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What is Dutoprol
HydrochlorothiazideThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a medication used to reduce swelling and high blood pressure. It is the most commonly prescribed drug in its class. However, it is being used less in favor of angiotensin converting enzyme inhibitors. Many combination products are available combining hydrochlorothiazide with ACE inhibitors or angiotensin II receptor blockers. The drug was approved by the FDA in 1959.
Esidrixis the brand name
Dutoprol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esidrix
Hydrochlorothiazide
1959
2181
Approved as Treatment by the FDA
Hydrochlorothiazide, also called Esidrix, is approved by the FDA for 22 uses including Stroke and Left Ventricular Hypertrophy .Stroke
Used to treat Cerebrovascular Accident in combination with Losartan
Left Ventricular Hypertrophy
Used to treat Left Ventricular Hypertrophy in combination with Losartan
Antepartum magnesium sulfate prophylaxis
Helps manage prophylaxis of preeclampsia
Edema
Helps manage Premenstrual tension with edema
Sodium retention
Used to treat Sodium retention in combination with Spironolactone
calcium channel blockers
Used to treat calcium channel blockers in combination with Eprosartan
Congestive Heart Failure
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
inadequate response to other therapeutic measures
Used to treat inadequate response to other therapeutic measures in combination with Spironolactone
Diuretics
Used to treat Hypokalemia caused by diuretics in combination with Amiloride
Hypertensive disease
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
Antihypertensive Treatment
Used to treat Antihypertensive Treatment in combination with Eprosartan
hypokalemia with solo treatment
Used to treat hypokalemia with solo treatment in combination with Triamterene
Ascites
Used to treat Ascites in combination with Spironolactone
Cirrhosis
Used to treat Cirrhosis of the Liver in combination with Spironolactone
inadequate control of blood pressure with monotherapy
Used to treat inadequate control of blood pressure with monotherapy in combination with Aliskiren
Therapeutic procedure
Used to treat inadequate response to treatment in combination with Spironolactone
blood pressure inadequately controlled with monotherapy
Used to treat blood pressure inadequately controlled with monotherapy in combination with Irbesartan
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Losartan
Swollen feet or ankles
Used to treat Edema in combination with Triamterene
Bedrest
Used to treat Bedrest in combination with Spironolactone
restriction of fluid and sodium
Used to treat restriction of fluid and sodium in combination with Spironolactone
Nephrotic Syndrome
Used to treat Nephrotic Syndrome in combination with Spironolactone
Effectiveness
How Dutoprol Affects PatientsHydrochlorothiazide helps the body get rid of extra water by preventing it from being reabsorbed in the kidneys. The amount of hydrochlorothiazide taken each day is customized, and typically ranges from 25-100mg. Those with reduced kidney or liver function should be careful when taking this drug.
How Dutoprol works in the bodyHydrochlorothiazide is taken into cells in the distal convoluted tubule of the kidney. From these cells, it is transported to the lumen of the tubule. Normally, sodium is reabsorbed into the cells and then pumped into the surrounding tissue. Hydrochlorothiazide prevents this from happening, reducing the amount of water reabsorbed by the cells and thus decreasing sodium levels in the body.
When to interrupt dosage
The amount of Dutoprol is contingent upon the diagnosed condition, including Antepartum magnesium sulfate prophylaxis, inadequately controlled blood pressure with monotherapy and antihypertensives. The dosage fluctuates as per the procedure of dispensation (e.g. Tablet, coated - Oral or Oral) presented in the table underneath.Condition
Dosage
Administration
Congestive Heart Failure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Ascites
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrotic Syndrome
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Left Ventricular Hypertrophy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
prophylaxis of calcium nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Renal tubular acidosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
inadequate control of blood pressure with monotherapy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
restriction of fluid and sodium
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antihypertensive Treatment
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Edema
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diuretics
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antepartum magnesium sulfate prophylaxis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Sodium retention
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Stroke
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diabetes Insipidus
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Bedrest
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Cirrhosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
calcium channel blockers
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Dutoprol has two contraindications, so it should not be employed when affected by any of the conditions described in the following table.Dutoprol ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
Common Dutoprol Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Fenofibrate
Major
The therapeutic efficacy of Fenofibrate can be decreased when used in combination with Hydrochlorothiazide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Hydroxyzine.
Dutoprol Toxicity & Overdose RiskThe lowest toxic dose of hydrochlorothiazide in mice and rats is over 10g/kg. Symptoms of overdose can include low levels of potassium, chlorine, and sodium in the blood. Treatment involves providing fluids and electrolytes to the patient, as well as administering vasopressors to treat low blood pressure and oxygen if there is difficulty breathing.
Dutoprol Novel Uses: Which Conditions Have a Clinical Trial Featuring Dutoprol?
158 active studies are assessing the potential of Dutoprol in treating Cirrhosis, Edema and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Antihypertensive Treatment
0 Actively Recruiting
Antepartum magnesium sulfate prophylaxis
18 Actively Recruiting
Phase 1, Not Applicable, Phase 3, Early Phase 1, Phase 2, Phase 4
inadequate control of blood pressure with monotherapy
0 Actively Recruiting
Stroke
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Congestive Heart Failure
24 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Cirrhosis
50 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Renal tubular acidosis
0 Actively Recruiting
Diabetes Insipidus
2 Actively Recruiting
Phase 1, Phase 2
Nephrolithiasis
0 Actively Recruiting
Ascites
10 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2
hypokalemia with solo treatment
0 Actively Recruiting
calcium channel blockers
0 Actively Recruiting
blood pressure inadequately controlled with monotherapy
0 Actively Recruiting
inadequate response to other therapeutic measures
0 Actively Recruiting
Diuretics
0 Actively Recruiting
Bedrest
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Sodium retention
0 Actively Recruiting
Dutoprol Reviews: What are patients saying about Dutoprol?
3.3Patient Review
12/27/2012 I felt good after taking this medication.
2.3Patient Review
4/28/2016 Dutoprol is a huge ripoff. It's nothing more than metoprolol ER and HCTZ, which are both available as generic drugs for around $10 each. This combination costs almost $200! Make sure to ask your doctor before taking this medicine.
1Patient Review
2/14/2013 I'm extremely angry that this drug is still on the market. It's doing terrible things to my mother and the list of side effects is atrocious. If her doctor had any consideration for her quality of life, he would have never prescribed this in the first place.
Patient Q&A Section about dutoprol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Dutoprol used for?
"It works by blocking the hormone epinephrine (adrenaline). This reduces heart rate, blood pressure, and strain on the heart. Hydrochlorothiazide belongs to a class of drugs known as diuretics ('water pills'). It works by causing you to make more urine, which helps to remove excess fluid from the body.
This medication is used to treat hypertension, which is high blood pressure. By lowering high blood pressure, this medication helps to prevent strokes, heart attacks, and kidney problems. This product contains two medications: metoprolol and hydrochlorothiazide. Metoprolol is a drug that belongs to a class of drugs known as beta blockers. This medication works by blocking the hormone epinephrine (adrenaline). When epinephrine is blocked, this reduces heart rate, blood pressure, and strain on the heart. Hydrochlorothiazide is a drug that belongs to a class of drugs known as diuretics ('water pills'). This medication works by causing the patient to make more urine. When there is more urine, this helps to remove excess fluid from the body."
Answered by AI
Is Dutoprol discontinued?
"All of the formulations mentioned above have been discontinued. Note: Illegal online pharmacies may try to sell a generic version of Dutoprol that is not authorized."
Answered by AI
Is Dutoprol same as metoprolol?
"DUTOPROL combines two drugs, metoprolol succinate (a beta blocker) and hydrochlorothiazide (a diuretic). It is indicated for the treatment of hypertension (high blood pressure)."
Answered by AI
What is the generic name for Dutoprol?
"Dutoprol is a combination medication that lowering blood pressure effectively. It is often used when other blood pressure medications have failed to produce desired results."
Answered by AI