Desloratadine

Catarrh, Asthma, nasal symptoms + 6 more
Treatment
6 FDA approvals
20 Active Studies for Desloratadine

What is Desloratadine

DesloratadineThe Generic name of this drug
Treatment SummaryDesloratadine is a medication used to treat allergy symptoms such as sneezing, runny nose, and itchy eyes. It is a second-generation antihistamine that works by blocking the action of histamine, a chemical released by the body that can cause allergic reactions. Desloratadine is an active metabolite of loratidine and works in the periphery of the body, so it does not cause drowsiness.
Clarinexis the brand name
image of different drug pills on a surface
Desloratadine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Clarinex
Desloratadine
2001
35

Approved as Treatment by the FDA

Desloratadine, also known as Clarinex, is approved by the FDA for 6 uses like Nasal Congestion and non-nasal symptoms .
Nasal Congestion
Used to treat Nasal Congestion in combination with Pseudoephedrine
non-nasal symptoms
Used to treat non-nasal symptoms in combination with Pseudoephedrine
Perennial Allergic Rhinitis (PAR)
Hay Fever
Chronic Urticaria
nasal symptoms
Used to treat nasal symptoms in combination with Pseudoephedrine

Effectiveness

How Desloratadine Affects PatientsDesloratadine is an antihistamine that helps treat the symptoms of allergies. Histamine, a chemical released during an allergic reaction, binds to receptors on cells and triggers other chemicals to cause the common signs of allergies. Desloratadine blocks histamine from attaching to these cells, preventing the allergic reaction. Unlike other antihistamines, Desloratadine does not cross into the brain, so it does not cause drowsiness.
How Desloratadine works in the bodyDesloratadine stops histamine from binding to receptors in the stomach, uterus, blood vessels, and lungs. By blocking histamine's action, it helps to reduce negative symptoms like nasal congestion and watery eyes.

When to interrupt dosage

The amount of Desloratadine is contingent upon the established illness, such as Hay Fever, Nasal Congestion and non-nasal indications. The quantity of dosage varies, according to the method of delivery (e.g. Oral or Tablet, orally disintegrating - Oral) featured in the table beneath.
Condition
Dosage
Administration
nasal symptoms
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
Chronic Urticaria
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
antihistamine
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
Hay Fever
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
Nasal Congestion
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
Asthma
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
Perennial Allergic Rhinitis (PAR)
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
non-nasal symptoms
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
Catarrh
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical

Warnings

Desloratadine Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Desloratadine.
Common Desloratadine Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Amiodarone.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Asenapine.
Desloratadine Toxicity & Overdose RiskThere is limited information about what happens when someone takes too much desloratadine. Somnolence, or extreme drowsiness, has been reported. To treat an overdose, doctors may try to remove any unabsorbed drug and provide supportive care. Desloratadine and its active metabolite 3-hydroxydesloratadine cannot be removed from the body through dialysis. In animal studies, doses of 250 mg/kg in rats and 353 mg/kg in mice have been found to be fatal, which is much higher than the recommended human dose. Monkeys did not experience any deaths at doses
image of a doctor in a lab doing drug, clinical research

Desloratadine Novel Uses: Which Conditions Have a Clinical Trial Featuring Desloratadine?

153 active trials are being conducted to assess the potential of Desloratadine to alleviate Asthma, Catarrh and Hay Fever.
Condition
Clinical Trials
Trial Phases
Asthma
160 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1, Phase 3
Perennial Allergic Rhinitis (PAR)
1 Actively Recruiting
Phase 3
Hay Fever
1 Actively Recruiting
Phase 3
nasal symptoms
0 Actively Recruiting
Catarrh
2 Actively Recruiting
Phase 2, Not Applicable
antihistamine
0 Actively Recruiting
Chronic Urticaria
1 Actively Recruiting
Phase 4
non-nasal symptoms
0 Actively Recruiting
Nasal Congestion
1 Actively Recruiting
Not Applicable

Desloratadine Reviews: What are patients saying about Desloratadine?

5Patient Review
1/16/2014
Desloratadine for Inflammation of the Nose due to an Allergy
I took Desloratadine for a week to treat my cough at the beginning of winter, and it worked great! I was cured and didn't have any problems for the next three years. The only side effects I experienced were fatigue, headaches (with warm ears), and a little bit of dry mouth.
5Patient Review
11/11/2014
Desloratadine for Allergic Conjunctivitis
I'm so glad I found this pill! My allergies have been getting worse every year, and it's a huge relief to find a medication that is affordable and covered by my insurance. This pill has made a big difference for me.
5Patient Review
11/30/2019
Desloratadine for Inflammation of the Nose due to an Allergy
I had nasal polyps and sinusitis, but this medication cleared it all up for me. I sometimes feel sleepy and have shortness of breath, but those are minor complaints in the face of how well this has worked for me.
5Patient Review
4/8/2008
Desloratadine for Seasonal Runny Nose
5Patient Review
2/9/2021
Desloratadine for Inflammation of the Nose due to an Allergy
I had a great night's sleep after taking this medication, and I woke up feeling well-rested and without any of the nose problems that had been keeping me awake.
5Patient Review
4/21/2014
Desloratadine for Non-Seasonal Allergic Runny Nose
Claritin didn't do much for me, but Clarinex really helped with my Phoenix allergies.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about desloratadine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is desloratadine a strong antihistamine?

"Both Desloratadine and Loratadine are effective, fast-acting, non-drowsy medication for treating hay fever and allergies with few side effects. In the event that side effects are experienced, they are usually mild and nothing to worry about."

Answered by AI

Is desloratadine the same as Claritin?

"Desloratadine, which is a metabolite of loratadine, is the newest medication that is indicated for the treatment of allergic rhinitis. A lot of people think that new drugs are always better than older drugs, but that is not necessarily the case."

Answered by AI

What desloratadine is used for?

"Desloratadine is an antihistamine that is used to relieve the symptoms of hay fever and hives of the skin. Antihistamines work by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose and watery eyes."

Answered by AI

Clinical Trials for Desloratadine

Have you considered Desloratadine clinical trials? We made a collection of clinical trials featuring Desloratadine, we think they might fit your search criteria.
Have you considered Desloratadine clinical trials? We made a collection of clinical trials featuring Desloratadine, we think they might fit your search criteria.
Have you considered Desloratadine clinical trials? We made a collection of clinical trials featuring Desloratadine, we think they might fit your search criteria.
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