Aptiom

Seizures

Treatment

2 FDA approvals

4 Active Studies for Aptiom

Treatment for

Seizures

What is Aptiom

Eslicarbazepine acetateThe Generic name of this drug

Treatment SummaryEslicarbazepine acetate (ESL) is a medication used to treat partial-onset seizures that are not adequately controlled with other treatments. It works by blocking the return of voltage-gated sodium channels to their activated state, thus preventing seizure activity. ESL is sold under the brand names Aptiom, Zebinix, and Exalief and comes in 200, 400, 600, or 800mg tablets that can be taken once daily with or without food. Side effects can include dizziness, drowsiness, nausea, vomiting, diarrhea, headache, difficulty concentrating, slowed thinking and speech, depression, and

Aptiomis the brand name

image of different drug pills on a surface

Aptiom Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Aptiom

Eslicarbazepine acetate

2014

Approved as Treatment by the FDA

Eslicarbazepine acetate, otherwise called Aptiom, is approved by the FDA for 2 uses which include Partial-Onset Seizures and Seizures .

Partial-Onset Seizures

Helps manage Partial-Onset Seizures

Seizures

Helps manage Partial-Onset Seizures

Effectiveness

How Aptiom Affects PatientsEslicarbazepine acetate will increase your heart rate and lengthen the time between each heartbeat as the dose increases.

How Aptiom works in the bodyEslicarbazepine acetate helps reduce seizures by blocking sodium and calcium channels in the brain. These channels control nerve firing, and when they are blocked, it prevents the repeated firing of neurons that can cause seizures. Eslicarbazepine prevents these channels from returning to their active state, which helps reduce epileptic activity.

When to interrupt dosage

The advisable dose of Aptiom is contingent on the identified affliction. The quantity of dosage fluctuates, depending on the approach of administration (e.g. Suspension or Tablet - Oral) as listed in the table beneath.

Condition

Dosage

Administration

Seizures

, 400.0 mg, 600.0 mg, 800.0 mg, 200.0 mg, 50.0 mg/mL

, Oral, Tablet, Tablet - Oral, Kit - Oral, Kit, Suspension, Suspension - Oral

Warnings

Aptiom Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Eslicarbazepine Acetate may interact with Pulse Frequency

There are 20 known major drug interactions with Aptiom.

Common Aptiom Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Eslicarbazepine acetate.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Eslicarbazepine acetate.

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Eslicarbazepine acetate.

Alpelisib

Major

The metabolism of Alpelisib can be increased when combined with Eslicarbazepine acetate.

Aminophylline

Major

The metabolism of Aminophylline can be increased when combined with Eslicarbazepine acetate.

Aptiom Toxicity & Overdose RiskNo studies have been done to examine the effects of eslicarbazepine acetate use in pregnant women. Animal studies have found that taking eslicarbazepine acetate during pregnancy can lead to birth defects, miscarriages, and slowed growth of the fetus. Taking eslicarbazepine acetate can also lead to mild to moderate liver damage, and overdosing can cause symptoms like low sodium levels, dizziness, nausea, vomiting, feeling very relaxed, tingling around the mouth, trouble with balance, double vision, and other symptoms. There is no specific antidote for an overdose of eslicarbazep

Aptiom Novel Uses: Which Conditions Have a Clinical Trial Featuring Aptiom?

Currently, two clinical trials are investigating the potential of Aptiom to provide relief for Seizure symptoms.

Condition

Clinical Trials

Trial Phases

Seizures

4 Actively Recruiting

Phase 3, Phase 2

Aptiom Reviews: What are patients saying about Aptiom?

5Patient Review

2/13/2017

Aptiom for Additional Medication to Treat Partial Seizures

I've been having seizures since the mid-1990's, related to a pituitary tumor. I tried Topamax first and found it uncomfortable. Now I'm using a low dose of Keppra and 1200mg of Aptiom, and no seizures for several years. BUT...it is expensive and if you do not have insurance, it will put you in debt.

5Patient Review

1/12/2018

Aptiom for Simple Seizure

So far, I haven't had any issues with side effects or seizures. This is really good news!

4.3Patient Review

7/7/2015

Aptiom for Additional Medication to Treat Partial Seizures

Aptiom has been a godsend. I've gone from having 3-4 seizures a month to only 3-4 per year. The downside is that I have to take it at night, which can sometimes lead to balance problems. But even that hasn't stopped me from living my life; I went through physical therapy and everything.

3.7Patient Review

10/4/2016

Aptiom for Additional Medication to Treat Partial Seizures

I'm feeling pretty tired and dizzy, plus my vision is blurry. I'm still having seizures unfortunately.

3.3Patient Review

11/22/2017

Aptiom for Additional Medication to Treat Partial Seizures

The side effects are really bad. I was sweating, agitated, and trembling. And the worst part is that it made me think about killing myself and act on impulse. Any drug that has those kinds of side effects shouldn't be allowed on the market.

View All Reviews

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about aptiom

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Aptiom medication used for?

"This drug is used to treat focal seizures. It may help to reduce the number of seizures you have."

Answered by AI

What kind of seizures does Aptiom treat?

"Aptiom is a prescription medicine typically used to treat focal seizures associated with epilepsy in adults and children four years of age or older. Aptiom can be administered orally as a tablet once per day, and can be used alone or in combination with other seizure medicines."

Answered by AI

What are the side effects of Aptiom?

"Common side effects for people taking APTIOM include dizziness, sleepiness, nausea, headache, double vision, vomiting, feeling tired, problems with coordination, blurred vision, and shakiness."

Answered by AI

What does Aptiom do to the brain?

"Aptiom is an antiepileptic (anti-seizure) medication that is believed to work by targeting the activity of sodium channels in the brain. This might help calm down signaling from nerves and brain activity, which can help prevent seizures."

Answered by AI