Kombiglyze Xr

Physical Activity, Type 2 Diabetes, Diet + 4 more

Treatment

7 FDA approvals

20 Active Studies for Kombiglyze Xr

Treatment for

Physical Activity

What is Kombiglyze Xr

SaxagliptinThe Generic name of this drug

Treatment SummaryMetformin is a drug used to treat type 2 diabetes. It is the most commonly prescribed drug for this condition and is used by at least 120 million people worldwide. Metformin helps to lower blood sugar without causing low blood sugar and can also improve insulin sensitivity, leading to a decrease in insulin resistance and lower plasma fasting insulin levels. Additionally, it can cause modest weight loss. Metformin was approved in Canada in 1972 and in the United States in 1995. It is available in regular and extended-release forms.

Onglyzais the brand name

image of different drug pills on a surface

Kombiglyze Xr Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Onglyza

Saxagliptin

2009

Approved as Treatment by the FDA

Saxagliptin, also known as Onglyza, is approved by the FDA for 7 uses which include Type 2 Diabetes Mellitus and Physical Activity .

Type 2 Diabetes Mellitus

Used to treat Type 2 Diabetes Mellitus in combination with Metformin

Physical Activity

Used to treat Exercise in combination with Metformin

Excercise

Used to treat Excercise in combination with Dapagliflozin

Type 2 Diabetes

Used to treat Type 2 Diabetes Mellitus in combination with Metformin

saxagliptin

Used to treat already treated with dapagliflozin and saxagliptin in combination with Dapagliflozin

dapagliflozin

Used to treat inadequate control with dapagliflozin in combination with Dapagliflozin

Diet

Used to treat Diet in combination with Metformin

Effectiveness

How Kombiglyze Xr Affects PatientsInsulin is a hormone that helps control the amount of sugar in the blood. People with type 2 diabetes can either be resistant to insulin, meaning they don't respond to it as well, or they may not produce enough insulin. Metformin works by reducing the amount of sugar produced by the liver, limiting how much sugar is absorbed from food, and making cells more sensitive to insulin. Unlike other diabetes drugs, Metformin doesn't increase the amount of insulin in your body. In one study, people taking Metformin saw their fasting plasma glucose levels go down by 59 mg/dL on average, compared to an average increase of

How Kombiglyze Xr works in the bodyMetformin works differently than other diabetes medications by decreasing the body's production of glucose, reducing glucose absorption in the intestines, and increasing insulin sensitivity. When taken, metformin accumulates in cells and the mitochondria, where it inhibits mitochondrial complex I and activates AMP-activated protein kinase. This enzyme helps regulate glucose metabolism by inhibiting fat synthesis, increasing fat oxidation, and reducing liver lipid stores, making it more sensitive to insulin. Metformin also increases the metabolism of glucose in the intestines, leading to reduced net glucose uptake and increased lactate delivery to the liver. It also promotes the metabolism of glucose

When to interrupt dosage

The measure of Kombiglyze Xr is contingent upon the established disorder, including Diet, inadequate response to metformin and Diabetic Ketoacidosis. The amount of dosage deviates, dependent on the method of delivery (e.g. Oral or Tablet - Oral) featured in the table beneath.

Condition

Dosage

Administration

Physical Activity

2.5 mg, , 5.0 mg