Alupent

Chronic Obstructive Pulmonary Disease (COPD), Bronchial Spasm, Asthma + 1 more

Treatment

8 FDA approvals

20 Active Studies for Alupent

Treatment for

Chronic Obstructive Pulmonary Disease (COPD)

What is Alupent

OrciprenalineThe Generic name of this drug

Treatment SummaryA medication used to treat asthma, bronchospasms, and other related lung conditions. It works by stimulating the beta-adrenergic receptors in the lungs, allowing them to open up and improve breathing.

Alupentis the brand name

image of different drug pills on a surface

Alupent Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Alupent

Orciprenaline

1973

Approved as Treatment by the FDA

Orciprenaline, also known as Alupent, is approved by the FDA for 8 uses which include Bronchospasm and Pulmonary Emphysema .

Bronchospasm

Pulmonary Emphysema

Helps manage Pulmonary Emphysema

Chronic Bronchitis

Helps manage Chronic Bronchitis

Asthma

Helps manage Asthma

Bronchial Spasm

Chronic Obstructive Pulmonary Disease (COPD)

Helps manage Pulmonary Emphysema

Bronchitis, Chronic

Helps manage Chronic Bronchitis

Asthma

Helps manage Asthma

Effectiveness

How Alupent Affects PatientsOrciprenaline, also known as metaproterenol, is a drug that helps to open up the airways in the lungs and make it easier to breathe. It works by targeting certain cells and enzymes in the lungs, which causes them to relax and reduces the release of substances that can cause allergic reactions.

How Alupent works in the bodyOrciprenaline works by stimulating certain receptors in the lungs, uterus, and muscles. It activates an enzyme called adenylate cyclase, which produces a molecule called cAMP. This molecule helps the cells respond to the drug and carries out its effects.

When to interrupt dosage

The recommended dosage of Alupent is contingent upon the indicated ailment, e.g. Chronic Bronchitis, Bronchospasm and Asthma. The amount of dosage can be found in the table below, contingent upon the method of administration (e.g. Oral or Liquid - Respiratory (inhalation)).

Condition

Dosage

Administration

Chronic Obstructive Pulmonary Disease (COPD)

10.0 mg/mL, , 10.0 mg, 20.0 mg, 0.75 mg, 6.0 mg/mL, 4.0 mg/mL, 0.65 mg, 15.0 mg/mL, 2.0 mg/mL, 50.0 mg/mL

, Oral, Syrup, Syrup - Oral, Tablet, Tablet - Oral, Aerosol, Liquid, Solution, Solution - Respiratory (inhalation), Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Liquid - Respiratory (inhalation), Aerosol - Respiratory (inhalation)

Bronchial Spasm

10.0 mg/mL, , 10.0 mg, 20.0 mg, 0.75 mg, 6.0 mg/mL, 4.0 mg/mL, 0.65 mg, 15.0 mg/mL, 2.0 mg/mL, 50.0 mg/mL

Asthma

10.0 mg/mL, , 10.0 mg, 20.0 mg, 0.75 mg, 6.0 mg/mL, 4.0 mg/mL, 0.65 mg, 15.0 mg/mL, 2.0 mg/mL, 50.0 mg/mL

Bronchitis, Chronic

10.0 mg/mL, , 10.0 mg, 20.0 mg, 0.75 mg, 6.0 mg/mL, 4.0 mg/mL, 0.65 mg, 15.0 mg/mL, 2.0 mg/mL, 50.0 mg/mL

Warnings

Alupent has one contraindication and must not be used when encountering any of the conditions shown in the following table.Alupent Contraindications

Condition

Risk Level

Notes

Cardiac Arrhythmia

Do Not Combine

There are 20 known major drug interactions with Alupent.

Common Alupent Drug Interactions

Drug Name

Risk Level

Description

Iobenguane

Major

Orciprenaline can cause a decrease in the absorption of Iobenguane resulting in a reduced serum concentration and potentially a decrease in efficacy.

1-benzylimidazole

Minor

The risk or severity of hypertension can be increased when Orciprenaline is combined with 1-benzylimidazole.

2,5-Dimethoxy-4-ethylamphetamine

Minor

The risk or severity of hypertension can be increased when Orciprenaline is combined with 2,5-Dimethoxy-4-ethylamphetamine.

2,5-Dimethoxy-4-ethylthioamphetamine

Minor

The risk or severity of hypertension can be increased when Orciprenaline is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.

4-Bromo-2,5-dimethoxyamphetamine

Minor

The risk or severity of hypertension can be increased when Orciprenaline is combined with 4-Bromo-2,5-dimethoxyamphetamine.

Alupent Toxicity & Overdose RiskOverdosing on amiodarone may result in chest pain, high or low blood pressure, abnormal heart rhythms, anxiety, headache, trembling, dry mouth, rapid heart rate, nausea, dizziness, tiredness, general discomfort, and trouble sleeping. The lowest toxic dose of amiodarone in rats has been found to be 42mg/kg.

image of a doctor in a lab doing drug, clinical research

Alupent Novel Uses: Which Conditions Have a Clinical Trial Featuring Alupent?

162 ongoing trials are examining the efficacy of Alupent in providing relief from Chronic Obstructive Pulmonary Disease (COPD), Chronic Bronchitis and Asthmatic conditions.

Condition

Clinical Trials

Trial Phases

Asthma

88 Actively Recruiting

Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 1, Phase 3

Bronchial Spasm

0 Actively Recruiting

Bronchitis, Chronic

0 Actively Recruiting

Chronic Obstructive Pulmonary Disease (COPD)

0 Actively Recruiting

Alupent Reviews: What are patients saying about Alupent?

5Patient Review

10/27/2009

Alupent for Asthma Attack

I was switched to this medication because albuterol caused me a lot of problems. I'm happy to say that I didn't experience any negative side effects with alupent. It really helped me and I'm grateful for it.

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Patient Q&A Section about alupent

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of drug is Alupent?

"Alupent is a bronchodilator that is used to relieve bronchial asthma and bronchospasm that may be associated with bronchitis and emphysema."

Answered by AI

What is the generic name for Alupent?

"The generic name for Metaproterenol Inhaler is metaproterenol."

Answered by AI

What is Alupent used for?

"This medication is used to treat wheezing and shortness of breath caused by lung problems such as asthma, chronic obstructive pulmonary disease (COPD), bronchitis, and emphysema. Controlling these symptoms can decrease time missed from work or school. Metaproterenol belongs to a class of drugs known as bronchodilators."

Answered by AI