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What is Imodium A-D
LoperamideThe Generic name of this drug
Treatment SummaryLoperamide is a long-acting medication used to treat diarrhea. It does not get absorbed into the bloodstream, so it does not affect the nervous system or the hormones that regulate blood pressure. It works by blocking the effects of histamine, which can reduce diarrhea, and it prevents the release of acetylcholine, which can also stop diarrhea.
Imodium A-Dis the brand name
Imodium A-D Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Imodium A-D
Loperamide
1989
401
Approved as Treatment by the FDA
Loperamide, otherwise called Imodium A-D, is approved by the FDA for 5 uses including Diarrhea and Chronic Functional Diarrhea .Diarrhea
Chronic Functional Diarrhea
Intestinal stoma leak
Gastroenteritis
Crohn's Disease
Effectiveness
How Imodium A-D Affects PatientsLoperamide is a medication used to treat diarrhea. It works by slowing down the movement of food through the digestive tract, allowing more water and electrolytes to be absorbed from the intestines. It also increases rectal tone, reducing fecal volume and making the stool firmer. It usually takes about an hour for it to start working and can last for up to three days. Although loperamide is an opioid, it does not produce pain relief at typical doses. However, very high doses can allow it to pass into the brain, where it can cause opioid effects and toxicity. In extreme cases, loperamide
How Imodium A-D works in the bodyLoperamide works by binding to opioid receptors on intestinal muscles. This causes a chain reaction that reduces nerve activity in the intestines and decreases the release of certain chemicals that cause muscle contractions. As a result, loperamide slows movement in the intestines, allowing more water and electrolytes to be absorbed. It also reduces the amount of muscle contractions, making stools harder and drier.
When to interrupt dosage
The advised dosage of Imodium A-D is contingent upon the determined disorder, including Diarrhea, Crohn's Disease and Ulcerative Colitis, as well as Intestinal stoma leakage. The extent of dosage depends on the technique of delivery, as exemplified in the table below.Condition
Dosage
Administration
Chronic Functional Diarrhea
, 2.0 mg, 1.0 mg/mL, 0.2 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, chewable, Tablet, chewable - Oral, Kit, Kit - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Crohn's Disease
, 2.0 mg, 1.0 mg/mL, 0.2 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, chewable, Tablet, chewable - Oral, Kit, Kit - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Intestinal stoma leak
, 2.0 mg, 1.0 mg/mL, 0.2 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, chewable, Tablet, chewable - Oral, Kit, Kit - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Diarrhea
, 2.0 mg, 1.0 mg/mL, 0.2 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, chewable, Tablet, chewable - Oral, Kit, Kit - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Gastroenteritis
, 2.0 mg, 1.0 mg/mL, 0.2 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, chewable, Tablet, chewable - Oral, Kit, Kit - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Warnings
Imodium A-D ContraindicationsCondition
Risk Level
Notes
Abdominal Pain
Do Not Combine
Therapeutic procedure
Do Not Combine
Pulse Frequency
Do Not Combine
Dysentery
Do Not Combine
Enterocolitis
Do Not Combine
Ulcerative Colitis
Do Not Combine
Common Imodium A-D Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Loperamide.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Loperamide.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Loperamide.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Loperamide.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Loperamide.
Imodium A-D Toxicity & Overdose RiskTaking more than the recommended dose of loperamide can be very dangerous and may lead to life-threatening heart issues such as abnormal heart rhythms, fainting, cardiac arrest, and even death. Loperamide overdoses can also cause confusion, sleepiness, decreased coordination, pinpoint pupils, muscle stiffness, slowed breathing, low blood pressure, difficulty urinating, and a blocked intestine. Naloxone can be used to reverse the opioid-related effects of an overdose.
Imodium A-D Novel Uses: Which Conditions Have a Clinical Trial Featuring Imodium A-D?
Investigation is currently underway to investigate the potential of Imodium A-D to ameliorate Chronic Functional Diarrhea, Intestinal stoma leakage and Gastroenteritis.Condition
Clinical Trials
Trial Phases
Gastroenteritis
26 Actively Recruiting
Phase 1, Phase 2, Phase 4, Phase 3, Not Applicable
Diarrhea
0 Actively Recruiting
Intestinal stoma leak
0 Actively Recruiting
Crohn's Disease
17 Actively Recruiting
Phase 1, Not Applicable, Early Phase 1, Phase 2, Phase 3, Phase 4
Chronic Functional Diarrhea
0 Actively Recruiting
Imodium A-D Reviews: What are patients saying about Imodium A-D?
5Patient Review
1/30/2016 Immodium A-D always does the trick for me when I need it. It's quick, painless, and easy with no real side effects that I've noticed.
5Patient Review
3/2/2018 This treatment always works perfectly for me.
4.3Patient Review
5/18/2017 Imodium AD helps to slow down my bowel motility and as a result, I'm not as worried about sudden onsets of diarrhea. It's not perfect, but it allows me to go out and do the things I need to do.
3.7Patient Review
4/29/2010 I experienced diarrhea after taking the drug Plaquenil, which was effective in other ways. However, it caused such severe dehydration that I suffered from double vision a few times before quitting the medication entirely.
3.7Patient Review
5/20/2009 I take a lot of this medication, and it still doesn't completely relieve my symptoms. I experience severe cramping and bloating, with pain from my belly button to my vaginal cavity. However, without the drug I couldn't function at all. If anyone has any suggestions, please let me know.
3.7Patient Review
5/15/2016 This medication was effective at stopping my diarrhea. However, I have now been constipated for the last three days. So, it seems I've traded one problem for another.
3.7Patient Review
1/23/2008 I developed blood in my stool after starting this medication.
3.7Patient Review
7/21/2014 At first, this medication worked great. But a few hours later I started having intense pain in my upper abdomen, gas and bad bloating.
Patient Q&A Section about imodium a-d
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.When do you take Imodium A-D?
"At first, adults should take 4 milligrams (mg) of loperamide after the first loose bowel movement. After the first dose, they should then take 2 mg of loperamide after each loose bowel movement. The doctor may adjust the dose as needed, but the usual dose is not more than 16 mg (8 capsules) per day."
Answered by AI
What does AD stand for in Imodium?
"There are two forms of Imodium available, one with just the active drug loperamide, and the other with loperamide and simethicone. Both forms are available as a generic drug."
Answered by AI
What is difference between Imodium and Imodium A-D?
"Loperamide is a medication used to treat diarrhea, while Imodium Multi-Symptom Relief can be used to treat diarrhea, bloating, cramps, and pressure caused by gas. Both medications are available over the counter."
Answered by AI
What does Imodium A-D do for you?
"This medication is used to treat sudden diarrhea. It works by slowing down the movement of the gut, which decreases the number of bowel movements and makes the stool less watery."
Answered by AI