Esidrix

Nephrotic Syndrome, Ascites, Edema + 23 more
Treatment
30 FDA approvals
20 Active Studies for Esidrix

What is Esidrix

HydrochlorothiazideThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a diuretic medicine that is used to treat swelling and high blood pressure. It is the most commonly prescribed diuretic and is usually combined with other medications, such as angiotensin converting enzyme inhibitors or angiotensin II receptor blockers. Hydrochlorothiazide was approved by the FDA in 1959 and is still used today, although its popularity has decreased in recent years.
Esidrixis the brand name
Esidrix Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esidrix
Hydrochlorothiazide
1959
2181

Approved as Treatment by the FDA

Hydrochlorothiazide, also called Esidrix, is approved by the FDA for 30 uses including Left Ventricular Hypertrophy and Congestive Heart Failure .
Left Ventricular Hypertrophy
Used to treat Left Ventricular Hypertrophy in combination with Losartan
Congestive Heart Failure
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Ascites
Used to treat Ascites in combination with Spironolactone
Hypertensive disease
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
Antepartum magnesium sulfate prophylaxis
Helps manage prophylaxis of preeclampsia
Swollen feet or ankles
Used to treat Edema in combination with Triamterene
Cirrhosis of the Liver
Used to treat Cirrhosis of the Liver in combination with Spironolactone
Hypertension, Essential Hypertension
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
Hypokalemia
Used to treat hypokalemia with solo treatment in combination with Triamterene
Hypertension
Used to treat blood pressure inadequately controlled with monotherapy in combination with Irbesartan
Hypertension
Used to treat inadequate control of blood pressure with monotherapy in combination with Aliskiren
Hypertrophy, Left Ventricular
Used to treat Left Ventricular Hypertrophy in combination with Losartan
prophylaxis of preeclampsia
Helps manage prophylaxis of preeclampsia
Congestive Heart Failure (CHF)
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Hypertension
Used to treat Antihypertensive Treatment in combination with Eprosartan
Nephrotic Syndrome
Used to treat Nephrotic Syndrome in combination with Spironolactone
Edema
Used to treat Edema in combination with Triamterene
Premenstrual tension with edema
Helps manage Premenstrual tension with edema
Therapeutic procedure
Used to treat inadequate response to treatment in combination with Spironolactone
Ascites
Used to treat Ascites in combination with Spironolactone
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Losartan
Stroke
Used to treat Cerebrovascular Accident in combination with Losartan
calcium channel blockers
Used to treat calcium channel blockers in combination with Eprosartan
Sodium retention
Used to treat Sodium retention in combination with Spironolactone
inadequate response to other therapeutic measures
Used to treat inadequate response to other therapeutic measures in combination with Spironolactone
Bedrest
Used to treat Bedrest in combination with Spironolactone
Cirrhosis
Used to treat Cirrhosis of the Liver in combination with Spironolactone
restriction of fluid and sodium
Used to treat restriction of fluid and sodium in combination with Spironolactone
Edema
Helps manage Premenstrual tension with edema
Diuretics
Used to treat Hypokalemia caused by diuretics in combination with Amiloride

Effectiveness

How Esidrix Affects PatientsHydrochlorothiazide helps the body get rid of excess water by blocking the reabsorption of sodium and water from the distal convoluted tubule. The amount of this drug taken each day varies from person to person, but is generally between 25-100mg. Those with reduced kidney or liver function should be careful when taking hydrochlorothiazide.
How Esidrix works in the bodyHydrochlorothiazide works by reducing the amount of salt and water reabsorbed by your kidneys. It is transported from the bloodstream into special cells in your kidneys and then transported to the tubule. Normally, these cells absorb salt and pump it into the area around them, creating an area with a higher salt concentration that draws in water. Hydrochlorothiazide blocks the cells from absorbing salt, weakening the salt gradient and reducing the amount of water reabsorbed.

When to interrupt dosage

The prescribed measure of Esidrix is contingent upon the determined condition, including Antepartum magnesium sulfate prophylaxis, blood pressure inadequately restrained by monotherapy and antihypertensives. The dosage shifts as per the technique of implementation (e.g. Tablet, coated - Oral or Oral) listed in the table underneath.
Condition
Dosage
Administration
Hypertension
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Edema
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diuretics
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypokalemia
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Cirrhosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertension
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
calcium channel blockers
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antepartum magnesium sulfate prophylaxis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Renal tubular acidosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
prophylaxis of calcium nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
inadequate response to other therapeutic measures
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Stroke
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertension
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrotic Syndrome
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Swollen feet or ankles
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Ascites
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diabetes Insipidus
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Congestive Heart Failure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Esidrix has two contraindications and should not be consumed when one is affected by any of the conditions mentioned in the following table.Esidrix Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
There are 20 known major drug interactions with Esidrix.
Common Esidrix Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Fenofibrate
Major
The therapeutic efficacy of Fenofibrate can be decreased when used in combination with Hydrochlorothiazide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Hydroxyzine.
Esidrix Toxicity & Overdose RiskThe lowest toxic dosage of hydrochlorothiazide in mice and rats is greater than 10g/kg. Overdosing on hydrochlorothiazide can lead to low potassium, chloride, and sodium levels in the blood. Treatments for overdose include administering fluids, electrolytes, and vasopressors to treat low blood pressure, and oxygen for breathing difficulty.
image of a doctor in a lab doing drug, clinical research

Esidrix Novel Uses: Which Conditions Have a Clinical Trial Featuring Esidrix?

158 active trials are in progress to investigate the potential of Esidrix in alleviating Cirrhosis, Edema and Congestive Heart Failure.
Condition
Clinical Trials
Trial Phases
Congestive Heart Failure
12 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Sodium retention
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Cirrhosis
56 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Early Phase 1
Diuretics
0 Actively Recruiting
Antepartum magnesium sulfate prophylaxis
18 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 2, Phase 1
Swollen feet or ankles
7 Actively Recruiting
Phase 2, Not Applicable
restriction of fluid and sodium
0 Actively Recruiting
Hypertrophy, Left Ventricular
0 Actively Recruiting
Nephrotic Syndrome
4 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Ascites
3 Actively Recruiting
Not Applicable, Phase 2
prophylaxis of calcium nephrolithiasis
0 Actively Recruiting
calcium channel blockers
0 Actively Recruiting
Hypokalemia
0 Actively Recruiting
Hypertension
0 Actively Recruiting
Hypertension
0 Actively Recruiting
Bedrest
0 Actively Recruiting
Edema
0 Actively Recruiting
Hypertension
294 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1, Phase 4
Diabetes Insipidus
1 Actively Recruiting
Phase 2

Esidrix Reviews: What are patients saying about Esidrix?

4.7Patient Review
12/23/2009
Esidrix for Visible Water Retention
Overall, this medication has been great for managing my blood pressure. But I have noticed some negative side effects like dizziness and stomach pain. If I stop taking the drug, my ankles swell up again.
3.3Patient Review
1/29/2014
Esidrix for High Blood Pressure
My cholesterol levels rose to 240 after taking this medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about esidrix

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the work of Esidrex 25 mg?

"This medication lowers blood pressure, which helps prevent strokes, heart attacks, and kidney problems."

Answered by AI

What does hydrochlorothiazide do for a person?

"Hydrochlorothiazide is a medication that helps the body get rid of excess water by increasing urine production. It may also be used to treat other conditions as prescribed by a doctor. This medicine can only be obtained with a doctor's prescription."

Answered by AI

What is esidrix used for?

"This helps your body get rid of extra salt and water.

This drug is used to lower blood pressure, which in turn reduces the risk of strokes, heart attacks, and kidney problems. Hydrochlorothiazide is a type of drug called a diuretic, which helps get rid of excess salt and water by making you urinate more often."

Answered by AI

What are the most common side effects of hydrochlorothiazide?

"The following are symptoms of low blood pressure: feeling dizzy, having a headache, feeling weak, having trouble getting or keeping an erection, and tingling in your extremities."

Answered by AI

Clinical Trials for Esidrix

Have you considered Esidrix clinical trials? We made a collection of clinical trials featuring Esidrix, we think they might fit your search criteria.
Have you considered Esidrix clinical trials? We made a collection of clinical trials featuring Esidrix, we think they might fit your search criteria.
Have you considered Esidrix clinical trials? We made a collection of clinical trials featuring Esidrix, we think they might fit your search criteria.
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