Avalide
Diabetic Nephropathies, Hypertensive disease, Treatment Naive + 2 more
Treatment
6 FDA approvals
20 Active Studies for Avalide
Treatment for
Diabetic Nephropathies
What is Avalide
Irbesartan
The Generic name of this drug
Treatment Summary
Hydrochlorothiazide is a medication used to treat swelling and high blood pressure. It was the most commonly prescribed thiazide diuretic, but its use has been declining in favor of other treatments like angiotensin converting enzyme inhibitors. It is often combined with other drugs like angiotensin converting enzyme inhibitors or angiotensin II receptor blockers to treat high blood pressure. Hydrochlorothiazide was approved by the FDA in 1959.
Avapro
is the brand name
Avalide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Avapro
Irbesartan
1997
246
Approved as Treatment by the FDA
Irbesartan, also called Avapro, is approved by the FDA for 6 uses such as Diabetic Nephropathies and multiple antihypertensive drugs likely required .
Diabetic Nephropathies
Helps manage Diabetic Nephropathy
multiple antihypertensive drugs likely required
Used to treat multiple antihypertensive drugs likely required in combination with Hydrochlorothiazide
Diabetic Nephropathy
Helps manage Diabetic Nephropathy
not adequately controlled with monotherapy
Used to treat not adequately controlled with monotherapy in combination with Hydrochlorothiazide
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Treatment Naive
Used to treat Treatment Naive in combination with Hydrochlorothiazide
Effectiveness
How Avalide Affects Patients
Hydrochlorothiazide helps the body get rid of water in the urine by blocking the absorption of sodium and water from the distal convoluted tubule. The dose of hydrochlorothiazide varies from person to person, but is typically between 25-100mg. People with kidney or liver problems need to be careful when taking this medication.
How Avalide works in the body
Hydrochlorothiazide is transported from your bloodstream into cells in your kidneys. It is then taken to the lumen of the tubule by a protein called MRP4. Normally, sodium is reabsorbed into these cells, but hydrochlorothiazide prevents that process. This reduces the concentration gradient between the cells and the tubule, which then reduces the reabsorption of water.
When to interrupt dosage
The measure of Avalide is contingent upon the recognized affliction, including Antepartum magnesium sulfate prophylaxis, blood pressure inadequately managed by monotherapy and antihypertensives. The quantity of dosage differs, depending on the technique of administration (e.g. Tablet, coated - Oral or Oral) as listed in the table below.
Condition
Dosage
Administration
Diabetic Nephropathies
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Tablet - Oral, Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Tablet - Oral, Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
not adequately controlled with monotherapy
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Tablet - Oral, Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
multiple antihypertensive drugs likely required
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Tablet - Oral, Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Treatment Naive
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Tablet - Oral, Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Avalide has two contraindications, and it should not be administered when encountering any of the conditions indicated in the subsequent table.
Avalide Contraindications
Condition
Risk Level
Notes
Hypesthesia
Do Not Combine
Dehydration
Do Not Combine
Chronic Kidney Disease
Do Not Combine
Renal Artery Stenosis
Do Not Combine
Type 2 Diabetes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Irbesartan may interact with Pulse Frequency
There are 20 known major drug interactions with Avalide.
Common Avalide Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Irbesartan.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Irbesartan.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Irbesartan.
Amifostine
Major
Irbesartan may increase the hypotensive activities of Amifostine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Irbesartan.
Avalide Toxicity & Overdose Risk
The lowest toxic dose of hydrochlorothiazide in rodents is greater than 10g/kg. Those who overdose may experience low levels of potassium, chloride, and sodium. Treatment typically involves replacing fluids and electrolytes, as well as providing oxygen and vasopressors for hypotension.
Avalide Novel Uses: Which Conditions Have a Clinical Trial Featuring Avalide?
158 experiments are presently underway to assess the effects of Avalide in managing Cirrhosis, Edema and Congestive Heart Failure.
Condition
Clinical Trials
Trial Phases
not adequately controlled with monotherapy
0 Actively Recruiting
Treatment Naive
0 Actively Recruiting
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Diabetic Nephropathies
0 Actively Recruiting
multiple antihypertensive drugs likely required
0 Actively Recruiting
Avalide Reviews: What are patients saying about Avalide?
5
Patient Review
5/23/2011
Avalide for High Blood Pressure
5
Patient Review
7/14/2011
Avalide for High Blood Pressure
5
Patient Review
1/20/2014
Avalide for High Blood Pressure
5
Patient Review
3/25/2011
Avalide for High Blood Pressure
5
Patient Review
4/3/2011
Avalide for High Blood Pressure
5
Patient Review
4/6/2011
Avalide for High Blood Pressure
5
Patient Review
4/8/2011
Avalide for High Blood Pressure
5
Patient Review
4/9/2011
Avalide for High Blood Pressure
4.7
Patient Review
8/26/2011
Avalide for High Blood Pressure
4.7
Patient Review
6/1/2011
Avalide for High Blood Pressure
4.3
Patient Review
3/20/2011
Avalide for High Blood Pressure
4
Patient Review
4/18/2012
Avalide for High Blood Pressure
4
Patient Review
4/20/2011
Avalide for High Blood Pressure
4
Patient Review
8/24/2013
Avalide for High Blood Pressure
3.7
Patient Review
10/11/2011
Avalide for High Blood Pressure
3.3
Patient Review
5/19/2011
Avalide for High Blood Pressure
2.7
Patient Review
2/18/2012
Avalide for High Blood Pressure
2.3
Patient Review
9/19/2011
Avalide for High Blood Pressure
2.3
Patient Review
5/7/2012
Avalide for High Blood Pressure
Patient Q&A Section about avalide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What are the side effects of Avalide?
"You may experience dizziness, lightheadedness, drowsiness, headache, blurred vision, stomach upset or pain, heartburn, or muscle pain."
Answered by AI
What is avalide used for?
"This drug is used to treat high blood pressure by lowering it. This can help prevent strokes, heart attacks, and kidney problems. This drug contains two different medications, irbesartan and hydrochlorothiazide."
Answered by AI
What is the generic name for Avalide?
"Irbesartan is a medication used to treat high blood pressure, and hydrochlorothiazide is a medication used to treat fluid retention. The 150mg/12.5mg formulation is a combination of both medications, and the 300mg/12.5mg formulation is a higher dose of the combination."
Answered by AI
What type of drug is avalide?
"Avalide is a combination of two drugs, an angiotensin II receptor blocker and a thiazide diuretic (water pill), that is prescribed for the treatment of high blood pressure."
Answered by AI