Bupivacaine Hydrochloride

Stevens-Johnson Syndrome, Ophthalmia, Sympathetic, Berylliosis + 71 more

Treatment

16 FDA approvals

20 Active Studies for Bupivacaine Hydrochloride

Treatment for

Stevens-Johnson Syndrome

What is Bupivacaine Hydrochloride

Bupivacaine

The Generic name of this drug

Treatment Summary

Bupivacaine is a type of anesthetic used to numb a specific area of the body and reduce pain.

Bupivacaine Hydrochloride and Epinephrine

is the brand name

image of different drug pills on a surface

Bupivacaine Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bupivacaine Hydrochloride and Epinephrine

Bupivacaine

1988

197

Approved as Treatment by the FDA

Bupivacaine, also known as Bupivacaine Hydrochloride and Epinephrine, is approved by the FDA for 16 uses including Alopecia Areata and Inflammation .

Alopecia Areata

Used to treat Alopecia Areata (AA) in combination with Lidocaine

Inflammation

Used to treat inflammatory lesions of lichen simplex in combination with Lidocaine

Psoriasis

Used to treat Psoriatic plaque in combination with Lidocaine

Inflammation

Used to treat inflammatory lesions of granuloma annulare in combination with Lidocaine

Nerve Block

Discoid Lupus Erythematosus (DLE)

Used to treat Discoid Lupus Erythematosus (DLE) in combination with Lidocaine

Flatfoot

Used to treat inflammatory lesions of lichen planus in combination with Lidocaine

Tendon structure

Used to treat cystic tumors of tendon in combination with Lidocaine

Alopecia Areata (AA)

Used to treat Alopecia Areata (AA) in combination with Lidocaine

Aponeurosis structure

Used to treat cystic tumors of aponeurosis in combination with Lidocaine

General Anesthesia

Keloids Scars

Used to treat Keloids Scars in combination with Lidocaine

Psoriatic plaque

Used to treat Psoriatic plaque in combination with Lidocaine

Lupus Erythematosus, Discoid

Used to treat Discoid Lupus Erythematosus (DLE) in combination with Lidocaine

Local Anaesthesia therapy

Necrobiosis Lipoidica

Used to treat Necrobiosis lipoidica diabeticorum in combination with Lidocaine

Effectiveness

How Bupivacaine Hydrochloride Affects Patients

Bupivacaine is a type of anesthetic used to reduce pain before and after surgery. It is long lasting compared to other anesthetics, but can be dangerous in large doses because it can affect the heart. To reduce this risk, other anesthetics such as ropivacaine and levobupivacaine, which is a variation of bupivacaine, are sometimes used. Taking too much of this drug can have effects on the cardiovascular and central nervous systems, such as changes in heart rate, difficulty breathing, and even death. It can also cause changes in the brain such as stimulation, depression

How Bupivacaine Hydrochloride works in the body

Bupivacaine is a local anesthetic that blocks nerve signals and prevents pain. It does this by blocking sodium channels on nerve cells and preventing them from sending out signals. Different nerve fibers are affected in order, starting with pain and ending with muscle tone. Bupivacaine also reduces inflammation and fever by binding to prostaglandin E2 receptors and preventing the production of prostaglandins.

When to interrupt dosage

The advocated dosage of Bupivacaine Hydrochloride is contingent upon the diagnosed condition, including Idiopathic Nephrotic Syndrome, Lupus and Thyroiditis. The magnitude of dosage depends on the technique of administration outlined in the table beneath.

Condition

Dosage

Administration

Berylliosis

, 5.0 mg/mL, 7.5 mg/mL, 2.5 mg/mL, 1.25 mg/mL, 1.0 mg/mL, 2.5 mg, 5.0 mg, 7.5 mg, 13.3 mg/mL, 15.0 mg, 100.0 mg, 50.0 mg, 150.0 mg, 125.0 mg, 250.0 mg, 3.0 mg/mL, 1.0 mg/mg, 3.75 mg/mL, 9.0 mg/mL, 12.5 mg/mL, 25.0 mg/mL, 26.6 mg/mL, 200.0 mg, 60.0 mg, 400.0 mg, 200.0 mg/mL, 30.0 mg/mL, 40.0 mg/mL, 60.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 660.0 mg/mL

, Injection, solution, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Retrobulbar, Injection, solution - Epidural; Infiltration; Intracaudal, Injection, solution - Subarachnoid, Subarachnoid, Epidural; Infiltration; Intracaudal, Injection, solution - Epidural; Retrobulbar, Epidural, Injection, solution - Epidural, Perineural, Injection, solution - Perineural, Injection, solution - Epidural; Infiltration, Epidural; Infiltration, Infiltration, Injection, solution - Infiltration, Injection, solution - Epidural; Intracaudal, Epidural; Intracaudal, Kit, Infiltration; Perineural, Injection, solution - Infiltration; Perineural, Epidural; Infiltration; Intracaudal; Perineural, Epidural; Intracaudal; Perineural, Injection, solution - Epidural; Infiltration; Intracaudal; Perineural, Injection, solution - Epidural; Intracaudal; Perineural, Solution, Solution - Epidural; Infiltration, Intraspinal, Solution - Intraspinal, Solution - Epidural; Retrobulbar, Solution - Infiltration, Liquid, Liquid - Epidural; Retrobulbar, Liquid - Epidural; Infiltration, Liquid - Intraspinal, Liquid - Infiltration, Solution - Epidural; Infiltration; Intracaudal, Kit - Topical, Topical, Injection, suspension, liposomal, Injection, suspension, liposomal - Infiltration, Injection, solution - Intraspinal, Kit - Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue, Kit - Epidural; Infiltration, Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Dental; Infiltration, Dental; Infiltration, Epidural; Infiltration; Intramuscular; Intrasynovial; Soft tissue; Topical, Kit - Epidural; Infiltration; Intramuscular; Intrasynovial; Soft tissue; Topical, Epidural; Infiltration; Intravenous, Kit - Epidural; Infiltration; Intravenous, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular, Epidural; Infiltration; Topical, Kit - Epidural; Infiltration; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Epidural; Infiltration; Intra-articular; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical, Epidural; Parenteral, Injection, Injection - Epidural; Parenteral, Injection - Epidural; Parenteral; Retrobulbar, Spray, metered - Topical, Spray, metered, Epidural; Intra-articular; Intramuscular; Topical, Kit - Epidural; Intra-articular; Intramuscular; Topical, Retrobulbar, Injection - Retrobulbar, Epidural; Parenteral; Retrobulbar, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Epidural; Infiltration; Parenteral, Injection - Epidural; Infiltration; Parenteral, Infiltration; Parenteral, Injection - Infiltration; Parenteral, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Parenteral, Injection - Parenteral, Kit - Epidural; Infiltration; Intracaudal; Perineural, Enteral; Epidural; Intracaudal, Injection, solution - Enteral; Epidural; Intracaudal, Injection - Subarachnoid, Injection - Epidural; Intracaudal; Perineural, Intravenous, Injection - Intravenous, Intra-articular; Intramuscular, Implant, Implant - Parenteral, Solution - Intralesional, Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Kit - Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Intralesional

Psoriasis

Psoriatic Arthritis

Red-Cell Aplasia, Pure

Arthritis, Gouty

General Anesthesia

Epidural Block

Anesthesia, Conduction

Idiopathic Nephrotic Syndrome

Inflammation

Analgesics

Multiple Sclerosis

Bullous dermatitis herpetiformis

Arthroscopy

Lupus

Anemia, Hemolytic

Lymphoma, Non-Hodgkin

Inflammation

Interscalene Nerve Block

Lupus erythematosus cell

Warnings

Bupivacaine Hydrochloride has seven contraindications. It should not be administered while having any of the conditions listed in the following table.

Bupivacaine Hydrochloride Contraindications

Condition

Risk Level

Notes

Coronary Artery Bypass Grafting

Do Not Combine

history of NSAID allergy

Do Not Combine

obstetrical paracervical block anesthesia

Do Not Combine

Asthma

Do Not Combine

obstetrical paracervical block anesthesia

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Bupivacaine may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Bupivacaine may interact with Pulse Frequency

There are 20 known major drug interactions with Bupivacaine Hydrochloride.

Common Bupivacaine Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Bupivacaine.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Bupivacaine.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Bupivacaine.

Azelastine

Major

Bupivacaine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Clomipramine

Major

The metabolism of Clomipramine can be decreased when combined with Bupivacaine.

Bupivacaine Hydrochloride Toxicity & Overdose Risk

The average amount of bupivacaine required to cause seizures in monkeys is 4.4mg/kg, with an average concentration of 4.5 mcg/mL in the bloodstream. The lowest toxic dose of bupivacaine in mice is 6-8mg/kg through an intravenous injection and 38-54mg/kg through a subcutaneous injection. When people have seizures due to bupivacaine, oxygen levels in their blood can drop very quickly, as well as carbon dioxide levels increasing, and pH levels becoming more acidic. It is important to give patients oxygen immediately and effectively to avoid a possible

image of a doctor in a lab doing drug, clinical research

Bupivacaine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Bupivacaine Hydrochloride?

An examination of 288 active trials is being conducted to assess the potential of Bupivacaine Hydrochloride in providing relief for Ulcerative Colitis, Lupus and Rheumatoid Arthritis.

Condition

Clinical Trials

Trial Phases

Lupus

65 Actively Recruiting

Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1

Rheumatoid Arthritis

55 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Labor Pain

0 Actively Recruiting

Osteoarthritis

0 Actively Recruiting

General Anesthesia

1 Actively Recruiting

Phase 4

Regional Analgesia

0 Actively Recruiting

Hypersensitivity

0 Actively Recruiting

Local Analgesia

0 Actively Recruiting

Craniotomy

0 Actively Recruiting

Alopecia Areata

1 Actively Recruiting

Phase 1

Local Anaesthesia therapy

0 Actively Recruiting

Idiopathic Nephrotic Syndrome

0 Actively Recruiting

Ulcerative Colitis

14 Actively Recruiting

Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1

Adrenal Insufficiency

0 Actively Recruiting

induction of Local Anaesthesia

0 Actively Recruiting

Inflammation

0 Actively Recruiting

Open Abdominal Surgery

1 Actively Recruiting

Not Applicable

Multiple Sclerosis

0 Actively Recruiting

Inflammation

0 Actively Recruiting

Tuberculosis, Pulmonary

0 Actively Recruiting

Bupivacaine Hydrochloride Reviews: What are patients saying about Bupivacaine Hydrochloride?

4.7

Patient Review

11/13/2008

Bupivacaine Hydrochloride for Major Nerve Block for Surgery

Patient Review

5/18/2009

Bupivacaine Hydrochloride for Major Nerve Block for Surgery

My doctor gave me five injections of this medication at trigger points in my lower back. It provided me with complete relief for about three hours, which was enough time for me to get up and move around. I wouldn't recommend it as a long-term solution, but it's good for severe pain.

Patient Review

11/17/2008

Bupivacaine Hydrochloride for Administration of Local Anesthetic Drug

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about bupivacaine hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the common name for bupivacaine?

"Bupivacaine is a local anesthetic that numbs the area where it is injected. It works by blocking pain signals from the nerves to the brain. Bupivacaine is sold under the brand names Marcaine and Sensorcaine."

Answered by AI

What class of drug is bupivacaine?

"Bupivacaine is a drug used to prevent pain and induce anesthesia. It belongs to a group of drugs called local anesthetics."

Answered by AI

What is bupivacaine HCL used for?

"Bupivacaine is a local anesthetic that is used to numb an area of the body during or after surgery, childbirth, or dental work. It can also be used to numb the shoulder after surgery for up to 72 hours."

Answered by AI

What is the difference between lidocaine and bupivacaine?

"Xylocaine and Marcaine are local anesthetics that numb the area they are used in. Marcaine is used for a spinal block and lasts longer than Xylocaine. Xylocaine is used for local or regional anesthesia."

Answered by AI