Duobrii

Acne Vulgaris, Hypopigmentation, Lentigo + 4 more

Treatment

9 FDA approvals

20 Active Studies for Duobrii

What is Duobrii

Tazarotene

The Generic name of this drug

Treatment Summary

Ulobetasol is a powerful steroid used to treat severe plaque psoriasis and other skin conditions. It is closely related to clobetasol and was approved by the FDA in 1990.

Tazorac

is the brand name

image of different drug pills on a surface

Duobrii Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Tazorac

Tazarotene

1997

29

Approved as Treatment by the FDA

Tazarotene, also known as Tazorac, is approved by the FDA for 9 uses including Lentigo and Acne Vulgaris .

Lentigo

Acne Vulgaris

Hypopigmentation

Psoriasis Vulgaris

Helps manage Psoriasis Vulgaris (Plaque Psoriasis)

mild Acne vulgaris

benign facial lentigines

Acne Vulgaris

facial fine wrinkling

facial hyperpigmentation

Effectiveness

How Duobrii Affects Patients

Corticosteroids, like Ulobetasol, work by blocking inflammation-causing signals and promoting anti-inflammatory signals. Ulobetasol needs to be applied once or twice each day, and the dose might be higher than the amount of corticosteroid hormones naturally produced by the body. It is important to remember that taking corticosteroids can lead to HPA axis suppression, which weakens the immune system, and increases the risk of infections.

How Duobrii works in the body

Corticosteroids help reduce inflammation and swelling in the body. They do this by blocking certain molecules and proteins that help cause inflammation. They also reduce the number of white blood cells that rush to sites of inflammation. Low doses of corticosteroids reduce inflammation, while higher doses weaken your immune system. High doses of corticosteroids also increase your sodium levels and decrease your potassium levels.

When to interrupt dosage

The measure of Duobrii hinges upon the verified affliction, including Pruritus, corticosteroid responsive, Inflammatory Dermatosis and Plaque Psoriasis. The amount also varies based on the method of administration (e.g. Lotion - Topical or Cream) tabulated in the table below.

Condition

Dosage

Administration

Acne Vulgaris

, 0.001 mg/mg, 0.0005 mg/mg, 0.1 %, 0.05 %, 0.00045 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.045 %

, Gel - Cutaneous, Cutaneous, Gel, Cream, Cream - Cutaneous, Oral, Gel - Oral, Topical, Gel - Topical, Cream - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical

Hypopigmentation

, 0.001 mg/mg, 0.0005 mg/mg, 0.1 %, 0.05 %, 0.00045 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.045 %

, Gel - Cutaneous, Cutaneous, Gel, Cream, Cream - Cutaneous, Oral, Gel - Oral, Topical, Gel - Topical, Cream - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical

Lentigo

, 0.001 mg/mg, 0.0005 mg/mg, 0.1 %, 0.05 %, 0.00045 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.045 %

, Gel - Cutaneous, Cutaneous, Gel, Cream, Cream - Cutaneous, Oral, Gel - Oral, Topical, Gel - Topical, Cream - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical

facial hyperpigmentation

, 0.001 mg/mg, 0.0005 mg/mg, 0.1 %, 0.05 %, 0.00045 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.045 %

, Gel - Cutaneous, Cutaneous, Gel, Cream, Cream - Cutaneous, Oral, Gel - Oral, Topical, Gel - Topical, Cream - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical

facial fine wrinkling

, 0.001 mg/mg, 0.0005 mg/mg, 0.1 %, 0.05 %, 0.00045 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.045 %

, Gel - Cutaneous, Cutaneous, Gel, Cream, Cream - Cutaneous, Oral, Gel - Oral, Topical, Gel - Topical, Cream - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical

Acne Vulgaris

, 0.001 mg/mg, 0.0005 mg/mg, 0.1 %, 0.05 %, 0.00045 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.045 %

, Gel - Cutaneous, Cutaneous, Gel, Cream, Cream - Cutaneous, Oral, Gel - Oral, Topical, Gel - Topical, Cream - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical

Psoriasis Vulgaris

, 0.001 mg/mg, 0.0005 mg/mg, 0.1 %, 0.05 %, 0.00045 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.045 %

, Gel - Cutaneous, Cutaneous, Gel, Cream, Cream - Cutaneous, Oral, Gel - Oral, Topical, Gel - Topical, Cream - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical

Warnings

Duobrii has one contraindication and should not be employed when dealing with the conditions enumerated in the table below.

There are 20 known major drug interactions with Duobrii.

Common Duobrii Drug Interactions

Drug Name

Risk Level

Description

Amiodarone

Major

The metabolism of Amiodarone can be decreased when combined with Tazarotene.

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Tazarotene.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Tazarotene.

Clomocycline

Major

The risk or severity of pseudotumor cerebri can be increased when Tazarotene is combined with Clomocycline.

Demeclocycline

Major

The risk or severity of pseudotumor cerebri can be increased when Tazarotene is combined with Demeclocycline.

Duobrii Toxicity & Overdose Risk

Taking too much of a glucocorticoid over a long period of time can lead to a number of health conditions, such as cataracts, glaucoma, high blood pressure, water retention, high cholesterol, ulcers, and even mental health issues like mood changes and psychosis. An overdose can be treated by reducing the dose or stopping the medication, as well as providing supportive care.

image of a doctor in a lab doing drug, clinical research

Duobrii Novel Uses: Which Conditions Have a Clinical Trial Featuring Duobrii?

18 active studies are currently examining the potential of Duobrii in alleviating Pruritus, Plaque Psoriasis and corticosteroid responsive Inflammatory Dermatoses.

Condition

Clinical Trials

Trial Phases

Lentigo

0 Actively Recruiting

Psoriasis Vulgaris

23 Actively Recruiting

Early Phase 1, Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1

Acne Vulgaris

0 Actively Recruiting

Hypopigmentation

0 Actively Recruiting

facial hyperpigmentation

0 Actively Recruiting

facial fine wrinkling

0 Actively Recruiting

Acne Vulgaris

0 Actively Recruiting

Duobrii Reviews: What are patients saying about Duobrii?

5

Patient Review

12/2/2019

Duobrii for Plaque Psoriasis

I've been using this cream for a few weeks now and the results have been amazing. My biopsy site is the only thing that hasn't cleared up yet, but I'm hopeful that a few more weeks will do the trick.

5

Patient Review

9/29/2019

Duobrii for Plaque Psoriasis

I've been using this cream for plaque psoriasis on my arms and legs, and it's working great! In just five days, I've seen a huge difference in the thickness of my psoriasis spots. They're redder now, but that's to be expected with any kind of treatment like this. My skin is peeling around the areas where I put the meds, but some lotion takes care of that.

5

Patient Review

10/10/2019

Duobrii for Plaque Psoriasis

After using this for less than a week, the thick bumps on my skin were gone. I experienced some peeling and redness, but no pain, and my skin felt much smoother. So far, so good!

3

Patient Review

10/2/2019

Duobrii for Plaque Psoriasis

I've only been using this product for a short while, so it's hard to tell if it's truly effective yet. So far, the results have been promising but I'm going to continue use and see how things go. The application process is straightforward which is great. My dermatologist didn't seem too familiar with the product, so that was a little frustrating; however, I reached out to the company directly and they were able to offer more guidance and support.

2.3

Patient Review

5/1/2020

Duobrii for Plaque Psoriasis

This treatment worked great at first, but after a couple of weeks my skin became red and began to burn and itch. It's almost worse than the psoriasis itself. I have stopped using this cream. I can't say I wouldn't recommend it because it does work, but it really depends on how your body reacts to it.

2.3

Patient Review

4/14/2020

Duobrii for Plaque Psoriasis

I was disappointed with this treatment. While it did help clear up a few spots, there were still several patches of skin that it did nothing for.

1.7

Patient Review

12/20/2019

Duobrii for Plaque Psoriasis

While this drug did help with my plaque psoriasis at first, the skin irritation it caused was much worse than the psoriasis. Early on, I saw good results: clearer, smoother skin with only a little irritation that seemed to go away. But then, about three weeks in, the reaction got much worse. My skin became very red in more than half of the treatment area; itchy, irritated, and painful to touch in some areas. Consequently, I cannot recommend this experience or this drug.

1

Patient Review

9/23/2019

Duobrii for Plaque Psoriasis

Though this cream helped to remove the scales of my psoriasis, it was very difficult to apply through my hair. After a few days of use, I developed an intense burning and itching sensation that forced me to discontinue use.

1

Patient Review

8/30/2019

Duobrii for Plaque Psoriasis

I did not have a positive experience with this medication. My plaque psoriasis actually got worse, and I developed painful sunburn-like symptoms on the treated area. I also now have an infection. Overall, I would not recommend this treatment to others.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about duobrii

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long can you use Duobrii for?

"Subjects applying DUOBRII Lotion or the placebo lotion to all affected areas once daily for up to 8 weeks."

Answered by AI

What is Duobrii cream used for?

"DUOBRII is a prescription lotion that contains halobetasol propionate and tazarotene. It is used to treat adults with plaque psoriasis."

Answered by AI

Is Duobrii a steroid?

"Duobrii Lotion is a combination of halobetasol and tazarotene. Halobetasol is a highly potent steroid. Tazarotene is a retinoid."

Answered by AI

How long does Duobrii take to work?

"In just 8 weeks, you can see dramatic results that last for 12 weeks. Your skin will be almost clear, with only a few small patches of scales or redness remaining. The bumps and lumps caused by psoriasis will be barely noticeable."

Answered by AI

Clinical Trials for Duobrii

Image of Department of Dermatology, SUNY Downstate Health Sciences University in New York, United States.

Total Coumarin Cream for Psoriasis

18 - 70
All Sexes
New York, NY

The goal of this clinical trial is to learn if a botanical Total Coumarin topical cream (TC Cream) works to treat psoriasis in adults. It will also learn about the safety of the topical TC Cream. The main questions it aims to answer are: * Does TC Cream improve the psoriasis disease symptoms? * What medical problems do participants have when applying TC Cream? * Does TC Cream improve the quality of life of psoriasis patients? Researchers will compare TC Cream to a placebo cream (a look-alike cream that contains no active drug) to see if TC Cream works to treat psoriasis. Participants will: * Topically apply the TC Cream or a placebo cream twice daily every day to affected skin for 8 weeks * Visit the clinic once every 2 weeks for checkups and tests * Keep a diary of their symptoms and their diseased skin conditions during the application of the topical cream

Phase 3
Recruiting

Department of Dermatology, SUNY Downstate Health Sciences University

Sharon A Glick, MD

Psoriasis Research Institute of Guangzhou

Have you considered Duobrii clinical trials?

We made a collection of clinical trials featuring Duobrii, we think they might fit your search criteria.
Go to Trials

Have you considered Duobrii clinical trials?

We made a collection of clinical trials featuring Duobrii, we think they might fit your search criteria.
Go to Trials

Have you considered Duobrii clinical trials?

We made a collection of clinical trials featuring Duobrii, we think they might fit your search criteria.
Go to Trials