Janumet Xr

Physical Activity, Type 2 Diabetes, Diet
Treatment
20 Active Studies for Janumet Xr

What is Janumet Xr

SitagliptinThe Generic name of this drug
Treatment SummarySitagliptin is a type of medication used to help manage blood sugar levels in people with type 2 diabetes. It works by blocking the enzyme DPP-4, which increases insulin and decreases glucagon, two hormones that regulate blood sugar. Sitagliptin was approved by the FDA in 2006 and must be used in combination with diet and exercise for best results.
Januviais the brand name
image of different drug pills on a surface
Janumet Xr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Januvia
Sitagliptin
2006
52

Effectiveness

How Janumet Xr Affects PatientsSitagliptin stops an enzyme (DPP-4) from working, which increases the amount of two hormones (glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide) in the body, decreases the amount of another hormone (glucagon), and makes the body better able to use insulin when blood sugar is high.
How Janumet Xr works in the bodySitagliptin helps regulate blood sugar levels by slowing the breakdown of incretins. Incretins are molecules released throughout the day, especially after meals, that help keep glucose levels balanced. When sitagliptin slows the breakdown of these molecules, they are able to keep working longer and more effectively, leading to better blood sugar control and lower glycosylated hemoglobin levels.

When to interrupt dosage

The amount of Janumet Xr is contingent upon the diagnosed condition. The amount of dosage is contingent upon the specified method of administration, featured in the table underneath.
Condition
Dosage
Administration
Physical Activity
, 100.0 mg, 50.0 mg, 25.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release
Type 2 Diabetes
, 100.0 mg, 50.0 mg, 25.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release
Diet
, 100.0 mg, 50.0 mg, 25.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release

Warnings

Janumet Xr has one contraindication, and should not be used in the presence of the circumstances indicated in the subsequent table.Janumet Xr Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Sitagliptin may interact with Pulse Frequency
There are 20 known major drug interactions with Janumet Xr.
Common Janumet Xr Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Sitagliptin.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Sitagliptin.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Sitagliptin.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Sitagliptin.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Sitagliptin.
Janumet Xr Toxicity & Overdose RiskAnimal studies have not shown any problems for mothers or babies when taking Sitagliptin at normal doses. However, there is a registry of fetal exposure to the drug. There have been reports of rib malformations with 100 times the maximum human dose in animal studies. It is unknown whether Sitagliptin is expressed in human breast milk. The risks and benefits of taking this medication must be carefully weighed. Safety and effectiveness data in children is lacking, and older people may need to use caution as they are more likely to have reduced kidney function. There is a 34% increased risk of infection when taking Sitagliptin, and no
image of a doctor in a lab doing drug, clinical research

Janumet Xr Novel Uses: Which Conditions Have a Clinical Trial Featuring Janumet Xr?

162 investigations are currently assessing the potential of Janumet XR to provide relief for Type 2 Diabetes.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
167 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Physical Activity
24 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Diet
5 Actively Recruiting
Not Applicable, Phase 1

Janumet Xr Reviews: What are patients saying about Janumet Xr?

5Patient Review
1/21/2016
Janumet Xr for Type 2 Diabetes Mellitus
For the first time in a while, my sugar levels are perfectly normal. I couldn't afford it at first, but Merck was kind enough to give me a year's worth for free. They're a great company.
5Patient Review
12/27/2015
Janumet Xr for Type 2 Diabetes Mellitus
This drug has helped me to maintain my target level of blood sugar 90% of the time. I have had to reduce my insulin intake to prevent lows, but other than that, no negative side effects.
5Patient Review
6/16/2013
Janumet Xr for Type 2 Diabetes Mellitus
4.3Patient Review
7/25/2013
Janumet Xr for Type 2 Diabetes Mellitus
I have been taking this medication for 1 week and I feel terrible. I have never felt this bad before and I am scared to continue taking it. I have stopped taking it on my own and have made an appointment with another doctor.
4.3Patient Review
3/15/2013
Janumet Xr for Type 2 Diabetes Mellitus
4Patient Review
6/29/2013
Janumet Xr for Type 2 Diabetes Mellitus
This medicine, combined with some over-the-counter supplements for blood sugar control, has been working well. I'm seeing much better numbers now, mostly in the normal range of 80 to 110.
4Patient Review
8/18/2013
Janumet Xr for Type 2 Diabetes Mellitus
For the first five days, this treatment successfully regulated my blood sugar. However, on the sixth day there was a sudden and unexplained jump in my blood sugar levels which I could not get under control again no matter what I tried. Additionally, I experienced some intestinal discomfort.
4Patient Review
9/30/2013
Janumet Xr for Type 2 Diabetes Mellitus
I've been taking this medication for a few years and it's working great!
3.3Patient Review
5/29/2016
Janumet Xr for Type 2 Diabetes Mellitus
So far, this medication has been really helpful. It's kept my insulin levels down and I haven't had too many side effects. After taking it for three months, I'm now up to two pills a day.
3.3Patient Review
3/23/2013
Janumet Xr for Type 2 Diabetes Mellitus
3Patient Review
10/20/2018
Janumet Xr for Type 2 Diabetes Mellitus
I've been on this medication for three months now and have noticed a difference in my fasting sugar levels. They were previously between 7-8 but are now more like 6-7.
3Patient Review
6/18/2013
Janumet Xr for Type 2 Diabetes Mellitus
3Patient Review
4/30/2014
Janumet Xr for Type 2 Diabetes Mellitus
This has been helpful in keeping my blood sugar levels down.
2.3Patient Review
10/10/2017
Janumet Xr for Type 2 Diabetes Mellitus
I've been using this for a while now and it's not doing much of anything.
1.3Patient Review
5/1/2014
Janumet Xr for Type 2 Diabetes Mellitus
I've been taking this medication for four months and recently, I've started passing the entire pill in my stool 90% of the time. This isn't a usual side effect that happens occasionally--it's happening all the time. Not to mention, it's expensive to keep taking something when you're not getting any benefit from it. I'm going to have to ask my doctor to switch me to something else...which is too bad because I was happy with the results up until now.
1Patient Review
1/28/2020
Janumet Xr for Type 2 Diabetes Mellitus
I would highly recommend avoiding Janumet. It's caused me a lot of problems like pancreatitis, headaches, and high blood sugar. Additionally, it keeps the pancreas inflamed and makes joints hurt. If you start having issues after taking this medication, chances are it's the Janumet causing them!
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about janumet xr

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does JANUMET XR do?

"Janumet XR is a prescription medication that contains two different prescription diabetes medicines, sitagliptin and extended-release metformin. This medication can be used in conjunction with diet and exercise to help lower blood sugar levels in adults who have type 2 diabetes."

Answered by AI

What is the difference between Janumet and JANUMET XR?

"Janumet is an IR medication, meaning the tablet is fast-acting and releases the drug into your body right away. Janumet XR is an ER medication, meaning the tablet is long-acting and releases the drug slowly into your body over time."

Answered by AI

What is the best time of day to take JANUMET XR?

"It is better to take JANUMET XR with your evening meal to help lower your chance of having an upset stomach. Once a day, take JANUMET XR by mouth with a meal as directed by your doctor."

Answered by AI

Is JANUMET XR the same as metformin?

"Sitagliptin, an inhibitor of dipeptidyl peptidase-4 (DPP-4), works by regulating the level of insulin your body produces after eating

Janumet is a combination of two drugs used to treat diabetes, sitagliptin and metformin. Metformin lowers the amount of sugar released by the liver into the bloodstream, and helps the body respond better to insulin. Sitagliptin regulates the level of insulin produced by the body after eating."

Answered by AI

Clinical Trials for Janumet Xr

Image of University of California, Los Angeles in Los Angeles, United States.

Tailored DPP for Prediabetes

17 - 25
All Sexes
Los Angeles, CA
The goal of this study is to enhance reach and uptake of diabetes prevention among young adults, with a focus on recruiting underserved and high-need students who face additional challenges, including food and financial insecurity. The specific aims are: Aim 1 - Evaluate the efficacy of an AYA-tailored version of the UC DPP for mitigating type 2 diabetes risk (i.e., weight change) in a pre/post pilot trial. The investigators hypothesize that the AYA-tailored intervention will be effective at producing 5% weight loss from baseline to program completion (at 9-months). Aim 2 - Assess the feasibility and acceptability of an AYA-tailored version of the UC DPP program. The investigators hypothesize that it will be feasible to recruit the desired number of participants given proposed innovative outreach strategies, and that the AYA-tailored intervention will be deemed acceptable to participants both qualitatively and in regards to their retention in the program at rates similar to the larger UC DPP. The investigators will recruit 80 UCLA undergraduate students. Participants will be asked to complete a brief screening online form to assess eligibility and to collect contact information. The PI and/or Research Assistants (RAs) will reach out to eligible participants to obtain informed consent and enroll them in the pilot trial. The investigators will randomize participants to the tailored DPP cohort vs control cohort. Control participants will be offered the opportunity to participate in the tailored DPP in the following academic year. The tailored DPP intervention will be online and asynchronously. Participants will be asked to complete the intervention lessons on their own time. Each lesson typically takes on average 15 minutes to complete. Control group will receive each intervention materials via e-mail for participants to review on their own time and will receive acceptability surveys. The interventions for the control group will be remote. A research assistant will meet with control participants via Zoom to explain the intervention materials. Control group will receive access to a study habits intervention, alcohol use intervention, and financial literacy intervention. At the end of each quarter (Fall, Winter, and Spring), both control and intervention participants will receive an email with a unique link to a brief REDCap survey to ascertain acceptability of sessions/lessons. Furthermore, participants will complete baseline and 9-month follow-up assessments. Participants will complete a 30 minute questionnaire and height/weight measurements will be collected by a RA. Participants will be asked to self-report weight and physical activity at the end of the fall and winter quarter; data will be collected via brief REDCap survey.
Recruiting
Has No Placebo
University of California, Los AngelesLauren E Wisk, PhD
Image of Medpace Clinical Pharmaology Unit in Cincinnati, United States.

PATAS for Type 2 Diabetes

18 - 55
All Sexes
Cincinnati, OH
The primary objective of Part 1 of this study is to evaluate safety and tolerability of single subcutaneous (SC) doses of PATAS in healthy subjects. The secondary objective of Part 1 of this study is to determine the pharmacokinetics (PK) of single SC doses of PATAS in healthy subjects. The primary objectives of Part 2 of this study are to evaluate the safety and tolerability of 4 weekly SC doses of PATAS in subjects with T2D; and to determine the PK and pharmacodynamics (PD) of 4 weekly SC doses of PATAS in subjects with T2D. The secondary objectives of Part 2 of this study are to evaluate the potential effect of multiple SC doses of PATAS on markers of glycemic control, as measured by glucose levels, insulin levels, and other metabolomic biomarkers; and to characterize the adverse event (AE) profiles of the various dose levels of PATAS.
Phase 1
Waitlist Available
Medpace Clinical Pharmaology UnitVincent Marion, Ph.D.AdipoPharma LLC
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Image of University of British Columbia - Okanagan in Kelowna, Canada.

Estrogen and Testosterone for Gender Differences in Physiology

18 - 40
All Sexes
Kelowna, Canada
Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute. As a result, many diagnoses and treatments are based on male physiology and may not be appropriate or effective for females. Females consistently experience greater risk and report worse neurological outcomes in many diseases, including stroke, cardiac arrest, and dementia. As research in females progresses, differences between sexes and changes throughout the lifespan (e.g., puberty, menopause) highlight the importance of understanding the effects of sex and sex-specific hormones on the body. The brain is arguably the most important organ in the body, consuming 20% of the body's total energy. Previous research supports higher blood flow to the brain in females, and research in animals suggests hormones such as estrogen, progesterone, and testosterone are responsible. However, it is extremely difficult to isolate these hormones in humans, due to natural fluctuations (i.e., menstrual cycle). Therefore, the investigators plan to explore the direct role of these sex-specific hormones in regulating blood flow to the brain by blocking hormone production in healthy males and females and giving back testosterone and estrogen, respectively. The investigators will then conduct a range of tests to look at blood flow to the brain at rest and during various stressors. This research will provide crucial insight into how males and females differ in regulation of brain blood flow and inform new treatments and therapies to a wide range of brain injuries and diseases, improving outcomes and reducing the sex disparity in clinical pathways.
Waitlist Available
Has No Placebo
University of British Columbia - OkanaganPhilip Ainslie, PhD
Have you considered Janumet Xr clinical trials? We made a collection of clinical trials featuring Janumet Xr, we think they might fit your search criteria.Go to Trials
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Aerobic Exercise with Blood Flow Restriction for Type 2 Diabetes

19 - 64
All Sexes
Okanagan, Canada
The goal of this trial is to learn if blood flow restriction training with treadmill walking is possible for individuals living with type 2 diabetes. It will also learn about how the blood flow restriction with treadmill walking could improve health. The main questions it aims to answer are: Is 6 weeks of treadmill walking with blood flow restriction reasonable for people with type 2 diabetes to perform? Does treadmill walking with blood flow restriction training help manage type 2 diabetes better than just treadmill walking? Researchers will compare treadmill walking with blood flow restriction to treadmill walking without blood flow restriction to see if blood flow restriction works to manage type 2 diabetes based on fitness and blood sugar levels. Participants will: Perform treadmill walking with or without blood flow restriction for 96 minutes a week for 6 weeks. Visit the lab before and after the exercise for tests and questionnaires.
Waitlist Available
Has No Placebo
Exercise Metabolism and Inflammation Laboratory (+2 Sites)Martin Senechal, PhD
Image of Jefferson Health New Jersey in Sewell, United States.

Continuous vs Finger-stick Glucose Monitoring for Type 2 Diabetes in Pregnancy

18+
Female
Sewell, NJ
The purpose of this study is to compare patient adherence to blood sugar monitoring during pregnancy using two different measurement methods in pregnancies complicated by pregestational type 2 diabetes (T2DM). Pregnant patients with T2DM are at risk of having larger babies, babies with low sugar levels in the first 24 hours of life, higher rates of cesarean delivery, stillbirth (death of baby inside the womb), and hypertensive or high blood pressure disorders of pregnancy, such as preeclampsia. Prior studies have shown that treating high blood sugars in pregnancy with medications can reduce these risks. To determine the amount of medication needed, recording of blood sugar levels is necessary. This trial aims to determine whether continuous blood sugar monitors have improved patient recording of blood sugar levels over finger stick blood sugar measurements. Patients involved in the study will be assigned to either: 1. Fingerstick glucose monitoring (FSG) 2. Continuous glucose monitoring (CGM) Patients will be randomize in a 1:1 ratio. FSG Group: blood sugar is tested four times daily - once fasting and two hours after every meal (post-prandial). Blood will be tested using a glucometer, and values will be recorded in a blood sugar log from the time of enrollment to the time of delivery. CGM Group: A CGM sensor will be placed on the patient's arm for blood sugar collection every 3-5 minutes. This data is sent to a phone application from the time of enrollment to the time of delivery. These sensors will need to be replaced every 14 days. Percent adherence will be recorded from the time you were randomized to a study group until delivery.
Recruiting
Has No Placebo
Jefferson Health New Jersey (+1 Sites)
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Health Coaching for Type 2 Diabetes and Mental Health

18+
All Sexes
Hamilton, Canada
Managing both type 2 diabetes and mental health challenges can be difficult, and many people do not receive care that supports both. This study looks at how virtual health coaching and support from interdisciplinary care teams can help people better manage their health. The purpose of this study is to test the effectiveness of a virtual health coaching program for adults living with type 2 diabetes and mental health challenges compared to usual care. The Technology-Enabled Collaborative Care for type 2 Diabetes and Mental health (TECC-DM) program includes weekly coaching calls, support from an interdisciplinary care team, and online tools to aid self-management. The findings from this study will be used to help improve services for people who have type 2 diabetes and co-occurring mental health symptoms.
Waitlist Available
Has No Placebo
McMaster UniversityCarly Whitmore, RN PhD
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