Kadian

Chronic Pain, Pain, Therapeutic procedure

Treatment

3 FDA approvals

0 Active Studies for Kadian

Treatment for

Chronic Pain

What is Kadian

Morphine

The Generic name of this drug

Treatment Summary

Morphine is a powerful painkiller that is derived from opium. It has been used since 1805, but is limited by tolerance, withdrawal and the potential for abuse. Morphine is still widely used, but there are also many other semi-synthetic opioid medications of varying strengths, such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone. Morphine was approved by the FDA in 1941.

Morphine Sulfate

is the brand name

image of different drug pills on a surface

Kadian Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Morphine Sulfate

Morphine

1971

459

Approved as Treatment by the FDA

Morphine, also known as Morphine Sulfate, is approved by the FDA for 3 uses including Pain, Chronic and Chronic Pain .

Pain, Chronic

Helps manage Pain, Chronic

Chronic Pain

Helps manage Pain, Chronic

Pain

Effectiveness

How Kadian Affects Patients

Morphine attaches to opioid receptors, which blocks signals in the body that cause pain. It takes 6-30 minutes for it to start working. Taking too much morphine and other opioids can change the way neurons in the brain function. Men and women respond differently to morphine; men need 76ng/mL for it to be effective, while women only need 22ng/mL. Morphine-6-glucuronide is much weaker than morphine and is only 22 times as effective at reducing pupil size.

How Kadian works in the body

Morphine-6-glucuronide is responsible for most of the effects of morphine. This molecule binds to the mu and kappa opioid receptors, which are responsible for morphine's effects on the brain and body. The mu-opioid receptor in particular is responsible for morphine's effects on the reward pathway, as well as its ability to modify the respiratory system and cause addiction.

When to interrupt dosage

The advocated dose of Kadian is subject to the diagnosed condition, including Therapeutic procedure, Pain and Chronic Pain. The dosage amount fluctuates in accordance with the method of administration specified in the table below.

Condition

Dosage

Administration

Therapeutic procedure

10.0 mg/mL, , 20.0 mg, 50.0 mg, 60.0 mg, 30.0 mg, 10.0 mg, 80.0 mg, 100.0 mg, 200.0 mg, 0.5 mg/mL, 1.0 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 3.0 mg/mL, 100.0 mg/mL, 5.0 mg, 15.0 mg, 20.0 mg/mL, 15.0 mg/mL, 5.0 mg/mL, 8.0 mg/mL, 4.0 mg/mL, 90.0 mg, 120.0 mg, 40.0 mg, 70.0 mg, 130.0 mg, 150.0 mg, 2.0 mg/mL, 45.0 mg, 75.0 mg, 25.0 mg, 40.0 mg/mL, 1.1 mg/mL, 0.1 mg/mL

Oral, Solution - Oral, Solution, , Capsule, extended release - Oral, Capsule, extended release, Epidural; Intrathecal; Intravenous, Injection, solution - Epidural; Intrathecal; Intravenous, Injection, solution, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution - Intravenous, Intravenous; Subcutaneous, Injection, solution - Intravenous; Subcutaneous, Rectal, Suppository - Rectal, Suppository, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Intrathecal; Intravenous, Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution - Epidural; Intramuscular; Intrathecal; Intravenous, Capsule, Capsule - Oral, Solution - Intravenous, Liquid - Intravenous, Tincture, Tincture - Oral, Suppository, extended release, Suppository, extended release - Rectal, Injection, solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Epidural; Intrathecal, Injection, solution - Epidural; Intrathecal, Solution, concentrate, Solution, concentrate - Oral, Liquid - Oral, Liquid, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Parenteral, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, solution - Intrathecal; Intravenous, Solution / drops, Solution / drops - Oral, Epidural, Solution - Epidural, Solution - Intramuscular; Intravenous; Subcutaneous, Solution - Intravenous; Subcutaneous, Epidural; Intravenous; Subcutaneous, Solution - Epidural; Intravenous; Subcutaneous, Syrup, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid - Intravenous; Subcutaneous, Syrup - Oral, Intramuscular, Injection - Intramuscular, Injection - Epidural; Intrathecal; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, lipid complex, Injection, lipid complex - Epidural, Injection - Parenteral, Solution - Parenteral, Injection - Epidural; Intrathecal, Injection, solution - Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Intrathecal, Injection, solution - Intrathecal

Pain

Chronic Pain

Warnings

Kadian has six contraindications and should not be utilized when facing any of the circumstances detailed in the following table.

Kadian Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Morphine may interact with Pulse Frequency

Pulse Frequency

Do Not Combine

Mental Depression

Do Not Combine

Asthma

Do Not Combine

Gastrointestinal obstruction

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Kadian.

Common Kadian Drug Interactions

Drug Name

Risk Level

Description

Azelastine

Major

Morphine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Morphine.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Morphine.

Eluxadoline

Major

The risk or severity of constipation can be increased when Morphine is combined with Eluxadoline.

Enasidenib

Major

The metabolism of Enasidenib can be decreased when combined with Morphine.

Kadian Toxicity & Overdose Risk

The lowest toxic dose of the drug for males is 0.78µg/mL and for females it is 0.98µg/mL. An overdose can cause difficulty breathing, drowsiness, weak muscles, cold and clammy skin, constricted pupils, and dilated pupils. Symptoms may worsen to include fluid in the lungs, a slow heart rate, low blood pressure, and even cardiac arrest and death. Treatment of an overdose may involve using oxygen, medications to increase blood pressure, and naloxone.

Kadian Novel Uses: Which Conditions Have a Clinical Trial Featuring Kadian?

24 active trials are being conducted to assess the potential of Kadian in providing therapeutic relief, Pain Management and Chronic Pain Treatment.

Condition

Clinical Trials

Trial Phases

Pain

0 Actively Recruiting

Therapeutic procedure

0 Actively Recruiting

Chronic Pain

0 Actively Recruiting

Kadian Reviews: What are patients saying about Kadian?

Patient Review

7/29/2014

Kadian for Chronic Pain

Kadian has been an amazing help for my severe scoliosis. I can finally function at work without feeling foggy and exhausted all the time. The only downside is that it's caused me some constipation issues, but hopefully I'll be able to wean myself off of it in the next year.

Patient Review

5/8/2013

Kadian for Chronic Pain

I have a lot of medical problems, but this treatment really helps with the pain.

Patient Review

2/10/2015

Kadian for Chronic Pain

Kadian was an excellent treatment for my spondylosis; however, over time I'm beginning to experience more breakthrough pain. Not sure if this is due to the progression of the disease or if the generic Kadian is not as effective?

Patient Review

3/24/2013

Kadian for Chronic Pain

The doctor is switching me from this to nuerotin and loritab because of my diabetes.

Patient Review

5/14/2015

Kadian for Chronic Pain

Out of all the drugs I've tried, this one had the least amount of side effects and was the most effective.

Patient Review

6/28/2013

Kadian for Chronic Pain

In my experience, this treatment just made me feel drowsy.

Patient Review

2/26/2015

Kadian for Chronic Pain

This medication is working well for me so far. I was on oxycodone before, 15mg x 6 a day, which didn't help at all. This is the first time in 20 years that I've felt relief from most of my pain.

Patient Review

2/13/2013

Kadian for Chronic Pain

4.7

Patient Review

12/9/2012

Kadian for Chronic Pain

4.3

Patient Review

8/8/2013

Kadian for Severe Pain

Kadian is the only time-release morphine that I've tried that actually works for 12 hours like it's supposed to. It's given me my life back--I'm working full-time and able to do things around the house and garden that I enjoy.

4.3

Patient Review

5/22/2018

Kadian for Neuropathic Pain

I found this treatment to be most effective a few hours after administration. I'm only on 60mg because that's all my insurance would cover, but I think it's working well so far. The only weird side effect I've experienced is an irregular heartbeat. Has anyone else had this issue?

Patient Review

6/22/2013

Kadian for Chronic Pain

I'm on a pretty high dose of Kadian, and it's not really doing much for me. I'm thinking about trying something else.

Patient Review

11/22/2012

Kadian for Neuropathic Pain

3.7

Patient Review

6/18/2014

Kadian for Severe Pain

Kadian has been an absolute godsend. I've been struggling with chronic pain for two decades and have tried almost everything on the market without much relief. Kadian finally gives me the around-the-clock coverage I need to live my life again.

3.7

Patient Review

3/26/2013

Kadian for Neuropathic Pain

I was taking generic, time-released morphine for my chronic pain associated with Multiple Sclerosis. Kadian has been much more effective for me and doesn't cause the drowsiness that the other medication did.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about kadian

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic name for Kadian?

"Kadian is a narcotic pain reliever that is used to treat moderate to severe pain. It can be taken as needed for pain or as an extended-release medication for around-the-clock pain relief."

Answered by AI

What class of drug is Kadian?

"Morphine is a narcotic analgesic that is used to treat severe chronic pain by increasing pain tolerance."

Answered by AI

What is the difference between Kadian and morphine?

"KADIAN can be taken once or twice daily, depending on the doctor's discretion. KADIAN, a 24 hour release long acting morphine capsule, has been added to formulary. It is different from other long acting morphine products on the market, like M-ESLON, which is a 12 hour release formulation."

Answered by AI