Corneal Collagen Crosslinking for Corneal Melting
(CXL-KPro Trial)
Trial Summary
What is the purpose of this trial?
The purpose of this study is to demonstrate the safety and efficacy of the corneal collagen crosslinking with riboflavin and ultraviolet A in aim to increase the resistance of the graft used as a support for the Boston keratoprosthesis (KPro) type I against corneal melting (keratolysis or sterile necrosis).
Research Team
Marie-Claude Robert, MD
Principal Investigator
Centre hospitalier de l'Université de Montréal (CHUM)
Eligibility Criteria
This trial is for individuals who need a Boston keratoprosthesis (KPro) type I due to severe eye conditions like intraocular tumors or terminal glaucoma. Participants must be able to give written consent and commit to the study's duration. Those unable to wear contact lenses due to eyelid issues or currently in another interventional study cannot join.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Patients receive KPro surgery with either a crosslinked or normal graft-support
Postoperative Follow-up
Postoperative care including visual acuity and intraocular pressure measurements, slit-lamp examination, and imaging
Long-term Follow-up
Continued monitoring for complications and visual acuity, with imaging repeated at 1, 2, and 5 years
Treatment Details
Interventions
- Corneal Collagen Crosslinking
Find a Clinic Near You
Who Is Running the Clinical Trial?
Marie-Claude Robert
Lead Sponsor
Centre hospitalier de l'Université de Montréal (CHUM)
Lead Sponsor
Maisonneuve-Rosemont Hospital
Collaborator