Argatroban
Thrombosis prophylaxis, Heparin Induced Thrombocytopenia (HIT), Angioplasty
Treatment
5 FDA approvals
6 Active Studies for Argatroban
Treatment for
Thrombosis prophylaxis
What is Argatroban
Argatroban
The Generic name of this drug
Treatment Summary
Argatroban is a medication used to prevent blood clots in people who have had, or are at risk for, heparin-induced thrombocytopenia (HIT). The American College of Cardiologists (ACC) recommends argatroban during percutaneous coronary intervention. It is a non-heparin anticoagulant that helps to normalize platelet counts and stop the formation of clots. Before using argatroban, other anticoagulant medications must be stopped and a baseline activated partial thromboplastin time must be obtained.
Argatroban
is the brand name
Argatroban Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Argatroban
Argatroban
2000
24
Approved as Treatment by the FDA
Argatroban, also known as Argatroban, is approved by the FDA for 5 uses such as Thrombosis and Thrombosis .
Thrombosis
Thrombosis
Heparin Induced Thrombocytopenia (HIT)
Thrombosis prophylaxis
Angioplasty
Effectiveness
How Argatroban Affects Patients
Argatroban is an anticoagulant medicine used to prevent or treat thrombosis in those with heparin-induced thrombocytopenia. It works by blocking thrombin, an enzyme that helps form blood clots. Argatroban specifically targets thrombin, and does not need another substance to work, unlike some other anticoagulants. It is very selective for thrombin and does not affect other enzymes like trypsin or factor Xa. Argatroban can stop both free-floating and clot-associated thrombin from working.
How Argatroban works in the body
Argatroban prevents blood clots from forming by inhibiting enzymes that lead to fibrin formation, activation of certain proteins, and platelet aggregation.
When to interrupt dosage
The measure of Argatroban is contingent upon the determined condition, including Heparin Induced Thrombocytopenia (HIT), Angioplasty and Thrombosis prophylaxis. The dosage also fluctuates, depending on the technique of delivery as indicated in the table beneath.
Condition
Dosage
Administration
Heparin Induced Thrombocytopenia (HIT)
, 1.0 mg/mL, 1.25 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 5.0 mg/mL
, Intravenous, Injection, solution, Solution - Intravenous, Injection, Solution, Injection - Intravenous, Injection, solution - Intravenous
Thrombosis prophylaxis
, 1.0 mg/mL, 1.25 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 5.0 mg/mL
, Intravenous, Injection, solution, Solution - Intravenous, Injection, Solution, Injection - Intravenous, Injection, solution - Intravenous
Angioplasty
, 1.0 mg/mL, 1.25 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 5.0 mg/mL
, Intravenous, Injection, solution, Solution - Intravenous, Injection, Solution, Injection - Intravenous, Injection, solution - Intravenous
Warnings
Argatroban has a single contraindication, so it should be avoided when dealing with any of the conditions mentioned in the table below.
Argatroban Contraindications
Condition
Risk Level
Notes
Hemorrhage
Do Not Combine
There are 20 known major drug interactions with Argatroban.
Common Argatroban Drug Interactions
Drug Name
Risk Level
Description
Albutrepenonacog alfa
Major
The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Argatroban.
Andexanet alfa
Major
The therapeutic efficacy of Andexanet alfa can be decreased when used in combination with Argatroban.
Anti-inhibitor coagulant complex
Major
The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Argatroban.
Antihemophilic factor (recombinant), PEGylated
Major
The therapeutic efficacy of Antihemophilic factor (recombinant), PEGylated can be decreased when used in combination with Argatroban.
Antihemophilic factor human
Major
The therapeutic efficacy of Antihemophilic factor human can be decreased when used in combination with Argatroban.
Argatroban Toxicity & Overdose Risk
Taking too much of a drug may result in excessive bleeding.
Argatroban Novel Uses: Which Conditions Have a Clinical Trial Featuring Argatroban?
7 active studies are assessing the potential of Argatroban to prevent Thrombosis, Angioplasty and Heparin Induced Thrombocytopenia (HIT).
Condition
Clinical Trials
Trial Phases
Heparin Induced Thrombocytopenia (HIT)
0 Actively Recruiting
Thrombosis prophylaxis
0 Actively Recruiting
Angioplasty
6 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4
Argatroban Reviews: What are patients saying about Argatroban?
4
Patient Review
2/23/2009
Argatroban for Blood Clot with Heparin-Induced Thrombocytopenia during Percutaneous Coronary Intervention
3
Patient Review
10/17/2013
Argatroban for Blood Clot with Platelet Decrease due to Heparin
2.3
Patient Review
11/10/2009
Argatroban for Blood Clot Prevention with Heparin-Induced Decreased Platelet Count
Patient Q&A Section about argatroban
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is the difference between argatroban and heparin?
"Argatroban does not have the same negative side effects as other similar medications. It does not cause HIT antibodies or alter its clearance."
Answered by AI
What is another name for argatroban?
"Argatroban is a medication that is used to treat blood clots. It is a synthetic version of a protein that occurs naturally in the body. Argatroban is used to prevent blood clots from forming or to break up existing blood clots. It is usually given as an injection into a vein."
Answered by AI
Why is argatroban used in HIT?
"Argatroban is a rapidly acting anticoagulant that has been shown to significantly reduce the risk of death or new thrombosis. A study by Lewis et al. found that treatment of HIT with argatroban successfully lowers mortality rates from thrombosis without increased bleeding risk."
Answered by AI
What is argatroban used for?
"Argatroban inhibits blood clotting and prevents the formation of harmful clots in blood vessels. It is used to treat or prevent blood clots in patients taking heparin for bleeding problems."
Answered by AI