Hydrea

Ovarian Neoplasms, Thrombocythemia, Essential, Anemia, Sickle Cell + 4 more
Treatment
2 FDA approvals
17 Active Studies for Hydrea

What is Hydrea

HydroxyureaThe Generic name of this drug
Treatment SummaryA medication used to inhibit the growth and spread of cancer cells by blocking the production of DNA in the cells.
Hydroxyureais the brand name
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Hydrea Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Hydroxyurea
Hydroxyurea
1998
25

Approved as Treatment by the FDA

Hydroxyurea, also known as Hydroxyurea, is approved by the FDA for 2 uses which include inoperable Ovarian cancer and Ovarian Neoplasms .
inoperable Ovarian cancer
Ovarian Neoplasms

Effectiveness

How Hydrea Affects PatientsWhen taken together, hydroxyurea and cisplatin have been shown to be effective against certain types of human lung cancer in both lab and animal studies. The greatest effect is seen when hydroxyurea is taken 4 hours before cisplatin.
How Hydrea works in the bodyHydroxyurea works by converting into a free radical and entering cells where it stops a protein from working. This protein is needed for cells to replicate, so blocking it prevents cells from reproducing. Hydroxyurea also helps repair damaged DNA, making it more effective when combined with radiation or chemicals. Lastly, it increases the amount of fetal hemoglobin in sickle cell anemia, reducing the risk of dangerous blockages.

When to interrupt dosage

The measure of Hydrea is contingent upon the diagnosed ailment, including Myeloid Leukemia, Hypereosinophilic Syndrome (HES) and Thrombocythemia, Essential. The dosage likewise fluctuates as per the technique of delivery featured in the table beneath.
Condition
Dosage
Administration
Thrombocythemia, Essential
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Sickle Cell Crisis
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Polycythemia Vera
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Hypereosinophilic Syndrome
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Ovarian Neoplasms
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Anemia, Sickle Cell
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Meningioma
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral

Warnings

There are 20 known major drug interactions with Hydrea.
Common Hydrea Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Hydroxyurea is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Hydroxyurea is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Acteoside.
Hydrea Toxicity & Overdose RiskThe lethal dose in mice is 7330mg/kg and in rats is 5760mg/kg. Animal studies have shown that hydroxyurea may cause birth defects. There have also been reports of humans using hydroxyurea during pregnancy without any adverse effects. Additionally, animal and human studies have suggested that hydroxyurea may cause mutations.
image of a doctor in a lab doing drug, clinical research

Hydrea Novel Uses: Which Conditions Have a Clinical Trial Featuring Hydrea?

63 active studies are being conducted to assess the effectiveness of Hydrea in treating Myeloid Leukemia, Polycythemia Vera (PV) and inoperable Ovarian Cancer.
Condition
Clinical Trials
Trial Phases
Thrombocythemia, Essential
14 Actively Recruiting
Phase 2, Phase 1, Phase 3
Sickle Cell Crisis
2 Actively Recruiting
Phase 2, Not Applicable
Anemia, Sickle Cell
1 Actively Recruiting
Not Applicable
Ovarian Neoplasms
0 Actively Recruiting
Hypereosinophilic Syndrome
0 Actively Recruiting
Polycythemia Vera
0 Actively Recruiting
Meningioma
0 Actively Recruiting

Hydrea Reviews: What are patients saying about Hydrea?

5Patient Review
3/30/2014
Hydrea for Increased Red Blood Cells
I've been taking this medication for 8 years to treat pv/mf. Recently, I've been having severe eye problems and upper gut issues including bloating and digestive disorders. I might need to cut back on the dosage to figure out what is causing what. Has anyone experienced upper stomach swelling and nausea with headaches?
4.7Patient Review
4/13/2013
Hydrea for Spontaneous Hemorrhages and Increase in Blood Platelets
4Patient Review
7/8/2014
Hydrea for Increased Red Blood Cells
I started feeling nauseous after 10 days of taking Hydrea.
3.7Patient Review
12/1/2013
Hydrea for Increased Red Blood Cells
I'm constantly exhausted and I can't tell if it's the hydrea or my low iron levels. Either way, it's really frustrating because I used to have so much energy.
3.7Patient Review
7/27/2017
Hydrea for Increased Red Blood Cells
I have polycythemia vera, and while this treatment has lowered my numbers, I don't like the side effects. I'm tired all the time, I've lost interest in things I used to enjoy, and my hair is falling out. I wish there was a treatment that didn't make me feel so lousy.
View All Reviews
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Patient Q&A Section about hydrea

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of Hydrea?

"These are some of the side effects that may occur. If you experience any of these side effects, speak to your doctor or pharmacist."

Answered by AI

What is Hydrea prescribed for?

"Hydroxyurea is used to prevent painful episodes and reduce the need for blood transfusions in patients with sickle cell anemia by making the red blood cells more flexible."

Answered by AI

Is Hydrea a cancer drug?

"Hydrea is a cancer treatment that works by inhibiting the metabolism of cancer cells. It is approved to treat certain forms of chronic myeloid leukemia and skin cancer."

Answered by AI

How long can someone take Hydrea?

"You can take hydroxyurea for an indefinite amount of time, as long as it is effective.How will you know that hydroxyurea is working? It usually takes a few months for hydroxyurea to start working, so you may not feel any immediate improvement."

Answered by AI

Clinical Trials for Hydrea

Have you considered Hydrea clinical trials? We made a collection of clinical trials featuring Hydrea, we think they might fit your search criteria.
Have you considered Hydrea clinical trials? We made a collection of clinical trials featuring Hydrea, we think they might fit your search criteria.
Have you considered Hydrea clinical trials? We made a collection of clinical trials featuring Hydrea, we think they might fit your search criteria.
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