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What is Darunavir
DarunavirThe Generic name of this drug
Treatment SummaryDarunavir is a drug used to treat HIV-1 infection. It is taken with other HIV protease inhibitor medications and ritonavir. Darunavir is a second-generation protease inhibitor that is designed to combat resistance to standard HIV therapy. It was approved by the FDA in 2006. Currently, it is being studied as a possible treatment for COVID-19 and the results of clinical trials are expected in August 2020.
Prezistais the brand name
Darunavir Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prezista
Darunavir
2006
25
Approved as Treatment by the FDA
Darunavir, otherwise known as Prezista, is approved by the FDA for 1 uses which include HIV .HIV
Used to treat Human Immunodeficiency Virus Type 1 (HIV-1) Infection in combination with Ritonavir
Effectiveness
How Darunavir Affects PatientsDarunavir is a drug used to treat HIV infection. Taken with ritonavir, it can reduce the amount of virus in the body and increase the number of CD4 cells, which helps lower the risk of serious illness.
How Darunavir works in the bodyDarunavir is a medication used to treat HIV infections. It works by attaching to the HIV-1 protease enzyme, which is necessary for the virus to replicate. By blocking the enzyme, darunavir stops the virus from forming mature particles and spreading the infection. Darunavir is able to adapt to changes in shape of the protease enzyme, making it more effective than other treatments.
When to interrupt dosage
The suggested dosage of Darunavir is predicated upon the recognized condition. The quantity of dosage can be found in the table below, contingent upon the method of administration (e.g. Tablet or Oral).Condition
Dosage
Administration
HIV
, 400.0 mg, 600.0 mg, 75.0 mg, 150.0 mg, 800.0 mg, 300.0 mg, 100.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Suspension, Suspension - Oral
Warnings
Darunavir ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Darunavir Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Darunavir.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Darunavir.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Darunavir.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be decreased when combined with Darunavir.
7-ethyl-10-hydroxycamptothecin
Major
The metabolism of 7-ethyl-10-hydroxycamptothecin can be decreased when combined with Darunavir.
Darunavir Toxicity & Overdose RiskThe toxic dose of darunavir is not known, but it has been tested on volunteers without causing major side effects in doses of up to 3,200 mg in liquid form and 1,600 mg in tablet form. If someone overdoses on this drug, general supportive measures should be taken. Monitor vital signs and watch for changes in their condition. Darunavir is highly protein-bound, so it cannot be removed from the body by dialysis.
Darunavir Novel Uses: Which Conditions Have a Clinical Trial Featuring Darunavir?
43 active clinical trials are currently examining the potential of Darunavir to ameliorate the symptoms of Human Immunodeficiency Virus (HIV).Condition
Clinical Trials
Trial Phases
HIV
42 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
Darunavir Reviews: What are patients saying about Darunavir?
3Patient Review
1/25/2013 I experience a lot of pain in various bones throughout my body. Sometimes it's my legs, sometimes my wrists and hands. I also have a rash that is slowly spreading and is sore all over my back, shoulders, chest, and face. I get palpitations and my skin feels strange. It can burn or feel like I'm in a draft even though I'm not. My brain feels like it's suffocating at times. I know that the Prizista 800mg daily can cause skin infections that are life-threatening. Help!
Patient Q&A Section about darunavir
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the mechanism of action of darunavir?
"Darunavir prevents the HIV-1 protease enzyme from cuting the HIV Gag-Pol polyprotein, which stops the virus from maturing into an infectious form."
Answered by AI
What is the generic Name for darunavir?
"Darunavir is a medication used to treat HIV. It is marketed under the brand name Prezista, but generic versions are also available. It is taken in combination with other antiretroviral drugs. The usual adult dose of darunavir is 800mg taken once a day, with a nutrient-rich diet."
Answered by AI
What is darunavir made of?
"(n.d.). Retrieved July 28, 2020, from https://pubchem.ncbi.nlm.nih.gov/compound/12677372
The chemical compound Darunavir has the chemical formula C27H37N3O7S."
Answered by AI
What is darunavir tablets used for?
"Darunavir is used in combination with a pharmacokinetic booster such as ritonavir (Norvir) or cobicistat (Tybost), and other medications to treat human immunodeficiency virus (HIV) infection in adults and children 3 years of age and older."
Answered by AI