Your session is about to expire
What is Daraprim
PyrimethamineThe Generic name of this drug
Treatment SummaryPyrimethamine is a medication used to treat malaria or toxoplasmosis, usually in combination with a sulfonamide. It works by blocking folic acid, which is needed for the growth of certain parasites.
Daraprimis the brand name
Daraprim Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Daraprim
Pyrimethamine
1953
13
Approved as Treatment by the FDA
Pyrimethamine, otherwise known as Daraprim, is approved by the FDA for 1 uses which include Toxoplasmosis .Toxoplasmosis
Used to treat Toxoplasmosis in combination with null
Effectiveness
How Daraprim Affects PatientsPyrimethamine is a drug used to treat malaria and help clear up parasites. It works by preventing the growth of certain parasites, specifically Plasmodium falciparum and Toxoplasma gondii. It can't kill any of the parasites' reproductive cells, but it can stop them from multiplying further. Taking it with sulfonamides can increase its effectiveness against Toxoplasma gondii.
How Daraprim works in the bodyPyrimethamine works against malaria by blocking the production of essential molecules needed for cell division. This works to stop malaria from reproducing, as it requires cell division to spread. By stopping the production of these molecules, Pyrimethamine prevents malaria from spreading.
When to interrupt dosage
The suggested dosage of Daraprim is contingent upon the recognized condition. The quantity of dosage fluctuates, depending on the technique of delivery noted in the table beneath.Condition
Dosage
Administration
Toxoplasmosis
, 25.0 mg, 12.5 mg, 50.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Warnings
There are 20 known major drug interactions with Daraprim.Common Daraprim Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Pyrimethamine.
Acepromazine
Major
The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Acepromazine.
Aceprometazine
Major
The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Aceprometazine.
Acetophenazine
Major
The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Acetophenazine.
Alimemazine
Major
The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Alimemazine.
Daraprim Novel Uses: Which Conditions Have a Clinical Trial Featuring Daraprim?
One ongoing investigation is assessing the potential of Daraprim to combat Toxoplasmosis.Condition
Clinical Trials
Trial Phases
Toxoplasmosis
1 Actively Recruiting
Phase 4
Daraprim Reviews: What are patients saying about Daraprim?
5Patient Review
3/17/2012 I've used Daraprim for three years to prevent malaria while traveling in mosquito-heavy areas, and it's been great. I never got sick, and the side effects were minimal.
4.3Patient Review
1/6/2011 I didn't love the feeling of nausea this medication gave me, but it was a small price to pay for how well it worked.
3Patient Review
2/21/2009 I found the side effects of this treatment to be really tough to deal with. Nausea, moodiness, and irritability were my main problems. It's hard to say which one was caused by the medicine itself and which ones were just a reaction to having toxoplasmosis in general.
1.3Patient Review
2/16/2009 The side effects of this treatment were so severe that I would have rather let the toxo kill me. Three doses and I was bedridden for two weeks, during which time I couldn't keep anything down. There are other, less intense treatments available that would have been a better choice.
Patient Q&A Section about daraprim
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does Daraprim cost now?
"A generic version of Daraprim is available, see pyrimethamine prices
A supply of 30 Daraprim oral tablets (25 mg each) costs approximately $23,702. The price varies depending on the pharmacy. This price is for cash-paying customers only; it is not valid with insurance plans. A generic version of Daraprim is available."
Answered by AI
Why is there no generic version of Daraprim?
"One of the main reasons for the decrease in generic drug production was the FDA's drug approval process, which was slow, inefficient, and confusing. Another reason was that certain loopholes prevented generic manufacturers from getting samples of the brand medication they needed to develop a generic."
Answered by AI
Which drug is Daraprim?
"An antiparasitic drug called Daraprim is used to treat and prevent malaria, and it is also used to treat toxoplasmosis."
Answered by AI
What is Daraprim used to treat?
"Pyrimethamine is used to treat toxoplasmosis, a serious infection caused by parasites. It is usually used with another medication, such as sulfonamide. Pyrimethamine belongs to a class of drugs called antiparasitics. It works by killing the parasites."
Answered by AI