Aptiom

Seizures

Treatment

2 FDA approvals

4 Active Studies for Aptiom

Treatment for

Seizures

What is Aptiom

Eslicarbazepine acetate

The Generic name of this drug

Treatment Summary

Eslicarbazepine acetate (ESL) is a medication used to treat partial-onset seizures that are not adequately controlled with other treatments. It works by blocking the return of voltage-gated sodium channels to their activated state, thus preventing seizure activity. ESL is sold under the brand names Aptiom, Zebinix, and Exalief and comes in 200, 400, 600, or 800mg tablets that can be taken once daily with or without food. Side effects can include dizziness, drowsiness, nausea, vomiting, diarrhea, headache, difficulty concentrating, slowed thinking and speech, depression, and

Aptiom

is the brand name

image of different drug pills on a surface

Aptiom Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Aptiom

Eslicarbazepine acetate

2014

Approved as Treatment by the FDA

Eslicarbazepine acetate, otherwise called Aptiom, is approved by the FDA for 2 uses which include Partial-Onset Seizures and Seizures .

Partial-Onset Seizures

Helps manage Partial-Onset Seizures

Seizures

Helps manage Partial-Onset Seizures

Effectiveness

How Aptiom Affects Patients

Eslicarbazepine acetate will increase your heart rate and lengthen the time between each heartbeat as the dose increases.

How Aptiom works in the body

Eslicarbazepine acetate helps reduce seizures by blocking sodium and calcium channels in the brain. These channels control nerve firing, and when they are blocked, it prevents the repeated firing of neurons that can cause seizures. Eslicarbazepine prevents these channels from returning to their active state, which helps reduce epileptic activity.

When to interrupt dosage

The advisable dose of Aptiom is contingent on the identified affliction. The quantity of dosage fluctuates, depending on the approach of administration (e.g. Suspension or Tablet - Oral) as listed in the table beneath.

Condition

Dosage

Administration

Seizures

, 400.0 mg, 600.0 mg, 800.0 mg, 200.0 mg, 50.0 mg/mL

, Oral, Tablet, Tablet - Oral, Kit - Oral, Kit, Suspension, Suspension - Oral

Warnings

Aptiom Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Eslicarbazepine Acetate may interact with Pulse Frequency

There are 20 known major drug interactions with Aptiom.

Common Aptiom Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Eslicarbazepine acetate.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Eslicarbazepine acetate.

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Eslicarbazepine acetate.

Alpelisib

Major

The metabolism of Alpelisib can be increased when combined with Eslicarbazepine acetate.

Aminophylline

Major

The metabolism of Aminophylline can be increased when combined with Eslicarbazepine acetate.

Aptiom Toxicity & Overdose Risk

No studies have been done to examine the effects of eslicarbazepine acetate use in pregnant women. Animal studies have found that taking eslicarbazepine acetate during pregnancy can lead to birth defects, miscarriages, and slowed growth of the fetus. Taking eslicarbazepine acetate can also lead to mild to moderate liver damage, and overdosing can cause symptoms like low sodium levels, dizziness, nausea, vomiting, feeling very relaxed, tingling around the mouth, trouble with balance, double vision, and other symptoms. There is no specific antidote for an overdose of eslicarbazep

Aptiom Novel Uses: Which Conditions Have a Clinical Trial Featuring Aptiom?

Currently, two clinical trials are investigating the potential of Aptiom to provide relief for Seizure symptoms.

Condition

Clinical Trials

Trial Phases

Seizures

5 Actively Recruiting

Phase 3, Phase 2, Phase 1

Aptiom Reviews: What are patients saying about Aptiom?

Patient Review

2/13/2017

Aptiom for Additional Medication to Treat Partial Seizures

I've been having seizures since the mid-1990's, related to a pituitary tumor. I tried Topamax first and found it uncomfortable. Now I'm using a low dose of Keppra and 1200mg of Aptiom, and no seizures for several years. BUT...it is expensive and if you do not have insurance, it will put you in debt.

Patient Review

1/12/2018

Aptiom for Simple Seizure

So far, I haven't had any issues with side effects or seizures. This is really good news!

4.3

Patient Review

7/7/2015

Aptiom for Additional Medication to Treat Partial Seizures

Aptiom has been a godsend. I've gone from having 3-4 seizures a month to only 3-4 per year. The downside is that I have to take it at night, which can sometimes lead to balance problems. But even that hasn't stopped me from living my life; I went through physical therapy and everything.

3.7

Patient Review

10/4/2016

Aptiom for Additional Medication to Treat Partial Seizures

I'm feeling pretty tired and dizzy, plus my vision is blurry. I'm still having seizures unfortunately.

3.3

Patient Review

11/22/2017

Aptiom for Additional Medication to Treat Partial Seizures

The side effects are really bad. I was sweating, agitated, and trembling. And the worst part is that it made me think about killing myself and act on impulse. Any drug that has those kinds of side effects shouldn't be allowed on the market.

3.3

Patient Review

12/4/2014

Aptiom for Additional Medication to Treat Partial Seizures

I unfortunately have not been feeling well since I started this medication. Headaches, nausea, muscle pains, and sweats have all become regular occurrences.

Patient Review

1/23/2015

Aptiom for Additional Medication to Treat Partial Seizures

I'm starting to feel nauseated on day four of this 400mg dosage. I puked earlier today. My neurologist wants me to eventually work up to an 800mg night dose, but I'm rethinking that plan after reading the pamphlet that came with the medicine. I do appreciate the 24 hour coverage though.

Patient Review

5/2/2016

Aptiom for Additional Medication to Treat Partial Seizures

I was doing well on the lower dosage of 400mg, but when I was increased to 800mg as per my doctor's suggestion, I began experiencing some serious side effects like headaches and difficulty thinking clearly. So,I went back down to 400mg and have been feeling better since.

2.7

Patient Review

9/21/2015

Aptiom for Additional Medication to Treat Partial Seizures

This medication has made me very tired. I have also experienced dizziness and nausea since the dosage was increased to 800mg.

2.3

Patient Review

11/25/2021

Aptiom for Simple Seizure

After taking my morning dose of Aptiom, I become a different person. I switch from being happy to seeing things like nasty spirits. When it starts levelling down mid afternoon I become more myself. Does not control my partial seizures. And by the way it causes me severe insomnia. It's by far the worse one I have been on.

1.3

Patient Review

12/3/2021

Aptiom for Simple Seizure

I took the pill as directed and within two hours, I was feeling so ill I had to go to bed. It's been 24 hours since I last took one and I'm still experiencing severe side effects.

Patient Review

2/7/2016

Aptiom for Simple Seizure

My girlfriend has been taking this medication for a few weeks now, and she's started seeing evil spirits that keep her up at night. Has anyone else had similar experiences? We're really struggling and could use some help.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about aptiom

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Aptiom medication used for?

"This drug is used to treat focal seizures. It may help to reduce the number of seizures you have."

Answered by AI

What kind of seizures does Aptiom treat?

"Aptiom is a prescription medicine typically used to treat focal seizures associated with epilepsy in adults and children four years of age or older. Aptiom can be administered orally as a tablet once per day, and can be used alone or in combination with other seizure medicines."

Answered by AI

What are the side effects of Aptiom?

"Common side effects for people taking APTIOM include dizziness, sleepiness, nausea, headache, double vision, vomiting, feeling tired, problems with coordination, blurred vision, and shakiness."

Answered by AI

What does Aptiom do to the brain?

"Aptiom is an antiepileptic (anti-seizure) medication that is believed to work by targeting the activity of sodium channels in the brain. This might help calm down signaling from nerves and brain activity, which can help prevent seizures."

Answered by AI