Dalvance

Gram-Positive Bacterial Infections, Acute Bacterial Skin and Skin Structure Infection (ABSSSI)

Treatment

1 Active Study for Dalvance

Treatment for

Gram-Positive Bacterial Infections

What is Dalvance

DalbavancinThe Generic name of this drug

Treatment SummaryDalbavancin is an antibiotic used to treat acute bacterial skin and skin structure infections caused by certain bacteria. It works by interfering with the bacteria's cell wall, preventing them from growing and spreading. Dalbavancin is a second generation drug that is more powerful and can be taken once a week instead of multiple times a day. It is used to treat infections caused by Staphylococcus aureus, S. pyogenes, S. agalactiae, S. dysgalactiae, the S. anginosus group, and Enterococcus faecalis.

Dalvanceis the brand name

image of different drug pills on a surface

Dalvance Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Dalvance

Dalbavancin

2014

Effectiveness

How Dalvance Affects PatientsDalbavancin is an antibacterial drug. It is usually given in two doses, either 1000 mg followed one week later by 500 mg, or a single dose of 1500 mg. It must be given as an intravenous infusion over 30 minutes. Studies have shown that dalbavancin does not have any negative effects on heart rhythm, even at a high dose.

How Dalvance works in the bodyDalbavancin works in a similar way to vancomycin, a naturally occurring antibiotic. It kills bacteria by stopping their cells from forming cell walls. Dalbavancin forms a bond with the molecules that make up the cell wall, preventing them from being incorporated into the cell. It also alters the bacterial cell membrane and stops the bacteria from making RNA.

When to interrupt dosage

The prescribed amount of Dalvance depends on the identified condition. The dosage also fluctuates in relation to the method of delivery (e.g. Intravenous or Injection, powder, for solution) specified in the table below.

Condition

Dosage

Administration

Gram-Positive Bacterial Infections

, 50.0 mg/mL, 500.0 mg

, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Powder, for solution - Intravenous, Powder, for solution

Acute Bacterial Skin and Skin Structure Infection (ABSSSI)

, 50.0 mg/mL, 500.0 mg

, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Powder, for solution - Intravenous, Powder, for solution

Warnings

There are 18 known major drug interactions with Dalvance.

Common Dalvance Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Dalbavancin.

Typhoid vaccine

Minor

The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Dalbavancin.

(R)-warfarin

Moderate

The risk or severity of bleeding can be increased when Dalbavancin is combined with (R)-warfarin.

(S)-Warfarin

Moderate

The risk or severity of bleeding can be increased when Dalbavancin is combined with (S)-Warfarin.

4-hydroxycoumarin

Moderate

The risk or severity of bleeding can be increased when Dalbavancin is combined with 4-hydroxycoumarin.

Dalvance Toxicity & Overdose RiskTaking dalbavancin can change the bacteria in your colon and cause a condition called C. difficile-associated diarrhea. Other common side effects of taking this drug include nausea, vomiting, diarrhea, headache, rash, and itching. Very rarely, people have had blood and lymphatic system disorders, gastrointestinal disorders, liver damage, allergic reactions, low blood sugar, dizziness, difficulty breathing, hives, and changes to their blood vessels. It is not known if taking this drug is safe during pregnancy or while breastfeeding.

image of a doctor in a lab doing drug, clinical research

Dalvance Novel Uses: Which Conditions Have a Clinical Trial Featuring Dalvance?

28 active studies are examining the potential of Dalvance in ameliorating Urinary Tract Infections (UTIs).

Condition

Clinical Trials

Trial Phases

Gram-Positive Bacterial Infections

0 Actively Recruiting

Acute Bacterial Skin and Skin Structure Infection (ABSSSI)

1 Actively Recruiting

Phase 2

Dalvance Reviews: What are patients saying about Dalvance?

1Patient Review

8/8/2017

Dalvance for Complicated Skin Infection

This treatment gave me a rash and hives that have lasted for 5 weeks so far.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about dalvance

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does it take DALVANCE to work?

"You will need to stay still for 30 minutes while the medicine is being injected slowly through your IV tube. Even if you start to feel better after a few days, it is important to finish the full course of treatment to make sure the infection is completely cleared up."

Answered by AI

What bacteria does DALVANCE treat?

"DALVANCE killed a range of gram-positive bacteria in lab tests, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes, as well as other streptococcal species."

Answered by AI

What is a DALVANCE infusion?

"Dalvance is a prescription medicine used to treat the symptoms of Acute Bacterial Skin Structure Infections. Dalvance may be used alone or with other medications. Dalvance belongs to a class of drugs called Glycopeptides."

Answered by AI

What is DALVANCE used for?

"This medication is used to treat serious bacterial infections of the skin. It works by interfering with the ability of bacteria to make proteins."

Answered by AI

What type of drug is DALVANCE?

"Dalbavancin is an antibiotic medication used to treat skin infections caused by certain types of bacteria. Dalbavancin belongs to a class of medications called lipoglycopeptide antibiotics. It works by killing bacteria. Antibiotics such as dalbavancin will not kill viruses that can cause colds, flu, or other infections."

Answered by AI