What is Cyclosporine
CyclosporineThe Generic name of this drug
Treatment SummaryCyclosporine is a medication that helps prevent organ transplant rejection and treats inflammation and autoimmune conditions. It is derived from a fungus called Beauveria nivea and was approved by the FDA in 1983. It is now produced by Novartis as various products.
Sandimmuneis the brand name
Cyclosporine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sandimmune
Cyclosporine
1983
68
Approved as Treatment by the FDA
Cyclosporine, also known as Sandimmune, is approved by the FDA for 25 uses which include inadequate response to conventional therapy and Psoriasis .inadequate response to conventional therapy
Helps manage inadequate response to conventional therapy
Psoriasis
Helps manage severe Psoriasis
severe, recalcitrant Plaque psoriasis
Helps manage severe, recalcitrant Plaque psoriasis
Heymann Nephritis
Helps manage Glomerulonephritis, Membranous
Therapeutic procedure
contraindication or intolerance to other therapy
Helps manage contraindication or intolerance to other therapy
Bone Marrow
Rheumatoid Arthritis
Used to treat Rheumatoid Arthritis in combination with Methotrexate
Chronic Graft Versus Host Disease
Prophylaxis against heart transplant rejection
Patients who do not adequately respond to methotrexate alone
Helps manage Patients who do not adequately respond to methotrexate alone
Glomerulosclerosis
Helps manage Glomerulosclerosis
Steroid Resistant Nephrotic Syndrome
Helps manage Steroid Resistant Nephrotic Syndrome
Focal Segmental Glomerulosclerosis (FSGS)
Helps manage Focal Segmental Glomerulosclerosis (FSGS)
Nephrotic Syndrome
Helps manage Steroid Dependent Nephrotic Syndrome
Prophylaxis against graft versus host disease
Not responsive to other therapy
Helps manage Not responsive to other therapy
Therapeutic immunosuppression
Bone Marrow Transplantation
Liver
Prophylaxis against stem cell transplant rejection
Kidney Transplantation
Used to treat prophylaxis of renal transplant rejection in combination with Azathioprine
Nephrotic Syndrome
Helps manage Nephrotic Syndrome
Rheumatoid Arthritis
Helps manage severe, active Rheumatoid arthritis
Transplantation
Effectiveness
How Cyclosporine Affects PatientsCyclosporine is a drug used to prevent organ and bone marrow transplants from being rejected, as well as to control serious immune reactions caused by autoimmune diseases. Common side effects include excessive hair growth, swollen gums, and high cholesterol levels. There is some controversy around the drug potentially damaging your kidneys.
How Cyclosporine works in the bodyCyclosporine is a medication that reduces inflammation. It does this by blocking a receptor in cells called cyclophilin-1. This stops the nuclear factor of activated T cells from being activated. This is important because NF-AT helps create cytokines which cause inflammation. Cyclosporine also stops the production of IL-2, which is necessary for the activation and growth of T cells. Finally, it decreases the levels of other factors related to T helper cell functioning and thymocyte development.
When to interrupt dosage
The prescribed amount of Cyclosporine is contingent upon the determined condition, including Interstitial Cystitis, Focal Segmental Glomerulosclerosis (FSGS) and Excessive tearing. The dosage is dependent on the administration approach (e.g. Liquid - Intravenous or Ophthalmic; Topical) specified in the following table.Condition
Dosage
Administration
severe, recalcitrant Plaque psoriasis
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Idiopathic Thrombocytopenic Purpura
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Glomerulosclerosis
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Kidney Transplantation
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Ulcerative Colitis
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Atopic Dermatitis
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Prophylaxis against stem cell transplant rejection
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Bulla
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Juvenile arthritis
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Excessive tearing
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Kidney Diseases
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Chronic Graft Versus Host Disease
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Disease
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Dry Eye Syndromes
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Interstitial Cystitis
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Bone Marrow Transplantation
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Liver
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Rejection; Transplant, Kidney
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
non-immunocompromised
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Transplantation
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Warnings
Cyclosporine ContraindicationsCondition
Risk Level
Notes
Ocular neoplasms malignancy unspecified
Do Not Combine
Rheumatoid Arthritis
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Hypertensive disease
Do Not Combine
Abnormal Renal Function
Do Not Combine
Psoriasis
Do Not Combine
active periocular infections
Do Not Combine
Rheumatoid Arthritis
Do Not Combine
Rheumatoid Arthritis
Do Not Combine
active ocular infections
Do Not Combine
Pulse Frequency
Do Not Combine
Infection
Do Not Combine
Rheumatoid Arthritis
Do Not Combine
Secondary Immunodeficiencies (SID)
Do Not Combine
Rheumatoid Arthritis
Do Not Combine
Hypertensive disease
Do Not Combine
Rheumatoid Arthritis
Do Not Combine
Rheumatoid Arthritis
Do Not Combine
Radiation Therapy
Do Not Combine
Abnormal Renal Function
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Cyclosporine may interact with Toxoplasma Infections
Common Cyclosporine Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Cyclosporine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Cyclosporine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Cyclosporine.
Aliskiren
Major
The serum concentration of Aliskiren can be increased when it is combined with Cyclosporine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Cyclosporine.
Cyclosporine Toxicity & Overdose RiskThe lowest toxic dose of cyclosporine in rats is 1480mg/kg and in humans is 12mg/kg. An overdose of cyclosporine may cause nausea, flushing, tremor, vertigo, vomiting, anorexia, and a feeling of increased body girth. If an overdose occurs, forced emesis and gastric lavage should be administered within two hours. Dialysis and charcoal hemoperfusion are not effective at removing cyclosporine from the body.
Cyclosporine Novel Uses: Which Conditions Have a Clinical Trial Featuring Cyclosporine?
81 active clinical trials are pursuing the potential of Cyclosporine to mitigate Chronic Graft Versus Host Disease, Kidney Diseases and Ulcerative Colitis.Condition
Clinical Trials
Trial Phases
Chronic Graft Versus Host Disease
32 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Atopic Dermatitis
75 Actively Recruiting
Phase 3, Phase 4, Not Applicable, Phase 1, Phase 2, Early Phase 1
Lupus Nephritis
20 Actively Recruiting
Phase 4, Phase 2, Phase 1, Phase 3
Dry Eye Syndromes
1 Actively Recruiting
Phase 3
Nephrotic Syndrome
0 Actively Recruiting
non-immunocompromised
0 Actively Recruiting
Transplantation
0 Actively Recruiting
Interstitial Cystitis
16 Actively Recruiting
Phase 2, Early Phase 1, Not Applicable, Phase 1, Phase 3
Kidney Diseases
0 Actively Recruiting
Ulcerative Colitis
0 Actively Recruiting
Excessive tearing
0 Actively Recruiting
Bulla
0 Actively Recruiting
Heart
2 Actively Recruiting
Phase 2, Not Applicable
Rejection; Transplant, Kidney
10 Actively Recruiting
Phase 3, Phase 1, Phase 2, Phase 4, Not Applicable, Early Phase 1
Rejection, Transplant
2 Actively Recruiting
Phase 2
severe, recalcitrant Plaque psoriasis
0 Actively Recruiting
Patients who do not adequately respond to methotrexate alone
0 Actively Recruiting
Rheumatoid Arthritis
0 Actively Recruiting
Rejection; Transplant, Liver
0 Actively Recruiting
Therapeutic immunosuppression
0 Actively Recruiting
Cyclosporine Reviews: What are patients saying about Cyclosporine?
5Patient Review
12/20/2014 I had severe psoriasis 95 percent of my body, and after just three months on this medication, most of it has cleared up. I'm now down to a smaller quantity. Side effects are minimal compared to the others who posted comments. Fatigue, some hair loss, higher blood pressure. I hope I can go off this soon.
5Patient Review
1/1/2016 I received a transplant 25 years ago and have had no issues since. Just the normal problems that come with age.
4.3Patient Review
5/16/2014 After three weeks of using this medication, my eczema was completely gone. However, I developed a boil that led to an infection. As a result, I had to discontinue use and go to the emergency room.
3.3Patient Review
2/21/2013 The fatigue from this treatment is really bad, and it's also made me feel slow mentally.
3Patient Review
9/1/2022 I've had some really unpleasant side effects from taking Cyclosporine. The smell of the pill is awful, and I've been dealing with nausea and abdominal pain that has made it hard to sleep.
2.3Patient Review
11/1/2014 I received this drug, alongside other medicines like steroids, for a cornea graft. Unfortunately, it didn't work; I had to get four different grafts in total. Additionally, I found that I frequently got sick while using this medication and that the nausea was especially bad.
1Patient Review
3/27/2022 The smell is incredibly bad, but I can hold my breath to take it because the alternative is worse. After taking this treatment for two weeks, I have more blemishes and my acne has worsened. I also experience terrible stomach upset and difficulty sleeping; on top of all that, I've gained weight. There needs to be a better treatment option because the side effects of this one are just awful.
Patient Q&A Section about cyclosporine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is cyclosporine is a steroid?
"Cyclosporine is a safe steroid-sparing agent to use topically for prolonged periods of time,” Dr."
Answered by AI
What is the drug cyclosporine used for?
"It works by weakening the body's natural defense (immune system) so that the transplanted organ is not rejected.
Cyclosporine is used in combination with other medications to prevent the body from rejecting a transplanted organ. It is classified as an immunosuppressive agent and works by weakening the body's immune system so that the transplanted organ is not rejected."
Answered by AI
Which class of drug is cyclosporine?
"This class of medication is designed to weaken the immune system by reducing the activity within it. This can help to prevent the body from attacking transplanted organs, for example."
Answered by AI
What are the side effects of taking cyclosporine?
"High blood pressure, increased hair growth, swollen or inflamed gums, numbness or tingling of the hands or feet, and other common side effects like tremors, restlessness, stomach upset, nausea, cramps, diarrhea, headache, and changes in blood sugar."
Answered by AI