Argatroban

Thrombosis prophylaxis, Heparin Induced Thrombocytopenia (HIT), Angioplasty

Treatment

5 FDA approvals

6 Active Studies for Argatroban

Treatment for

Thrombosis prophylaxis

What is Argatroban

ArgatrobanThe Generic name of this drug

Treatment SummaryArgatroban is a medication used to prevent blood clots in people who have had, or are at risk for, heparin-induced thrombocytopenia (HIT). The American College of Cardiologists (ACC) recommends argatroban during percutaneous coronary intervention. It is a non-heparin anticoagulant that helps to normalize platelet counts and stop the formation of clots. Before using argatroban, other anticoagulant medications must be stopped and a baseline activated partial thromboplastin time must be obtained.

Argatrobanis the brand name

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Argatroban Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Argatroban

2000

Approved as Treatment by the FDA

Argatroban, also known as Argatroban, is approved by the FDA for 5 uses such as Thrombosis and Thrombosis .

Thrombosis

Heparin Induced Thrombocytopenia (HIT)

Thrombosis prophylaxis

Angioplasty

Effectiveness

How Argatroban Affects PatientsArgatroban is an anticoagulant medicine used to prevent or treat thrombosis in those with heparin-induced thrombocytopenia. It works by blocking thrombin, an enzyme that helps form blood clots. Argatroban specifically targets thrombin, and does not need another substance to work, unlike some other anticoagulants. It is very selective for thrombin and does not affect other enzymes like trypsin or factor Xa. Argatroban can stop both free-floating and clot-associated thrombin from working.

How Argatroban works in the bodyArgatroban prevents blood clots from forming by inhibiting enzymes that lead to fibrin formation, activation of certain proteins, and platelet aggregation.

When to interrupt dosage

The measure of Argatroban is contingent upon the determined condition, including Heparin Induced Thrombocytopenia (HIT), Angioplasty and Thrombosis prophylaxis. The dosage also fluctuates, depending on the technique of delivery as indicated in the table beneath.

Condition

Dosage

Administration

Thrombosis prophylaxis

, 1.0 mg/mL, 1.25 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 5.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous

Heparin Induced Thrombocytopenia (HIT)

, 1.0 mg/mL, 1.25 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 5.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous

Angioplasty

, 1.0 mg/mL, 1.25 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 5.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous

Warnings

Argatroban has a single contraindication, so it should be avoided when dealing with any of the conditions mentioned in the table below.Argatroban Contraindications

Condition

Risk Level

Notes

Hemorrhage

Do Not Combine

There are 20 known major drug interactions with Argatroban.

Common Argatroban Drug Interactions

Drug Name

Risk Level

Description

Albutrepenonacog alfa

Major

The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Argatroban.

Andexanet alfa

Major

The therapeutic efficacy of Andexanet alfa can be decreased when used in combination with Argatroban.

Anti-inhibitor coagulant complex

Major

The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Argatroban.

Antihemophilic factor (recombinant), PEGylated

Major

The therapeutic efficacy of Antihemophilic factor (recombinant), PEGylated can be decreased when used in combination with Argatroban.

Antihemophilic factor human

Major

The therapeutic efficacy of Antihemophilic factor human can be decreased when used in combination with Argatroban.

Argatroban Toxicity & Overdose RiskTaking too much of a drug may result in excessive bleeding.

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Argatroban Novel Uses: Which Conditions Have a Clinical Trial Featuring Argatroban?

7 active studies are assessing the potential of Argatroban to prevent Thrombosis, Angioplasty and Heparin Induced Thrombocytopenia (HIT).

Condition

Clinical Trials

Trial Phases

Heparin Induced Thrombocytopenia (HIT)

0 Actively Recruiting

Thrombosis prophylaxis

0 Actively Recruiting

Angioplasty

6 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Argatroban Reviews: What are patients saying about Argatroban?

4Patient Review

2/23/2009

Argatroban for Blood Clot with Heparin-Induced Thrombocytopenia during Percutaneous Coronary Intervention

3Patient Review

10/17/2013

Argatroban for Blood Clot with Platelet Decrease due to Heparin

Unfortunately, this drug didn't work for me.

2.3Patient Review

11/10/2009

Argatroban for Blood Clot Prevention with Heparin-Induced Decreased Platelet Count

I was airlifted to a second hospital with an EF of 18%. The doctors began argatroban IV immediately. My EF is now at 42, even with 5 of 6 grafts occluded...

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Patient Q&A Section about argatroban

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the difference between argatroban and heparin?

"Argatroban does not have the same negative side effects as other similar medications. It does not cause HIT antibodies or alter its clearance."

Answered by AI

What is another name for argatroban?

"Argatroban is a medication that is used to treat blood clots. It is a synthetic version of a protein that occurs naturally in the body. Argatroban is used to prevent blood clots from forming or to break up existing blood clots. It is usually given as an injection into a vein."

Answered by AI

Why is argatroban used in HIT?

"Argatroban is a rapidly acting anticoagulant that has been shown to significantly reduce the risk of death or new thrombosis. A study by Lewis et al. found that treatment of HIT with argatroban successfully lowers mortality rates from thrombosis without increased bleeding risk."

Answered by AI

What is argatroban used for?

"Argatroban inhibits blood clotting and prevents the formation of harmful clots in blood vessels. It is used to treat or prevent blood clots in patients taking heparin for bleeding problems."

Answered by AI

Clinical Trials for Argatroban

Have you considered Argatroban clinical trials? We made a collection of clinical trials featuring Argatroban, we think they might fit your search criteria.