Clobetasol Propionate

Alopecia, Psoriasis, Severe Plaque psoriasis + 4 more

Treatment

14 Active Studies for Clobetasol Propionate

What is Clobetasol Propionate

Clobetasol propionate

The Generic name of this drug

Treatment Summary

Clobetasol Propionate is a steroid medication used to treat skin conditions. It is more effective than other similar medications and was first approved for use in 1974. It was officially approved by the FDA in 1985 and is commonly used to treat various skin conditions.

Temovate Scalp Application

is the brand name

image of different drug pills on a surface

Clobetasol Propionate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Temovate Scalp Application

Clobetasol propionate

1990

245

Effectiveness

How Clobetasol Propionate Affects Patients

Corticosteroids, such as clobetasol propionate, can reduce inflammation and are usually applied twice daily for a long-lasting effect. Generally, patients need to take much higher doses than the body naturally produces. It is important to talk to a doctor about the potential risks associated with taking corticosteroids, such as suppressing the body's natural hormones and being more susceptible to infections.

How Clobetasol Propionate works in the body

Corticosteroids reduce swelling and fluid buildup in the body, as well as the number of white blood cells that travel to sites of inflammation. They do this by changing how genes are expressed in the body. Corticosteroids also stop the body from breaking down fats, and decrease the activity of molecules that cause inflammation. Low doses of corticosteroids are used to reduce inflammation, while higher doses reduce the strength of your immune system. High doses can also raise your sodium levels and lower your potassium levels.

When to interrupt dosage

The suggested dosage of Clobetasol Propionate is contingent upon the ascertained situation, such as Psoriasis, corticosteroid responsive, Inflammatory Dermatosis and Pruritus. The amount of dosage varies, in line with the delivery system (e.g. Topical or Ointment) noted in the following table.

Condition

Dosage

Administration

Pruritus

0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg

Topical, Solution, , Solution - Topical, Ointment, Cream, Ointment - Topical, Cream - Topical, Gel, Gel - Topical, Shampoo, Lotion, Lotion - Topical, Spray, Shampoo - Topical, Spray - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Emulsion, Emulsion - Topical, Liquid, Liquid - Topical, Kit - Topical

Psoriasis

0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg

Topical, Solution, , Solution - Topical, Ointment, Cream, Ointment - Topical, Cream - Topical, Gel, Gel - Topical, Shampoo, Lotion, Lotion - Topical, Spray, Shampoo - Topical, Spray - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Emulsion, Emulsion - Topical, Liquid, Liquid - Topical, Kit - Topical

Alopecia

0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg

Topical, Solution, , Solution - Topical, Ointment, Cream, Ointment - Topical, Cream - Topical, Gel, Gel - Topical, Shampoo, Lotion, Lotion - Topical, Spray, Shampoo - Topical, Spray - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Emulsion, Emulsion - Topical, Liquid, Liquid - Topical, Kit - Topical

Psoriasis

0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg

Topical, Solution, , Solution - Topical, Ointment, Cream, Ointment - Topical, Cream - Topical, Gel, Gel - Topical, Shampoo, Lotion, Lotion - Topical, Spray, Shampoo - Topical, Spray - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Emulsion, Emulsion - Topical, Liquid, Liquid - Topical, Kit - Topical

Psoriasis

0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg

Topical, Solution, , Solution - Topical, Ointment, Cream, Ointment - Topical, Cream - Topical, Gel, Gel - Topical, Shampoo, Lotion, Lotion - Topical, Spray, Shampoo - Topical, Spray - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Emulsion, Emulsion - Topical, Liquid, Liquid - Topical, Kit - Topical

Severe Plaque psoriasis

0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg

Topical, Solution, , Solution - Topical, Ointment, Cream, Ointment - Topical, Cream - Topical, Gel, Gel - Topical, Shampoo, Lotion, Lotion - Topical, Spray, Shampoo - Topical, Spray - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Emulsion, Emulsion - Topical, Liquid, Liquid - Topical, Kit - Topical

corticosteroid responsive, Inflammatory Dermatosis

0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg

Topical, Solution, , Solution - Topical, Ointment, Cream, Ointment - Topical, Cream - Topical, Gel, Gel - Topical, Shampoo, Lotion, Lotion - Topical, Spray, Shampoo - Topical, Spray - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Emulsion, Emulsion - Topical, Liquid, Liquid - Topical, Kit - Topical

Warnings

There are 20 known major drug interactions with Clobetasol Propionate.

Common Clobetasol Propionate Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abatacept

Major

The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Abatacept.

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Clobetasol propionate.

Abetimus

Major

The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Abetimus.

Clobetasol Propionate Toxicity & Overdose Risk

Taking too much glucocorticoid, such as clobetasol propionate, can cause problems with the body's natural production of hormones, and cause other long-term issues. These issues may include cataracts, glaucoma, high blood pressure, water retention, increased fat in the blood, peptic ulcers, muscle weakness, depression, skin thinning and hair growth, weakened immune system, acne, diabetes, low calcium, or low phosphorus levels. Treatment of an overdose includes stopping or adjusting the dose of the glucocorticoid and treating any symptoms that are present.

image of a doctor in a lab doing drug, clinical research

Clobetasol Propionate Novel Uses: Which Conditions Have a Clinical Trial Featuring Clobetasol Propionate?

47 active clinical trials are currently investigating the potential of Clobetasol Propionate to provide corticosteroid responsive relief of Inflammatory Dermatosis, Psoriasis and Alopecia.

Condition

Clinical Trials

Trial Phases

Alopecia

14 Actively Recruiting

Early Phase 1, Not Applicable, Phase 3, Phase 2, Phase 1

Severe Plaque psoriasis

0 Actively Recruiting

Psoriasis

0 Actively Recruiting

Psoriasis

0 Actively Recruiting

corticosteroid responsive, Inflammatory Dermatosis

0 Actively Recruiting

Pruritus

0 Actively Recruiting

Psoriasis

0 Actively Recruiting

Patient Q&A Section about clobetasol propionate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is clobetasol a strong steroid?

"Clobetasol is a very powerful steroid medication used to soothe inflammation and itching on the skin that is brought on by certain skin conditions."

Answered by AI

What is clobetasol propionate used for?

"Clobetasol propionate is a medicine that is applied to the skin to relieve swelling, itching, and irritation. It can be used to treat skin conditions such as eczema and contact dermatitis."

Answered by AI

What are the side effects of clobetasol?

"The skin may feel burning, dry, flushed or red, itchy, scaley, severely red, sore, or swollen. The skin may also be irritated, have a rash, be encrusted, scaly, and oozing."

Answered by AI

How long does it take clobetasol to work?

"Clobetasol propionate is a common treatment for psoriasis that is often successful in clearing or nearly clearing psoriasis patches within 2-4 weeks, according to research."

Answered by AI

Clinical Trials for Clobetasol Propionate

Image of Advanced Dermatology & Cosmetic Surgery in Maitland, United States.

Xtresse Serum for Hair Loss

18 - 65
All Sexes
Maitland, FL

The goal of this study is to determine how safe and effective it is to improve hair growth by applying a serum daily on the scalp of men and women with thinning hair. The main aims of this trial are: 1. To confirm using photographic analysis, changes in the quality, volume, and thickness of hair. 2. To gauge patient satisfaction with hair changes and application process. 3. Monitor and report any adverse events associated with the daily usage of Xtressé serum. Participants who qualify will complete 4 visits after voluntary consent has been given. Participants will be given 4 bottles of serum to use during the study. The product will be applied daily over a 4-month period. Photographs and scalp analysis will be performed at each visit to measure changes in hair volume, thickness, and growth. Participants will complete a survey at the end of the study.

Waitlist Available
Has No Placebo

Advanced Dermatology & Cosmetic Surgery (+2 Sites)

Melissa Rayner, MS

Restore Biologics Holdings, Inc. dba Xtressé

Image of Advanced Dermatology & Cosmetic Surgery in Maitland, United States.

Xtressé Gummies for Alopecia

18 - 65
Female
Maitland, FL

The goal of this study is to determine how safe and effective it is to improve hair growth using an active gummy treatment in women with self-perceived thinning hair. The main aims of this trial are: 1. To confirm using photographic analysis, changes in the quality, volume, and thickness of hair. 2. To gauge patient satisfaction with hair changes and application process. 3. Monitor and report any adverse events associated with the daily intake of Xtressé Participants who qualify will complete 5 visits after voluntary consent has been given. Participants will be given a 30-day supply of the gummies at each visit over a 4-month period. Photographs and scalp analysis will be performed at each visit to measure changes in hair volume, thickness, and growth.

Waitlist Available
Has No Placebo

Advanced Dermatology & Cosmetic Surgery (+3 Sites)

Melissa Y Rayner, MS

Restore Biologics Holdings, Inc. dba Xtressé

Image of Advanced Dermatology & Cosmetic Surgery in Maitland, United States.

XVIE for Alopecia

28 - 65
Female
Maitland, FL

The goal of this study is to determine how safe and effective it is to improve hair growth using XVIE solution applied on the scalp of women with self-perceived thinning hair. The main aims of this trial are: 1. To confirm using photographic analysis, changes in the quality, volume, and thickness of hair. 2. To gauge patient satisfaction with hair changes and application process. Participants who qualify will complete 5 to 6 visits after voluntary consent has been given. Participant's scalp will be numbed and the XVIE solution will be applied by microneedling. Photographs will be taken at each visit to measure changes in hair volume, thickness, and growth. Every participant will receive active treatment twice over the 4 month period.

Waitlist Available
Has No Placebo

Advanced Dermatology & Cosmetic Surgery (+1 Sites)

Melissa Y Rayner, MS

Restore Biologics Holdings, Inc. dba Xtressé

Have you considered Clobetasol Propionate clinical trials?

We made a collection of clinical trials featuring Clobetasol Propionate, we think they might fit your search criteria.
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Image of Skin Wellness Dermatology in Birmingham, United States.

Xtressé Supplement and Serum for Alopecia

28 - 65
Female
Birmingham, AL

The goal of this clinical trial is to test how safe and effective it is to improve hair growth using an active gummy and serum combination treatment when compared to an inactive treatment combination in women with self-perceived thinning hair. The main questions this trial aims to answer are: * to confirm using photograph analytics, how much hair growth has increased in a marked area when using active treatment versus inactive treatment, and * participants assessment and satisfaction with the hair growth using scaled assessments. Participants who qualify will be asked to complete 6 to 7 visits after voluntarily consent has been given. The study is divided into two parts. In Part A participants will be randomly given either active or inactive treatment to use over 3 months. After 3 months, all participants will enter Part B of the study and will be given active treatment to use over the final 6 months of the study.

Recruiting
Paid Trial

Skin Wellness Dermatology (+1 Sites)

Danielle Leavitt

Restore Biologics Holdings, Inc. dba Xtressé

Image of Marc Avram MD in New York, United States.

TargetCool + Benev Exosomes for Alopecia

18 - 70
All Sexes
New York, NY

This clinical trial is testing a new approach to help improve hair thinning using a combination of cosmetic treatments. The purpose of the study is to learn whether applying exosomes to the scalp, along with microneedling and a precision cooling device called TargetCool™. This study aims to determine whether this combination approach offers synergistic benefits for individuals with hair thinning. Exosomes are tiny particles that come from stem cells and contain growth factors and other nutrients. They are being studied for their potential to help regenerate skin and hair. TargetCool™ is an FDA-cleared device that uses precision cooling to reduce inflammation and improve comfort. Microneedling is a common, minimally invasive procedure that uses small needles to stimulate the skin and help absorb topical products more effectively. The study will include healthy men (ages 18 to 70) and women (ages approximately 45 to 70) who are not of childbearing potential. A total of 9 to 15 participants will be randomly placed into one of three groups: Group 1: Exosomes with TargetCool™ Group 2: Microneedling followed by exosomes and TargetCool™ Group 3: Microneedling followed by exosomes only Participants will receive four treatments over 9 weeks. Each visit may include microneedling, TargetCool™ treatment, and exosome application depending on group assignment. A small tattoo will be placed on the scalp to help capture consistent photographs, and a special imaging system (Canfield HairMetrix®) will be used to measure hair changes. Participants will return for follow-up visits at 3 and 6 months after the final treatment. The results will help determine whether this combination of cosmetic treatments is safe and beneficial for people experiencing hair thinning.

Waitlist Available
Has No Placebo

Marc Avram MD

Dawn Queen, MD

Recens Medical, Inc.

Have you considered Clobetasol Propionate clinical trials?

We made a collection of clinical trials featuring Clobetasol Propionate, we think they might fit your search criteria.
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Image of University of California, Irvine, Department of Dermatology, Dermatology Clinical Research Center, Hewitt Hall in Irvine, United States.

Fractional Photothermolysis for Alopecia

18 - 90
All Sexes
Irvine, CA

This study is being done to evaluate the effects of fractional photothermolysis (known as laser resurfacing) using fractional laser for the induction of hair follicles via skin rejuvenation in subjects with scalp alopecia (specifically, alopecia on the superior forehead at the frontal hairline). Fractional photothermolysis has been shown to be effective in promoting hair growth. The investigators will study 50 subjects who will be treated 6-10 times at 2-4 week intervals. Each participant will have half of their head treated with a laser, either Fraxel DUAL 1550 or Halo by Sciton, and the other half of their head will be left untreated as a control. Half of the individuals will randomly be assigned to the group to be treated with Fraxel DUAL 1550, and the other half will be treated with Halo by Sciton. Visual observation and digital, photographic, non-invasive imaging will be used to compare the treated and untreated area to assess for differences in hair follicle stimulation rates, number and density of hairs. As noted above, the types of lasers we plan to use include the non-ablative fractional laser settings for the Fraxel DUAL 1550 and Halo by Sciton. A fractional laser is a laser that directs an intense burst of laser energy on the skin. The treatment deposits heat deep into the dermis to tighten skin and stimulate collagen remodeling. The necrotic (death of cells or tissue) injury heals rapidly and adverse effects are few. Laser resurfacing is commonly used for rejuvenation of the skin to improve quality, tone, and texture.

Phase < 1
Waitlist Available

University of California, Irvine, Department of Dermatology, Dermatology Clinical Research Center, Hewitt Hall