Avalide

Diabetic Nephropathies, Hypertensive disease, Treatment Naive + 2 more

Treatment

6 FDA approvals

20 Active Studies for Avalide

Treatment for

Diabetic Nephropathies

What is Avalide

IrbesartanThe Generic name of this drug

Treatment SummaryHydrochlorothiazide is a medication used to treat swelling and high blood pressure. It was the most commonly prescribed thiazide diuretic, but its use has been declining in favor of other treatments like angiotensin converting enzyme inhibitors. It is often combined with other drugs like angiotensin converting enzyme inhibitors or angiotensin II receptor blockers to treat high blood pressure. Hydrochlorothiazide was approved by the FDA in 1959.

Avaprois the brand name

Avalide Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Avapro

Irbesartan

1997

246

Approved as Treatment by the FDA

Irbesartan, also called Avapro, is approved by the FDA for 6 uses such as Diabetic Nephropathies and multiple antihypertensive drugs likely required .

Diabetic Nephropathies

Helps manage Diabetic Nephropathy

multiple antihypertensive drugs likely required

Used to treat multiple antihypertensive drugs likely required in combination with Hydrochlorothiazide

Diabetic Nephropathy

Helps manage Diabetic Nephropathy

not adequately controlled with monotherapy

Used to treat not adequately controlled with monotherapy in combination with Hydrochlorothiazide

Hypertensive disease

Helps manage High Blood Pressure (Hypertension)

Treatment Naive

Used to treat Treatment Naive in combination with Hydrochlorothiazide

Effectiveness

How Avalide Affects PatientsHydrochlorothiazide helps the body get rid of water in the urine by blocking the absorption of sodium and water from the distal convoluted tubule. The dose of hydrochlorothiazide varies from person to person, but is typically between 25-100mg. People with kidney or liver problems need to be careful when taking this medication.

How Avalide works in the bodyHydrochlorothiazide is transported from your bloodstream into cells in your kidneys. It is then taken to the lumen of the tubule by a protein called MRP4. Normally, sodium is reabsorbed into these cells, but hydrochlorothiazide prevents that process. This reduces the concentration gradient between the cells and the tubule, which then reduces the reabsorption of water.

When to interrupt dosage

The measure of Avalide is contingent upon the recognized affliction, including Antepartum magnesium sulfate prophylaxis, blood pressure inadequately managed by monotherapy and antihypertensives. The quantity of dosage differs, depending on the technique of administration (e.g. Tablet, coated - Oral or Oral) as listed in the table below.

Condition

Dosage

Administration

Diabetic Nephropathies

150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg

, Tablet - Oral, Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral

Hypertensive disease

150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg

, Tablet - Oral, Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral

not adequately controlled with monotherapy

150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg

, Tablet - Oral, Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral

multiple antihypertensive drugs likely required

150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg

, Tablet - Oral, Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral

Treatment Naive

150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg

, Tablet - Oral, Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Avalide has two contraindications, and it should not be administered when encountering any of the conditions indicated in the subsequent table.Avalide Contraindications

Condition

Risk Level

Notes

Hypesthesia

Do Not Combine

Dehydration

Do Not Combine

Chronic Kidney Disease

Do Not Combine

Renal Artery Stenosis

Do Not Combine

Type 2 Diabetes

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Irbesartan may interact with Pulse Frequency

There are 20 known major drug interactions with Avalide.

Common Avalide Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Irbesartan.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Irbesartan.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Irbesartan.

Amifostine

Major

Irbesartan may increase the hypotensive activities of Amifostine.

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Irbesartan.

Avalide Toxicity & Overdose RiskThe lowest toxic dose of hydrochlorothiazide in rodents is greater than 10g/kg. Those who overdose may experience low levels of potassium, chloride, and sodium. Treatment typically involves replacing fluids and electrolytes, as well as providing oxygen and vasopressors for hypotension.

image of a doctor in a lab doing drug, clinical research

Avalide Novel Uses: Which Conditions Have a Clinical Trial Featuring Avalide?

158 experiments are presently underway to assess the effects of Avalide in managing Cirrhosis, Edema and Congestive Heart Failure.

Condition

Clinical Trials

Trial Phases

not adequately controlled with monotherapy

0 Actively Recruiting

Treatment Naive

0 Actively Recruiting

Hypertensive disease

27 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Diabetic Nephropathies

0 Actively Recruiting

multiple antihypertensive drugs likely required

0 Actively Recruiting