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What is Avalide
IrbesartanThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a medication used to treat swelling and high blood pressure. It was the most commonly prescribed thiazide diuretic, but its use has been declining in favor of other treatments like angiotensin converting enzyme inhibitors. It is often combined with other drugs like angiotensin converting enzyme inhibitors or angiotensin II receptor blockers to treat high blood pressure. Hydrochlorothiazide was approved by the FDA in 1959.
Avaprois the brand name
Avalide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Avapro
Irbesartan
1997
246
Approved as Treatment by the FDA
Irbesartan, also called Avapro, is approved by the FDA for 5 uses such as not adequately controlled with monotherapy and multiple antihypertensive drugs likely required .not adequately controlled with monotherapy
Used to treat not adequately controlled with monotherapy in combination with Hydrochlorothiazide
multiple antihypertensive drugs likely required
Used to treat multiple antihypertensive drugs likely required in combination with Hydrochlorothiazide
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Treatment Naive
Used to treat Treatment Naive in combination with Hydrochlorothiazide
Diabetic Nephropathy
Helps manage Diabetic Nephropathy
Effectiveness
How Avalide Affects PatientsHydrochlorothiazide helps the body get rid of water in the urine by blocking the absorption of sodium and water from the distal convoluted tubule. The dose of hydrochlorothiazide varies from person to person, but is typically between 25-100mg. People with kidney or liver problems need to be careful when taking this medication.
How Avalide works in the bodyHydrochlorothiazide is transported from your bloodstream into cells in your kidneys. It is then taken to the lumen of the tubule by a protein called MRP4. Normally, sodium is reabsorbed into these cells, but hydrochlorothiazide prevents that process. This reduces the concentration gradient between the cells and the tubule, which then reduces the reabsorption of water.
When to interrupt dosage
The measure of Avalide is contingent upon the recognized affliction, including Antepartum magnesium sulfate prophylaxis, blood pressure inadequately managed by monotherapy and antihypertensives. The quantity of dosage differs, depending on the technique of administration (e.g. Tablet, coated - Oral or Oral) as listed in the table below.Condition
Dosage
Administration
Diabetic Nephropathy
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
multiple antihypertensive drugs likely required
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
not adequately controlled with monotherapy
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Treatment Naive
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Avalide has two contraindications, and it should not be administered when encountering any of the conditions indicated in the subsequent table.Avalide ContraindicationsCondition
Risk Level
Notes
Hypesthesia
Do Not Combine
Volume depletion
Do Not Combine
Chronic Kidney Disease
Do Not Combine
Renal Artery Stenosis
Do Not Combine
Type 2 Diabetes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Irbesartan may interact with Pulse Frequency
Common Avalide Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Irbesartan.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Irbesartan.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Irbesartan.
Amifostine
Major
Irbesartan may increase the hypotensive activities of Amifostine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Irbesartan.
Avalide Toxicity & Overdose RiskThe lowest toxic dose of hydrochlorothiazide in rodents is greater than 10g/kg. Those who overdose may experience low levels of potassium, chloride, and sodium. Treatment typically involves replacing fluids and electrolytes, as well as providing oxygen and vasopressors for hypotension.
Avalide Novel Uses: Which Conditions Have a Clinical Trial Featuring Avalide?
158 experiments are presently underway to assess the effects of Avalide in managing Cirrhosis, Edema and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Treatment Naive
0 Actively Recruiting
multiple antihypertensive drugs likely required
0 Actively Recruiting
not adequately controlled with monotherapy
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Avalide Reviews: What are patients saying about Avalide?
5Patient Review
5/23/2011 I had no negative side effects while using this treatment, which is really saying something considering I have a lot of allergies. Unfortunately, my insurance company stopped paying for it and I haven't been able to find anything that works as well without making me feel bad.
5Patient Review
7/14/2011 I've been taking Avalide for a long time and it's really helped me. I'm 92 years old.
5Patient Review
1/20/2014 I have high blood pressure that is within the normal range. No problems here!
5Patient Review
3/25/20115Patient Review
4/3/20115Patient Review
4/6/20115Patient Review
4/8/20115Patient Review
4/9/2011 I've been taking this medication for five years to keep my blood pressure in check. The diuretic effect can be a bit inconvenient, but overall it's not bad. I've been having some trouble getting the prescription filled recently, though.
4.7Patient Review
8/26/2011 I've been taking Avaline for a couple months now, and I can't say that I'm impressed. I'm constantly tired, sweating more than usual, and have started experiencing dizzy spells. Today I found out that there's been a recall on the drug; apparently it lowers blood pressure but comes with some awful side effects.
4.7Patient Review
6/1/2011 I have been on Avalide for several years and it has worked well for me. However, recently I have noticed increased dizziness and numbness in my hands when I sleep.
4.3Patient Review
3/20/20114Patient Review
4/18/2012 I've been taking this medication for six years, and within the last six months have developed severe leg cramps.
4Patient Review
4/20/2011 This was a very good treatment.
4Patient Review
8/24/2013 I noticed that I was feeling very tired, so I went to get my cholesterol and triglyceride levels checked.
3.7Patient Review
10/11/2011 This works well for me as a heart patient.
3.3Patient Review
5/19/2011 I was taking AVALIDE and my insurance changed it to a generic, SERTRALINE HCL 100 MG. My blood pressure has gone up since the switch.
2.7Patient Review
2/18/2012 Avalide is the first medication I've tried that doesn't have any negative side effects. This is amazing because I've tried similar medications to this in the past, and they made me feel terrible. Some of those include Cozaar, Benicar, Lisinopril, etc. With those medications, I constantly felt dizzy, had leg and muscle cramps, felt exhausted, and my ankles would swell up. None of that happens with Avalide though! Even though it's not generic and my insurance company makes me pay more for it, it's totally worth it given how well it works.
2.3Patient Review
9/19/2011 This is the only medication that brought my blood pressure to a truly healthy position, on all other medications I have tried I continue to border on high blood pressure
2.3Patient Review
5/7/2012 This didn't work unfortunately.
Patient Q&A Section about avalide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of Avalide?
"You may experience dizziness, lightheadedness, drowsiness, headache, blurred vision, stomach upset or pain, heartburn, or muscle pain."
Answered by AI
What is avalide used for?
"This drug is used to treat high blood pressure by lowering it. This can help prevent strokes, heart attacks, and kidney problems. This drug contains two different medications, irbesartan and hydrochlorothiazide."
Answered by AI
What is the generic name for Avalide?
"Irbesartan is a medication used to treat high blood pressure, and hydrochlorothiazide is a medication used to treat fluid retention. The 150mg/12.5mg formulation is a combination of both medications, and the 300mg/12.5mg formulation is a higher dose of the combination."
Answered by AI
What type of drug is avalide?
"Avalide is a combination of two drugs, an angiotensin II receptor blocker and a thiazide diuretic (water pill), that is prescribed for the treatment of high blood pressure."
Answered by AI