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Functional CT Assessment for Emphysema
Study Summary
This trial will use DECT to see if there is a relationship between different types of perfusion, hypoxia, and the widening of pulmonary arteries in smokers to emphysema.
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Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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- Your kidneys are not filtering blood well, with a rate of 60 cc per minute or less.If you are taking nitroglycerin or other nitrates, or if you have used certain medications for erectile dysfunction within the last 7 days, you cannot participate. Also, if you are allergic to Sildenafil, you cannot participate.Your body mass index (BMI) is higher than 32.You have a history of heart disease, kidney disease, or diabetes.You have been diagnosed with asthma.You have a serious disease in any major organ system, according to the study medical team's judgment.You must be between 25 and 65 years old.You must currently be smoking at least half a pack of cigarettes per day, as confirmed by a test for cotinine.Your lung function test results need to show that your breathing is not restricted, and that your lungs are working well.You weigh more than 220 pounds (100 kilograms).You are allergic to shellfish, seafood, eggs, or iodine.You're taking certain medications for your heart or lungs, but not aspirin, high blood pressure, or digestive issues.You have metal inside or on your body from your nose to your abdomen.
- Group 1: Hyperoxia Administration study group
- Group 2: Hypoxia Administration study group
- Group 3: Sildenafil
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Approved for 5 Other Conditions - This treatment demonstrated efficacy for 5 other conditions.
- Drug Has Already Been Approved - The FDA has already approved this drug, and is just seeking more data.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What is the aggregate number of participants in this experiment?
"Affirmative. The clinicaltrials.gov database exhibits that this medical trial is presently enrolling participants, which was first advertised on July 10th 2017 and recently updated on August 29th 2022. 80 patients need to be recruited from a single research site participating in the study."
Are there any opportunities for new participants to join this clinical experiment?
"Affirmative. Clinicaltrials.gov's records indicate that this clinical investigation, initially listed on July 10th 2017, is still actively recruiting participants. Eighty individuals are sought after from a single research location."
Do I meet the requirements for enrolling in this research project?
"This clinical trial is accepting applications from individuals aged 25 to 65 who suffer from emphysema. Approximately 80 patient slots are available for participation."
Is the cohort receiving Hyperoxia treatments at risk of any adverse effects?
"With the Hyperoxia administration study group having already been approved, there is obviously a great deal of supporting evidence for its safety; as such it was awarded a score of 3."
To what condition is the Hyperoxia administration study group typically prescribed?
"Hyperoxia administration research group is most commonly applied to treat hypoxemia but can be efficient at diminishing symptoms of erectile dysfunction, anemia, and malignant diseases."
Does this medical research accept applicants aged 75 and below?
"According to the prerequisites for this trial, individuals aged 25-65 are eligible to enrol."
Who else is applying?
What state do they live in?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
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