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What is Janumet Xr
SitagliptinThe Generic name of this drug
Treatment SummarySitagliptin is a type of medication used to help manage blood sugar levels in people with type 2 diabetes. It works by blocking the enzyme DPP-4, which increases insulin and decreases glucagon, two hormones that regulate blood sugar. Sitagliptin was approved by the FDA in 2006 and must be used in combination with diet and exercise for best results.
Januviais the brand name
Janumet Xr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Januvia
Sitagliptin
2006
52
Effectiveness
How Janumet Xr Affects PatientsSitagliptin stops an enzyme (DPP-4) from working, which increases the amount of two hormones (glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide) in the body, decreases the amount of another hormone (glucagon), and makes the body better able to use insulin when blood sugar is high.
How Janumet Xr works in the bodySitagliptin helps regulate blood sugar levels by slowing the breakdown of incretins. Incretins are molecules released throughout the day, especially after meals, that help keep glucose levels balanced. When sitagliptin slows the breakdown of these molecules, they are able to keep working longer and more effectively, leading to better blood sugar control and lower glycosylated hemoglobin levels.
When to interrupt dosage
The amount of Janumet Xr is contingent upon the diagnosed condition. The amount of dosage is contingent upon the specified method of administration, featured in the table underneath.Condition
Dosage
Administration
Type 2 Diabetes
, 100.0 mg, 50.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Diet
, 100.0 mg, 50.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Physical Activity
, 100.0 mg, 50.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Warnings
Janumet Xr has one contraindication, and should not be used in the presence of the circumstances indicated in the subsequent table.Janumet Xr ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Sitagliptin may interact with Pulse Frequency
Common Janumet Xr Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Sitagliptin.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Sitagliptin.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Sitagliptin.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Sitagliptin.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Sitagliptin.
Janumet Xr Toxicity & Overdose RiskAnimal studies have not shown any problems for mothers or babies when taking Sitagliptin at normal doses. However, there is a registry of fetal exposure to the drug. There have been reports of rib malformations with 100 times the maximum human dose in animal studies. It is unknown whether Sitagliptin is expressed in human breast milk. The risks and benefits of taking this medication must be carefully weighed. Safety and effectiveness data in children is lacking, and older people may need to use caution as they are more likely to have reduced kidney function. There is a 34% increased risk of infection when taking Sitagliptin, and no
Janumet Xr Novel Uses: Which Conditions Have a Clinical Trial Featuring Janumet Xr?
162 investigations are currently assessing the potential of Janumet XR to provide relief for Type 2 Diabetes.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Physical Activity
38 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Diet
5 Actively Recruiting
Not Applicable
Janumet Xr Reviews: What are patients saying about Janumet Xr?
5Patient Review
1/21/2016 For the first time in a while, my sugar levels are perfectly normal. I couldn't afford it at first, but Merck was kind enough to give me a year's worth for free. They're a great company.
5Patient Review
12/27/2015 This drug has helped me to maintain my target level of blood sugar 90% of the time. I have had to reduce my insulin intake to prevent lows, but other than that, no negative side effects.
5Patient Review
6/16/20134.3Patient Review
7/25/2013 I have been taking this medication for 1 week and I feel terrible. I have never felt this bad before and I am scared to continue taking it. I have stopped taking it on my own and have made an appointment with another doctor.
4.3Patient Review
3/15/20134Patient Review
6/29/2013 This medicine, combined with some over-the-counter supplements for blood sugar control, has been working well. I'm seeing much better numbers now, mostly in the normal range of 80 to 110.
4Patient Review
8/18/2013 For the first five days, this treatment successfully regulated my blood sugar. However, on the sixth day there was a sudden and unexplained jump in my blood sugar levels which I could not get under control again no matter what I tried. Additionally, I experienced some intestinal discomfort.
4Patient Review
9/30/2013 I've been taking this medication for a few years and it's working great!
3.3Patient Review
5/29/2016 So far, this medication has been really helpful. It's kept my insulin levels down and I haven't had too many side effects. After taking it for three months, I'm now up to two pills a day.
3.3Patient Review
3/23/20133Patient Review
10/20/2018 I've been on this medication for three months now and have noticed a difference in my fasting sugar levels. They were previously between 7-8 but are now more like 6-7.
3Patient Review
6/18/20133Patient Review
4/30/2014 This has been helpful in keeping my blood sugar levels down.
2.3Patient Review
10/10/2017 I've been using this for a while now and it's not doing much of anything.
1.3Patient Review
5/1/2014 I've been taking this medication for four months and recently, I've started passing the entire pill in my stool 90% of the time. This isn't a usual side effect that happens occasionally--it's happening all the time. Not to mention, it's expensive to keep taking something when you're not getting any benefit from it. I'm going to have to ask my doctor to switch me to something else...which is too bad because I was happy with the results up until now.
1Patient Review
1/28/2020 I would highly recommend avoiding Janumet. It's caused me a lot of problems like pancreatitis, headaches, and high blood sugar. Additionally, it keeps the pancreas inflamed and makes joints hurt. If you start having issues after taking this medication, chances are it's the Janumet causing them!
Patient Q&A Section about janumet xr
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does JANUMET XR do?
"Janumet XR is a prescription medication that contains two different prescription diabetes medicines, sitagliptin and extended-release metformin. This medication can be used in conjunction with diet and exercise to help lower blood sugar levels in adults who have type 2 diabetes."
Answered by AI
What is the difference between Janumet and JANUMET XR?
"Janumet is an IR medication, meaning the tablet is fast-acting and releases the drug into your body right away. Janumet XR is an ER medication, meaning the tablet is long-acting and releases the drug slowly into your body over time."
Answered by AI
What is the best time of day to take JANUMET XR?
"It is better to take JANUMET XR with your evening meal to help lower your chance of having an upset stomach. Once a day, take JANUMET XR by mouth with a meal as directed by your doctor."
Answered by AI
Is JANUMET XR the same as metformin?
"Sitagliptin, an inhibitor of dipeptidyl peptidase-4 (DPP-4), works by regulating the level of insulin your body produces after eating
Janumet is a combination of two drugs used to treat diabetes, sitagliptin and metformin. Metformin lowers the amount of sugar released by the liver into the bloodstream, and helps the body respond better to insulin. Sitagliptin regulates the level of insulin produced by the body after eating."
Answered by AI