Your session is about to expire
What is Esterified Estrogens
Esterified estrogensThe Generic name of this drug
Treatment SummaryEsterified estrogens are a man-made mix of different estrogen substances used to treat symptoms of menopause, such as hot flashes and vaginal dryness, as well as to prevent and treat osteoporosis. The drug is composed of 75-85% sodium estrone sulfate and 6-15% sodium equilin sulfate, with the total amount never lower than 90%.
Menestis the brand name
Esterified Estrogens Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Menest
Esterified estrogens
1977
8
Approved as Treatment by the FDA
Esterified estrogens, also known as Menest, is approved by the FDA for 9 uses including Advance Directives and Hot flashes .Advance Directives
Hot flashes
Helps manage Menopause
severe menopausal vulvovaginal atrophy
Helps manage severe menopausal vulvovaginal atrophy
moderate Menopausal Vasomotor Symptoms
Helps manage moderate Menopausal Vasomotor Symptoms
Premature Menopause
Helps manage Premature Ovarian Failure (POF)
moderate Vulvovaginal atrophy
Helps manage moderate Vulvovaginal atrophy
Menopause
Helps manage severe Vasomotor Symptoms Associated With Menopause
Low Testosterone
Helps manage Hypogonadism
Metastatic Breast Cancer
Effectiveness
How Esterified Estrogens Affects PatientsEstrogens are hormones that help to create and maintain female reproductive organs and other physical characteristics. Estradiol is the main type of estrogen in the body and is more powerful than estrone and estriol when it interacts with the body's receptors. This hormone is the main type of estrogen produced in women before menopause.
How Esterified Estrogens works in the bodyEstrogens work to balance the hormones that control reproduction in the body. When estrogen levels are high, they send a signal to the pituitary gland to reduce the production of hormones that control reproduction like luteinizing hormone and follicle-stimulating hormone.
When to interrupt dosage
The proposed measure of Esterified Estrogens is contingent upon the diagnosed state, such as moderate Menopausal Vasomotor Symptoms, moderate Vulvovaginal atrophy and Menopause. The dosage fluctuates according to the administration approach highlighted in the table below.Condition
Dosage
Administration
Low Testosterone
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Advance Directives
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
moderate Menopausal Vasomotor Symptoms
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Metastatic Breast Cancer
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Menopause
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
severe menopausal vulvovaginal atrophy
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
moderate Vulvovaginal atrophy
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Premature Menopause
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Hot flashes
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Esterified Estrogens has eight restricted usages, so it should not be administered in the presence of any of the conditions mentioned in the table below.Esterified Estrogens ContraindicationsCondition
Risk Level
Notes
Neoplasms, Hormone-Dependent
Do Not Combine
suspected pregnancy
Do Not Combine
Thromboembolism
Do Not Combine
Breast
Do Not Combine
active thrombophlebitis
Do Not Combine
abnormal genital bleeding
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Breast Cancer
Do Not Combine
Common Esterified Estrogens Drug Interactions
Drug Name
Risk Level
Description
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Esterified estrogens.
Dasabuvir
Major
The risk or severity of liver enzyme elevations can be increased when Esterified estrogens is combined with Dasabuvir.
Exemestane
Major
The therapeutic efficacy of Exemestane can be decreased when used in combination with Esterified estrogens.
Ombitasvir
Major
The risk or severity of liver enzyme elevations can be increased when Esterified estrogens is combined with Ombitasvir.
Ospemifene
Major
The risk or severity of adverse effects can be increased when Esterified estrogens is combined with Ospemifene.
Esterified Estrogens Toxicity & Overdose RiskThe lowest dose of this drug to cause death in a rat when injected into the blood stream is 325mg/kg, and the lowest dose to cause death in a mouse when injected into the blood stream is 1740mg/kg. When given orally, the lowest dose of this drug to cause death in a rat is greater than 5000mg/kg.
Esterified Estrogens Novel Uses: Which Conditions Have a Clinical Trial Featuring Esterified Estrogens?
111 active trials are currently assessing the efficacy of Esterified Estrogens in treating severe menopausal vulvovaginal atrophy, Metastatic Breast Cancer, and Advance Directives.Condition
Clinical Trials
Trial Phases
severe menopausal vulvovaginal atrophy
0 Actively Recruiting
Menopause
0 Actively Recruiting
Metastatic Breast Cancer
95 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 3, Phase 4, Early Phase 1
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Premature Menopause
1 Actively Recruiting
Phase 2
Low Testosterone
15 Actively Recruiting
Phase 1, Phase 4, Phase 2, Not Applicable
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Advance Directives
6 Actively Recruiting
Phase 1, Phase 2, Not Applicable
moderate Vulvovaginal atrophy
0 Actively Recruiting
Esterified Estrogens Reviews: What are patients saying about Esterified Estrogens?
5Patient Review
10/2/20083Patient Review
8/15/2013 I didn't find this treatment very effective. All it did was give me headaches.
1Patient Review
8/15/2011 I've been on zoloft for years now, and it's helped with my moodiness and mental clarity. I still get heavy bleeding and clots every month, but hopefully this new treatment will help alleviate that.
Patient Q&A Section about esterified estrogens
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What drug class is esterified estrogens?
"Estratest is a drug that is used to treat menopausal symptoms such as hot flashes. It can be used alone or with other medications. Estratest is a type of drug that is a combination of estrogen and androgen."
Answered by AI
What is esterified testosterone?
"Covaryx is a medication that's used to treat symptoms of menopause, such as hot flashes and night sweats, when estrogen alone is not enough. It has many serious risks, including blood clots and breast and uterine cancer."
Answered by AI
Are esterified estrogens synthetic?
"Chemistry. EEs contain synthetic, plant-derived estrogens that are manufactured from soybeans and yams."
Answered by AI
What is esterified estrogens methyltestosterone used for?
"The combination of esterified estrogens and methyltestosterone is used to treat the symptoms of menopause in patients who did not get relief from being treated with estrogens alone."
Answered by AI