Your session is about to expire
What is Hydroxocobalamin
HydroxocobalaminThe Generic name of this drug
Treatment SummaryHydroxocobalamin is an injectable form of vitamin B12 used to treat a vitamin B12 deficiency. It can also be used to treat cyanide poisoning, Leber's optic atrophy, and toxic amblyopia. The drug is also known as vitamin B12a and hydroxycobalamin.
Cyanokitis the brand name
Hydroxocobalamin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cyanokit
Hydroxocobalamin
2007
7
Approved as Treatment by the FDA
Hydroxocobalamin, also known as Cyanokit, is approved by the FDA for 2 uses like Vitamin B12 Deficiency and Schilling Test .Vitamin B12 Deficiency
Schilling Test
Effectiveness
How Hydroxocobalamin Affects PatientsHydroxocobalamin is a form of Vitamin B12 that is given as an injection. Vitamin B12 and a related vitamin (methylcobalamin) both play a role in several biological processes. Low levels of this vitamin can cause problems with nerve cells and the production of lipoprotein. It also affects how folic acid is processed in the body, which can interfere with cell maturation. Vitamin B12 is important for growth, how cells replicate, how blood is made, and how proteins are made. It also helps to break down fats, carbohydrates, and proteins.
How Hydroxocobalamin works in the bodyVitamin B12 has four forms: deoxyadenosylcobalamin, methylcobalamin, hydroxocobalamin, and cyanocobalamin. The body mainly uses two of these forms, methylcobalamin and 5-deoxyadenosyl cobalamin. Methylcobalamin helps the body to convert the amino acid homocysteine into methionine. Methionine is important for DNA methylation. 5-Deoxyadenosyl cobalamin helps with the conversion of L-methylmalonyl-CoA to succinyl-CoA. This conversion helps the body get energy
When to interrupt dosage
The proposed dosage of Hydroxocobalamin is contingent upon the diagnosed affliction, such as Neurodegenerative Diseases, Fractures, Multiple and Anger Management Therapy. The sum of dosage diversifies, depending on the approach of administration (e.g. Injection, powder, lyophilized, for solution - Intravenous or Tablet, chewable) highlighted in the table beneath.Condition
Dosage
Administration
Fractures, Multiple
, 25.0 mg/mL, 2500.0 mg, 1.0 mg/mL, 5000.0 mg, 50.0 mg/mL, 0.006 mg, 0.015 mg, 0.00522 mg
Intravenous, Injection, powder, lyophilized, for solution, , Injection, powder, lyophilized, for solution - Intravenous, Intramuscular, Liquid, Liquid - Intramuscular, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intramuscular, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Paralysis
, 25.0 mg/mL, 2500.0 mg, 1.0 mg/mL, 5000.0 mg, 50.0 mg/mL, 0.006 mg, 0.015 mg, 0.00522 mg
Intravenous, Injection, powder, lyophilized, for solution, , Injection, powder, lyophilized, for solution - Intravenous, Intramuscular, Liquid, Liquid - Intramuscular, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intramuscular, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Burn Patients
, 25.0 mg/mL, 2500.0 mg, 1.0 mg/mL, 5000.0 mg, 50.0 mg/mL, 0.006 mg, 0.015 mg, 0.00522 mg
Intravenous, Injection, powder, lyophilized, for solution, , Injection, powder, lyophilized, for solution - Intravenous, Intramuscular, Liquid, Liquid - Intramuscular, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intramuscular, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Vitamin B12 Deficiency
, 25.0 mg/mL, 2500.0 mg, 1.0 mg/mL, 5000.0 mg, 50.0 mg/mL, 0.006 mg, 0.015 mg, 0.00522 mg
Intravenous, Injection, powder, lyophilized, for solution, , Injection, powder, lyophilized, for solution - Intravenous, Intramuscular, Liquid, Liquid - Intramuscular, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intramuscular, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Toxic effect of hydrocyanic acid and cyanides
, 25.0 mg/mL, 2500.0 mg, 1.0 mg/mL, 5000.0 mg, 50.0 mg/mL, 0.006 mg, 0.015 mg, 0.00522 mg
Intravenous, Injection, powder, lyophilized, for solution, , Injection, powder, lyophilized, for solution - Intravenous, Intramuscular, Liquid, Liquid - Intramuscular, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intramuscular, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Schilling Test
, 25.0 mg/mL, 2500.0 mg, 1.0 mg/mL, 5000.0 mg, 50.0 mg/mL, 0.006 mg, 0.015 mg, 0.00522 mg
Intravenous, Injection, powder, lyophilized, for solution, , Injection, powder, lyophilized, for solution - Intravenous, Intramuscular, Liquid, Liquid - Intramuscular, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intramuscular, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Behavior Disorders
, 25.0 mg/mL, 2500.0 mg, 1.0 mg/mL, 5000.0 mg, 50.0 mg/mL, 0.006 mg, 0.015 mg, 0.00522 mg
Intravenous, Injection, powder, lyophilized, for solution, , Injection, powder, lyophilized, for solution - Intravenous, Intramuscular, Liquid, Liquid - Intramuscular, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intramuscular, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Anemia, Pernicious
, 25.0 mg/mL, 2500.0 mg, 1.0 mg/mL, 5000.0 mg, 50.0 mg/mL, 0.006 mg, 0.015 mg, 0.00522 mg
Intravenous, Injection, powder, lyophilized, for solution, , Injection, powder, lyophilized, for solution - Intravenous, Intramuscular, Liquid, Liquid - Intramuscular, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intramuscular, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Anger Management Therapy
, 25.0 mg/mL, 2500.0 mg, 1.0 mg/mL, 5000.0 mg, 50.0 mg/mL, 0.006 mg, 0.015 mg, 0.00522 mg
Intravenous, Injection, powder, lyophilized, for solution, , Injection, powder, lyophilized, for solution - Intravenous, Intramuscular, Liquid, Liquid - Intramuscular, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intramuscular, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Vitamin B complex deficiency
, 25.0 mg/mL, 2500.0 mg, 1.0 mg/mL, 5000.0 mg, 50.0 mg/mL, 0.006 mg, 0.015 mg, 0.00522 mg
Intravenous, Injection, powder, lyophilized, for solution, , Injection, powder, lyophilized, for solution - Intravenous, Intramuscular, Liquid, Liquid - Intramuscular, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intramuscular, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Therapeutic Agent Toxicity
, 25.0 mg/mL, 2500.0 mg, 1.0 mg/mL, 5000.0 mg, 50.0 mg/mL, 0.006 mg, 0.015 mg, 0.00522 mg
Intravenous, Injection, powder, lyophilized, for solution, , Injection, powder, lyophilized, for solution - Intravenous, Intramuscular, Liquid, Liquid - Intramuscular, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intramuscular, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Iron Deficiency Anemia
, 25.0 mg/mL, 2500.0 mg, 1.0 mg/mL, 5000.0 mg, 50.0 mg/mL, 0.006 mg, 0.015 mg, 0.00522 mg
Intravenous, Injection, powder, lyophilized, for solution, , Injection, powder, lyophilized, for solution - Intravenous, Intramuscular, Liquid, Liquid - Intramuscular, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intramuscular, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Neurological Disorders
, 25.0 mg/mL, 2500.0 mg, 1.0 mg/mL, 5000.0 mg, 50.0 mg/mL, 0.006 mg, 0.015 mg, 0.00522 mg
Intravenous, Injection, powder, lyophilized, for solution, , Injection, powder, lyophilized, for solution - Intravenous, Intramuscular, Liquid, Liquid - Intramuscular, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intramuscular, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
prophylaxis of Vitamin B12 deficiency
, 25.0 mg/mL, 2500.0 mg, 1.0 mg/mL, 5000.0 mg, 50.0 mg/mL, 0.006 mg, 0.015 mg, 0.00522 mg
Intravenous, Injection, powder, lyophilized, for solution, , Injection, powder, lyophilized, for solution - Intravenous, Intramuscular, Liquid, Liquid - Intramuscular, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intramuscular, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Warnings
There are 20 known major drug interactions with Hydroxocobalamin.Common Hydroxocobalamin Drug Interactions
Drug Name
Risk Level
Description
Abacavir
Minor
Hydroxocobalamin may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acetaminophen
Minor
Hydroxocobalamin may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
Aclidinium
Minor
Hydroxocobalamin may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Hydroxocobalamin may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Hydroxocobalamin may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Hydroxocobalamin Novel Uses: Which Conditions Have a Clinical Trial Featuring Hydroxocobalamin?
202 active clinical trials are currently being conducted to evaluate the potential of Hydroxocobalamin in the management of Iron Deficiency Anemia, Vitamin B12 Deficiency and Behavioral Disorders.Condition
Clinical Trials
Trial Phases
Behavior Disorders
0 Actively Recruiting
Iron Deficiency Anemia
114 Actively Recruiting
Phase 1, Not Applicable, Phase 2, Phase 3, Phase 4, Early Phase 1
Schilling Test
0 Actively Recruiting
Burn Patients
0 Actively Recruiting
Paralysis
48 Actively Recruiting
Phase 1, Not Applicable, Phase 2, Early Phase 1, Phase 3
Fractures, Multiple
5 Actively Recruiting
Early Phase 1, Not Applicable
Therapeutic Agent Toxicity
3 Actively Recruiting
Phase 2, Phase 1
Toxic effect of hydrocyanic acid and cyanides
0 Actively Recruiting
Anger Management Therapy
0 Actively Recruiting
Neurological Disorders
62 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Phase 4, Phase 3, Early Phase 1
Vitamin B12 Deficiency
0 Actively Recruiting
Anemia, Pernicious
0 Actively Recruiting
Vitamin B complex deficiency
0 Actively Recruiting
prophylaxis of Vitamin B12 deficiency
0 Actively Recruiting
Hydroxocobalamin Reviews: What are patients saying about Hydroxocobalamin?
4.3Patient Review
4/23/2013 The hydro b12 injections have really helped me with my PA. I didn't see any improvement with the cyano b12 sublinguals, but the hydro b12 injections have made a huge difference in my thinking, pain levels, and energy levels.
1.7Patient Review
10/21/2015 After being exposed to mold, I started feeling awful. Extreme fatigue, aching body, brain fog, itchy skin, liver pain and related issues. It was like I had been hit by a baseball bat all over my body! If you're allergic to mold or fungi in any way, stay away from this treatment.
Patient Q&A Section about hydroxocobalamin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What hydroxocobalamin is used for?
"Hydroxocobalamin is a manufactured form of vitamin B12. It is used to treat and prevent vitamin B12 deficiency anaemia, which is when you have low levels of this vitamin in your body."
Answered by AI
How often should hydroxocobalamin be given?
"If a lack of vitamin B12 in your diet is not the cause of your vitamin B12 deficiency, you will likely need to get an injection of hydroxocobalamin every 2 to 3 months for the rest of your life."
Answered by AI
Does hydroxocobalamin contain cyanide?
"Hydroxocobalamin (vitamin B12a) is not universally available, however the older kits still have a role. Hydroxocobalamin has a central cobalt atom that binds cyanide ions, forming cyanocobalamin (vitamin B12), which is nontoxic and renally excreted."
Answered by AI
How do you administer hydroxocobalamin?
"Reveal the upper arm or outer thigh where the injection is to occur. Take off the needle cover. Gently push the needle into the skin until it cannot go any further. Push the plunger down slowly until the syringe is emptied."
Answered by AI