Aventyl

Postherpetic Neuralgia, Irritable Bowel Syndrome (IBS), Depression + 3 more
Treatment
1 FDA approval
20 Active Studies for Aventyl

What is Aventyl

NortriptylineThe Generic name of this drug
Treatment SummaryNortriptyline hydrochloride is an antidepressant medication derived from amitriptyline. It is used to treat depression and can also be prescribed off-label to treat chronic pain and other conditions.
Pameloris the brand name
image of different drug pills on a surface
Aventyl Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Pamelor
Nortriptyline
1977
190

Approved as Treatment by the FDA

Nortriptyline, also known as Pamelor, is approved by the FDA for 1 uses including Depression .
Depression

Effectiveness

How Aventyl Affects PatientsNortriptyline helps to treat depression by blocking the removal of serotonin and norepinephrine at nerve endings. It also affects the acetylcholine receptor which can cause muscle-related effects.
How Aventyl works in the bodyNortriptyline works by preventing certain brain chemicals (neurotransmitters) from being taken back up into the nerve cells that released them. This helps keep those chemicals active in the brain and helps improve symptoms. Nortriptyline is especially good at blocking the reuptake of noradrenaline, which may be why it is particularly effective at treating symptoms. Nortriptyline also has an affinity for other receptors outside of the brain, such as mACh receptors and histamine receptors.

When to interrupt dosage

The urged dosage of Aventyl is contingent upon the diagnosed state, including Irritable Bowel Syndrome (IBS), Depression and Chronic Pain. The magnitude of dosage varies, in agreement with the method of delivery (e.g. Oral or Capsule) specified in the table beneath.
Condition
Dosage
Administration
Pain, Orofacial
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet - Oral, Tablet
Pain
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet - Oral, Tablet
Depression
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet - Oral, Tablet
Irritable Bowel Syndrome (IBS)
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet - Oral, Tablet
Chronic Pain
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet - Oral, Tablet
Postherpetic Neuralgia
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet - Oral, Tablet

Warnings

Aventyl Contraindications
Condition
Risk Level
Notes
Dibenzazepines
Do Not Combine
Myocardial Infarction
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Nortriptyline may interact with Pulse Frequency
There are 20 known major drug interactions with Aventyl.
Common Aventyl Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Major
Nortriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Nortriptyline is combined with Aclidinium.
Alfuzosin
Major
Nortriptyline may increase the hypotensive activities of Alfuzosin.
Amoxapine
Major
Nortriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amoxapine.
Aripiprazole
Major
Nortriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.
Aventyl Toxicity & Overdose RiskThe lowest toxic dose of nortriptyline in rats has been found to be 405mg/kg. Overdosing on nortriptyline can lead to abnormal heart rhythms, dangerously low blood pressure, heart failure, fluid build-up in the lungs, seizures, loss of consciousness, and depression of the central nervous system. Changes in the electrocardiogram may also be present.
image of a doctor in a lab doing drug, clinical research

Aventyl Novel Uses: Which Conditions Have a Clinical Trial Featuring Aventyl?

222 active clinical trials are currently investigating the potential of Aventyl in providing relief from Pain, Orofacial, Depression and Irritable Bowel Syndrome (IBS).
Condition
Clinical Trials
Trial Phases
Pain, Orofacial
3 Actively Recruiting
Not Applicable, Early Phase 1
Postherpetic Neuralgia
0 Actively Recruiting
Irritable Bowel Syndrome (IBS)
9 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Pain
4 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1
Depression
203 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Chronic Pain
32 Actively Recruiting
Phase 2, Not Applicable, Phase 3

Aventyl Reviews: What are patients saying about Aventyl?

4.7Patient Review
7/26/2015
Aventyl for Neuropathic Pain
I believe this drug should be banned as it destroys peoples' lives.
4.3Patient Review
11/19/2013
Aventyl for Neuropathic Pain
This medication has been really helpful in managing my headaches.
4.3Patient Review
6/27/2016
Aventyl for Neuropathic Pain
This medication has helped me to better tolerate the pain I experience in my legs and feet.
4Patient Review
3/9/2010
Aventyl for Neuropathic Pain
I originally started taking this medication for migraines but found that it helped my fibromyalgia and arthritis more than it helped with headaches.
3.7Patient Review
10/8/2011
Aventyl for Neuropathic Pain
I experienced really bad dry mouth while using this treatment. I had to stop taking it immediately. If anyone knows of a safe way to quit, please let me know.
3.3Patient Review
12/8/2009
Aventyl for Depression
3Patient Review
5/1/2013
Aventyl for Neuropathic Pain
This medication has been very effective in preventing my migraines. However, I now need to take it every night to sleep, which makes me feel dependent and dizzy. It's a necessary evil at this point.
2.7Patient Review
3/24/2008
Aventyl for Depression
2.3Patient Review
7/16/2010
Aventyl for Depression
I took this medication for my depression, but I didn't see any improvements. Additionally, I experienced some pretty unwanted side effects like a dry mouth, decreased sex drive, constipation, and fatigue.
2Patient Review
11/3/2013
Aventyl for Depression
I tried this medication for my depression after getting off of Effexor, but I saw no real improvement. If anything, my appetite increased while taking this.
1.3Patient Review
3/4/2009
Aventyl for Neuropathic Pain
1Patient Review
8/9/2010
Aventyl for Neuropathic Pain
I was really exhausted after taking this medication, to the point where I couldn't function normally. I also felt very heavyheaded and dizzy.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about aventyl

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Aventyl the same as nortriptyline?

"The drug Pamelor, which is used to treat depression and attention-deficit hyperactivity disorder, is also known by the brand name Aventyl in Canada."

Answered by AI

What are the most common side effects of nortriptyline?

"You may experience nausea, drowsiness, weakness or tiredness, excitement or anxiety, nightmares, dry mouth, changes in appetite or weight, or constipation when taking this medication."

Answered by AI

What is Aventyl used for?

"This drug is meant to alleviate mental/mood issues such as depression. It could improve your mood and sense of wellbeing, ease anxiety and tension, and boost your energy levels. This medication is classified as a tricyclic antidepressant."

Answered by AI

When is the best time to take Aventyl?

"Nortriptyline is most often taken once a day, before bedtime. If it is causing drowsiness, it may be taken earlier in the evening. This medication rarely causes stomach upset."

Answered by AI

Clinical Trials for Aventyl

Have you considered Aventyl clinical trials? We made a collection of clinical trials featuring Aventyl, we think they might fit your search criteria.
Have you considered Aventyl clinical trials? We made a collection of clinical trials featuring Aventyl, we think they might fit your search criteria.
Have you considered Aventyl clinical trials? We made a collection of clinical trials featuring Aventyl, we think they might fit your search criteria.