Ethyol

Advance Directives, prophylaxis of renal toxicity, Xerostomia + 4 more
Treatment
7 FDA approvals
2 Active Studies for Ethyol

What is Ethyol

AmifostineThe Generic name of this drug
Treatment SummaryA phosphorothioate is a drug used to protect against radiation exposure. It works by widening the blood vessels in the spleen and blocking nerve signals to certain parts of the body.
Ethyolis the brand name
Ethyol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ethyol
Amifostine
1995
6

Approved as Treatment by the FDA

Amifostine, also known as Ethyol, is approved by the FDA for 7 uses like prophylaxis of renal toxicity and Advance Directives .
prophylaxis of renal toxicity
Advance Directives
Malignant Neoplasms
Nephrotoxicity
prophylaxis of Xerostomia
Xerostomia
Xerostomia

Effectiveness

How Ethyol Affects PatientsAmifostine is a drug used to protect the kidneys from damage caused by repeated doses of chemotherapy drug cisplatin. It is also used to prevent dry mouth in patients undergoing radiation therapy for head and neck cancer. Amifostine is a prodrug, meaning it is changed in the body into an active form. This active form helps protect healthy cells from the toxic effects of cancer treatments, as it is found in healthy cells in much higher concentrations than in cancer cells.
How Ethyol works in the bodyAmifostine helps protect cells from radiation and other toxins. It does this by binding to and neutralizing any reactive molecules that may be present, as well as scavenging free radicals. It may also help prevent cell death and modify how genes are expressed.

When to interrupt dosage

The quantity of Ethyol is dependent upon the diagnosed affliction, including Nephrotoxicity, Dry Mouth and Proctitis. The amount of dosage is determined by the selected administration method, as illustrated in the below table.
Condition
Dosage
Administration
Advance Directives
50.0 mg/mL, , 500.0 mg
, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous
Malignant Neoplasms
50.0 mg/mL, , 500.0 mg
, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous
Nephrotoxicity
50.0 mg/mL, , 500.0 mg
, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous
Xerostomia
50.0 mg/mL, , 500.0 mg
, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous
prophylaxis of renal toxicity
50.0 mg/mL, , 500.0 mg
, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous
Xerostomia
50.0 mg/mL, , 500.0 mg
, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous
Proctitis
50.0 mg/mL, , 500.0 mg
, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous

Warnings

There are 20 known major drug interactions with Ethyol.
Common Ethyol Drug Interactions
Drug Name
Risk Level
Description
Amyl Nitrite
Minor
The risk or severity of adverse effects can be increased when Amifostine is combined with Amyl Nitrite.
Arotinolol
Minor
The risk or severity of adverse effects can be increased when Amifostine is combined with Arotinolol.
Arsenic trioxide
Minor
The risk or severity of adverse effects can be increased when Amifostine is combined with Arsenic trioxide.
Barnidipine
Minor
The risk or severity of adverse effects can be increased when Amifostine is combined with Barnidipine.
Bromocriptine
Minor
The risk or severity of adverse effects can be increased when Amifostine is combined with Bromocriptine.
Ethyol Toxicity & Overdose RiskThe toxic dose for rats of this drug is 826mg/kg.
image of a doctor in a lab doing drug, clinical research

Ethyol Novel Uses: Which Conditions Have a Clinical Trial Featuring Ethyol?

Two ongoing investigations are exploring the potential of Ethyol to treat Malignant Neoplasms, Dry Mouth and provide prophylaxis against renal toxicity.
Condition
Clinical Trials
Trial Phases
prophylaxis of renal toxicity
0 Actively Recruiting
Advance Directives
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Xerostomia
0 Actively Recruiting
Proctitis
0 Actively Recruiting
Nephrotoxicity
2 Actively Recruiting
Phase 2, Phase 3
Xerostomia
0 Actively Recruiting

Ethyol Reviews: What are patients saying about Ethyol?

1Patient Review
4/2/2010
Ethyol for Prevent Mucous Membrane Inflammation from Chemotherapy
I had a really severe allergic reaction to this medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ethyol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How is amifostine administered?

"Usually, a nurse or doctor starts the infusion and the chemotherapy, radiation therapy, or both are given at the same time.

The text is saying that Amifostine is given intravenously, and that patients should drink plenty of fluids beforehand. It also says that patients usually lie down during the infusion, and that their blood pressure is monitored frequently."

Answered by AI

What is amifostine used for?

"Amifostine is used to protect the kidneys from the harmful effects of the chemotherapy drug cisplatin in patients that receive cisplatin for the treatment of ovarian cancer. Amifostine is also used to decrease dry mouth caused by radiation treatment after surgery for head and neck cancer."

Answered by AI

When do you give amifostine?

"The text is saying that Amifostine is administered intravenously, before radiation or chemotherapy treatments. Patients receiving the infusion will have their blood pressure monitored frequently, and may be instructed to drink more fluids leading up to the treatment."

Answered by AI

What are chemo pills?

"Oral chemotherapy is a cancer-fighting drug that is taken by mouth in pill, capsule, or liquid form. Like chemotherapy given through infusion, it is prescribed by a medical professional and comes with benefits and risks. Today, many cancer patients receive oral chemotherapy treatments."

Answered by AI

Clinical Trials for Ethyol

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