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What is Felbamate
FelbamateThe Generic name of this drug
Treatment SummaryFelbamate is a medication used to treat epilepsy. It can be used to reduce the occurrence of partial seizures in adults and both partial and generalized seizures associated with Lennox-Gastaut Syndrome in children. Felbamate works by inhibiting the binding of the GABA receptor, a type of protein that helps control brain activity.
Felbatolis the brand name
Felbamate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Felbatol
Felbamate
1993
41
Approved as Treatment by the FDA
Felbamate, also called Felbatol, is approved by the FDA for 3 uses including Lennox-Gastaut syndrome and Seizures .Lennox-Gastaut syndrome
Used in combination with other therapies
Seizures
Helps manage Refractory Partial Seizures
Status Epilepticus (Convulsive)
Helps manage Status Epilepticus (Convulsive)
Effectiveness
How Felbamate Affects PatientsFelbamate is a medication used to treat seizures caused by epilepsy. It works by blocking certain receptors in the brain that are responsible for causing seizures. It has weak effects on some receptors, and does not affect others. However, it does act as an antagonist at the glycine receptor of the NMDA receptor-ionophore complex.
How Felbamate works in the bodyIt's not yet known how felbamate works to treat seizures, but it appears to have similar effects as other anticonvulsants. In experiments, felbamate appears to block the activity of a certain type of receptor which is involved in causing seizures. It raises the threshold for seizures to occur and can stop them from spreading. It also weakly blocks the binding of GABA and benzodiazepine receptors, which are also involved in seizures.
When to interrupt dosage
The measure of Felbamate is contingent upon the determined condition, including Status Epilepticus (Convulsive), Lennox-Gastaut syndrome and Seizures. The amount of dosage is contingent upon the delivery technique (e.g. Tablet - Oral or Suspension - Oral) shown in the following table.Condition
Dosage
Administration
Seizures
400.0 mg, , 600.0 mg, 600.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral
Lennox-Gastaut syndrome
400.0 mg, , 600.0 mg, 600.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral
Status Epilepticus (Convulsive)
400.0 mg, , 600.0 mg, 600.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral
Warnings
There are 20 known major drug interactions with Felbamate.Common Felbamate Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Felbamate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Felbamate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Felbamate.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Felbamate.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Felbamate.
Felbamate Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats has been found to be 5000mg/kg when administered orally.
Felbamate Novel Uses: Which Conditions Have a Clinical Trial Featuring Felbamate?
One ongoing investigation is assessing the utility of Felbamate in alleviating Lennox-Gastaut syndrome, Seizures and Convulsive Status Epilepticus.Condition
Clinical Trials
Trial Phases
Seizures
0 Actively Recruiting
Lennox-Gastaut syndrome
0 Actively Recruiting
Status Epilepticus (Convulsive)
0 Actively Recruiting
Felbamate Reviews: What are patients saying about Felbamate?
5Patient Review
6/23/2015 I am now seizure-free and haven't taken the medication in almost 8 months!
5Patient Review
1/17/20135Patient Review
3/30/2015 This treatment has helped my anemia and low white blood cell count. I've also experienced fewer seizures, and when I do have them they're less severe. Overall, this has been a huge help.
4.7Patient Review
10/20/2015 Robin, 38 years old, has been on this for 20 years and it's the only drug that has come close to stopping his seizures.
4Patient Review
3/10/2017 This medication was the only one that worked for me. I switched to it after trying (and failing) with Topamax, Keppra, and Depakote. With this med, I had to get my blood checked regularly for aplastic anemia risk; however, it was worth it because I didn't experience any grand mals. The downside is that I have to take 600mg 6x a day, which is a lot!
1.7Patient Review
11/10/2014 This medication has been outstanding for me. I can't take any other one. The only downside is that insurance companies charge an ancillary fee when I can't take a generic and I was unaware of any generic for Felbatol.
Patient Q&A Section about felbamate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is felbamate used for?
"Felbamate is a medication used to control partial seizures. It can be used alone or with other medications. It is typically used when other therapies have failed or are not right for the patient. It is also used in children to control partial and generalized seizures caused by Lennox-Gastaut syndrome."
Answered by AI
Does felbamate cause weightloss?
"The average treatment time for felbamate was 23 weeks with a standard deviation of 16 weeks. Out of the 49 patients, 75% of them lost weight during the trials. For subjects that were older than 15 years, the average weight loss was 3.17 kg or 4.11% of their body weight. This information was collected from 191.5 trials and the probability that this occurred by chance is less than 0.001."
Answered by AI
What are the side effects of felbamate?
"You should also speak to your doctor if you experience any of the following side effects as they may worsen over time: drowsiness, dizziness, nausea, vomiting, diarrhoea, constipation, difficulty sleeping, lack of coordination, headache, blurred/double vision, hiccups or loss of appetite."
Answered by AI
What is the mechanism of felbamate?
"The first anticonvulsant drug with dual actions on excitatory and inhibitory brain mechanisms is felbamate. This combination of effects could account for felbamate's broad spectrum of anticonvulsant activity in animal seizure models and its distinctive clinical efficacy and safety profile."
Answered by AI