Ismo

Treatment

2 FDA approvals

0 Active Studies for Ismo

What is Ismo

Vismodegib

The Generic name of this drug

Treatment Summary

Vismodegib is a medication used to treat adult basal cell carcinoma, a form of skin cancer. It works by blocking the hedgehog signaling pathway. This drug was approved by the FDA in 2012.

Erivedge

is the brand name

image of different drug pills on a surface

Ismo Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Erivedge

Vismodegib

2012

Approved as Treatment by the FDA

Vismodegib, also called Erivedge, is approved by the FDA for 2 uses such as metastatic Basal cell carcinoma and Locally Advanced Basal Cell Carcinoma .

metastatic Basal cell carcinoma

Locally Advanced Basal Cell Carcinoma

Effectiveness

How Ismo Affects Patients

Vismodegib blocks a specific protein (SMO) that is involved in the Hedgehog signalling pathway. This stops the pathway from working properly.

How Ismo works in the body

Vismodegib works by targeting a protein called Smoothened homologue (SMO). This protein is involved in a process called the Hedgehog pathway, which helps control the growth and division of skin cells. By blocking SMO, Vismodegib prevents the Hedgehog pathway from working properly, which can help reduce the uncontrolled growth of skin cells.

Warnings

Ismo Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Ismo.

Common Ismo Drug Interactions

Drug Name

Risk Level

Description

Ozanimod

Major

Vismodegib may decrease the excretion rate of Ozanimod which could result in a higher serum level.

Rimegepant

Major

The serum concentration of Rimegepant can be increased when it is combined with Vismodegib.

(S)-Warfarin

Minor

The metabolism of (S)-Warfarin can be decreased when combined with Vismodegib.

Abrocitinib

Minor

The metabolism of Abrocitinib can be decreased when combined with Vismodegib.

Asunaprevir

Minor

The metabolism of Asunaprevir can be decreased when combined with Vismodegib.

Ismo Toxicity & Overdose Risk

Taking this drug increases the risk of fetal death and severe birth defects. Common side effects include muscle spasms, hair loss, changes in taste, weight loss, tiredness, nausea, diarrhea, decreased appetite, constipation, joint pain, vomiting, and loss of taste.

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Ismo Reviews: What are patients saying about Ismo?

Patient Review

1/4/2009

Ismo for Angina Pectoris Prevention

2.3

Patient Review

3/27/2011

Ismo for Angina Pectoris Prevention

I've been using Ismo for almost two decades with good results. I experienced angina in 2005 and had to get two stents, but other than that I haven't had any issues.

Patient Review

4/16/2021

Ismo for prevention of anginal chest pain associated with coronary artery disease

I was prescribed this medication by my cardiologist a few months ago, and slowly after starting to take it I started having breathing problems and got a really bad rash on my arms, face, and stomach. It was almost like chickenpox! I had to take antihistamines and prednisone to try and alleviate the symptoms but nothing really worked. So I stopped taking the medication 5 days ago and I can finally breathe again. For me, this was a killer drug.