Entereg
Colonic anastomosis, Operative Surgical Procedures, Gastrointestinal Recovery
Treatment
0 Active Studies for Entereg
Treatment for
Colonic anastomosis
What is Entereg
Alvimopan
The Generic name of this drug
Treatment Summary
Alvimopan is a medication used to reduce the intestinal paralysis (postoperative ileus) that can occur after abdominal surgery. It helps speed up the recovery period following small or large bowel resection.
Entereg
is the brand name
Entereg Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Entereg
Alvimopan
2008
3
Effectiveness
How Entereg works in the body
Alvimopan connects to mu-opioid receptors in the digestive system. This connection is different from other drugs because it is based on its chemical makeup, not its electrical charge. Alvimopan binds to these receptors very strongly, with a Ki of 0.2 ng/mL.
When to interrupt dosage
The dosage of Entereg is contingent upon the diagnosed condition, including Colonic anastomosis, Operative Surgical Procedures and Gastrointestinal Recovery. The amount of dosage hinges upon the mode of administration specified in the table below.
Condition
Dosage
Administration
Colonic anastomosis
12.0 mg,
, Oral, Capsule, Capsule - Oral
Operative Surgical Procedures
12.0 mg,
, Oral, Capsule, Capsule - Oral
Gastrointestinal Recovery
12.0 mg,
, Oral, Capsule, Capsule - Oral
Warnings
Entereg has two contraindications and should be avoided in the event of any of the conditions in the following table.
Entereg Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 2 known major drug interactions with Entereg.
Common Entereg Drug Interactions
Drug Name
Risk Level
Description
Methylnaltrexone
Major
Alvimopan may increase the opioid antagonism activities of Methylnaltrexone.
Naloxegol
Major
Alvimopan may increase the opioid antagonism activities of Naloxegol.
Entereg Novel Uses: Which Conditions Have a Clinical Trial Featuring Entereg?
No active studies are presently assessing the capability of Entereg to expedite Gastrointestinal Recovery, and optimize Operative Surgical Procedures and Colonic Anastomosis.
Condition
Clinical Trials
Trial Phases
Operative Surgical Procedures
0 Actively Recruiting
Gastrointestinal Recovery
0 Actively Recruiting
Colonic anastomosis
0 Actively Recruiting
Patient Q&A Section about entereg
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is entereg FDA approved?
"This document was approved on 05/20/2008."
Answered by AI
Does entereg cause diarrhea?
"If you have recently been exposed to opioids, you may be more sensitive to the effects of alvimopan. This could include abdominal pain, nausea and vomiting, and diarrhea. Taking benzhydrocodone/acetaminophen at the same time as alvimopan can increase the effects of alvimopan by competing for receptor binding. Therefore, it is contraindicated."
Answered by AI
When do you hold entereg?
"The recommended adult dosage of ENTEREG is 12 mg administered 30 minutes to 5 hours prior to surgery. After surgery, the dosage is 12 mg twice daily for a maximum of 7 days."
Answered by AI
What is entereg used for?
"Alvimopan is a drug that helps the intestines recover after surgery. It is taken by mouth and works by blocking the effects of opioids. This prevents or reduces postoperative ileus, which is when the intestines do not work properly after surgery."
Answered by AI