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What is Alupent
OrciprenalineThe Generic name of this drug
Treatment SummaryA medication used to treat asthma, bronchospasms, and other related lung conditions. It works by stimulating the beta-adrenergic receptors in the lungs, allowing them to open up and improve breathing.
Alupentis the brand name
Alupent Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Alupent
Orciprenaline
1973
10
Approved as Treatment by the FDA
Orciprenaline, also known as Alupent, is approved by the FDA for 4 uses which include Bronchospasm and Chronic Bronchitis .Bronchospasm
Chronic Bronchitis
Helps manage Chronic Bronchitis
Asthma
Helps manage Asthma
Chronic Obstructive Pulmonary Disease (COPD)
Helps manage Pulmonary Emphysema
Effectiveness
How Alupent Affects PatientsOrciprenaline, also known as metaproterenol, is a drug that helps to open up the airways in the lungs and make it easier to breathe. It works by targeting certain cells and enzymes in the lungs, which causes them to relax and reduces the release of substances that can cause allergic reactions.
How Alupent works in the bodyOrciprenaline works by stimulating certain receptors in the lungs, uterus, and muscles. It activates an enzyme called adenylate cyclase, which produces a molecule called cAMP. This molecule helps the cells respond to the drug and carries out its effects.
When to interrupt dosage
The recommended dosage of Alupent is contingent upon the indicated ailment, e.g. Chronic Bronchitis, Bronchospasm and Asthma. The amount of dosage can be found in the table below, contingent upon the method of administration (e.g. Oral or Liquid - Respiratory (inhalation)).Condition
Dosage
Administration
Chronic Obstructive Pulmonary Disease (COPD)
10.0 mg/mL, , 10.0 mg, 20.0 mg, 0.75 mg, 6.0 mg/mL, 4.0 mg/mL, 0.65 mg, 15.0 mg/mL, 2.0 mg/mL, 50.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, Tablet - Oral, Aerosol, Liquid, Solution, Solution - Respiratory (inhalation), Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Liquid - Respiratory (inhalation), Aerosol - Respiratory (inhalation)
Asthma
10.0 mg/mL, , 10.0 mg, 20.0 mg, 0.75 mg, 6.0 mg/mL, 4.0 mg/mL, 0.65 mg, 15.0 mg/mL, 2.0 mg/mL, 50.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, Tablet - Oral, Aerosol, Liquid, Solution, Solution - Respiratory (inhalation), Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Liquid - Respiratory (inhalation), Aerosol - Respiratory (inhalation)
Chronic Bronchitis
10.0 mg/mL, , 10.0 mg, 20.0 mg, 0.75 mg, 6.0 mg/mL, 4.0 mg/mL, 0.65 mg, 15.0 mg/mL, 2.0 mg/mL, 50.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, Tablet - Oral, Aerosol, Liquid, Solution, Solution - Respiratory (inhalation), Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Liquid - Respiratory (inhalation), Aerosol - Respiratory (inhalation)
Bronchospasm
10.0 mg/mL, , 10.0 mg, 20.0 mg, 0.75 mg, 6.0 mg/mL, 4.0 mg/mL, 0.65 mg, 15.0 mg/mL, 2.0 mg/mL, 50.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, Tablet - Oral, Aerosol, Liquid, Solution, Solution - Respiratory (inhalation), Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Liquid - Respiratory (inhalation), Aerosol - Respiratory (inhalation)
Warnings
Alupent has one contraindication and must not be used when encountering any of the conditions shown in the following table.Alupent ContraindicationsCondition
Risk Level
Notes
Cardiac Arrhythmia
Do Not Combine
Common Alupent Drug Interactions
Drug Name
Risk Level
Description
Iobenguane
Major
Orciprenaline can cause a decrease in the absorption of Iobenguane resulting in a reduced serum concentration and potentially a decrease in efficacy.
1-benzylimidazole
Minor
The risk or severity of hypertension can be increased when Orciprenaline is combined with 1-benzylimidazole.
2,5-Dimethoxy-4-ethylamphetamine
Minor
The risk or severity of hypertension can be increased when Orciprenaline is combined with 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamine
Minor
The risk or severity of hypertension can be increased when Orciprenaline is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
Minor
The risk or severity of hypertension can be increased when Orciprenaline is combined with 4-Bromo-2,5-dimethoxyamphetamine.
Alupent Toxicity & Overdose RiskOverdosing on amiodarone may result in chest pain, high or low blood pressure, abnormal heart rhythms, anxiety, headache, trembling, dry mouth, rapid heart rate, nausea, dizziness, tiredness, general discomfort, and trouble sleeping. The lowest toxic dose of amiodarone in rats has been found to be 42mg/kg.
Alupent Novel Uses: Which Conditions Have a Clinical Trial Featuring Alupent?
162 ongoing trials are examining the efficacy of Alupent in providing relief from Chronic Obstructive Pulmonary Disease (COPD), Chronic Bronchitis and Asthmatic conditions.Condition
Clinical Trials
Trial Phases
Asthma
160 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1, Phase 3
Chronic Obstructive Pulmonary Disease (COPD)
11 Actively Recruiting
Phase 3, Phase 4, Phase 1, Phase 2, Not Applicable
Bronchospasm
0 Actively Recruiting
Chronic Bronchitis
5 Actively Recruiting
Not Applicable, Phase 3, Phase 4
Alupent Reviews: What are patients saying about Alupent?
5Patient Review
10/27/2009 I was switched to this medication because albuterol caused me a lot of problems. I'm happy to say that I didn't experience any negative side effects with alupent. It really helped me and I'm grateful for it.
Patient Q&A Section about alupent
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the generic name for Alupent?
"The generic name for Metaproterenol Inhaler is metaproterenol."
Answered by AI
What is Alupent used for?
"This medication is used to treat wheezing and shortness of breath caused by lung problems such as asthma, chronic obstructive pulmonary disease (COPD), bronchitis, and emphysema. Controlling these symptoms can decrease time missed from work or school. Metaproterenol belongs to a class of drugs known as bronchodilators."
Answered by AI
Is Alupent still available?
"The brand name Alupent is no longer being used, but generic versions may be available."
Answered by AI