Ismo

Treatment
2 FDA approvals
0 Active Studies for Ismo

What is Ismo

VismodegibThe Generic name of this drug
Treatment SummaryVismodegib is a medication used to treat adult basal cell carcinoma, a form of skin cancer. It works by blocking the hedgehog signaling pathway. This drug was approved by the FDA in 2012.
Erivedgeis the brand name
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Ismo Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Erivedge
Vismodegib
2012
1

Approved as Treatment by the FDA

Vismodegib, also called Erivedge, is approved by the FDA for 2 uses such as Locally Advanced Basal Cell Carcinoma and metastatic Basal cell carcinoma .
Locally Advanced Basal Cell Carcinoma
metastatic Basal cell carcinoma

Effectiveness

How Ismo Affects PatientsVismodegib blocks a specific protein (SMO) that is involved in the Hedgehog signalling pathway. This stops the pathway from working properly.
How Ismo works in the bodyVismodegib works by targeting a protein called Smoothened homologue (SMO). This protein is involved in a process called the Hedgehog pathway, which helps control the growth and division of skin cells. By blocking SMO, Vismodegib prevents the Hedgehog pathway from working properly, which can help reduce the uncontrolled growth of skin cells.

Warnings

Ismo Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Ismo.
Common Ismo Drug Interactions
Drug Name
Risk Level
Description
Ozanimod
Major
Vismodegib may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Rimegepant
Major
The serum concentration of Rimegepant can be increased when it is combined with Vismodegib.
(S)-Warfarin
Minor
The metabolism of (S)-Warfarin can be decreased when combined with Vismodegib.
Abrocitinib
Minor
The metabolism of Abrocitinib can be decreased when combined with Vismodegib.
Asunaprevir
Minor
The metabolism of Asunaprevir can be decreased when combined with Vismodegib.
Ismo Toxicity & Overdose RiskTaking this drug increases the risk of fetal death and severe birth defects. Common side effects include muscle spasms, hair loss, changes in taste, weight loss, tiredness, nausea, diarrhea, decreased appetite, constipation, joint pain, vomiting, and loss of taste.
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Ismo Reviews: What are patients saying about Ismo?

5Patient Review
1/4/2009
Ismo for Angina Pectoris Prevention
2.3Patient Review
3/27/2011
Ismo for Angina Pectoris Prevention
I've been using Ismo for almost two decades with good results. I experienced angina in 2005 and had to get two stents, but other than that I haven't had any issues.
2Patient Review
4/16/2021
Ismo for prevention of anginal chest pain associated with coronary artery disease
I was prescribed this medication by my cardiologist a few months ago, and slowly after starting to take it I started having breathing problems and got a really bad rash on my arms, face, and stomach. It was almost like chickenpox! I had to take antihistamines and prednisone to try and alleviate the symptoms but nothing really worked. So I stopped taking the medication 5 days ago and I can finally breathe again. For me, this was a killer drug.
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Patient Q&A Section about ismo

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Where IS ISMO from?

"Jyväskylä is situated in the western part of the Finnish Lakeland, approximately 150 km north-east of Tampere and 270 km north of Helsinki."

Answered by AI
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