Hydroxyprogesterone Caproate

history of singleton spontaneous preterm birth, Adenocarcinoma, prophylaxis of preterm birth + 5 more
Treatment
8 FDA approvals
20 Active Studies for Hydroxyprogesterone Caproate

What is Hydroxyprogesterone Caproate

Hydroxyprogesterone caproateThe Generic name of this drug
Treatment SummaryHydroxyprogesterone caproate is a synthetic steroid hormone used to treat preterm delivery in pregnant women with a history of preterm delivery. The drug was first marketed under the name Delalutin by Squibb in 1956 and was approved by the FDA. It was withdrawn from the market in 1999 but was re-introduced in 2011 under the brand name Makena, sparking controversy over its pricing.
Makenais the brand name
image of different drug pills on a surface
Hydroxyprogesterone Caproate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Makena
Hydroxyprogesterone caproate
2011
20

Approved as Treatment by the FDA

Hydroxyprogesterone caproate, otherwise known as Makena, is approved by the FDA for 8 uses including history of singleton spontaneous preterm birth and Adenocarcinoma .
history of singleton spontaneous preterm birth
Adenocarcinoma
Primary Amenorrhoea
Helps manage Primary Amenorrhoea
Uterine hemorrhage
Helps manage Abnormal Uterine Bleeding
Secondary Amenorrhea
Helps manage Secondary Amenorrhea
Adenocarcinoma
prophylaxis of preterm birth
Premature Birth

Effectiveness

How Hydroxyprogesterone Caproate Affects PatientsIt is not known exactly how hydroxyprogesterone caproate injections work, but it is thought that they make progesterone in the body interact more with its receptors.
How Hydroxyprogesterone Caproate works in the bodyProgesterone helps prevent preterm birth, though we don't know exactly how it works. It is known to be important for carrying a baby to term, likely due to its ability to attach to different receptors in the uterus, ovaries, breasts, and central nervous system. This attachment then helps to regulate gene transcription, and produces an anti-inflammatory effect. This calms the pro-inflammatory state that happens when labor begins, and keeps the uterus relaxed.

When to interrupt dosage

The proposed dose of Hydroxyprogesterone Caproate is contingent upon the determined disorder, such as Uterine hemorrhage, Secondary Amenorrhea and past of singleton unpremeditated preterm birth. The dosage shifts as per the system of introduction (e.g. Liquid - Intramuscular or Injection - Subcutaneous) specified in the table underneath.
Condition
Dosage
Administration
Uterine hemorrhage
250.0 mg/mL, , 1250.0 mg/mL
, Intramuscular, Injection, Injection - Intramuscular, Injection - Subcutaneous, Subcutaneous, Liquid, Liquid - Intramuscular
Primary Amenorrhoea
250.0 mg/mL, , 1250.0 mg/mL
, Intramuscular, Injection, Injection - Intramuscular, Injection - Subcutaneous, Subcutaneous, Liquid, Liquid - Intramuscular
Adenocarcinoma
250.0 mg/mL, , 1250.0 mg/mL
, Intramuscular, Injection, Injection - Intramuscular, Injection - Subcutaneous, Subcutaneous, Liquid, Liquid - Intramuscular
Adenocarcinoma
250.0 mg/mL, , 1250.0 mg/mL
, Intramuscular, Injection, Injection - Intramuscular, Injection - Subcutaneous, Subcutaneous, Liquid, Liquid - Intramuscular
history of singleton spontaneous preterm birth
250.0 mg/mL, , 1250.0 mg/mL
, Intramuscular, Injection, Injection - Intramuscular, Injection - Subcutaneous, Subcutaneous, Liquid, Liquid - Intramuscular
Secondary Amenorrhea
250.0 mg/mL, , 1250.0 mg/mL
, Intramuscular, Injection, Injection - Intramuscular, Injection - Subcutaneous, Subcutaneous, Liquid, Liquid - Intramuscular
Premature Birth
250.0 mg/mL, , 1250.0 mg/mL
, Intramuscular, Injection, Injection - Intramuscular, Injection - Subcutaneous, Subcutaneous, Liquid, Liquid - Intramuscular
prophylaxis of preterm birth
250.0 mg/mL, , 1250.0 mg/mL
, Intramuscular, Injection, Injection - Intramuscular, Injection - Subcutaneous, Subcutaneous, Liquid, Liquid - Intramuscular

Warnings

Hydroxyprogesterone Caproate Contraindications
Condition
Risk Level
Notes
Breast Cancer
Do Not Combine
Liver Dysfunction
Do Not Combine
history of breast carcinoma
Do Not Combine
Thromboembolism
Do Not Combine
diagnostic use for pregnancy
Do Not Combine
Missed Abortion
Do Not Combine
history of hormone-sensitive cancer
Do Not Combine
Vaginal Hemorrhage
Do Not Combine
Thromboembolism
Do Not Combine
Breast
Do Not Combine
Thrombosis
Do Not Combine
history of thrombotic disorder
Do Not Combine
hormone-sensitive cancer
Do Not Combine
There are 20 known major drug interactions with Hydroxyprogesterone Caproate.
Common Hydroxyprogesterone Caproate Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be increased when combined with Hydroxyprogesterone caproate.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Hydroxyprogesterone caproate.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Hydroxyprogesterone caproate.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Hydroxyprogesterone caproate.
Clomipramine
Major
The metabolism of Clomipramine can be increased when combined with Hydroxyprogesterone caproate.
Hydroxyprogesterone Caproate Toxicity & Overdose RiskPain at the injection site is the most common side effect of hydroxyprogesterone caproate. Other potential effects include swelling, hives, itching, nausea, lumps, and diarrhea.
image of a doctor in a lab doing drug, clinical research

Hydroxyprogesterone Caproate Novel Uses: Which Conditions Have a Clinical Trial Featuring Hydroxyprogesterone Caproate?

Currently, 29 active trials are analyzing the potential of Hydroxyprogesterone Caproate to ameliorate Adenocarcinoma, Adenocarcinoma and a history of singleton spontaneous preterm birth.
Condition
Clinical Trials
Trial Phases
Secondary Amenorrhea
0 Actively Recruiting
prophylaxis of preterm birth
0 Actively Recruiting
Adenocarcinoma
0 Actively Recruiting
Primary Amenorrhoea
0 Actively Recruiting
Uterine hemorrhage
3 Actively Recruiting
Phase 3, Phase 2, Not Applicable
history of singleton spontaneous preterm birth
0 Actively Recruiting
Premature Birth
24 Actively Recruiting
Not Applicable, Phase 2, Phase 4
Adenocarcinoma
0 Actively Recruiting

Hydroxyprogesterone Caproate Reviews: What are patients saying about Hydroxyprogesterone Caproate?

4.3Patient Review
5/15/2013
Hydroxyprogesterone Caproate for Risk Reduction for Recurrent Preterm Birth
I have a history of preterm labor and the pain from my back is unbearable. I've only had 5 shots so far, but I would not recommend this treatment to anyone else. The studies are conflicting and it's inconvenient to have to go to the doctor every week.
3.7Patient Review
4/14/2008
Hydroxyprogesterone Caproate for Female Hormone Disturbance
I'm using this to help with PTL, but it seems like the more shots I get, the more pain I'm in. My nurse says that's due to scar tissue build-up, but it's keeping me pregnant so far, so I guess it's worth it.
2Patient Review
5/23/2008
Hydroxyprogesterone Caproate for Female Hormone Disturbance
I've been getting this shot for seven weeks now. I'm not sure if it's working or not, but I'm 23 weeks into my pregnancy and things seem to be going well.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about hydroxyprogesterone caproate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is hydroxyprogesterone caproate used for?

"Hydroxyprogesterone caproate is an injection of man-made progestin hormone. It is given to pregnant women to help lower the risk of preterm birth."

Answered by AI

How does hydroxyprogesterone work?

"Hydroxyprogesterone is a manmade form of the female hormone progesterone. It's used to lower the risk of premature birth in a woman who's already had a premature baby. Hydroxyprogesterone won't stop premature labor that's already started."

Answered by AI

Why progesterone injection is given during pregnancy?

"Progesterone is a hormone that helps with the growth of the uterus during pregnancy and prevents it from contracting. If you have a short cervix, treatment with vaginal progesterone gel may help prevent premature birth."

Answered by AI

Clinical Trials for Hydroxyprogesterone Caproate

Have you considered Hydroxyprogesterone Caproate clinical trials? We made a collection of clinical trials featuring Hydroxyprogesterone Caproate, we think they might fit your search criteria.
Have you considered Hydroxyprogesterone Caproate clinical trials? We made a collection of clinical trials featuring Hydroxyprogesterone Caproate, we think they might fit your search criteria.
Have you considered Hydroxyprogesterone Caproate clinical trials? We made a collection of clinical trials featuring Hydroxyprogesterone Caproate, we think they might fit your search criteria.
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