugs but worth the price.

Kombiglyze lower blood sugar levels effectively, but may not be a good choice of medication if you have heart or kidney problems. Janumet is a combination of two anti-diabetic medicines that work better together, but is only available as a brand name drug. It is more expensive than some other diabetes medications, but is worth the price."

Answered by AI

What is KOMBIGLYZE XR used for?

"KOMBIGLYZE XR is a prescription medicine that contains saxagliptin and metformin hydrochloride. KOMBIGLYZE XR is used with diet and exercise to help control high blood sugar (hyperglycemia) in adults with type 2 diabetes. Your doctor will decide if treatment with KOMBIGLYZE XR is right for you."

Answered by AI

Is kombiglyze the same as metformin?

"Metformin can cause a serious condition called lactic acidosis, which is a build-up of an acid in the blood. Lactic acidosis is a medical emergency and requires hospital treatment."

Answered by AI

Clinical Trials for Kombiglyze Xr

Have you considered Kombiglyze Xr clinical trials? We made a collection of clinical trials featuring Kombiglyze Xr, we think they might fit your search criteria.
Have you considered Kombiglyze Xr clinical trials? We made a collection of clinical trials featuring Kombiglyze Xr, we think they might fit your search criteria.
Have you considered Kombiglyze Xr clinical trials? We made a collection of clinical trials featuring Kombiglyze Xr, we think they might fit your search criteria.