Treatment for Tremor

1
Effectiveness
1
Safety
Oregon Health & Science University, Portland, OR
Tremor+1 More
Eligibility
18+
All Sexes
Eligible conditions
Tremor

Study Summary

This study is evaluating whether a specific type of deep brain stimulation may help individuals with essential tremor.

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Eligible Conditions

  • Tremor
  • Familial Tremor
  • Essential Tremor

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 1 primary outcome and 4 secondary outcomes in patients with Tremor. Measurement will happen over the course of 3 months.

3 months
Compare the effects of directional versus nondirectional DBS on balance and gait
Compare the effects of directional versus nondirectional DBS on perceptual assessment of voice and speech
Compare the effects of directional versus nondirectional DBS on self perception of speech
Improvement of tremor
Therapeutic window

Trial Safety

Safety Estimate

1 of 3

Trial Design

2 Treatment Groups

Nondirectional deep brain stimulation

This trial requires 24 total participants across 2 different treatment groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Nondirectional deep brain stimulation
Device
Deep brain stimulation delivered in a nondirectional manner within an axial plane
Directional deep brain stimulation
Device
Deep brain stimulation delivered in a directional manner within an axial plane

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 3 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 3 months for reporting.

Who is running the study

Principal Investigator
M. B.
Prof. Matthew Brodsky, Associate Professor of Neurology
Oregon Health and Science University

Closest Location

Oregon Health & Science University - Portland, OR

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There is one eligibility criterion to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
A tremor syndrome of bilateral upper limb action tremor with at least 3 years' duration

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can tremor be cured?

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Tremor is probably not the result of a specific disease or injury, but may be a symptom of a more pervasive disorder, such as a psychiatric disorder, [hypothyroidism](https://www.withpower.com/clinical-trials/hypothyroidism), or chronic alcoholism. Tremor should be treated as such (by reducing the alcohol intake and improving nutritional and thyroid status).

Unverified Answer

What causes tremor?

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No specific cause is clearly identified, although some risk factors are identified, including family history of tremor, and history of trauma. Other risk factors include a family history of tremor, high-heel shoes and being a female.\n

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What is tremor?

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There is a group of patients who have tremors, which have a definite cause. A few may have a familial tremor. Other tremor problems, including dystonia, bradykinesia, and intention tremors, need more attention. The patients with Parkinson's disease are usually first diagnosed as dystonia. This is the first article regarding Parkinson's disease and tremor. These symptoms should always be questioned, especially in patients who present with only a tremor.

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What are the signs of tremor?

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Patients with tremor may also complain of abnormal muscle tone, muscle fatigue, muscle pain, or tremor during locomotion. Clinical examination detects tremor mostly in the extremities and less often in the face or neck.

Unverified Answer

What are common treatments for tremor?

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There is no common medical treatment for tremor, since tremor can resolve or worsen upon treatment. Tremor can be treated through medication and through physiotherapy, such as using a stretchy ball. Tremor in the early stages, or in the absence of muscle contraction (postural tremor), may resolve regardless of treatment. Tremor that worsens after muscle contraction and is present throughout the limbs, will tend to be progressive and more difficult to treat. In patients with early-stage disease and no treatment history, the course of the tremor is unpredictable: it can resolve, or progress to postural tremor in the shoulders. Medications may be prescribed as a temporary measure before further evaluation with other treatment options.

Unverified Answer

Have there been other clinical trials involving treatment?

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A search using Power provides a quick and easy way to find cancer clinical trials. For this study, searching by condition, treatment, and type of cancer will allow you to find trials for hypersexuality related to PTSD.

Unverified Answer

How does treatment work?

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After initial remission is observed without further therapy for more than one year, most patients experience a subsequent bout of tumour growth with subsequent relapse.

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What are the latest developments in treatment for therapeutic use?

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It is difficult to get evidence-based treatment for tremors in the developed world, due to the limited availability of research funding and limited access to the newest treatments - in particular, deep brain stimulation. More research is needed in the right patient population - people with tremor who have poor outcomes with other medications - to determine which treatment strategies provide a satisfactory balance between cost and benefit.

Unverified Answer

Does treatment improve quality of life for those with tremor?

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Although the SF-36 demonstrated significant improvements, there was no significant improvement in HRQL in patients with tremors after receiving BTX. Further investigation is needed to determine the optimal type, dosage, and duration of BTX treatment with this group of patients.

Unverified Answer

What is the average age someone gets tremor?

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Tremor typically presents in adolescence (14 years - 15 years) and is fairly common. There is much variability in what a patient feels like each morning.

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Who should consider clinical trials for tremor?

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Tremor is one of the most disabling and costly neurodegenerative movement disorders. Clinical trials in this area are few and far between. In terms of the most effective agents, there are a number of questions that remain unanswered. While further research may find answers to these critical questions, clinicians in all levels are urged to consider tremor as an area in which clinical trials should occur to examine the potential efficacy of new agents.

Unverified Answer
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