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What is Bextra
ValdecoxibThe Generic name of this drug
Treatment SummaryValdecoxib was taken off the market in 2005 due to worries that it could raise the risk of heart attack and stroke.
Bextrais the brand name
Bextra Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Bextra
Valdecoxib
2001
4
Effectiveness
How Bextra Affects PatientsValdecoxib is a type of nonsteroidal anti-inflammatory drug (NSAID) that selectively blocks the cyclooxygenase-2 (COX-2) enzyme. It is used to reduce inflammation, pain, and fever in those with osteoarthritis and to treat dysmenorrhea and acute pain. Valdecoxib differs from celecoxib in that it doesn't contain a sulfonamide chain and doesn't need to be broken down by the CYP450 enzymes in the body for it to take effect.
How Bextra works in the bodyValdecoxib is designed to reduce inflammation and pain by targeting the enzyme COX-2. This enzyme helps form prostaglandins, which are involved in pain and inflammation. Valdecoxib specifically blocks this enzyme, without affecting platelet aggregation like non-selective NSAIDs.
When to interrupt dosage
The proposed dose of Bextra is influenced by the diagnosed malady, including Primary Dysmenorrhoea, Osteoarthritis (OA) and Rheumatoid Arthritis. The amount of dosage is contingent upon the administration mode (e.g. Tablet, film coated - Oral or Oral) as outlined in the table beneath.Condition
Dosage
Administration
Rheumatoid Arthritis
, 20.0 mg, 10.0 mg
Oral, , Tablet, film coated, Tablet, film coated - Oral
Primary Dysmenorrhoea
, 20.0 mg, 10.0 mg
Oral, , Tablet, film coated, Tablet, film coated - Oral
Osteoarthritis (OA)
, 20.0 mg, 10.0 mg
Oral, , Tablet, film coated, Tablet, film coated - Oral
Warnings
Bextra ContraindicationsCondition
Risk Level
Notes
Postoperative Pain
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Valdecoxib may interact with Pulse Frequency
Common Bextra Drug Interactions
Drug Name
Risk Level
Description
Cabozantinib
Major
The metabolism of Cabozantinib can be decreased when combined with Valdecoxib.
Capecitabine
Major
The metabolism of Capecitabine can be decreased when combined with Valdecoxib.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Valdecoxib.
Dacomitinib
Major
The metabolism of Dacomitinib can be decreased when combined with Valdecoxib.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Valdecoxib.
Bextra Toxicity & Overdose RiskAn overdose of NSAIDs may lead to drowsiness, nausea, vomiting, stomach pain, and internal bleeding. In rare cases, high blood pressure, kidney damage or failure, difficulty breathing, or unconsciousness may occur.
Bextra Novel Uses: Which Conditions Have a Clinical Trial Featuring Bextra?
79 active trials are being conducted to assess the potential of Bextra in alleviating Rheumatoid Arthritis, Osteoarthritis (OA) and Primary Dysmenorrhoea.Condition
Clinical Trials
Trial Phases
Rheumatoid Arthritis
61 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Osteoarthritis (OA)
0 Actively Recruiting
Primary Dysmenorrhoea
2 Actively Recruiting
Phase 4, Not Applicable
Bextra Reviews: What are patients saying about Bextra?
5Patient Review
4/7/2010 I can't believe how much this medication helped me. I feel like a whole new person- it's like a real life fountain of youth! Please bring it back!
5Patient Review
10/1/2011 I felt like this treatment gave me a new body overnight! I was really energized and happy afterwards.
5Patient Review
6/11/20095Patient Review
9/2/20095Patient Review
9/2/2011 After just one dose of this medication, I was so dizzy that I could barely stand. The world around me was spinning and I felt nauseous. This is the first time I've ever had such a reaction to any kind of medicine.
5Patient Review
6/8/2010 I've been itchy for six years straight since taking this medication, and it's only getting worse.
4.7Patient Review
10/2/2010 This treatment is highly effective for me in relieving my arthritis pain. I'm 75 years old and it allows me to stay active. However, I have been unable to find a place to purchase it in the United States.
3Patient Review
2/1/2011 I've had lower back pain for years, but bextra completely alleviated it the very first day I used it.
3Patient Review
2/1/2011 This drug is effective. I'm grateful for modern medicine.
3Patient Review
2/3/2011 This drug is great. It really helped me out.
3Patient Review
2/1/2011 This drug is effective. I'm grateful for modern medicine.
3Patient Review
11/8/2013 Bextra was the only medication that worked for me.
3Patient Review
2/4/2011 This drug is great. It really helped me out.
3Patient Review
2/1/2011 This drug is effective. I appreciate its help.
3Patient Review
2/4/2011 This drug is great. It really helped me.
1Patient Review
3/23/2011 This drug is terrible. It didn't help me at all.
Patient Q&A Section about bextra
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What were the side effects of Bextra?
"The following are potential side effects of the medication: diarrhea, nausea, upset stomach, headache, indigestion, stomach cramps, upper respiratory tract infection, back pain."
Answered by AI
Is Bextra the same as Celebrex?
"Bextra and Celebrex are both part of a group of painkillers that work in a similar way to Vioxx, which was taken off the market after it was linked to heart attacks in people who had used it for a long time. Merck has reached an agreement with most of the thousands of American patients who said they were harmed by its drug, and has agreed to pay them $4.85 billion."
Answered by AI
Why was Bextra taken off the market?
"The FDA requested that Pfizer voluntarily withdraw Bextra from the market because the risks of the drug outweigh the benefits. The FDA Advisory Panel had met on February 16-18, 2005 and recommended that the medication remain on the market."
Answered by AI
Is Bextra still on the market?
"The drug Bextra was removed from the shelves in the United States in 2005. Bextra is a medication that falls under the category of nonsteroidal anti-inflammatory drugs (NSAIDs). The way that Bextra works is by reducing the amount of substances in the body that create inflammation, pain, and fever."
Answered by AI