Dimethyl Sulfoxide

extravasation of chemotherapy drugs, Cystitis, Interstitial
Treatment
0 Active Studies for Dimethyl Sulfoxide

What is Dimethyl Sulfoxide

Dimethyl sulfoxideThe Generic name of this drug
Treatment SummaryDimethyl sulfoxide is a clear, highly polar liquid that is used as a chemical solvent. It can easily pass through biological membranes and also act as a protective agent during cryopreservation. Dimethyl sulfoxide has been used to apply topical medications and also has pain-relieving and anti-inflammatory effects.
Rimso-50is the brand name
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Dimethyl Sulfoxide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Rimso-50
Dimethyl sulfoxide
1978
1

Effectiveness

How Dimethyl Sulfoxide Affects PatientsDimethyl Sulfoxide has been used to reduce inflammation, prevent damage from oxidation, and treat pain. It can penetrate through cell membranes, which makes it useful for helping other substances to be absorbed through the skin. In some places, mixtures of dimethyl sulfoxide and idoxuridine have been used to treat herpes zoster when applied to the skin.
How Dimethyl Sulfoxide works in the bodyThe exact way that dimethyl sulfoxide works is not known. It has been shown to act as an antioxidant in some cases, which could explain its possible anti-inflammatory effects. It is also believed to help protect the heart in copper-deficient rats by acting as an antioxidant.

When to interrupt dosage

The prescribed measure of Dimethyl Sulfoxide is contingent upon the diagnosed circumstance. The quantity of dosage differs, based on the method of delivery as detailed in the table below.
Condition
Dosage
Administration
extravasation of chemotherapy drugs
, 540.0 mg/mL, 70.0 %, 0.5 mg/mg
, Intravesical, Irrigant, Irrigant - Intravesical, Solution, Solution - Intravesical, Topical, Solution - Topical
Cystitis, Interstitial
, 540.0 mg/mL, 70.0 %, 0.5 mg/mg
, Intravesical, Irrigant, Irrigant - Intravesical, Solution, Solution - Intravesical, Topical, Solution - Topical

Warnings

Dimethyl Sulfoxide Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Dimethyl Sulfoxide.
Common Dimethyl Sulfoxide Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Dimethyl sulfoxide.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Dimethyl sulfoxide.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Dimethyl sulfoxide.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Dimethyl sulfoxide.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Dimethyl sulfoxide.
Dimethyl Sulfoxide Toxicity & Overdose RiskIt would be very difficult for a person to overdose on dimethyl sulfoxide orally, as the toxic dosage level in dogs is greater than 10 g/kg.
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Dimethyl Sulfoxide Novel Uses: Which Conditions Have a Clinical Trial Featuring Dimethyl Sulfoxide?

16 active trials are assessing the potential of Dimethyl Sulfoxide to mitigate the effects of chemotherapy drug extravasation.
Condition
Clinical Trials
Trial Phases
extravasation of chemotherapy drugs
0 Actively Recruiting
Cystitis, Interstitial
0 Actively Recruiting

Patient Q&A Section about dimethyl sulfoxide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is dimethyl sulfoxide toxic?

"DMSO is less toxic than ethanol, with a median lethal dose of 14,500 mg/kg for rats."

Answered by AI

Is DMSO harmful to humans?

"DMSO is rapidly absorbed into the body through the skin, causing a number of side effects such as skin reactions, dry skin, headache, dizziness, drowsiness, nausea, vomiting, diarrhea, constipation, breathing problems, and allergic reactions."

Answered by AI

How does DMSO relieve pain?

"A recent trial that neither the patients nor the researchers knew which patients were receiving the real treatment or the placebo found that DMSO relieved pain significantly better than the placebo. DMSO seems to work by reducing the amount of pain signals that are sent by the nerves rather than by actually healing the damage to the joints."

Answered by AI

What is a dimethyl sulfoxide used for?

"Since the 1960s, DMSO has been used for medical treatment and as a pharmacological agent in humans. Today, DMSO is used mostly for cryopreservation of stem cells, treatment of interstitial cystitis, and as a penetrating vehicle for various drugs."

Answered by AI
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