Aplenzin

Smoke, Reducing diet, Seasonal Affective Disorder + 5 more
Treatment
4 FDA approvals
20 Active Studies for Aplenzin

What is Aplenzin

BupropionThe Generic name of this drug
Treatment SummaryBupropion (also known as Wellbutrin®) is a medication used to treat Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. It works by blocking the enzymes that take up norepinephrine and dopamine, which are chemicals in the brain that help regulate mood. Unlike other antidepressants, bupropion does not cause sexual side effects, sedation, or weight gain. When combined with naltrexone (in the product Contrave®) it has been shown to help people lose weight. Bupropion is also sometimes used in combination with
Wellbutrinis the brand name
image of different drug pills on a surface
Aplenzin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Wellbutrin
Bupropion
1986
741

Approved as Treatment by the FDA

Bupropion, also known as Wellbutrin, is approved by the FDA for 4 uses which include Smoking Cessation and Smoke .
Smoking Cessation
Smoke
Depression
Obesity
Used to treat Obesity in combination with Naltrexone

Effectiveness

How Aplenzin Affects PatientsBupropion is a drug that is not related to other commonly used antidepressant medications. It is believed to have a mild stimulant effect and to have some potential for abuse, as well as the ability to lower the seizure threshold. Bupropion can also increase blood pressure, which may be an issue for those with pre-existing hypertension. However, in clinical trials it has not been found to increase the risk of stroke or heart attack.
How Aplenzin works in the bodyBupropion works by preventing norepinephrine and dopamine from leaving the brain. This makes them last longer, and creates effects on the body that are different than other antidepressants. Bupropion is less likely to cause sexual side effects, sedation, or weight gain than other antidepressants. When used to help people quit smoking, bupropion blocks the rewarding effects of nicotine and helps replace the nicotine with its own stimulating effects. When used with naltrexone to help control weight, bupropion and naltrexone work together to reduce appetite and increase energy expenditure. They do this by affecting brain areas that control appetite

When to interrupt dosage

The prescribed dosage of Aplenzin is dependent upon the diagnosed condition, including Depressive Bipolar Disorder, Depression and Disease. The quantum of dosage is contingent upon the delivery approach (e.g. Tablet, extended release or Tablet, film coated, extended release) outlined in the table below.
Condition
Dosage
Administration
Obesity
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Reducing diet
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Seasonal Affective Disorder
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Mood Disorders
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Smoking Cessation
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Attention Deficit Hyperactivity Disorder
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Smoke
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Depression
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit

Warnings

Aplenzin has fifteen contraindications, so it should not be used when confronting any of the conditions documented in the following table.Aplenzin Contraindications
Condition
Risk Level
Notes
Bulimia Nervosa
Do Not Combine
ethanol
Do Not Combine
Hypertensive disease
Do Not Combine
Anorexia Nervosa
Do Not Combine
abrupt cessation of barbiturates
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Epilepsy
Do Not Combine
abrupt cessation of antiepileptic drugs
Do Not Combine
Benzodiazepines
Do Not Combine
Pulse Frequency
Do Not Combine
Anorexia Nervosa
Do Not Combine
Anorexia Nervosa
Do Not Combine
There are 20 known major drug interactions with Aplenzin.
Common Aplenzin Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Bupropion.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Bupropion.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Bupropion.
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Bupropion.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Bupropion.
Aplenzin Toxicity & Overdose RiskOverdosing on a drug may result in seizures, hallucinations, fainting, a rapid heartbeat, and heart failure.
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Aplenzin Novel Uses: Which Conditions Have a Clinical Trial Featuring Aplenzin?

490 active trials are in progress to assess the potential of Aplenzin to treat Attention Deficit Hyperactivity Disorder, Depression and Smoking Cessation.
Condition
Clinical Trials
Trial Phases
Obesity
55 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3
Depression
195 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3
Smoking Cessation
95 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4, Phase 2, Phase 3, Phase 1
Attention Deficit Hyperactivity Disorder
66 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 2, Phase 1, Early Phase 1
Mood Disorders
14 Actively Recruiting
Not Applicable, Early Phase 1, Phase 2, Phase 4, Phase 1, Phase 3
Seasonal Affective Disorder
0 Actively Recruiting
Smoke
0 Actively Recruiting
Reducing diet
0 Actively Recruiting

Aplenzin Reviews: What are patients saying about Aplenzin?

5Patient Review
2/27/2019
Aplenzin for Bipolar Depression
I've been taking this drug for six months and it's done wonders. I was slightly manic after ramping up to the 522mg dosage, but reducing it to 348 has worked great. I still have some issues with sleep, but that could be from other things too. The only way I can afford this medication is through my doctor providing samples, but even so it's worth it because I have more energy and focus than years.
5Patient Review
6/30/2012
Aplenzin for Major Depressive Disorder
I've been on this medication for a year, and it's really helped me. I'm finally losing weight and have a sex drive again. This is the best medicine I've taken so far.
5Patient Review
12/8/2010
Aplenzin for Attention Deficit Disorder with Hyperactivity
I'm not entirely healed yet, but this treatment has helped me a lot.
5Patient Review
12/9/2010
Aplenzin for Bipolar Depression
I was thrilled to see results from this treatment within just one week.
5Patient Review
7/12/2011
Aplenzin for Depression
This seems to be the best formulation I've tried.
View All Reviews
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Patient Q&A Section about aplenzin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can APLENZIN make you gain weight?

"The following antidepressants may cause modest weight gain with long-term use: escitalopram (Lexapro, Cipralex), duloxetine (Cymbalta), and bupropion (Wellbutrin, Forfivo, and Aplenzin)."

Answered by AI

Is APLENZIN the same as Wellbutrin?

"Aplenzin and Wellbutrin XL are both brand-name drugs. Aplenzin does not have a generic form, while Wellbutrin XL does. Brand-name medications are typically more expensive than their generic counterparts. GoodRx.com estimates show that Aplenzin is more costly than both Wellbutrin XL and the generic form of Wellbutrin XL."

Answered by AI

What is APLENZIN used to treat?

"APLENZIN can be used to treat adults with major depressive disorder and to prevent seasonal affective disorder."

Answered by AI

What are the side effects of APLENZIN?

"The following side effects may occur: dry mouth, sore throat, dizziness, nausea, vomiting, ringing in the ears, headache, decreased appetite, weight loss, constipation, trouble sleeping, increased sweating, or shaking (tremor). If you experience any of these side effects, tell your doctor or pharmacist."

Answered by AI

Clinical Trials for Aplenzin

Have you considered Aplenzin clinical trials? We made a collection of clinical trials featuring Aplenzin, we think they might fit your search criteria.
Have you considered Aplenzin clinical trials? We made a collection of clinical trials featuring Aplenzin, we think they might fit your search criteria.
Have you considered Aplenzin clinical trials? We made a collection of clinical trials featuring Aplenzin, we think they might fit your search criteria.
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