What is Kadian
MorphineThe Generic name of this drug
Treatment SummaryMorphine is a powerful painkiller that is derived from opium. It has been used since 1805, but is limited by tolerance, withdrawal and the potential for abuse. Morphine is still widely used, but there are also many other semi-synthetic opioid medications of varying strengths, such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone. Morphine was approved by the FDA in 1941.
Morphine Sulfateis the brand name
Kadian Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Morphine Sulfate
Morphine
1971
459
Approved as Treatment by the FDA
Morphine, also known as Morphine Sulfate, is approved by the FDA for 2 uses including Chronic Pain and Pain .Chronic Pain
Helps manage Pain, Chronic
Pain
Effectiveness
How Kadian Affects PatientsMorphine attaches to opioid receptors, which blocks signals in the body that cause pain. It takes 6-30 minutes for it to start working. Taking too much morphine and other opioids can change the way neurons in the brain function. Men and women respond differently to morphine; men need 76ng/mL for it to be effective, while women only need 22ng/mL. Morphine-6-glucuronide is much weaker than morphine and is only 22 times as effective at reducing pupil size.
How Kadian works in the bodyMorphine-6-glucuronide is responsible for most of the effects of morphine. This molecule binds to the mu and kappa opioid receptors, which are responsible for morphine's effects on the brain and body. The mu-opioid receptor in particular is responsible for morphine's effects on the reward pathway, as well as its ability to modify the respiratory system and cause addiction.
When to interrupt dosage
The advocated dose of Kadian is subject to the diagnosed condition, including Therapeutic procedure, Pain and Chronic Pain. The dosage amount fluctuates in accordance with the method of administration specified in the table below.Condition
Dosage
Administration
Therapeutic procedure
, 8.0 mg/mL, 80.0 mg, 70.0 mg, 60.0 mg, 100.0 mg/mL, 200.0 mg, 4.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL, 2.0 mg/mL, 15.0 mg/mL, 100.0 mg, 10.0 mg, 15.0 mg, 30.0 mg, 20.0 mg, 50.0 mg, 25.0 mg, 20.0 mg/mL, 1.0 mg/mL, 5.0 mg, 120.0 mg, 1.1 mg/mL, 50.0 mg/mL, 5.0 mg/mL, 25.0 mg/mL, 0.1 mg/mL, 3.0 mg/mL, 75.0 mg, 45.0 mg, 40.0 mg/mL, 90.0 mg, 150.0 mg, 40.0 mg, 130.0 mg
, Injection, solution - Intravenous; Subcutaneous, Injection, Injection, solution - Epidural; Intrathecal, Oral, Tablet, Capsule, extended release, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution - Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Solution, Intrathecal; Intravenous, Epidural; Intrathecal, Syrup - Oral, Solution - Intravenous; Subcutaneous, Capsule, extended release - Oral, Tablet - Oral, Tablet, extended release - Oral, Suppository, Solution - Epidural; Intravenous; Subcutaneous, Capsule, coated, extended release, Epidural; Intravenous; Subcutaneous, Rectal, Suppository - Rectal, Intravenous, Injection, solution, concentrate, Tablet, multilayer, extended release, Capsule, Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution, Intramuscular, Suppository, extended release - Rectal, Epidural, Capsule - Oral, Tablet, extended release, Injection - Epidural; Intrathecal, Solution - Epidural, Intravenous; Subcutaneous, Capsule, coated, extended release - Oral, Tablet, film coated - Oral, Injection - Epidural; Intrathecal; Intravenous, Liquid, Solution - Parenteral, Injection - Intramuscular; Intravenous; Subcutaneous, Tablet, film coated, extended release, Tablet, multilayer, extended release - Oral, Injection, solution - Epidural; Intrathecal; Intravenous, Injection - Intramuscular, Epidural; Intrathecal; Intravenous, Syrup, Tablet, film coated, Injection, solution - Intramuscular; Intravenous, Solution / drops - Oral, Liquid - Intramuscular; Intravenous; Subcutaneous, Solution - Oral, Intramuscular; Intravenous, Tablet, film coated, extended release - Oral, Solution, concentrate - Oral, Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Injection, lipid complex - Epidural, Intramuscular; Intravenous; Subcutaneous, Parenteral, Injection, solution - Epidural; Intramuscular; Intrathecal; Intravenous, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intravenous, Suppository, extended release, Intrathecal, Solution, concentrate, Injection, lipid complex, Tincture, Injection, solution - Intrathecal, Liquid - Oral, Solution - Intravenous, Solution / drops, Liquid - Intravenous; Subcutaneous, Injection - Parenteral, Injection, solution - Intrathecal; Intravenous, Tincture - Oral, Injection, solution, concentrate - Intravenous
Pain
, 8.0 mg/mL, 80.0 mg, 70.0 mg, 60.0 mg, 100.0 mg/mL, 200.0 mg, 4.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL, 2.0 mg/mL, 15.0 mg/mL, 100.0 mg, 10.0 mg, 15.0 mg, 30.0 mg, 20.0 mg, 50.0 mg, 25.0 mg, 20.0 mg/mL, 1.0 mg/mL, 5.0 mg, 120.0 mg, 1.1 mg/mL, 50.0 mg/mL, 5.0 mg/mL, 25.0 mg/mL, 0.1 mg/mL, 3.0 mg/mL, 75.0 mg, 45.0 mg, 40.0 mg/mL, 90.0 mg, 150.0 mg, 40.0 mg, 130.0 mg
, Injection, solution - Intravenous; Subcutaneous, Injection, Injection, solution - Epidural; Intrathecal, Oral, Tablet, Capsule, extended release, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution - Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Solution, Intrathecal; Intravenous, Epidural; Intrathecal, Syrup - Oral, Solution - Intravenous; Subcutaneous, Capsule, extended release - Oral, Tablet - Oral, Tablet, extended release - Oral, Suppository, Solution - Epidural; Intravenous; Subcutaneous, Capsule, coated, extended release, Epidural; Intravenous; Subcutaneous, Rectal, Suppository - Rectal, Intravenous, Injection, solution, concentrate, Tablet, multilayer, extended release, Capsule, Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution, Intramuscular, Suppository, extended release - Rectal, Epidural, Capsule - Oral, Tablet, extended release, Injection - Epidural; Intrathecal, Solution - Epidural, Intravenous; Subcutaneous, Capsule, coated, extended release - Oral, Tablet, film coated - Oral, Injection - Epidural; Intrathecal; Intravenous, Liquid, Solution - Parenteral, Injection - Intramuscular; Intravenous; Subcutaneous, Tablet, film coated, extended release, Tablet, multilayer, extended release - Oral, Injection, solution - Epidural; Intrathecal; Intravenous, Injection - Intramuscular, Epidural; Intrathecal; Intravenous, Syrup, Tablet, film coated, Injection, solution - Intramuscular; Intravenous, Solution / drops - Oral, Liquid - Intramuscular; Intravenous; Subcutaneous, Solution - Oral, Intramuscular; Intravenous, Tablet, film coated, extended release - Oral, Solution, concentrate - Oral, Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Injection, lipid complex - Epidural, Intramuscular; Intravenous; Subcutaneous, Parenteral, Injection, solution - Epidural; Intramuscular; Intrathecal; Intravenous, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intravenous, Suppository, extended release, Intrathecal, Solution, concentrate, Injection, lipid complex, Tincture, Injection, solution - Intrathecal, Liquid - Oral, Solution - Intravenous, Solution / drops, Liquid - Intravenous; Subcutaneous, Injection - Parenteral, Injection, solution - Intrathecal; Intravenous, Tincture - Oral, Injection, solution, concentrate - Intravenous
Chronic Pain
, 8.0 mg/mL, 80.0 mg, 70.0 mg, 60.0 mg, 100.0 mg/mL, 200.0 mg, 4.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL, 2.0 mg/mL, 15.0 mg/mL, 100.0 mg, 10.0 mg, 15.0 mg, 30.0 mg, 20.0 mg, 50.0 mg, 25.0 mg, 20.0 mg/mL, 1.0 mg/mL, 5.0 mg, 120.0 mg, 1.1 mg/mL, 50.0 mg/mL, 5.0 mg/mL, 25.0 mg/mL, 0.1 mg/mL, 3.0 mg/mL, 75.0 mg, 45.0 mg, 40.0 mg/mL, 90.0 mg, 150.0 mg, 40.0 mg, 130.0 mg
, Injection, solution - Intravenous; Subcutaneous, Injection, Injection, solution - Epidural; Intrathecal, Oral, Tablet, Capsule, extended release, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution - Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Solution, Intrathecal; Intravenous, Epidural; Intrathecal, Syrup - Oral, Solution - Intravenous; Subcutaneous, Capsule, extended release - Oral, Tablet - Oral, Tablet, extended release - Oral, Suppository, Solution - Epidural; Intravenous; Subcutaneous, Capsule, coated, extended release, Epidural; Intravenous; Subcutaneous, Rectal, Suppository - Rectal, Intravenous, Injection, solution, concentrate, Tablet, multilayer, extended release, Capsule, Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution, Intramuscular, Suppository, extended release - Rectal, Epidural, Capsule - Oral, Tablet, extended release, Injection - Epidural; Intrathecal, Solution - Epidural, Intravenous; Subcutaneous, Capsule, coated, extended release - Oral, Tablet, film coated - Oral, Injection - Epidural; Intrathecal; Intravenous, Liquid, Solution - Parenteral, Injection - Intramuscular; Intravenous; Subcutaneous, Tablet, film coated, extended release, Tablet, multilayer, extended release - Oral, Injection, solution - Epidural; Intrathecal; Intravenous, Injection - Intramuscular, Epidural; Intrathecal; Intravenous, Syrup, Tablet, film coated, Injection, solution - Intramuscular; Intravenous, Solution / drops - Oral, Liquid - Intramuscular; Intravenous; Subcutaneous, Solution - Oral, Intramuscular; Intravenous, Tablet, film coated, extended release - Oral, Solution, concentrate - Oral, Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Injection, lipid complex - Epidural, Intramuscular; Intravenous; Subcutaneous, Parenteral, Injection, solution - Epidural; Intramuscular; Intrathecal; Intravenous, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intravenous, Suppository, extended release, Intrathecal, Solution, concentrate, Injection, lipid complex, Tincture, Injection, solution - Intrathecal, Liquid - Oral, Solution - Intravenous, Solution / drops, Liquid - Intravenous; Subcutaneous, Injection - Parenteral, Injection, solution - Intrathecal; Intravenous, Tincture - Oral, Injection, solution, concentrate - Intravenous
Warnings
Kadian has six contraindications and should not be utilized when facing any of the circumstances detailed in the following table.Kadian ContraindicationsCondition
Risk Level
Notes
Mental Depression
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Gastrointestinal obstruction
Do Not Combine
Asthma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Morphine may interact with Toxoplasma Infections
Common Kadian Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Morphine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Morphine.
Eluxadoline
Major
The risk or severity of constipation can be increased when Morphine is combined with Eluxadoline.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Morphine.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Morphine.
Kadian Toxicity & Overdose RiskThe lowest toxic dose of the drug for males is 0.78µg/mL and for females it is 0.98µg/mL. An overdose can cause difficulty breathing, drowsiness, weak muscles, cold and clammy skin, constricted pupils, and dilated pupils. Symptoms may worsen to include fluid in the lungs, a slow heart rate, low blood pressure, and even cardiac arrest and death. Treatment of an overdose may involve using oxygen, medications to increase blood pressure, and naloxone.
Kadian Novel Uses: Which Conditions Have a Clinical Trial Featuring Kadian?
24 active trials are being conducted to assess the potential of Kadian in providing therapeutic relief, Pain Management and Chronic Pain Treatment.Condition
Clinical Trials
Trial Phases
Therapeutic procedure
0 Actively Recruiting
Chronic Pain
30 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Pain
0 Actively Recruiting
Kadian Reviews: What are patients saying about Kadian?
5Patient Review
7/29/2014 Kadian has been an amazing help for my severe scoliosis. I can finally function at work without feeling foggy and exhausted all the time. The only downside is that it's caused me some constipation issues, but hopefully I'll be able to wean myself off of it in the next year.
5Patient Review
5/8/2013 I have a lot of medical problems, but this treatment really helps with the pain.
5Patient Review
2/10/2015 Kadian was an excellent treatment for my spondylosis; however, over time I'm beginning to experience more breakthrough pain. Not sure if this is due to the progression of the disease or if the generic Kadian is not as effective?
5Patient Review
3/24/2013 The doctor is switching me from this to nuerotin and loritab because of my diabetes.
5Patient Review
5/14/2015 Out of all the drugs I've tried, this one had the least amount of side effects and was the most effective.
5Patient Review
6/28/2013 In my experience, this treatment just made me feel drowsy.
5Patient Review
2/26/2015 This medication is working well for me so far. I was on oxycodone before, 15mg x 6 a day, which didn't help at all. This is the first time in 20 years that I've felt relief from most of my pain.
5Patient Review
2/13/20134.7Patient Review
12/9/20124.3Patient Review
8/8/2013 Kadian is the only time-release morphine that I've tried that actually works for 12 hours like it's supposed to. It's given me my life back--I'm working full-time and able to do things around the house and garden that I enjoy.
4.3Patient Review
5/22/2018 I found this treatment to be most effective a few hours after administration. I'm only on 60mg because that's all my insurance would cover, but I think it's working well so far. The only weird side effect I've experienced is an irregular heartbeat. Has anyone else had this issue?
4Patient Review
6/22/2013 I'm on a pretty high dose of Kadian, and it's not really doing much for me. I'm thinking about trying something else.
4Patient Review
11/22/20123.7Patient Review
6/18/2014 Kadian has been an absolute godsend. I've been struggling with chronic pain for two decades and have tried almost everything on the market without much relief. Kadian finally gives me the around-the-clock coverage I need to live my life again.
3.7Patient Review
3/26/2013 I was taking generic, time-released morphine for my chronic pain associated with Multiple Sclerosis. Kadian has been much more effective for me and doesn't cause the drowsiness that the other medication did.
Patient Q&A Section about kadian
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the generic name for Kadian?
"Kadian is a narcotic pain reliever that is used to treat moderate to severe pain. It can be taken as needed for pain or as an extended-release medication for around-the-clock pain relief."
Answered by AI
What class of drug is Kadian?
"Morphine is a narcotic analgesic that is used to treat severe [chronic pain](https://www.withpower.com/clinical-trials/chronic-pain) by increasing pain tolerance."
Answered by AI
What is the difference between Kadian and morphine?
"KADIAN can be taken once or twice daily, depending on the doctor's discretion. KADIAN, a 24 hour release long acting morphine capsule, has been added to formulary. It is different from other long acting morphine products on the market, like M-ESLON, which is a 12 hour release formulation."
Answered by AI
Is Kadian a controlled substance?
"The abuse potential for KADIAN is similar to that of other opioid agonists, legal or illegal."
Answered by AI