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What is Hydrea
HydroxyureaThe Generic name of this drug
Treatment SummaryA medication used to inhibit the growth and spread of cancer cells by blocking the production of DNA in the cells.
Hydroxyureais the brand name
Hydrea Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Hydroxyurea
Hydroxyurea
1998
25
Approved as Treatment by the FDA
Hydroxyurea, also known as Hydroxyurea, is approved by the FDA for 1 uses which include inoperable Ovarian cancer .inoperable Ovarian cancer
Effectiveness
How Hydrea Affects PatientsWhen taken together, hydroxyurea and cisplatin have been shown to be effective against certain types of human lung cancer in both lab and animal studies. The greatest effect is seen when hydroxyurea is taken 4 hours before cisplatin.
How Hydrea works in the bodyHydroxyurea works by converting into a free radical and entering cells where it stops a protein from working. This protein is needed for cells to replicate, so blocking it prevents cells from reproducing. Hydroxyurea also helps repair damaged DNA, making it more effective when combined with radiation or chemicals. Lastly, it increases the amount of fetal hemoglobin in sickle cell anemia, reducing the risk of dangerous blockages.
When to interrupt dosage
The measure of Hydrea is contingent upon the diagnosed ailment, including Myeloid Leukemia, Hypereosinophilic Syndrome (HES) and Thrombocythemia, Essential. The dosage likewise fluctuates as per the technique of delivery featured in the table beneath.Condition
Dosage
Administration
Thrombocythemia, Essential
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Sickle Cell Anemia
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Polycythemia Vera (PV)
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Sickle Cell Crisis
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Hypereosinophilic Syndrome (HES)
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
inoperable Ovarian cancer
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Meningiomas
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Warnings
There are 20 known major drug interactions with Hydrea.Common Hydrea Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Hydroxyurea is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Hydroxyurea is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Acteoside.
Hydrea Toxicity & Overdose RiskThe lethal dose in mice is 7330mg/kg and in rats is 5760mg/kg. Animal studies have shown that hydroxyurea may cause birth defects. There have also been reports of humans using hydroxyurea during pregnancy without any adverse effects. Additionally, animal and human studies have suggested that hydroxyurea may cause mutations.
Hydrea Novel Uses: Which Conditions Have a Clinical Trial Featuring Hydrea?
63 active studies are being conducted to assess the effectiveness of Hydrea in treating Myeloid Leukemia, Polycythemia Vera (PV) and inoperable Ovarian Cancer.Condition
Clinical Trials
Trial Phases
inoperable Ovarian cancer
0 Actively Recruiting
Meningiomas
1 Actively Recruiting
Phase 2
Hypereosinophilic Syndrome (HES)
0 Actively Recruiting
Sickle Cell Crisis
2 Actively Recruiting
Phase 2, Not Applicable
Polycythemia Vera (PV)
0 Actively Recruiting
Sickle Cell Anemia
7 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3
Thrombocythemia, Essential
15 Actively Recruiting
Phase 1, Phase 2, Phase 3
Hydrea Reviews: What are patients saying about Hydrea?
5Patient Review
3/30/2014 I've been taking this medication for 8 years to treat pv/mf. Recently, I've been having severe eye problems and upper gut issues including bloating and digestive disorders. I might need to cut back on the dosage to figure out what is causing what. Has anyone experienced upper stomach swelling and nausea with headaches?
4.7Patient Review
4/13/20134Patient Review
7/8/2014 I started feeling nauseous after 10 days of taking Hydrea.
3.7Patient Review
12/1/2013 I'm constantly exhausted and I can't tell if it's the hydrea or my low iron levels. Either way, it's really frustrating because I used to have so much energy.
3.7Patient Review
7/27/2017 I have polycythemia vera, and while this treatment has lowered my numbers, I don't like the side effects. I'm tired all the time, I've lost interest in things I used to enjoy, and my hair is falling out. I wish there was a treatment that didn't make me feel so lousy.
3.3Patient Review
5/3/2015 I felt really tired and sluggish after taking this, almost like I had no energy. Additionally, I experienced constipation.
3Patient Review
6/22/2017 This treatment has been effective in keeping my blood disorder under control for the last six years, but now I have developed cancer in my mouth.
2.3Patient Review
5/24/2015 I'm already having a lot of negative side effects after only three days on this medication. I have shortness of breath, bad vision, numbness, vomiting, loose bowels, pain, and a dry stomach. I've called the pharmacy and my doctor but no one is answering. I wouldn't recommend this treatment to anyone.
Patient Q&A Section about hydrea
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of Hydrea?
"These are some of the side effects that may occur. If you experience any of these side effects, speak to your doctor or pharmacist."
Answered by AI
What is Hydrea prescribed for?
"Hydroxyurea is used to prevent painful episodes and reduce the need for blood transfusions in patients with sickle cell anemia by making the red blood cells more flexible."
Answered by AI
Is Hydrea a cancer drug?
"Hydrea is a cancer treatment that works by inhibiting the metabolism of cancer cells. It is approved to treat certain forms of chronic myeloid leukemia and skin cancer."
Answered by AI
How long can someone take Hydrea?
"You can take hydroxyurea for an indefinite amount of time, as long as it is effective.How will you know that hydroxyurea is working? It usually takes a few months for hydroxyurea to start working, so you may not feel any immediate improvement."
Answered by AI