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What is Fingolimod Hydrochloride
FingolimodThe Generic name of this drug
Treatment SummaryFingolimod is a medication used to treat Multiple Sclerosis (MS), a chronic inflammatory disorder that can cause physical, cognitive, and neurological impairments. It was created by Novartis and approved by the FDA in 2010. It is currently being tested to see if it can help treat COVID-19, the disease caused by SARS-CoV-2 virus, with Phase 2 clinical trials expected to be completed in July 2020.
Gilenyais the brand name
Fingolimod Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Gilenya
Fingolimod
2010
16
Effectiveness
How Fingolimod Hydrochloride Affects PatientsFingolimod is used to treat multiple sclerosis, and may also help reduce lung inflammation in people with COVID-19. However, taking it may cause a decrease in heart rate and prolong the QT interval.
How Fingolimod Hydrochloride works in the bodyFingolimod is a drug that helps regulate inflammation in people with Multiple Sclerosis (MS). It works by binding to certain receptors in the body, including the cardiovascular, immune, and central nervous systems. When bound, it stops lymphocytes from leaving the lymph nodes and entering the circulation. This reduces the inflammation associated with MS. It's also sometimes used to prevent Acute Respiratory Distress Syndrome (ARDS) caused by COVID-19.
When to interrupt dosage
The measure of Fingolimod Hydrochloride is contingent upon the diagnosed ailment, including Multiple Sclerosis, Relapsing Remitting Multiple Sclerosis (RRMS) and Alternative Treatment. The magnitude of dosage is contingent upon the method of administration (e.g. Capsule - Oral or Capsule) presented in the table below.Condition
Dosage
Administration
Multiple Sclerosis
, 0.5 mg, 0.25 mg
, Oral, Capsule, Capsule - Oral
Relapsing Remitting Multiple Sclerosis
, 0.5 mg, 0.25 mg
, Oral, Capsule, Capsule - Oral
Alternative Treatment
, 0.5 mg, 0.25 mg
, Oral, Capsule, Capsule - Oral
Carcinoma in Situ
, 0.5 mg, 0.25 mg
, Oral, Capsule, Capsule - Oral
active Secondary Progressive Multiple Sclerosis (SPMS)
, 0.5 mg, 0.25 mg
, Oral, Capsule, Capsule - Oral
Warnings
Fingolimod Hydrochloride has fifteen contraindications, so its use should be avoided in circumstances involving any of the conditions in the following table.Fingolimod Hydrochloride ContraindicationsCondition
Risk Level
Notes
Atrioventricular Block
Do Not Combine
Atrioventricular Block
Do Not Combine
Stroke
Do Not Combine
Unstable Angina Pectoris
Do Not Combine
Transient Ischemic Attack (TIA)
Do Not Combine
Atrioventricular Block
Do Not Combine
Heart Decompensation
Do Not Combine
Sick Sinus Syndrome
Do Not Combine
Heart failure
Do Not Combine
Pulse Frequency
Do Not Combine
Atrioventricular Block
Do Not Combine
Pulse Frequency
Do Not Combine
Heart Attack
Do Not Combine
Pulse Frequency
Do Not Combine
Heart failure
Do Not Combine
Common Fingolimod Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Adenovirus type 7 vaccine live
Major
The therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Fingolimod.
Ajmaline
Major
Fingolimod may increase the arrhythmogenic activities of Ajmaline.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Fingolimod.
Amiodarone
Major
Fingolimod may increase the arrhythmogenic activities of Amiodarone.
Anthrax vaccine
Major
The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Fingolimod.
Fingolimod Hydrochloride Toxicity & Overdose RiskThe lowest toxic dose of fingolimod in rats is between 300 - 600 mg/kg. In one case report, an intentional overdose of 14mg of fingolimod and 2g of phenoxymethylpenicillin caused low blood pressure and a slow heartbeat, both of which were reversed by taking atropine. As fingolimod has been linked to heart problems, it is likely that an overdose could cause similar issues such as a slow heartbeat and blockage of the heart's electrical signals.
Fingolimod Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Fingolimod Hydrochloride?
At present, 44 active studies are being conducted to assess the effectiveness of Fingolimod Hydrochloride in treating active Secondary Progressive Multiple Sclerosis (SPMS), Multiple Sclerosis and Carcinoma in Situ.Condition
Clinical Trials
Trial Phases
Carcinoma in Situ
5 Actively Recruiting
Not Applicable, Phase 4
active Secondary Progressive Multiple Sclerosis (SPMS)
0 Actively Recruiting
Alternative Treatment
1 Actively Recruiting
Phase 4
Relapsing Remitting Multiple Sclerosis
13 Actively Recruiting
Not Applicable, Phase 3, Phase 1, Phase 2, Phase 4
Multiple Sclerosis
21 Actively Recruiting
Phase 3, Phase 2, Phase 4, Phase 1
Fingolimod Hydrochloride Reviews: What are patients saying about Fingolimod Hydrochloride?
5Patient Review
6/17/2012 This treatment has been wonderful. I'm unable to take any other treatments, so this really was a blessing. In the two years that I've been taking it, I've only had one flare-up compared to six to ten per year previously. Additionally, I haven't felt this good in a long time.
5Patient Review
12/21/2010 I've been in a clinical trial for this medicine for 3+ years and it's going great! I've had mild side effects and excellent results. No new MS attacks in over 3 years.
Patient Q&A Section about fingolimod hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is fingolimod used for MS?
"Fingolimod is an immunotherapeutic drug that is used to target the sphingosine-1-phosphate receptor. It is a widely used medication for relapsing-remitting multiple sclerosis (MS)."
Answered by AI
What is fingolimod used for?
"Fingolimod is used to help manage relapsing-remitting forms of multiple sclerosis (where symptoms flare up from time to time) in adults and children 10 years and older. It may help prevent episodes of symptoms and slow the progression of disability caused by MS."
Answered by AI
What is the brand name for fingolimod?
"Gilenya is a prescription medicine that is used to treat the symptoms of Multiple sclerosis. It is an immunomodulator and sphingosine 1-phosphate receptor modulator that can be used alone or with other medications."
Answered by AI
What is the mechanism of action of fingolimod?
"Fingolimod works by binding to and activating the S1P1 receptor, which is found on the surface of lymphocytes. This prevents the lymphocytes from leaving the lymph nodes, and reduces the amount of autoaggressive lymphocytes that can enter the central nervous system."
Answered by AI