Janumet Xr

Physical Activity, Type 2 Diabetes, Diet
Treatment
20 Active Studies for Janumet Xr

What is Janumet Xr

SitagliptinThe Generic name of this drug
Treatment SummarySitagliptin is a type of medication used to help manage blood sugar levels in people with type 2 diabetes. It works by blocking the enzyme DPP-4, which increases insulin and decreases glucagon, two hormones that regulate blood sugar. Sitagliptin was approved by the FDA in 2006 and must be used in combination with diet and exercise for best results.
Januviais the brand name
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Janumet Xr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Januvia
Sitagliptin
2006
52

Effectiveness

How Janumet Xr Affects PatientsSitagliptin stops an enzyme (DPP-4) from working, which increases the amount of two hormones (glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide) in the body, decreases the amount of another hormone (glucagon), and makes the body better able to use insulin when blood sugar is high.
How Janumet Xr works in the bodySitagliptin helps regulate blood sugar levels by slowing the breakdown of incretins. Incretins are molecules released throughout the day, especially after meals, that help keep glucose levels balanced. When sitagliptin slows the breakdown of these molecules, they are able to keep working longer and more effectively, leading to better blood sugar control and lower glycosylated hemoglobin levels.

When to interrupt dosage

The amount of Janumet Xr is contingent upon the diagnosed condition. The amount of dosage is contingent upon the specified method of administration, featured in the table underneath.
Condition
Dosage
Administration
Physical Activity
, 100.0 mg, 50.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Type 2 Diabetes
, 100.0 mg, 50.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Diet
, 100.0 mg, 50.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral

Warnings

Janumet Xr has one contraindication, and should not be used in the presence of the circumstances indicated in the subsequent table.Janumet Xr Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Sitagliptin may interact with Pulse Frequency
There are 20 known major drug interactions with Janumet Xr.
Common Janumet Xr Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Sitagliptin.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Sitagliptin.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Sitagliptin.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Sitagliptin.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Sitagliptin.
Janumet Xr Toxicity & Overdose RiskAnimal studies have not shown any problems for mothers or babies when taking Sitagliptin at normal doses. However, there is a registry of fetal exposure to the drug. There have been reports of rib malformations with 100 times the maximum human dose in animal studies. It is unknown whether Sitagliptin is expressed in human breast milk. The risks and benefits of taking this medication must be carefully weighed. Safety and effectiveness data in children is lacking, and older people may need to use caution as they are more likely to have reduced kidney function. There is a 34% increased risk of infection when taking Sitagliptin, and no
image of a doctor in a lab doing drug, clinical research

Janumet Xr Novel Uses: Which Conditions Have a Clinical Trial Featuring Janumet Xr?

162 investigations are currently assessing the potential of Janumet XR to provide relief for Type 2 Diabetes.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
174 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Physical Activity
35 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1
Diet
5 Actively Recruiting
Not Applicable, Phase 1

Janumet Xr Reviews: What are patients saying about Janumet Xr?

5Patient Review
1/21/2016
Janumet Xr for Type 2 Diabetes Mellitus
For the first time in a while, my sugar levels are perfectly normal. I couldn't afford it at first, but Merck was kind enough to give me a year's worth for free. They're a great company.
5Patient Review
12/27/2015
Janumet Xr for Type 2 Diabetes Mellitus
This drug has helped me to maintain my target level of blood sugar 90% of the time. I have had to reduce my insulin intake to prevent lows, but other than that, no negative side effects.
5Patient Review
6/16/2013
Janumet Xr for Type 2 Diabetes Mellitus
4.3Patient Review
7/25/2013
Janumet Xr for Type 2 Diabetes Mellitus
I have been taking this medication for 1 week and I feel terrible. I have never felt this bad before and I am scared to continue taking it. I have stopped taking it on my own and have made an appointment with another doctor.
4.3Patient Review
3/15/2013
Janumet Xr for Type 2 Diabetes Mellitus
View All Reviews
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Patient Q&A Section about janumet xr

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does JANUMET XR do?

"Janumet XR is a prescription medication that contains two different prescription diabetes medicines, sitagliptin and extended-release metformin. This medication can be used in conjunction with diet and exercise to help lower blood sugar levels in adults who have type 2 diabetes."

Answered by AI

What is the difference between Janumet and JANUMET XR?

"Janumet is an IR medication, meaning the tablet is fast-acting and releases the drug into your body right away. Janumet XR is an ER medication, meaning the tablet is long-acting and releases the drug slowly into your body over time."

Answered by AI

What is the best time of day to take JANUMET XR?

"It is better to take JANUMET XR with your evening meal to help lower your chance of having an upset stomach. Once a day, take JANUMET XR by mouth with a meal as directed by your doctor."

Answered by AI

Is JANUMET XR the same as metformin?

"Sitagliptin, an inhibitor of dipeptidyl peptidase-4 (DPP-4), works by regulating the level of insulin your body produces after eating

Janumet is a combination of two drugs used to treat diabetes, sitagliptin and metformin. Metformin lowers the amount of sugar released by the liver into the bloodstream, and helps the body respond better to insulin. Sitagliptin regulates the level of insulin produced by the body after eating."

Answered by AI

Clinical Trials for Janumet Xr

Have you considered Janumet Xr clinical trials? We made a collection of clinical trials featuring Janumet Xr, we think they might fit your search criteria.
Have you considered Janumet Xr clinical trials? We made a collection of clinical trials featuring Janumet Xr, we think they might fit your search criteria.
Have you considered Janumet Xr clinical trials? We made a collection of clinical trials featuring Janumet Xr, we think they might fit your search criteria.
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