Ergomar

Vascular Headaches, Postpartum state, Cluster Headache + 2 more
Treatment
4 FDA approvals
20 Active Studies for Ergomar

What is Ergomar

ErgotamineThe Generic name of this drug
Treatment SummaryErgotamine is a drug found in ergot, a fungus that grows on rye grain. It is used to treat migraine headaches by narrowing the blood vessels. Ergotamine is classified as an alpha-1 selective adrenergic agonist and works by stimulating certain receptors in the body.
Cafergotis the brand name
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Ergomar Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cafergot
Ergotamine
1953
15

Approved as Treatment by the FDA

Ergotamine, also known as Cafergot, is approved by the FDA for 4 uses which include Vascular Headaches and Cluster Headache .
Vascular Headaches
Used to treat Vascular Headaches in combination with Caffeine
Cluster Headache
Migraine
Neuralgia

Effectiveness

How Ergomar Affects PatientsErgotamine is a drug that affects multiple systems in the body. It constricts peripheral and cranial blood vessels, influences the activity of tryptaminergic, dopaminergic, and alpha adrenergic receptors, and can stimulate the uterus. It is thought to help with migraine pain by decreasing the pulsations in the cranial arteries and reducing blood flow in the extracranial area. It does not, however, affect cerebral hemispheric blood flow.
How Ergomar works in the bodyErgotamine works to stop migraines by constricting blood vessels in the head and blocking the release of pro-inflammatory chemicals from nerves in the trigeminal system. This is done by stimulating 5-HT1D receptors, which are located on both blood vessels and nerve endings.

When to interrupt dosage

The recommended dose of Ergomar is contingent upon the acknowledged condition, like Postpartum state, Cluster Headache and Uterine Atony. The magnitude of dosage varies as indicated by the mode of delivery noted in the table beneath.
Condition
Dosage
Administration
Migraine
1.0 mg, , 2.0 mg, 0.6 mg, 0.3 mg, 9.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Rectal, Suppository, Suppository - Rectal, Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Tablet - Sublingual, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Aerosol, Aerosol - Oral
Vascular Headaches
1.0 mg, , 2.0 mg, 0.6 mg, 0.3 mg, 9.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Rectal, Suppository, Suppository - Rectal, Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Tablet - Sublingual, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Aerosol, Aerosol - Oral
Cluster Headache
1.0 mg, , 2.0 mg, 0.6 mg, 0.3 mg, 9.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Rectal, Suppository, Suppository - Rectal, Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Tablet - Sublingual, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Aerosol, Aerosol - Oral
Postpartum state
1.0 mg, , 2.0 mg, 0.6 mg, 0.3 mg, 9.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Rectal, Suppository, Suppository - Rectal, Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Tablet - Sublingual, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Aerosol, Aerosol - Oral
Uterine Inertia
1.0 mg, , 2.0 mg, 0.6 mg, 0.3 mg, 9.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Rectal, Suppository, Suppository - Rectal, Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Tablet - Sublingual, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Aerosol, Aerosol - Oral

Warnings

Ergomar Contraindications
Condition
Risk Level
Notes
Liver Diseases
Do Not Combine
Renal Insufficiency
Do Not Combine
Coronary Heart Disease
Do Not Combine
Peripheral Vascular Disease
Do Not Combine
Pulse Frequency
Do Not Combine
Hypertensive disease
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Ergomar.
Common Ergomar Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Ergotamine.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Ergotamine.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Ergotamine.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Ergotamine.
4-Bromo-2,5-dimethoxyphenethylamine
Major
Ergotamine may increase the hypertensive and vasoconstricting activities of 4-Bromo-2,5-dimethoxyphenethylamine.
Ergomar Toxicity & Overdose RiskSigns of an overdose on a drug may include irritation, nausea, vomiting, headache, diarrhea, increased thirst, cold skin, itching, weak heartbeat, numbness and tingling in the limbs, and confusion.
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Ergomar Novel Uses: Which Conditions Have a Clinical Trial Featuring Ergomar?

69 active clinical trials are currently being conducted to assess the potential of Ergomar to alleviate Migraine, Uterine Atony and Postpartum state disorders.
Condition
Clinical Trials
Trial Phases
Migraine
53 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1
Vascular Headaches
0 Actively Recruiting
Postpartum state
9 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Phase 2
Uterine Inertia
0 Actively Recruiting
Cluster Headache
3 Actively Recruiting
Phase 1, Phase 2

Ergomar Reviews: What are patients saying about Ergomar?

5Patient Review
4/3/2012
Ergomar for Migraine Headache
This medication always abort my migraines, and I'm so thankful for that!
5Patient Review
2/1/2008
Ergomar for Migraine Headache
4.7Patient Review
2/6/2008
Ergomar for Migraine Headache
I'm using this medication for the first time tonight in hopes that it will help to reduce my migraines and vomiting. So far, I don't have much to go off of.
4.3Patient Review
6/12/2011
Ergomar for Migraine Headache
This medication quickly and effectively relieved my migraine pain.
3.7Patient Review
1/6/2008
Ergomar for Migraine Headache
View All Reviews
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Patient Q&A Section about ergomar

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What ergotamine is used for?

"Dihydroergotamine and ergotamine areReduce the size of blood vessels and relieve the pain of throbbing headaches, such as migraine and cluster headaches. Dihydroergotamine and ergotamine are not painkillers that will relieve any other type of pain."

Answered by AI

What is Ergomar used for?

"Ergomar is an ergot alkaloid used to treat a migraine type headache that has already begun, but will not prevent migraine headaches or reduce the number of attacks."

Answered by AI

What is the drug Cafergot used for?

"This drug is a combination of two medications, ergotamine and caffeine, which are used to relieve pain from migraines and cluster headaches. The ergotamine works by constricting the blood vessels in the head, which alleviates the pain."

Answered by AI

Is Ergomar a triptan?

"Ergomar and triptan medications like Imitrex and Maxalt have similar mechanism of action and side effects. Simultaneous use of these medications can lead to increased blood pressure and other serious side effects."

Answered by AI

Clinical Trials for Ergomar

Have you considered Ergomar clinical trials? We made a collection of clinical trials featuring Ergomar, we think they might fit your search criteria.
Have you considered Ergomar clinical trials? We made a collection of clinical trials featuring Ergomar, we think they might fit your search criteria.
Have you considered Ergomar clinical trials? We made a collection of clinical trials featuring Ergomar, we think they might fit your search criteria.
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