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What is Calan Sr
VerapamilThe Generic name of this drug
Treatment SummaryVerapamil is a medication used to lower high blood pressure, control heart arrhythmias, and treat chest pain. It was the first calcium channel blocker to become available as a treatment in the 1960s. Verapamil belongs to a group of drugs known as non-dihydropyridine calcium channel blockers, which includes drugs like diltiazem and flunarizine. It is a combination of two versions of the drug (called enantiomers), one of which is more powerful but breaks down faster in the body.
Calanis the brand name
Calan Sr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Calan
Verapamil
1984
357
Approved as Treatment by the FDA
Verapamil, also called Calan, is approved by the FDA for 3 uses which include Atrial Fibrillation or Flutter and Hypertensive disease .Atrial Fibrillation or Flutter
Used to treat Atrial Fibrillation or Flutter in combination with Digitoxin
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Trandolapril
Heart Rate
Used to treat Heart Rate in combination with Digitoxin
Effectiveness
How Calan Sr Affects PatientsVerapamil is a medication used to treat irregular heartbeats, chest pain, and high blood pressure. It works by blocking certain channels in the heart muscle, reducing the strength of the heart's contractions. Depending on the formulation, verapamil may need to be taken 3-4 times per day or once daily. People with severe heart problems should not take verapamil as it could make their condition worse.
How Calan Sr works in the bodyVerapamil works by blocking L-type calcium channels, which are found in muscle and heart tissue. This blocks calcium from entering the cell, which reduces the force with which the heart has to push, lowering blood pressure and helping with angina. It also slows down the electrical activity of the heart, helping to control heart rate in those with arrhythmia. Verapamil may also work on other calcium channels, potassium channels, and adrenergic receptors.
When to interrupt dosage
The amount of Calan Sr is contingent upon the determined issue, including Tachycardia, Ventricular, Unstable Angina Pectoris and Vasospastic Angina. The quantity of dosage revolves around the approach of delivery as highlighted in the table below.Condition
Dosage
Administration
Tachycardia, Ventricular
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Heart Rate
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Paroxysmal Supraventricular Tachycardia (PSVT)
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Atrial Fibrillation or Flutter
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Cluster Headache
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
prophylaxis of Cluster headaches
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Unstable Angina Pectoris
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Vasospastic Angina
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Chronic Stable Angina Pectoris
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Warnings
Calan Sr has eleven disclaimers and should not be used for the conditions given in the table below.Calan Sr ContraindicationsCondition
Risk Level
Notes
third degree AV block
Do Not Combine
Ventricular Tachycardia
Do Not Combine
Atrial Fibrillation
Do Not Combine
Shock, Cardiogenic
Do Not Combine
accessory bypass tract
Do Not Combine
severe Left Ventricular Dysfunction
Do Not Combine
Pulse Frequency
Do Not Combine
Sick Sinus Syndrome
Do Not Combine
absence of a functioning ventricular pacemaker
Do Not Combine
Hypotension
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Verapamil may interact with Pulse Frequency
Common Calan Sr Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Verapamil.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Verapamil.
Acepromazine
Major
Verapamil may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Verapamil.
Alfuzosin
Major
Verapamil may increase the hypotensive activities of Alfuzosin.
Calan Sr Toxicity & Overdose RiskThe lowest toxic dose of verapamil for women is 14.4 mg/kg and for men is 3.429 mg/kg. The lethal dose of verapamil for rats and mice is 150 mg/kg and 163 mg/kg respectively. There is no antidote for verapamil overdose, so treatment focuses on managing the symptoms, which can include low blood pressure, slow heartbeat, and irregular heart rhythm. In cases of large overdoses (up to 9 grams), non-cardiogenic pulmonary edema has been reported. To treat an overdose, doctors may use medications to empty the stomach, cathartics and
Calan Sr Novel Uses: Which Conditions Have a Clinical Trial Featuring Calan Sr?
34 active studies are currently being conducted to investigate the potential of Calan SR in alleviating symptoms of Chronic Stable Angina Pectoris, Tachycardia, Ventricular and Paroxysmal Supraventricular Tachycardia (PSVT).Condition
Clinical Trials
Trial Phases
prophylaxis of Cluster headaches
0 Actively Recruiting
Tachycardia, Ventricular
0 Actively Recruiting
Atrial Fibrillation or Flutter
1 Actively Recruiting
Not Applicable
Unstable Angina Pectoris
0 Actively Recruiting
Vasospastic Angina
0 Actively Recruiting
Cluster Headache
4 Actively Recruiting
Phase 1, Phase 3, Phase 2
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Heart Rate
1 Actively Recruiting
Not Applicable
Paroxysmal Supraventricular Tachycardia (PSVT)
2 Actively Recruiting
Phase 3, Phase 2
Chronic Stable Angina Pectoris
1 Actively Recruiting
Not Applicable
Calan Sr Reviews: What are patients saying about Calan Sr?
5Patient Review
6/24/2009 I've been taking 120 mg/day for the past 6 months as a prophylactic measure against severe headaches. So far, it's working great--I've only had two headaches in that time.
5Patient Review
4/22/2009 Finally found a medication that works for my son's migraines! We've been using it for two months now with no issues.
4Patient Review
2/15/2008 I still have some heart rate issues and bouts of depression, but since I started taking Calan SR Oral, I haven't had a single migraine. That's been an incredible relief for me.
3.3Patient Review
8/4/2010 I was originally prescribed this medication to help with my Raynauld's condition. However, since taking it I have developed high blood pressure and high cholesterol. I'm otherwise healthy for my age. Could there be an underlying condition that I am unaware of?
2Patient Review
6/19/2009 Unfortunately, this medication not only failed to alleviate my boyfriend's cluster headaches, but it also had the adverse effect of slowing his heart rate. I would not recommend this drug to anyone seeking relief from cluster headaches.
1Patient Review
11/7/2012 I started taking this medication for about a month to help with my migraines. However, after starting this medication I began experiencing vertigo so severe that I would pass out. This happened on three separate occasions and my doctor took me off the medication immediately.
Patient Q&A Section about calan sr
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of CALAN?
"The following effects may occur: dizziness, slow heartbeat, constipation, nausea, headache, or tiredness. If you experience any of these effects for an extended period of time, or if they worsen, contact your doctor or pharmacist. To reduce your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position."
Answered by AI
Is Calan SR a beta blocker?
"The drug Calan SR is used to treat hypertension, angina, and certain heart rhythm disorders. It works by relaxing the muscles of the heart and blood vessels."
Answered by AI
Is Calan SR the same as verapamil?
"CALAN SR is a drug that inhibits the influx of calcium ions, slowing down the body's channels or calcium ion antagonist. CALAN SR is taken orally as a light green, capsule-shaped pill that is scored and film-coated."
Answered by AI
What is Calan SR used for?
"Verapamil can be used to lower high blood pressure, which in turn can help to prevent strokes, heart attacks, and kidney problems. Verapamil belongs to a class of drugs known as calcium channel blockers. These drugs work by relaxing blood vessels so that blood can flow more easily."
Answered by AI