Extina

Histoplasmosis, Paracoccidioidomycosis, Chromoblastomycosis + 22 more
Treatment
8 Active Studies for Extina

What is Extina

KetoconazoleThe Generic name of this drug
Treatment SummaryKetoconazole is an antifungal drug approved by the FDA in 1981 to treat fungal infections. It works by blocking the synthesis of a type of cholesterol found in fungi, which prevents the fungi from growing. While it was originally considered a good drug for treating fungal infections, it had frequent side effects in the stomach and liver, so newer drugs like fluconazole, itraconazole, voriconazole, and posaconazole were developed to replace it. Despite this, ketoconazole is still used in topical formulations.
Nizoralis the brand name
image of different drug pills on a surface
Extina Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nizoral
Ketoconazole
1981
135

Effectiveness

How Extina Affects PatientsKetoconazole is an antifungal medicine that works by stopping the growth and spread of fungi in the body. It is a type of medicine called an azole antifungal and has been shown to be effective at preventing fungus from growing and spreading.
How Extina works in the bodyKetoconazole stops fungi cells from making a special type of cholesterol called ergosterol. This stops the cells from functioning properly and makes them more permeable. As a result, the cells become less tightly packed, which stops the cells from working correctly. The drug also produces a toxic by-product that further inhibits the cell's activity.

When to interrupt dosage

The prescribed dose of Extina is contingent upon the diagnosed condition, for example Vulvovaginal Candidiasis, Cushing Syndrome and Chromomycosis. The amount of dosage is reliant on the technique of delivery (e.g. Cream or Aerosol, foam - Topical) featured in the table below.
Condition
Dosage
Administration
Histoplasmosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Paracoccidioidomycosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Chromoblastomycosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Blastomycosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Coccidioidomycosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Dandruff
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
cutaneous candidiasis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Candidiasis, Vulvovaginal
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Candidiasis, Chronic Mucocutaneous
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Dermatitis, Seborrheic
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Candidiasis, Vulvovaginal
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Cushing Syndrome
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Bacterial Vaginosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Trichophyton mentagrophytes
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Tinea cruris
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Tinea Pedis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Tinea Pedis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Tinea corporis (disorder)
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Tinea Pedis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
recalcitrant Dermatophytosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Warnings

Extina has forty-three contraindications and should not be administered if the individual is affected by any of the conditions in the table below.Extina Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Liver Dysfunction
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Long QT Syndrome
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Long QT Syndrome
Do Not Combine
Renal Insufficiency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ketoconazole may interact with Pulse Frequency
There are 20 known major drug interactions with Extina.
Common Extina Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Ketoconazole.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Ketoconazole.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Ketoconazole.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Ketoconazole.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Ketoconazole.
Extina Toxicity & Overdose RiskAn overdose of ketoconazole can cause liver problems, such as appetite loss, tiredness, nausea, and yellowing of the skin. Within an hour of taking ketoconazole, doctors may administer activated charcoal to reduce the effects. If a patient shows signs of adrenal insufficiency, they should be given 100mg of hydrocortisone, as well as saline and glucose solution. Blood pressure and electrolyte levels should be monitored in the following days.
image of a doctor in a lab doing drug, clinical research

Extina Novel Uses: Which Conditions Have a Clinical Trial Featuring Extina?

A total of 6 active trials are currently exploring the potential of Extina to treat Trichophyton mentagrophytes, Vaginal Candidiasis and Vulvovaginal Candidiasis.
Condition
Clinical Trials
Trial Phases
Coccidioidomycosis
0 Actively Recruiting
Chromoblastomycosis
0 Actively Recruiting
Paracoccidioidomycosis
0 Actively Recruiting
Tinea corporis (disorder)
0 Actively Recruiting
Tinea corporis (disorder)
0 Actively Recruiting
Blastomycosis
0 Actively Recruiting
Candidiasis, Chronic Mucocutaneous
0 Actively Recruiting
Tinea Pedis
0 Actively Recruiting
Malassezia
0 Actively Recruiting
Candidiasis, Vulvovaginal
2 Actively Recruiting
Early Phase 1
recalcitrant Dermatophytosis
0 Actively Recruiting
Candidiasis, Systemic
0 Actively Recruiting
Trichophyton mentagrophytes
0 Actively Recruiting
Cushing Syndrome
0 Actively Recruiting
Tinea cruris
0 Actively Recruiting
Tinea Corporis caused by Trichophyton mentagrophytes
0 Actively Recruiting
Trichophyton rubrum
0 Actively Recruiting
cutaneous candidiasis
0 Actively Recruiting
Candidiasis, Vulvovaginal
0 Actively Recruiting
Bacterial Vaginosis
6 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1, Phase 1

Extina Reviews: What are patients saying about Extina?

5Patient Review
7/28/2011
Extina for Scaly Oily Skin Problem Primarily On Face and Scalp
This has been an absolute godsend for my seborrheic dermatitis. Within just a few uses, the foam has cleared up my flares. I haven't experienced any real drying or extra flaking, which is great. I'm using it about once every two days, and so far so good. Overall, I absolutely love this medication!
5Patient Review
5/9/2017
Extina for Scaly Oily Skin Problem Primarily On Face and Scalp
After just two days, I noticed drastic differences. This cleared up problem areas without any observed side effects. Even when using it only occasionally for maintenance (not daily), the benefits remain.
4Patient Review
12/16/2008
Extina for Scaly Oily Skin Problem Primarily On Face and Scalp
This effectively removed the flakes on my scalp after just two uses. You have to keep using it to maintain the results, but it's worth it to me.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about extina

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is extina used for?

"This medication is used to treat seborrheic dermatitis. Seborrheic dermatitis is a skin condition caused by a fungus called Malassezia furfur. Symptoms of seborrheic dermatitis include dry, flaky skin (scaling) on the scalp, face, ears, chest, or upper back."

Answered by AI

What is ketoconazole mainly used for?

"Ketoconazole is used to treat infections caused by fungi or yeast. By killing the fungus or yeast, or preventing its growth, the Ketoconazole cream can treat: Athlete's foot (tinea pedis; ringworm of the foot); Feb 1, 2022."

Answered by AI

Is extina a prescription drug?

"Extina is a prescription medicine that can be used to treat the symptoms of various conditions, including Seborrheic Dermatitis, Dandruff (Seborrhea), Tinea Versicolor, Tinea Corporis (Ringworm), Tinea Cruris (Jock Itch), and Tinea Pedis (Athlete's Foot)."

Answered by AI

What is mycelex cream used for?

"This medication is used to treat vaginal yeast infections. Clotrimazole reduces vaginal burning, itching, and discharge that may occur with this condition by stopping the growth of yeast (fungus) that causes the infection."

Answered by AI

Clinical Trials for Extina

Have you considered Extina clinical trials? We made a collection of clinical trials featuring Extina, we think they might fit your search criteria.
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