Cresemba
Treatment
0 Active Studies for Cresemba
What is Cresemba
Isavuconazole
The Generic name of this drug
Treatment Summary
Isavuconazonium is a medication used to treat serious fungal infections. It is marketed under the brand name Cresemba and is available in both oral and injectable forms. It is a prodrug of isavuconazole, the active compound, which has low solubility in water. Isavuconazonium has high water solubility, which makes it suitable for intravenous administration without the use of a cyclodextrin vehicle, thus avoiding potential nephrotoxicity. It is well-tolerated and has good bioavailability and predictable pharmacokinetics.
Cresemba Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Isavuconazole
0
Effectiveness
How Cresemba works in the body
Isavuconazonium is an antifungal that targets and blocks a fungal enzyme called sterol 14-α-demethylase. This stops the production of a molecule, called ergosterol, which is found in the cells of certain fungi like Aspergillus, Candida, and Mucorales. The blockage by isavuconazonium builds up toxic precursors to ergosterol, which then kills the fungal cells.
Warnings
Cresemba has nine counterindications and should not be taken if you have any of the conditions outlined in the below table.
There are 20 known major drug interactions with Cresemba.
Common Cresemba Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Isavuconazole.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Isavuconazole.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Isavuconazole.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Isavuconazole.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Isavuconazole.
Cresemba Toxicity & Overdose Risk
Isavuconazonium is not recommended for pregnant or breastfeeding women, as animal studies have shown that its active ingredient, isavuconazole, is excreted in breast milk.
Patient Q&A Section about cresemba
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is CRESEMBA used for?
"An azole antifungal medication, CRESEMBA is indicated for the treatment of invasive aspergillosis and invasive mucormycosis in patients 18 years of age and older."
Answered by AI
What is the generic name for CRESEMBA?
"The recommended dose of CRESEMBA for the treatment of invasive aspergillosis and mucormycosis is 600mg.
The recommended dose of CRESEMBA for the treatment of invasive aspergillosis and mucormycosis is 600mg. CRESEMBA is the prodrug of isavuconazole, which is an azole antifungal drug."
Answered by AI
How long do you take CRESEMBA for?
"If you have a weakened immune system or a difficult infection, you may need to be on CRESEMBA for a longer period of time. Your doctor may switch you from the CRESEMBA IV Injection to the CRESEMBA Capsules once your condition improves. Continue taking CRESEMBA for as long as your doctor tells you to."
Answered by AI
Is CRESEMBA an antibiotic?
"Cresemba is an antifungal agent that is used to treat fungal infections, such as aspergillosis or mucormycosis. It is available by prescription only and should not be used in patients under the age of 18."
Answered by AI